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INTRODUCTION
CALPOL 500MG TABLET contains Paracetamol which belongs to the group of medicines called Analgesics and Antipyretics. It is used to relieve mild to moderate pain (including headaches, backache, toothache, severe nerve pain, sore throat, period pain, low back and leg pain, muscle, connective tissue and joint pain, symptomatic relief of sprains, strain, joint swelling and stiffness). It is also used to lower fever (high body temperature) and relieve cold or flu symptoms.
Before taking CALPOL 500MG TABLET, inform your doctor if you or your child have liver or kidney problems or any allergies. It should be used with caution in patients with liver problems due to alcohol to prevent the risk of liver damage.
CALPOL 500MG TABLET should be used with caution in pregnant women only if clearly advised by the doctor and can be used in breastfeeding women. CALPOL 500MG TABLET is not recommended for use in children less than 10 years of age and should be used with caution in elderly patients.
Consult your doctor if you experience any side effects or unusual effects during treatment with CALPOL 500MG TABLET.
USES OF CALPOL 500MG TABLET
- relieves mild to moderate pain (such as headache, toothache, joint pain)
- lowers fever and relieves the symptoms of cold or flu
HOW CALPOL 500MG TABLET WORKS
CALPOL 500MG TABLET relieves pain by increasing the pain threshold by inhibiting certain enzymes (COX-1 and COX-2) involved in the synthesis of chemicals responsible for inducing pain (prostaglandins). It reduces fever by directly acting on heat-regulating centers in the brain, resulting in vessel relaxation, sweating and loss of body heat.
DIRECTIONS FOR USE
Take CALPOL 500MG TABLET as advised by your physician. It can be taken with or without food.
For Tablet, Capsule: Swallow CALPOL 500MG TABLET with a glass of water. Do not crush or chew the medicine.
For Dispersible Tablet: Disperse the medicine in the specified quantity of water as mentioned on the label. Consume the medicine immediately after reconstitution.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the condition.
SIDE EFFECTS OF CALPOL 500MG TABLET
RARE
- reduced white blood cells (infections are more likely to occur)
Stop taking CALPOL 500MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction (swelling of the hands, feet, ankles, face, lips or throat which may cause trouble swallowing or breathing, an itchy, lumpy rash or nettle rash, runny nose)
WARNING & PRECAUTIONS
PREGNANCY
CALPOL 500MG TABLET should be used with caution in pregnant women only if considered clearly necessary. Your doctor may use the lowest possible dose to reduce the pain and fever only for a shorter duration in pregnant women. Consult your doctor before taking CALPOL 500MG TABLET.
BREASTFEEDING
CALPOL 500MG TABLET should be used with caution in breastfeeding women. Consult your doctor before taking it.
DRIVING AND USING MACHINES
CALPOL 500MG TABLET has no influence on the ability to drive and operate machinery.
ALCOHOL
CALPOL 500MG TABLET should be used with caution in patients with chronic alcoholism. Consult your doctor before taking it.
KIDNEY
CALPOL 500MG TABLET should be used with caution in patients with severe kidney problems. Consult your doctor before taking it.
LIVER
CALPOL 500MG TABLET should be used with caution in patients with severe liver problems or liver problems due to alcohol. Consult your doctor before taking it.
ALLERGY
Do not take CALPOL 500MG TABLET if you are allergic to Paracetamol or any other ingredients of this medicine.
OTHERS
Before taking CALPOL 500MG TABLET, inform your doctor if you:
- have sepsis (circulation of bacteria and their toxins in the blood leading to organ damage)
- are malnourished
Use in pediatrics:
CALPOL 500MG TABLET is not recommended for use in children less than 10 years of age. It can be used in children and adolescents aged above 10 and your child’s doctor may adjust the dose based on the child’s age and body weight. Consult your child’s doctor for advice.
Use in geriatrics:
CALPOL 500MG TABLET should be used with caution in elderly patients. Consult your doctor before taking it.
INTERACTIONS
A. Drug - Drug interactions:
Before taking CALPOL 500MG TABLET, inform your doctor if you are taking any of the following medicines:
- other medicines containing paracetamol
- medicines to treat nausea and vomiting (Ex. metoclopramide, domperidone)
- cholestyramine (used to control blood lipid levels)
- warfarin (used for treating blood clots)
- medicines used to treat bacterial infections (Ex. rifampicin, flucloxacillin, chloramphenicol)
Overdosage:
If you or anyone else accidentally takes too much of CALPOL 500MG TABLET, consult your doctor immediately or visit the nearby hospital, even if you feel well, as it can cause delayed, serious liver damage.
SYNOPSIS
| Drug | : | Paracetamol |
| Pharmacological Category | : | Para aminophenol derivative |
| Therapeutic Indication | : | Pain, Fever |
| Dosage Forms | : | Tablet, Dispersible tablet, Drops, Syrup, Oral suspension, Liquid, Oral solution, Suppositories, Infusion, Injection |
MORE INFORMATION
- Keep CALPOL 500MG TABLET out of reach of children
- Store below 25°C
FAQs ABOUT CALPOL 500MG TABLET
What if I forget to take a dose of CALPOL 500MG TABLET?
If you forget to take a dose of CALPOL 500MG TABLET, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not take the medicine twice to make up for the missed dose.
Can CALPOL 500MG TABLET be used during pregnancy?
CALPOL 500MG TABLET should be used with caution in pregnant women only if considered clearly necessary. Your doctor may use the lowest possible dose to reduce the pain and fever only for a shorter duration in pregnant women. Consult your doctor before taking CALPOL 500MG TABLET.
How does CALPOL 500MG TABLET work?
CALPOL 500MG TABLET relieves pain by increasing the pain threshold by inhibiting certain enzymes (COX-1 and COX-2) involved in the synthesis of chemicals responsible for inducing pain (prostaglandins). It reduces fever by directly acting on heat-regulating centers in the brain, resulting in vessel relaxation, sweating and loss of body heat.
Can CALPOL 500MG TABLET be used in children?
CALPOL 500MG TABLET is not recommended for use in children less than 10 years of age. It can be used in children and adolescents aged above 10 and your child’s doctor may adjust the dose based on the child’s age and body weight. Consult your child’s doctor for advice.
Is CALPOL 500MG TABLET safe to use in patients with liver problems?
CALPOL 500MG TABLET should be used with caution in patients with severe liver problems or liver problems due to alcohol. Your doctor may monitor your liver function test before and during treatment with this medicine to prevent the risk of liver damage. Consult your doctor before taking CALPOL 500MG TABLET.
REFERENCES
1. Tilo Grosser, Emer Smyth and Garret A. FitzGerald. Anti-inflammatory, Antipyretic and Analgesic agents; Pharmacotherapy of gout. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 693.
2. KD. Tripathi. NSAIDs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 206.
3. Ulderico Freo, Chiara Ruocco, Alessandra Valerio, Irene Scagnol and Enzo Nisoli. Paracetamol: A Review of Guideline Recommendations. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. August 2021. [Accessed on 12th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347233/
4. Ohashi N and Kohno T. Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action. Pharmacology. Frontiers. November 2020. [Accessed on 12th August 2022] https://www.frontiersin.org/articles/10.3389/fphar.2020.580289/full
5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 12th August 2022] https://www.medicines.org.uk/emc/files/pil.1958.pdf
6. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 12th August 2022] https://www.medicines.org.uk/emc/files/pil.4195.pdf
7. GlaxoSmithKline Asia Private Limited. Crocin 500 mg and Crocin 650 mg (Paracetamol). [Accessed on 12th August 2022] https://www.crocin.com/content/dam/cf-consumer-healthcare/panadol/en_in/adult/productshots/pdfs/Crocin-650-mg-Product-Info.pdf
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- Liver function test
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 27 Mar 2023 | 05:45 PM(IST)
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