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Introduction About AVIL INJECTION
AVIL INJECTION contains Pheniramine which belongs to the group of medicines called Antihistamines. It is used in the management of allergic conditions (such as hay fever, angioneurotic oedema, drug rashes, serum sickness, allergic conjunctivitis, food allergy), conditions of the respiratory tract which involves increased secretions (vasomotor rhinitis, acute rhinitis).
It is also used to manage itching skin conditions (such as neurodermatitis, lichen planus, eczema, acute and chronic urticaria, pruritus in jaundice and diabetes, pruritis of the anus or genitals, radiation sickness). It is also used to manage motion sickness and nausea, vomiting and vertigo due to Meniere’s disease (diseases of the inner ear) and other disturbances.
AVIL INJECTION should be used with caution in patients having asthma, severe liver or heart diseases, narrow angle glaucoma (increased pressure within the eye) or men with enlarged prostate.
AVIL INJECTION should be used with caution in pregnant and breast-feeding women only if clearly advised by the doctor. AVIL INJECTION is not recommended for use in premature infants and new-born babies.
The most common side effect of receiving AVIL INJECTION is sedation (sleepiness). Inform your doctor if the symptom worsens or bothers you.
Uses Of AVIL INJECTION
Manage:
- allergic conditions (such as hay fever, angioneurotic oedema, drug rashes, serum sickness, allergic conjunctivitis, food allergy)
- conditions of the respiratory tract which involves increased secretions (vasomotor rhinitis, acute rhinitis)
- itching skin conditions (such as neurodermatitis, lichen planus, eczema, acute and chronic urticaria, pruritus in jaundice and diabetes, pruritis of the anus or genitals, radiation sickness)
- motion sickness, nausea, vomiting and vertigo due to Meniere’s disease (diseases of the inner ear) and other disturbances
How AVIL INJECTION Works
AVIL INJECTION acts on certain receptors called H1 receptors and inhibits the action of a chemical called histamine. This inhibition reduces itching, allergic reactions and reduces the dilation of the vessels leading to less redness and oedema (swelling).
How to use AVIL INJECTION
AVIL INJECTION will be administered to you only by a doctor or a nurse into a vein as slow intravenous injection or into a muscle (intramuscularly). To infants and children up to 12 years of age, the medicine will be given intramuscularly. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and general health condition.
Side Effects Of AVIL INJECTION
Common
- sedation (drowsiness)
How To Manage Side Effects
Drowsiness:
Try maintaining consistent sleep schedule. Move slowly and carefully to manage the risk of falling down. Inform your doctor for advice if the symptom gets worse.
Warning & Precautions
Pregnancy
AVIL INJECTION should be used with caution in pregnant women only if clearly advised by the doctor. Consult your doctor before receiving it.
Breastfeeding
AVIL INJECTION should be used with caution in breast-feeding women only if clearly advised by the doctor. Consult your doctor before receiving it.
Driving and Using Machines
Do not drive or use machines if you feel drowsy after receiving AVIL INJECTION.
Alcohol
Avoid consumption of alcohol while receiving AVIL INJECTION as it may increase the adverse central nervous system effects of this medicine.
Liver
AVIL INJECTION should be used with caution in patients having severe hepatic disease and your doctor may adjust the dose in such patients. Consult your doctor before receiving it.
Allergy
Before receiving AVIL INJECTION, tell your doctor if you are allergic to Pheniramine or any other ingredients of this medicine.
Lungs
AVIL INJECTION should be used with caution in patients having lung diseases such as asthma. Consult your doctor before receiving it.
Heart Disease
AVIL INJECTION should be used with caution in patients having severe cardiovascular disease. Consult your doctor before receiving it.
Others
Before receiving AVIL INJECTION inform your doctor if you have:
- narrow angle glaucoma (increased pressure within the eye)
- enlarged prostate
Use in paediatrics:
AVIL INJECTION is not recommended for use in premature infants and new-born babies. Your child’s doctor may administer the medicine either intravenously or intramuscularly depending upon child’s age. Consult your child’s doctor for advice before administration of AVIL INJECTION.
Interactions
A. Drug–Drug Interactions:
Before receiving AVIL INJECTION inform your doctor if you have received or taking any of the following medicines:
- monoamine oxidase inhibitors (MAOIs) such as isocarboxazid, phenelzine (used to manage depression)
- zolpidem, triazolam, alprazolam, diazepam (used to manage sleep disturbances and anxiety)
- atropine (used to manage low heart rate and reduce bronchial secretions)
- other anticholinergic drugs (used to manage nausea and vomiting due to motion sickness (Ex. scopolamine) and parkinson’s disease (Ex. benztropine))
Overdosage:
AVIL INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms such as agitation and convulsions especially in children and hallucinations, restlessness, disorientation in adults.
Synopsis
| Drug | : |
Pheniramine |
| Pharmacological Category | : |
Antihistamine |
| Therapeutic Indication | : |
Allergic conditions, Conditions of the respiratory tract Itching skin conditions, Motion sickness and symptoms of Meniere’s disease |
| Dosage Forms | : |
Tablet, Injection |
More Information
- Store below 25°C
FAQs About AVIL INJECTION
Is AVIL INJECTION safe for use in asthmatic patients?
AVIL INJECTION should be used with caution in patients having lung diseases such as asthma. Since AVIL INJECTION is an antihistamine which means it dry up the secretions in the upper and lower respiratory tract which may cause difficulty in breathing. Consult with your doctor for advice before receiving AVIL INJECTION.
Can AVIL INJECTION be used in pregnant women?
AVIL INJECTION should be used with caution in pregnant women only if clearly advised by the doctor. Consult your doctor before receiving AVIL INJECTION if you are pregnant or planning to get pregnant.
Is AVIL INJECTION safe to use in patients with liver disease?
AVIL INJECTION should be used with caution in patients having severe hepatic disease and your doctor may adjust the dose in such patients. Your doctor may monitor your liver function test during management with this medicine to manage the risk of any unusual effects. Consult your doctor for advice before receiving AVIL INJECTION.
Can AVIL INJECTION impair my ability to drive?
The most common side effect of AVIL INJECTION is sedation (drowsiness), which means it can make you sleepy. Do not drive or use machines if you feel drowsy after receiving AVIL INJECTION. You can continue with the activities once you feel normal again.
How is AVIL INJECTION administered?
AVIL INJECTION will be administered to you only by a doctor or a nurse into a vein as slow intravenous injection or into a muscle (intramuscularly). To infants and children up to 12 years of age, the medicine will be given intramuscularly. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and general health condition.
References
1. K.D. Tripathi. Histamines and Antihistamines. Essentials of medical pharmacology. Seventh edition. 2013. Page – 164.
2. C Collins-Williams. Antihistamines in Asthma. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 1987 [Accessed on 6th July 2022] https://pubmed.ncbi.nlm.nih.gov/3333250/
3. Aastha Gupta, Pooja Arora, Purnima Malhotra, Kabir Sardana. Pheniramine maleate: an apparently safe drug causing bullous fixed drug eruption. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2018. [Accessed on 6th July 2022] https://pubmed.ncbi.nlm.nih.gov/30142724/
4. Pheniramine. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Revised in September 2022] [Accessed on 6th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Pheniramine
5. Sanofi India Limited. Avil. Pheniramine Maleate [Revised in February 2021]. [Accessed on 6th July 2022] https://www.sanofi.in/dam/jcr:a419c36b-e92e-4a38-8b6f-9aefe636b9e7/Avil%20-%20PI%2025072019.pdf
Useful Diagnostic Tests
- Chest X-ray
- Complete blood count
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