Atrest 12.5mg Tablet 10'S

ADHD Rx required

Best Price*  ₹ 123.23
MRP ₹154.04
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mfr: Centaur Pharmaceuticals Pvt Ltd * Country of Origin: India
TOTAL AMOUNT ₹ 154.04

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INTRODUCTION

ATREST 12.5MG contain Tetrabenazine which belongs to a group of medicine called monoamine depletors. It is used to treat nervous system disorders and treatment of disease-causing jerky, irregular, uncontrollable movements (hyperkinetic motor disorders with Huntington’s chorea). Huntington's disease is an inherited, rare disease that cause the progressive degeneration of nerve cells in the brain. It works by decreasing the amount of monoamines such as dopamine, serotonin, and norepinephrine. These are certain natural substances present in the brain which are involved with nerve and muscle function that helps in controlling body movements.

Always take ATREST 12.5MG exactly as your doctor has told you. This medicine must be taken with or without food. It is not recommended for use in children. Do not drive or operate machinery while taking this medicine, since it may cause drowsiness. Before taking this medicine talk to your doctor if you have any kidney, liver, heart problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine. The most common side effects are drowsiness, depression, parkinson-like syndrome (uncontrollable movements of the hand, arm, leg and head, with higher dose), confusion, anxiety, sleeplessness, trouble sleeping, low blood pressure, dysphagia (difficulty in swallowing), nausea, vomiting, diarrhoea and constipation.

USES OF ATREST 12.5MG

  • Treat Huntington’s chorea

HOW ATREST 12.5MG WORKS

ATREST 12.5MG works by decreasing the amount of monoamines such as dopamine, serotonin, and norepinephrine. These are certain natural substances present in the brain which are involved with nerve and muscle function that helps in controlling body movements.

DIRECTIONS FOR USE

Always take ATREST 12.5MG exactly as your doctor has told you. This medicine must be taken with or without food. Try to take this medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.

SIDE EFFECTS OF ATREST 12.5MG

SERIOUS

  • suicidal thoughts or actions
  • neuroleptic malignant syndrome (symptoms such as high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, increased sweating)
  • dizziness due to blood pressure change when you change position (orthostatic hypotension)
  • tardive dyskinesia

COMMON

  • drowsiness
  • depression
  • parkinson-like syndrome (uncontrollable movements of the hand, arm, leg and head, with higher dose)
  • confusion, anxiety
  • sleeplessness, trouble sleeping
  • low blood pressure
  • dysphagia (difficulty in swallowing)
  • nausea, vomiting
  • diarrhoea
  • constipation
  • autonomic dysfunction (sweating and fluctuation in blood pressure)
  • tiredness
  • restlessness, agitation

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.

Diarrhoea:

Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without speaking to a doctor.

Constipation:

Eat fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

WARNING & PRECAUTIONS

PREGNANCY

ATREST 12.5MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

ATREST 12.5MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES

Do not drive or operate machinery while taking this medicine, since it may cause drowsiness.

ALCOHOL

Consumption of alcohol is not recommended during treatment with ATREST 12.5MG.

KIDNEY

ATREST 12.5MG not recommended in patients with active kidney diseases. Before taking, this medicine. Consult your doctor for advice.

LIVER

ATREST 12.5MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.

ALLERGY

Do not take ATREST 12.5MG if you are allergic (hypersensitive) to tetrabenazine or any other ingredients in this medicine.

HEART DISEASE

ATREST 12.5MG should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.

OTHERS

Tell your doctor if you have or had a condition such as,

  • suffer from parkinson-like symptoms
  • depression, suicidal thoughts
  • suffer from pheochromocytoma (tumour of the adrenal gland)
  • suffer from pro-lactin-dependent tumours (e.g. pituitary or breast cancer)

INTERACTIONS

Talk to your doctor if you are taking,

  • reserpine (used to control high blood pressure and treat psychotic states)
  • MAO inhibitors (used to treat depression)
  • levodopa (used to treat parkinson’s disease)
  • certain types of antidepressants, opioids, beta-blockers, antihypertensive drug (used to treat high blood pressure)
  • hypnotics and neuroleptics (used to treat psychotic disorders)
  • fluoxetine, paroxetine, terbinafine, moclobemide and quinidine
  • antibiotic such as gatifloxacin, moxifloxacin (used to treat infection)
  • quinidine, procainamide, amiodarone, sotalol (used to treat heart rhythm problems)

SYNOPSIS

Drug :   Tetrabenazine
Pharmacological Category :   Monoamine depletors
Therapeutic Indication :   Huntington’s chorea
Dosage Forms :   Tablet

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT ATREST 12.5MG

Can ATREST 12.5MG be crushed?

No, swallow the medicine as whole with a drink of water. Do not crush and chew the medicine.

How does ATREST 12.5MG treat tardive dyskinesia?

It inhibits presynaptic dopamine release and blocks postsynaptic dopamine receptors. It has been used for decades to treat a variety of hyperkinetic movement disorders including tardive dyskinesia.

Can ATREST 12.5MG be used in children?

No, this medicine is strictly not recommended for use in children.

REFERENCES

1. Bertram G. Katzung, Pharmacologic management of Parkinsonism and Other Movement Disorders, Basic & Clinical Pharmacology, Fourteenth Edition, 2015. Page – 505.

2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page – 3736-3737.

3. Linda H Poon 1, Gail A Kang, Audrey J Lee. Role of tetrabenazine for Huntington's disease-associated chorea. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Jun 2010. [Accessed 06 Nov 2020] https://pubmed.ncbi.nlm.nih.gov/20442355/

4. Sun Pharmaceutical Industries Europe B.V; Electronic Medicines Compendium (EMC); [Revised on Mar 2018] [Accessed 06 Nov 2020] https://www.medicines.org.uk/emc/files/pil.2668.pdf

5. AOP Orphan Pharmaceuticals AG; Electronic Medicines Compendium (EMC); [Revised on Nov 2018] [Accessed 06 Nov 2020] https://www.medicines.org.uk/emc/files/pil.8961.pdf

6. Prestwick pharmaceuticals, Inc; U.S. Food & Drug Administration; [Accessed 06 Nov 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021894lbl.pdf

Marketer DETAILS

    Country Of Origin
    India
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Atrest 12.5mg Tablet 10'S

Atrest 12.5mg Tablet 10'S Mfr: Centaur Pharmaceuticals Pvt Ltd

M.R.P.: Rs.154.04
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