BARINAT 4 Tablet 14's

Arthritis Rx required

Best Price* ₹ 335.20 MRP ₹ 419.00
(Inclusive of all taxes) *14 Tablet(s) in a Strip * Mkt: Natco Pharma Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

BARINAT 4 contains Baricitinib which belongs to a group of medicines called Janus kinase inhibitors, which reduces inflammation. It is indicated to treat moderate to severe rheumatoid arthritis and atopic dermatitis (atopic eczema). Rheumatoid arthritis is an inflammatory disease of the joints. This medicine can also be used alone or together with some other medicines.

Baricitinib is a selective and reversible inhibitor of Janus kinase (JAK)1 and JAK2, which inhibits Janus kinase (JAK) enzymes, which are intracellular enzymes involved in stimulating hematopoiesis and immune cell function through a signaling pathway. JAKs activates signal transducers and activators of transcription (STATs), which regulate gene expression and intracellular activity.  

Always take BARINAT 4 exactly as directed by your doctor. Tell your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding. This medicine is not recommended for use in children and adolescents below 18 years of age. The common side effects are headache, nausea, vomiting, cough and infections.

USES OF BARINAT 4

  • Treats rheumatoid arthritis and atopic dermatitis (atopic eczema)

HOW BARINAT 4 WORKS

For rheumatoid arthritis, BARINAT 4 works by reducing the activity of an enzyme called Janus kinase, which is involved in inflammation. By reducing the activity of this enzyme, it helps to reduce pain, stiffness and swelling in your joints, tiredness and helps to slow down the damage to the bone and cartilage in the joints.

For atopic dermatitis, BARINAT 4 works by reducing the activity of Janus kinase enzyme, and helps to improve the condition of skin and reduce itching. It also helps to improve your sleep disturbance (due to itch) and overall quality of life.

DIRECTIONS FOR USE

Always take BARINAT 4 exactly as your doctor has told you. Swallow this medicine with a glass of water and do not crush or chew.  

SIDE EFFECTS OF BARINAT 4

SERIOUS

  • painful skin rash with blisters and fever
  • chest tightness, wheezing
  • dizziness or light-headedness
  • swelling of the lips, tongue or throat
  • hives (itching or skin rash)
  • abdominal pain accompanied with fever, nausea and vomiting

COMMON

  • throat and nose infections
  • high levels of blood fat
  • cold sores  
  • infection causing a sick stomach or diarrhoea  
  • urinary infection
  • pneumonia  
  • high number of platelets  
  • headache
  • nausea
  • stomach pain
  • high levels of liver enzymes
  • rash
  • acne  
  • increase in enzymes

HOW TO MANAGE SIDE EFFECTS

Nausea:

Stick to regular meals and do not eat spicy foods.

Headache:

Rest and drink plenty of fluids. Apply a wet or cold cloth to forehead and rest in a quiet, comfortable, dark room.

Stomach pain:

Place a warm bottle or heated bag on your abdomen and drink plenty of clear fluids and water. 

WARNING & PRECAUTIONS

PREGNANCY

BARINAT 4 is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your Doctor.

BREASTFEEDING

BARINAT 4 is not recommended during breastfeeding. Discuss the risks and benefits with your Doctor.

DRIVING AND USING MACHINES

BARINAT 4 has no effect on the ability to drive and use machines.

KIDNEY

BARINAT 4 should be used with caution in patients suffering from kidney function impairment or active kidney diseases. Consult your doctor for advice.

LIVER

BARINAT 4 should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.

ALLERGY

Tell your doctor if you are allergic (hypersensitive) to Baricitinib.

OTHERS

Tell your physician, if you have or had:

  • any infections
  • tuberculosis
  • herpes infection (shingles)
  • hepatitis B or C
  • are going to have vaccine
  • cancer
  • blood clots in the veins of your legs or lungs
  • diverticulitis

INTERACTIONS

Tell your doctor if you are taking,

  • probenecid (used for gout)
  • injectable anti-rheumatic medicine
  • targeted biologic (antibody) therapies
  • azathioprine, tacrolimus, ciclosporin (used to control the body’s immune response)
  • ruxolitinib
  • non-steroidal anti-inflammatory medicines, opioids (treats pain)
  • corticosteroids (treats inflammatory conditions)

SYNOPSIS

Drug :   Baricitinib
Pharmacological Category :   Janus kinase inhibitors
Therapeutic Indication :   Treats rheumatoid arthritis and atopic dermatitis (atopic eczema)
Dosage Forms :   Tablet

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT BARINAT 4

Can BARINAT 4 be used during breastfeeding?

No, it should not be used during breastfeeding. Consult your doctor for advice.

Does BARINAT 4 cause nausea?

It may cause nausea in some individuals, if this persists for a long time. Consult your doctor for advice.

Is BARINAT 4 safe?

Yes, it is safe if prescribed by your physician. However, tell your doctor if you have any liver, kidney or heart diseases.

REFERENCES

1. Fabrizio Cantini, Laura Niccoli, Daniela Matarrese, Emanuele Nicastri, Paolo Stobbione and Delia Goletti. Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact. April 23, 2020. [Accessed on June 17, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177073/

2. Roy Fleischmann, Jahangir Alam, Vipin Arora, John Bradley, Douglas E Schlichting, David Muram and Josef S Smolen. Safety and efficacy of baricitinib in elderly patients with rheumatoid arthritis. August 1, 2017. [Revised on Sep 05, 2017] [Accessed on June 17, 2021] https://rmdopen.bmj.com/content/rmdopen/3/2/e000546.full.pdf

3. Napolitano M, Fabbrocini G, Cinelli E, Stingeni L, Patruno. Profile of Baricitinib and Its Potential in the Treatment of Moderate to Severe Atopic Dermatitis: A Short Review on the Emerging Clinical Evidence. Dec 03, 2019. [Accessed on June 17, 2021] https://www.dovepress.com/profile-of-baricitinib-and-its-potential-in-the-treatment-of-moderate--peer-reviewed-fulltext-article-JAA

4. Eli Lilly Nederland B. Electronic Medicines Compendium (EMC); [Revised on Nov, 2020] [Accessed on June 17, 2021] https://www.medicines.org.uk/emc/files/pil.2434.pdf

5. Lilly S.A. Feb 13, 2017. [Accessed on June 17, 2021] https://www.ema.europa.eu/en/documents/product-information/olumiant-epar-product-information_en.pdf

6. Eli Lilly Canada Inc. [Revised on August 14, 2018] [Accessed on June 17, 2021]  https://pdf.hres.ca/dpd_pm/00046964.PDF

PRODUCT DETAILS

    Country Of Origin
    India
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BARINAT 4 Tablet 14's

BARINAT 4 Tablet 14's Mkt: Natco Pharma Ltd

M.R.P.: Rs.419.00
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