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MRP ₹318.27
(Inclusive of all taxes) *15 Tablet(s) in a Strip * Mkt: Cipla Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

ASSURANS contains Sildenafil which belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors, which brings down blood pressure in the lungs. It is used to treat pulmonary arterial hypertension (high blood pressure in the blood vessels in the lungs). Sildenafil decreases the activity of (phosphodiesterase type 5) PDE5, so that more cyclic GMP (guanosine monophosphate) is available for the blood vessels inside the lungs. This leads to relaxation and widening of the blood vessels in the lungs decreases the pulmonary blood pressure to the heart and improves its function.

Always take this ASSURANS exactly as directed by your doctor. Before taking this medicine, tell your doctor if you have liver, kidney or heart problems and if you are a pregnant women or breastfeeding mother. It is not recommended for use in children below 1 year of age. Do not drink grapefruit juice while you are being treated with this medicine. The common side effects are headache, diarrhoea and vomiting and facial flushing.

USES OF ASSURANS

  • Treats Pulmonary arterial hypertension

HOW ASSURANS WORKS

Sildenafil is a phosphodiesterase (PDE-5) inhibitor works by relaxing and widening of the blood vessels in the lungs decreases the pulmonary blood pressure to the heart and improves its function.

DIRECTIONS FOR USE

Always take this medicine exactly as your doctor has directed you. Swallow medicine whole with a glass of water. It can be taken with or without food.

SIDE EFFECTS OF ASSURANS

SERIOUS

  • erection (priapism)
  • sudden vision loss (one or both eyes)

COMMON

  • headache
  • facial flushing
  • indigestion
  • diarrhoea
  • pain in the arms or legs
  • infection under the skin
  • flu-like symptoms
  • inflammation of the sinuses
  • reduced number of red blood cells
  • fluid retention
  • difficulty sleeping, anxiety, migraine, shaking
  • bleeding at the back of the eye, effects on vision, blurred vision
  • nosebleed, runny nose, cough, stuffy nose, stomach inflammation, gastroenteritis, heartburn
  • piles, abdominal distension, dry mouth, hair loss, redness of the skin, night sweats, muscle aches, back pain
  • increased body temperature
  • for children and adolescents: vomiting, infection of the throat, nausea, increased erections, pneumonia

HOW TO MANAGE SIDE EFFECTS

Feeling sick (nausea) or indigestion:

Stick to simple normal meals and do not eat rich or spicy foods.

Headache:

Rest and drink plenty of fluids.

Diarrhoea:

Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.

Vomiting:

Drink clear or ice-cold drinks.Eat light, bland foods and avoid fried, greasy, or sweet foods.

WARNING & PRECAUTIONS

PREGNANCY

ASSURANS is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

ASSURANS should be used with caution as it may pass into breast milk at very low levels and would not be expected to harm the baby. Consult your doctor for advice.

DRIVING AND USING MACHINES

ASSURANS may cause dizziness or affect your vision. Do not drive or handle any machines while taking this medicine.

KIDNEY

ASSURANS should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.

LIVER

ASSURANS is not recommended in patients with severe liver disease. Consult your doctor for advice.

ALLERGY

Do not take if you are allergic (hypersensitive) to Sildenafil.

HEART DISEASE

ASSURANS is not recommended if you had a stroke, heart attack or any other severe heart disease. Consult your doctor for advice.

OTHERS

Tell your doctor if you have or had a condition such as,

  • low blood pressure
  • sickle cell anaemia, leukaemia, multiple myeloma (cancer of bone marrow)
  • inherited eye diseases (retinitis pigmentosa)
  • loss of vision
  • deformity of your penis or Peyronie’s disease
  • stomach ulcer or bleeding problem (haemophilia)

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:

  • ketoconazole and itraconazole (used to treat fungal infection)
  • nitroglycerin, amyl nitrite (used to relieve angina pectoris)
  • riociguat, bosentan, iloprost (used to treat pulmonary arterial hypertension)
  • rifampicin, erythromycin, clarithromycin, telithromycin (used to treat bacterial infections)
  • carbamazepine, phenytoin, phenobarbital (used to treat epilepsy)
  • warfarin (used to thin blood)
  • saquinavir (used for HIV)
  • nefazodone (used to treat mental depression)
  • doxazosin (used to treat high blood pressure or prostate problems)
  • St. John’s Wort (herbal medicine)

SYNOPSIS

Drug :   Sildenafil
Pharmacological Category :   Phosphodiesterase-5 Enzyme Inhibitor
Therapeutic Indication :   Pulmonary arterial hypertension
Dosage Forms :   Tablet, Injection, Oral suspension

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

REFERENCES

1. KD Tripathi MD. Hormones and related drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 304.

2. Michel T, Hoffman BB. Treatment of Myocardial Ischemia and Hypertension. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page 752-53.

3. Katzung BG, Chatterjee K. Vasodilator & the Treatment of Angina Pectoris. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 197.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page 1261-62.

5. Senad Pesto,  Zijo Begic, Sabina Prevljak,  Ehlimana Pecar, Nihad Kukavica and Edin Begic. Pulmonary Hypertension – New Trends of Diagnostic and Therapy. [Accessed Dec 30, 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034989/

6. Upjohn UK Limited,Fareva Amboise, Zone Industrielle. Electronic Medicines Compendium (EMC); [Revised Nov 2020] [Accessed Dec 30, 2020] https://www.medicines.org.uk/emc/files/pil.181.pdf

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PRODUCT DETAILS

    Net Qty
    1
    Item Weight
    25
    Ingredient
    SILDENAFIL CITRATE 20MG
    Hsn Code
    30049099
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DISCLAIMER

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Assurans Tablet 15'S

Assurans Tablet 15'S Mkt: Cipla Ltd

M.R.P.: Rs.318.27
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