INTRODUCTION

CLINMISKIN contains Clindamycin which belongs to the group of medicines called Topical antibiotics. It is indicated in the topical treatment of acne vulgaris. Acne vulgaris is a common skin condition that occurs in teens, when hair follicles of the skin plug with oil and dead skin cells. Symptoms includes inflammation, large, reddish pus-filled pimples and formation of comedones.

Clindamycin deeply penetrates into the skin and kills the pimple-causing bacteria by inhibiting the bacterial protein synthesis. It is for external use only. Apply a thin layer of this medicine on the affected area as required. Topical application of clindamycin may also result in systemic absorption and can cause diarrhea, bloody diarrhea or colitis (including pseudomembranous colitis) in patients. In such cases, contact your doctor immediately.

The most common side effects of this medicine are application site reactions such as itching, burning, peeling of skin, dryness or seborrhoea. Do not touch, rub or scratch the affected area. Regularly use moisturizers to soothe and hydrate the affected area. If it does not get better, contact your doctor. Before applying this medicine, inform your doctor if you have or ever had any GI disorders. CLINMISKIN should be used with caution in pregnant or breastfeeding women. Consult your doctor before application.

USES OF CLINMISKIN

• Treats acne vulgaris

HOW CLINMISKIN WORKS

Topically applied clindamycin penetrates deep into the skin and kills the acne-producing bacteria by inhibiting the bacterial protein synthesis. It acts by reversibly binding to the 50S ribosomal subunits of the bacteria, which prevents peptide bond formation thus inhibiting bacterial protein synthesis. Inhibition of protein synthesis stops the growth of acne-producing bacteria leading to prevention of acne outbreaks.

DIRECTIONS FOR USE

Apply this medicine as directed by your physician. It is for external use only. Shake well before use. Wash the affected area before application. Apply a thin film of the medicine to the affected skin surface once or twice daily. Replace the cap tightly after use. Wash your hands thoroughly after application. Avoid contact of this medicine with eyes, ears, nose or mouth. If this happens, rinse it thoroughly with plenty of cool water. Continue to apply this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF CLINMISKIN

HOW TO MANAGE SIDE EFFECTS

Skin irritation or dryness:

Avoid hot showers because hot water can irritate the skin. Do not rub or scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use moisturizers to soothe and hydrate the affected area. If it does not get better, speak to your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your healthcare provider about all the medicines you take, including:

• any other skin products that contain benzoyl peroxide

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT CLINMISKIN

Can I apply CLINMISKIN on my face?

Yes. This medicine is intended for application on the face to cure acne outbreaks.

How to use CLINMISKIN?

Wash your face and pat it dry. Apply a thin film of the medicine to the affected skin surface once or twice daily. Wash your hands thoroughly after application.

Can I apply moisturizer after applying CLINMISKIN?

Yes. If your skin feels too dry after using this medicine, you can apply a moisturizer to soothe and hydrate the affected area.

REFERENCES

1. KD. Tripathi. Macrolide, Lincosamide, Glycopeptide and Other Antibacterial Antibiotics; Urinary Antiseptics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 756-757.

2. KD. Tripathi. Drugs Acting on Skin and Mucous Membranes. Essentials of medical pharmacology. Seventh edition. 2013. Page – 894.

3. Conan MacDougall and Henry F. Chambers. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1534-1535.

4. Gerald G. Briggs and Roger K. Freeman. C. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 856-857.

5. Stiefel. Trial of Clindamycin / Benzoyl Peroxide Gel in Subjects with Acne. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on November 2016] [Accessed 9th December 2020] https://clinicaltrials.gov/ct2/show/NCT00776919

6. Akorn, Inc. Bioequivalence Study of Clindamycin Gel 1% in Treatment of Acne Vulgaris. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on October 2020] [Accessed 9th December 2020] https://clinicaltrials.gov/ct2/show/NCT03522441

7. Bhavik Bhavsar, Bimal Choksi, Jayesh Sanmukhani, Alka Dogra, Rizwan Haq, Sudhanshu Mehta, Santanu Mukherjee, V Subramanian, Shafiq Sheikh and Ravindra Mittal. Clindamycin 1% Nano-emulsion Gel Formulation for the Treatment of Acne Vulgaris: Results of a Randomized, Active Controlled, Multicentre, Phase IV Clinical Trial. NCBI; PMC US National Library of Medicine, National Institute of Health. January-August 2014. [Accessed 9th December 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190779/

8. Pfizer Service Company BVBA. Electronic Medicines Compendium (EMC); [Revised on October 2020] [Accessed 9th December 2020] https://www.medicines.org.uk/emc/files/pil.3844.pdf