INTRODUCTION

AZIRIN 500MG contain Azithromycin which belongs to a group of medicine called macrolide antibiotics. It is used to treat infections caused by micro-organisms such as bacteria including chest, throat or nasal infection, ear infections, skin and soft tissue infections, sexually transmitted diseases and infection of the tube that carries urine from the bladder (urethra) or the neck of the womb (cervix).

AZIRIN 500MG is a broad-spectrum type of antibiotic. It is effective in killing many types of gram-positive bacteria, some types of gram-negative bacteria and other microorganisms. This medicine is not recommended for use in children and adolescents under 45 kg. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.

USES OF AZIRIN 500MG

Treat bacterial infections such as

• chest, throat, or nasal infections (such as bronchitis, pneumonia, tonsillitis, sore throat and sinusitis)
• ear infections
• skin and soft tissue infections (such as abscess or boil)
• sexually transmitted diseases caused by Chlamydia trachomatis and Neisseria gonorrhoea
• infection of the tube that carries urine from the bladder (urethra) or the neck of the womb (cervix) caused by Chlamidia trachomatis

HOW AZIRIN 500MG WORKS

AZIRIN 500MG inhibits the synthesis of essential protein required by bacteria to grow and multiply and thus prevents the infection from spreading.

DIRECTIONS FOR USE

Always take AZIRIN 500MG exactly as your doctor has told you. It must be taken with or without food. Try to take this medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.

SIDE EFFECTS OF AZIRIN 500MG

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. Eat and drink slowly and smaller and frequent meals. Applying a heat pad or covered hot water bottle on your stomach may also help. If still pain persists, speak to your doctor.

Nausea and Vomiting:

Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.

Headache:

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor if you are taking,

• colchicine (used to treat gout and familial mediterranean fever)
• antacids (used to treat heartburn and indigestion)
• ergot derivatives such as ergot or ergotamine (used to treat migraine)
• warfarin (used to prevent blood clots)
• ciclosporin (used to suppress the immune system to prevent and treat rejection of a transplanted organ or bone marrow)
• digoxin (used to treat heart failure)
• terfenadine (used to treat hay fever or a skin allergy)
• statins (used for cholesterol lowering medicines)
• cisapride (used to treat stomach problems)
• zidovudine or nelfinavir (used to treat HIV infections)
• rifabutin (used to treat tuberculosis)
• quinidine (used to treat heart rhythm problems)
• theophylline (used to treat breathing problems such as asthma and chronic obstructive pulmonary disease)
• pimozide (used to treat mental health problems)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT AZIRIN 500MG

Can AZIRIN 500MG be crushed?

No, swallow the medicine as whole with a drink of water. Do not crush or chew the medicine.

REFERENCES

1. Bertram G. Katzung, Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidinones, Basic & Clinical Pharmacology, Fourteenth Edition, 2015. Page - 820.

2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 360-365.

3. Fabian Yuh Shiong Kong 1, Patrick Horner 2 3, Magnus Unemo 4, Jane S Hocking 1. Pharmacokinetic considerations regarding the treatment of bacterial sexually transmitted infections with azithromycin: a review. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. 1 May 2019. [Accessed 10 Nov 2020] https://pubmed.ncbi.nlm.nih.gov/30649333/

4. Zentiva Pharma UK Limited; Electronic Medicines Compendium (EMC); [Revised on Jul 2020] [Accessed 10 Nov 2020] https://www.medicines.org.uk/emc/files/pil.8663.pdf

5. APL Swift Services (Malta) Limited; Electronic Medicines Compendium (EMC); [Revised on Apr 2018] [Accessed 10 Nov 2020] https://www.medicines.org.uk/emc/files/pil.2276.pdf

USEFUL DIAGNOSTIC TESTS

• Complete Blood Count
• Peripheral Smear Examination