New Revised MRP, 100% GST benefit passed CLEXANE 40mg Prefilled Syringe(Pfs) 10X0.4ml
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INTRODUCTION ABOUT CLEXANE 40MG PREFILLED SYRINGE(PFS)
CLEXANE 40MG PREFILLED SYRINGE(PFS) contains Enoxaparin which belongs to the group of medicines called Anticoagulants. It is used to manage blood clot formation in the body.
CLEXANE 40MG PREFILLED SYRINGE(PFS) works by stopping the blood clots formation. It also manages the existing blood clots from growing bigger in size. Due to this property, it is highly used as a prophylactic therapy for managing blood clot formation during risky conditions that involves clot formation such as before or after a surgery, during dialysis or after a heart attack or a severe chest pain (angina).
It can also be used to reduce the risk of blood clot formation caused due to prolong period of immobility or due to cancer therapy.
Before receiving CLEXANE 40MG PREFILLED SYRINGE(PFS) inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have diabetes, high blood pressure or a history of stomach ulcer.
CLEXANE 40MG PREFILLED SYRINGE(PFS) is not recommended for use in patients who are bleeding heavily or have any pre-existing conditions (such as stomach ulcer or stroke) that can increase the risk of internal bleeding. It is also not suitable for use in patients scheduled for spinal anesthesia or lumbar puncture.
Inform your doctor before receiving CLEXANE 40MG PREFILLED SYRINGE(PFS) if you are pregnant or breastfeeding. The most common side effects of receiving CLEXANE 40MG PREFILLED SYRINGE(PFS) are injection site reactions (such as pain or irritation), skin rashes, low platelet count, bleeding or bruising and headache. Consult your doctor if any of these side effect worsens.
USES OF CLEXANE 40MG PREFILLED SYRINGE(PFS)
- Manage and manages blood clots in the body
HOW CLEXANE 40MG PREFILLED SYRINGE(PFS) WORKS
CLEXANE 40MG PREFILLED SYRINGE(PFS) is an anticoagulant medicine. It inactivates certain proteins (such as coagulation factor II a and X a) in the blood that causes blood clotting. This reduces the chances of blood clot formation within the body which therefore manages blockage of blood vessels.
DIRECTIONS FOR USE
CLEXANE 40MG PREFILLED SYRINGE(PFS) will be given to you only by a doctor or a nurse into the vein (intravenously) or under the skin (subcutaneously).
It can also be self-administered by the patients if advised by the physician. Carefully, follow the instructions given by the doctor in case of self-administration.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF CLEXANE 40MG PREFILLED SYRINGE(PFS)
COMMON
- Bleeding, bruising
- Injection site reactions (such as pain or redness)
- pinky patches on the skin (especially in the injection site)
- skin rash, itching, redness
- low RBC count in blood
- headache
UNCOMMON
- sudden severe headache
- tender and swollen stomach
RARE
- increased blood potassium levels
- hair loss
- osteoporosis (weak and brittle bones)
- tingling, numbness and muscular weakness (especially in the lower part of the body) especially if you have had a spinal puncture or a spinal anesthetic
- loss of control over the intestine or bladder
Contact your doctor immediately if you experience any of the following side effects after receiving CLEXANE 40MG PREFILLED SYRINGE(PFS):
- severe allergic reactions (such as skin rash, itching, swelling of the face, mouth, throat, tongue leading to difficulty in breathing or swallowing)
- signs of excessive bleeding (excessive weakness, tiredness, paleness, dizziness, headache or unexplained swelling)
- severe skin reactions (such as skin rash, itching, skin redness with blisters or peeling of the skin, which may be associated with high fever and joint pains, dark red spots under the skin)
- cramping pain, redness, warmth, swelling in one of the legs
- breathlessness, chest pain, coughing up blood
HOW TO MANAGE SIDE EFFECTS
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Injection Site Reactions
Place an ice pack on the affected area. Do not frequently move the injection site. Consult your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredCLEXANE 40MG PREFILLED SYRINGE(PFS) should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before receiving it.
BREASTFEEDING
Use with CautionCLEXANE 40MG PREFILLED SYRINGE(PFS) should be used with caution in breastfeeding women. Therefore, consult your doctor before receiving it.
DRIVING AND USING MACHINES
Use with CautionCLEXANE 40MG PREFILLED SYRINGE(PFS) does not affect your ability to drive or operate machinery. However, do not drive or handle any heavy tools or machines if your ability is affected by CLEXANE 40MG PREFILLED SYRINGE(PFS).
ALCOHOL
Consult your doctorAvoid consumption of alcohol before receiving CLEXANE 40MG PREFILLED SYRINGE(PFS).
KIDNEY
Use with CautionCLEXANE 40MG PREFILLED SYRINGE(PFS) should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.
LIVER
Use with CautionCLEXANE 40MG PREFILLED SYRINGE(PFS) should be used with caution in patients with liver problems. Therefore, consult your doctor before receiving it.
ALLERGY
ContraindicatedTalk to your doctor before receiving CLEXANE 40MG PREFILLED SYRINGE(PFS) if you are allergic to Enoxaparin or to any other low molecular weight heparins (such as nadroparin, tinzaparin or dalteparin).
HEART DISEASE
Use with CautionCLEXANE 40MG PREFILLED SYRINGE(PFS) should be used with caution in patients fitted with heart valves and in patients with heart problems (such as heart infections or high blood pressure). Therefore, consult your doctor before receiving it.
USE IN PEDIATRICS
Consult your doctorThe safety and effectiveness of CLEXANE 40MG PREFILLED SYRINGE(PFS) have not been established in children and adolescents (aged below 18 years). Your doctor will decide about administering CLEXANE 40MG PREFILLED SYRINGE(PFS) to your child after evaluating the risks and benefits of the therapy.
USE IN GERIATRICS
Use with CautionCLEXANE 40MG PREFILLED SYRINGE(PFS) should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor before receiving it.
OTHERS
CLEXANE 40MG PREFILLED SYRINGE(PFS) is not recommended for use if you:
- have a previous history of heparin-induced thrombocytopenia (low platelet count in blood)
- have antibodies against enoxaparin in your blood
- are bleeding heavily
- have any internal condition that can increase the risk of heavy bleeding (such as stomach ulcer, stroke, surgery)
- are scheduled for any spinal procedures (such as spinal anesthesia or lumbar puncture)
Before receiving CLEXANE 40MG PREFILLED SYRINGE(PFS), inform your doctor if you:
- have a history of stomach ulcers
- recently had stroke
- have diabetes
- have diabetic retinopathy (eye damage caused due to diabetes)
- recently had surgery on your brain or eyes
- are underweight or overweight
- have hyperkalemia (high blood potassium levels)
INTERACTIONS
A. Drug-Drug interactions:
Before receiving CLEXANE 40MG PREFILLED SYRINGE(PFS), inform your doctor if you are taking any of the following medicines:
- warfarin (a medicine used for blood thinning)
- other medicines used to stop blood clots from forming (Ex. aspirin, clopidogrel, dipyridamole)
- dextran injection (used to replace blood)
- medicines used to relieve pain and swelling (Ex. ibuprofen, diclofenac, ketorolac, tromethamine)
- medicines used to manage asthma, rheumatoid arthritis, and other conditions (Ex. prednisolone, dexamethasone)
- medicines that increase blood potassium levels (Ex. spironolactone, triamterene, amiloride)
- sulfinpyrazone (used to manage gout)
Overdosage:
CLEXANE 40MG PREFILLED SYRINGE(PFS) will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
SYNOPSIS
| Drug | : | Enoxaparin |
| Pharmacological Category | : | Parenteral Anticoagulants |
| Therapeutic Indication | : | Blood clots |
| Dosage Forms | : | Injection, Pre-filled syringes (PFS), Pen, Cartridge |
MORE INFORMATION
- Keep CLEXANE 40MG PREFILLED SYRINGE(PFS) out of reach of children
- Store CLEXANE 40MG PREFILLED SYRINGE(PFS) at room temperature
FAQs ABOUT CLEXANE 40MG PREFILLED SYRINGE(PFS)
Q: What is the use of CLEXANE 40MG PREFILLED SYRINGE(PFS)?
A: CLEXANE 40MG PREFILLED SYRINGE(PFS) is an anticoagulant used to manage blood clots in the body. It works by stopping the blood clots formation and manages the existing blood clots from growing bigger in size.
Q: How CLEXANE 40MG PREFILLED SYRINGE(PFS) works?
A: CLEXANE 40MG PREFILLED SYRINGE(PFS) is an anticoagulant medicine. It inactivates certain proteins (such as coagulation factor II a and X a) in the blood that causes blood clotting. This reduces the chances of blood clot formation within the body which therefore manages blockage of blood vessels.
Q: How CLEXANE 40MG PREFILLED SYRINGE(PFS) is administered?
A: CLEXANE 40MG PREFILLED SYRINGE(PFS) will be given to you only by a doctor or a nurse into the vein (intravenously) or under the skin (subcutaneously). It can also be self-administered by the patients if advised by the physician. Carefully, follow the instructions given by the doctor in case of self-administration.
Q: What precautions must be followed while receiving CLEXANE 40MG PREFILLED SYRINGE(PFS)?
A: Before receiving CLEXANE 40MG PREFILLED SYRINGE(PFS) inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have diabetes, high blood pressure or a history of stomach ulcer. CLEXANE 40MG PREFILLED SYRINGE(PFS) is not recommended for use in patients who are bleeding heavily or have any pre-existing conditions (such as stomach ulcer or stroke) that can increase the risk of internal bleeding. It is also not suitable for use in patients scheduled for spinal anesthesia or lumbar puncture. Inform your doctor before receiving CLEXANE 40MG PREFILLED SYRINGE(PFS) if you are pregnant or breastfeeding.
Q: Is CLEXANE 40MG PREFILLED SYRINGE(PFS) safe?
A: CLEXANE 40MG PREFILLED SYRINGE(PFS) is considered safe at the doses administered by the physician. However, consult your doctor if you experience any unusual side effects.
Q: What are the common side effects of receiving CLEXANE 40MG PREFILLED SYRINGE(PFS)?
A: The most common side effects of receiving CLEXANE 40MG PREFILLED SYRINGE(PFS) are injection site reactions (such as pain or irritation), skin rashes, low platelet count, bleeding or bruising and headache. Consult your doctor if any of these side effect worsens.
Q: Can the use of CLEXANE 40MG PREFILLED SYRINGE(PFS) make me bleed more?
A: As CLEXANE 40MG PREFILLED SYRINGE(PFS) is a blood thinning medicine, it makes your blood thin and flowy which might increase the risk of excessive bleeding. To avoid this, your doctor will carefully evaluate your condition and prescribe a suitable dose for you. As a precaution, you must also inform your doctor if you have or recently had any surgery or have any pre-existing conditions (such as stomach ulcer or stroke) that can increase the risk of internal bleeding.
Q: Can CLEXANE 40MG PREFILLED SYRINGE(PFS) be used during heart attack?
A: CLEXANE 40MG PREFILLED SYRINGE(PFS) can be used to manage blood clots in patients who suffered a heart attack. However, consult your doctor before taking it.
Q: Who should not receive CLEXANE 40MG PREFILLED SYRINGE(PFS)?
A: CLEXANE 40MG PREFILLED SYRINGE(PFS) is not recommended for use in patients who are bleeding heavily or have any pre-existing conditions (such as stomach ulcer or stroke) that can increase the risk of internal bleeding. It is also not suitable for use in patients scheduled for spinal anaesthesia or lumbar puncture.
Q: Can I stop receiving CLEXANE 40MG PREFILLED SYRINGE(PFS) once my symptoms subside?
A: Do not stop taking CLEXANE 40MG PREFILLED SYRINGE(PFS) without consulting your doctor. You need to receive CLEXANE 40MG PREFILLED SYRINGE(PFS) for the duration recommended by your doctor to achieve complete management of blood clot formation within your body.
Q: Is CLEXANE 40MG PREFILLED SYRINGE(PFS) heparin?
A: Yes. CLEXANE 40MG PREFILLED SYRINGE(PFS) contains a medicine called enoxaparin which is a low molecular weight heparin.
Q: Can I use CLEXANE 40MG PREFILLED SYRINGE(PFS) during pregnancy?
A: CLEXANE 40MG PREFILLED SYRINGE(PFS) should be used with caution in pregnant women especially those with a mechanical heart valve. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before receiving CLEXANE 40MG PREFILLED SYRINGE(PFS).
Q: Can CLEXANE 40MG PREFILLED SYRINGE(PFS) be used in children?
A: The safety and effectiveness of CLEXANE 40MG PREFILLED SYRINGE(PFS) have not been established in children and adolescents (aged below 18 years). Your doctor will decide about administering CLEXANE 40MG PREFILLED SYRINGE(PFS) to your child after evaluating the risks and benefits of the therapy.
Q: Can CLEXANE 40MG PREFILLED SYRINGE(PFS) be given IV?
A: CLEXANE 40MG PREFILLED SYRINGE(PFS) will be given to you only by a physician or a nurse under the skin (subcutaneously). It can also be given into your vein (intravenously) during surgeries or after heart attack. Your doctor will decide the appropriate route of administration for you depending upon your medical condition.
Q: Can CLEXANE 40MG PREFILLED SYRINGE(PFS) cause thrombocytopenia?
A: CLEXANE 40MG PREFILLED SYRINGE(PFS) can lower your blood platelet count (thrombocytopenia), making you bruise more easily than usual. Consult your doctor if you experience any unusual bruising.
REFERENCES
1. KD. Tripathi. Drugs affected coagulation, bleeding and thrombosis. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 619.
2. Takeo Nomura, Mika Takahashi, Kazunori Iwasaki, Tomoya Oribe, Mayuka Shinohara, Yuko Fukuda, Shinsuke Mizoguchi, Fuminori Sato, Hiromitsu Mimata. Efficacy and Safety of Enoxaparin for Preventing Venous Thromboembolic Events following Urologic Laparoscopic Surgery. International Scholarly Research Notices. April 2013. [Accessed on 28th October 2022] https://www.hindawi.com/journals/isrn/2013/415918/
3. Health-Med spólka z ograniczona odpowiedzialnoscia spólka jawna. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 28th October 2022] https://www.medicines.org.uk/emc/files/pil.782.pdf
4. Sanofi-aventis U.S. LLC. Enoxaparin. [Revised in April 2022] [Accessed on 28th October 2022] https://products.sanofi.us/lovenox/lovenox.pdf
5. Bharat Serums and Vaccines Limited. Lonopin. Enoxaparin Injection. IP. 20mg/40mg/60mg. [Revised in November 2018]. [Accessed on 28th October 2022] https://bsvgroup.com/assets/pdf/products/Re-LONOPIN-20-40-60mg-Common-Pack-Insert-for-Domestic-(Zen-Pharma-LL)-03-12-18-App.pdf
6. Central Drugs Standard Control Organization. Enoxaparin Sodium Injection (Addl. Indication). [Revised in August 2009]. Sodium Enoxaparin (LMWH) [Revised in March 1992]. Enoxaparin Sodium Inj. [Revised in March 2000]. [Accessed on 28th October 2022] https://cdscoonline.gov.in/CDSCO/Drugs
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