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Roche Diabetes Care GmbH

Available substitute for AVIGLEN FORTE Tablet 10's 1 substitute/s available
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Please note, before you can choose the low cost generic option, please ask your doctor to add the generic drug to your prescription.

Drug Information for AVIGLEN FORTE Tablet 10's

What is Glibenclamide + Metformin combination used for?

Glibenclamide + Metformin combination is used to control blood sugar levels in the patients with type 2 diabetes. This combination should be used in conjunction with diet and exercise to improve glycemic control.

Glibenclamide + Metformin combination may also be prescribed for other conditions as determined by the doctor.

How does Glibenclamide + Metformin combination work?

Glibenclamide + Metformin combination is an oral anti-diabetic medicine. It helps in the production of endogenous insulin by stimulating the pancreatic cells. This results in lowering the glucose concentration in the blood.

Metformin helps in decreasing the amount of glucose absorbed from food in the intestine and decreases glucose production in the liver. Thus, it lowers blood glucose levels.

How to take Glibenclamide + Metformin combination?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Take Glibenclamide as prescribed by your doctor.

Swallow the whole tablet, but do not crush or chew the tablet. Take the drug with food.

If you miss a dose of Glibenclamide + Metformin combination, take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

What are the drugs that interact with Glibenclamide + Metformin?

Drugs that interact with Glibenclamide + Metformin combination include the following:

  • Amiloride
  • Clarithromycin
  • Clonidine
  • Clozapine
  • Oestrogen
  • Fluoxetine
  • Fosphenytoin
  • Lamivudine
  • Morphine
  • Nadolol
  • Niacin
  • Phenytoin
  • Prednisone
  • Procainamide
  • Progesterone
  • Reserpine
  • Rifabutin
  • Rifampin
  • Tacrolimus
  • Trimethoprim
  • Vancomycin
  • Zonisamide

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Glibenclamide + Metformin combination?

The following are the most common side effects of Glibenclamide + Metformin combination:

  • Diarrhoea
  • Nausea
  • Upset stomach
  • Dizziness
  • Headache
  • Metallic taste
  • Gas
The following are the severe side effects and you may require immediate medical attention:

  • Loss of consciousness
  • Blurred vision
  • Profuse sweating
  • Sore throat
  • Confusion
  • Increased hunger
  • Dark-coloured urine
  • Allergic skin reactions
  • Trouble breathing

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions Glibenclamide + Metformin combination?

  • Avoid using the medicine if you are allergic to Glibenclamide + Metformin or similar drugs.
  • Seek doctor’s advice before taking any other drug or herbal products while on Glibenclamide + Metformin combination.
  • Avoid consumption of alcohol as it increases the risk of severe hypoglycaemia (low blood sugar levels) while taking Glibenclamide + Metformin combination.
  • Do not exceed the dose more than what is prescribed.
  • Be cautious while taking Glibenclamide + Metformin combination if you have any kidney or liver impairment.
  • Do not use Glibenclamide + Metformin combination if you have a history of lactic acidosis.

You are advised not to take Glibenclamide + Metformin combination if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking Glibenclamide + Metformin combination?

  • Tell your doctor if you have any history of kidney problem, liver problem, adrenal or pituitary gland problem, diabetic ketoacidosis, polycystic ovarian syndrome or gastrointestinal problems.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • Tell your doctor about the usage of the drug before undergoing any medical procedures.

Frequently asked questions about Glibenclamide + Metformin combination


  1. How should Glibenclamide + Metformin combination be stored?
  2. Store the drug at room temperature and avoid exposure to sunlight and moisture.

  3. I am on Glibenclamide + Metformin combination for type 2 diabetes. Can I stop the drug if I feel better?
  4. No. Continue using Glibenclamide + Metformin until your doctor instructs you to stop using it. Abrupt discontinuation would lead to changes in the blood sugar levels.

  5. What are the other formulations available for Glibenclamide + Metformin combination?
  6. Glibenclamide + Metformin combination is available only in the form of a tablet.

  7. Is it safe to take Glibenclamide + Metformin combination during pregnancy?
  8. Yes, Glibenclamide + Metformin combination is known to be safe during pregnancy. However, you must consult the doctor before taking any drug during pregnancy.

  9. Is it safe to use Glibenclamide + Metformin combination in elderly with type 2 diabetes?
  10. Use of Glibenclamide + Metformin combination should be avoided in elderly as it may increase the risk of low blood sugar levels. Consult your doctor before taking the drug.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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