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INTRODUCTION
CANDITRAL 200MG contains itraconazole which belongs to a group of medicines called antifungals. It used for infections caused by fungi or yeasts in adults such as infections of mouth or vagina, skin infections and infections affecting other parts of the body. It acts by inhibiting the fungal cytochrome P-450 dependent enzyme lanosterol which in turn blocks the conversion of lanosterol to ergosterol, which disrupts the synthesis of fungal cell membrane.
It may take a few weeks for the skin patches to completely clear up and may take several months for finger and toenails to completely clear up after the treatment with this medicine. Your skin or nail will only look normal after new skin or nail has grown, even though the medicine has killed the fungus.
CANDITRAL 200MG are not normally given to children under 12 years of age. Always take this medicine straight after a meal as this helps your body to use the medicine. Swallow the medicine whole with some liquid. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, or pancreas problems. Pregnant and breastfeeding women. The most common side effects are nausea, vomiting, headache.
USES OF CANDITRAL 200MG
- Treat infections caused by fungi and yeasts
HOW CANDITRAL 200MG WORKS
Itraconazole acts by inhibiting the fungal cytochrome P-450 dependent enzyme lanosterol which in turn blocks the conversion of lanosterol to ergosterol, which disrupts the synthesis of fungal cell membrane.
DIRECTIONS FOR USE
Always take CANDITRAL 200MG exactly as prescribed by your doctor. Swallow the medicine whole with plenty of water.
SIDE EFFECTS OF CANDITRAL 200MG
SERIOUS
- signs of allergy such as rash, hives, severe irritation of your skin, swelling of the face, lips, tongue or other parts of the body
- severe peeling and/ or rashes of skin associated with fever, chills, aching muscles
- tingling sensation, numbness or weakness in limbs
- signs of liver problem such as yellowing of your skin or whites of your eyes, lack of appetite, tiredness, stomach pain, muscle weakness, unusually dark urine, pale stools or hair loss
- signs of heart failure such as shortness of breath, unexpected weight gain, swelling of your legs or abdomen, feeling unusually tired or waking up short of breath at night
COMMON
- stomach ache
- nausea, vomiting
- headache
RARE
- increases in liver function tests
- unexpected passing of urine or need to urinate more often
- problems with the sight including blurred vision and double vision
- change in taste
- certain blood disorders which may increase risk of the infections
- ringing in your ears
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Keep try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
Headache:
Rest and drink plenty of fluids. Apply a cold, wet cloth or ice pack to your forehead. Rest in a quiet, comfortable, dark room.
Stomach pain:
Try to rest and relax. You can eat and drink slowly or have frequent meals. Keeping a heat pad or a covered hot water pack on your stomach may also help. If still pain persists, speak to your doctor.
Diarrhea:
Drink lot of fluid, such as water or squash, to avoid dehydration. Do not take any other medicine without consulting your doctor.
WARNING & PRECAUTIONS
PREGNANCY
CANDITRAL 200MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
CANDITRAL 200MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate any machinery while taking this medicine, it may make you feel dizziness, blurred vision.
ALCOHOL
Avoid consumption of alcohol while taking this medicine.
KIDNEY
CANDITRAL 200MG should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.
LIVER
CANDITRAL 200MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic to the medicine.
LUNGS
CANDITRAL 200MG should be taken with caution in patients with lung disease. Consult your doctor for advice.
HEART DISEASE
If you have any heart related problems, consult your doctor for advice before taking this medicine.
INTERACTIONS
Talk to your doctor if you are taking:
- medicines used for hay fever or allergy
- medicines to lower cholesterol
- medicines used for an irregular heartbeat
- medicines used to treat the angina and high blood pressure
- medicines used for migraine headaches called dihydroergotamine and ergotamine
- medicines used for the treatment of drug abuse called levacetylmethadol and methadone
- cisapride
- colchicine (in patients with kidney and liver problems as well)
- eplerenone
- ergometrine (ergonovine) and methylergometrine (methylergonovine)
- halofantrine
SYNOPSIS
| Drug | : | Itraconazole |
| Pharmacological Category | : | Antifungal medicine |
| Therapeutic Indication | : | Fungal infections |
| Dosage Forms | : | Tablet, Capsule, Eye ointment, Eye drops, Powder, Gel, Cream, Soap |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT CANDITRAL 200MG
Is CANDITRAL 200MG a steroid?
CANDITRAL 200MG can not only decrease the fungal colonization but also can be considered as steroid sparing agent with decreasing the inflammation and polyposis.
What are the common side effects of CANDITRAL 200MG?
Nausea, vomiting, diarrhea, headache, stomach upset, or dizziness may occur. If any of the effects of last or get worse, tell your doctor.
How long does it to take for a fungal skin infection to clear up?
The symptoms of fungal infections, such as itching or soreness, should get the better within a few days of the treatment. Red and scaly skin may take longer to get the better. You may need a treatment for the 1 to 4 weeks.
REFERENCES
1. Goodman and Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical, 2011. Page – 1578.
2. Ya-Chu Tsai and Tsen-Fang Tsai; Itraconazole in the Treatment of Nonfungal Cutaneous Diseases: A Review; [Published on April 2019] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522620/
3. Laboratorios LICONSA, S.A; Electronic Medicines Compendium (EMC); [Revised on Aug 2019] [Accessed 02 NOV 2020] https://www.medicines.org.uk/emc/files/pil.5914.pdf
4. Janssen-Cilag SpA, Via C Janssen, 04100 Borgo San Michele, Latina, Italy; Electronic Medicines Compendium (EMC); [Revised on May 2015] [Accessed 02 NOV 2020] https://www.medicines.org.uk/emc/files/pil.1513.pdf
5. EOP leaflet NL/H/0640-641; [Revised on 3 Nov 2009] [Accessed 02 NOV 2020] https://mri.cts-mrp.eu/human/downloads/NL_H_0745_001_FinalPL_5of7.pdf
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