Check Availability & Expiry
INTRODUCTION
ASSURANS contains Sildenafil which belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors, which brings down blood pressure in the lungs. It is used to treat pulmonary arterial hypertension (high blood pressure in the blood vessels in the lungs). Sildenafil decreases the activity of (phosphodiesterase type 5) PDE5, so that more cyclic GMP (guanosine monophosphate) is available for the blood vessels inside the lungs. This leads to relaxation and widening of the blood vessels in the lungs decreases the pulmonary blood pressure to the heart and improves its function.
Always take this ASSURANS exactly as directed by your doctor. Before taking this medicine, tell your doctor if you have liver, kidney or heart problems and if you are a pregnant women or breastfeeding mother. It is not recommended for use in children below 1 year of age. Do not drink grapefruit juice while you are being treated with this medicine. The common side effects are headache, diarrhoea and vomiting and facial flushing.
USES OF ASSURANS
- Treats Pulmonary arterial hypertension
HOW ASSURANS WORKS
Sildenafil is a phosphodiesterase (PDE-5) inhibitor works by relaxing and widening of the blood vessels in the lungs decreases the pulmonary blood pressure to the heart and improves its function.
DIRECTIONS FOR USE
Always take this medicine exactly as your doctor has directed you. Swallow medicine whole with a glass of water. It can be taken with or without food.
SIDE EFFECTS OF ASSURANS
SERIOUS
- erection (priapism)
- sudden vision loss (one or both eyes)
COMMON
- headache
- facial flushing
- indigestion
- diarrhoea
- pain in the arms or legs
- infection under the skin
- flu-like symptoms
- inflammation of the sinuses
- reduced number of red blood cells
- fluid retention
- difficulty sleeping, anxiety, migraine, shaking
- bleeding at the back of the eye, effects on vision, blurred vision
- nosebleed, runny nose, cough, stuffy nose, stomach inflammation, gastroenteritis, heartburn
- piles, abdominal distension, dry mouth, hair loss, redness of the skin, night sweats, muscle aches, back pain
- increased body temperature
- for children and adolescents: vomiting, infection of the throat, nausea, increased erections, pneumonia
HOW TO MANAGE SIDE EFFECTS
Feeling sick (nausea) or indigestion:
Stick to simple normal meals and do not eat rich or spicy foods.
Headache:
Rest and drink plenty of fluids.
Diarrhoea:
Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.
Vomiting:
Drink clear or ice-cold drinks.Eat light, bland foods and avoid fried, greasy, or sweet foods.
WARNING & PRECAUTIONS
PREGNANCY
ASSURANS is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
ASSURANS should be used with caution as it may pass into breast milk at very low levels and would not be expected to harm the baby. Consult your doctor for advice.
DRIVING AND USING MACHINES
ASSURANS may cause dizziness or affect your vision. Do not drive or handle any machines while taking this medicine.
KIDNEY
ASSURANS should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
ASSURANS is not recommended in patients with severe liver disease. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic (hypersensitive) to Sildenafil.
HEART DISEASE
ASSURANS is not recommended if you had a stroke, heart attack or any other severe heart disease. Consult your doctor for advice.
OTHERS
Tell your doctor if you have or had a condition such as,
- low blood pressure
- sickle cell anaemia, leukaemia, multiple myeloma (cancer of bone marrow)
- inherited eye diseases (retinitis pigmentosa)
- loss of vision
- deformity of your penis or Peyronie’s disease
- stomach ulcer or bleeding problem (haemophilia)
INTERACTIONS
Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:
- ketoconazole and itraconazole (used to treat fungal infection)
- nitroglycerin, amyl nitrite (used to relieve angina pectoris)
- riociguat, bosentan, iloprost (used to treat pulmonary arterial hypertension)
- rifampicin, erythromycin, clarithromycin, telithromycin (used to treat bacterial infections)
- carbamazepine, phenytoin, phenobarbital (used to treat epilepsy)
- warfarin (used to thin blood)
- saquinavir (used for HIV)
- nefazodone (used to treat mental depression)
- doxazosin (used to treat high blood pressure or prostate problems)
- St. John’s Wort (herbal medicine)
SYNOPSIS
| Drug | : | Sildenafil |
| Pharmacological Category | : | Phosphodiesterase-5 Enzyme Inhibitor |
| Therapeutic Indication | : | Pulmonary arterial hypertension |
| Dosage Forms | : | Tablet, Injection, Oral suspension |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
REFERENCES
1. KD Tripathi MD. Hormones and related drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 304.
2. Michel T, Hoffman BB. Treatment of Myocardial Ischemia and Hypertension. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page 752-53.
3. Katzung BG, Chatterjee K. Vasodilator & the Treatment of Angina Pectoris. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 197.
4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page 1261-62.
5. Senad Pesto, Zijo Begic, Sabina Prevljak, Ehlimana Pecar, Nihad Kukavica and Edin Begic. Pulmonary Hypertension – New Trends of Diagnostic and Therapy. [Accessed Dec 30, 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034989/
6. Upjohn UK Limited,Fareva Amboise, Zone Industrielle. Electronic Medicines Compendium (EMC); [Revised Nov 2020] [Accessed Dec 30, 2020] https://www.medicines.org.uk/emc/files/pil.181.pdf
Find Doctors' Answers for Common Medical Questions
PRODUCT DETAILS
ALTERNATE BRANDS View All
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
