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Introduction About AMPILOX C 500MG INJECTION
AMPILOX C 500MG INJECTION is a combination of Ampicillin and Cloxacillin which belongs to the group of medicines called Penicillin Antibiotics. It is used to manage respiratory tract infections, bacterial meningitis, septicaemia, endocarditis, urinary tract infections, pelvic infections, skin and soft tissue infections, gastrointestinal infections, infected wounds or lung infections after surgery, puerperal fever, ear, nose and throat infections in moderately severe and severe infections and for patients who are unable to take the oral forms.
Before receiving AMPILOX C 500MG INJECTION inform your doctor if you have liver or kidney disease. AMPILOX C 500MG INJECTION should be used with caution in pregnant women. Contact your doctor before receiving.
AMPILOX C 500MG INJECTION is generally not recommended for use in breast feeding women as it may pass through the breast milk. Contact your doctor before receiving.
AMPILOX C 500MG INJECTION should be used with caution in children. Contact your doctor before receiving. AMPILOX C 500MG INJECTION should be used with caution in elderly patients (aged 65 years above). Contact your doctor before receiving.
The most common side effects of this medicine are nausea, vomiting, diarrhea, flatulence, stomach pain or stomach upset and mouth sores. Contact your doctor if any of the symptoms worsen.
Uses Of AMPILOX C 500MG INJECTION
It is used for:
- respiratory tract infections
- stomach infection
- urinary tract infections
- fever associated with bacterial infection
- blood poisoning, caused by bacteria and inflammation of the endocardium
How AMPILOX C 500MG INJECTION Works
AMPILOX C 500MG INJECTION is a combination of Ampicillin and cloxacillin where ampicillin (has a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. It acts through the inhibition of cell wall mucopeptide biosynthesis during the stage of active multiplication.) Cloxacillin manages bacteria from reproducing, which allows your body to fight only the existing bacteria.
How to use AMPILOX C 500MG INJECTION
AMPILOX C 500MG INJECTION will be administered into a vein or muscle as intravenously or intramuscularly. Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of AMPILOX C 500MG INJECTION
Common
- nausea
- stomach pain or stomach upset
- flatulence
- diarrhea
- skin rash
- mouth sores
Uncommon
- vomiting
Rare
Stop receiving AMPILOX C 500MG INJECTION and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction such as rash, itching, skin redness, sneezing, swelling of face, lips and tongue, body causing trouble breathing
- rash or pinpoint flat red round spots under the skin surface or bruising of the skin due to inflammation of blood vessel caused by an allergic reaction, along with joint pains and kidney problems
- delayed allergic reaction signs include rashes, fever, joint pains and enlargement of the lymph nodes especially under the arms
- skin reaction such as erythema multiforme, itchy reddish-purple patches on the skin especially on the palms of the hands and soles of the feet, hive-like raised swollen areas on the skin, tender areas on the surfaces of the mouth, eyes and private parts, fever and tiredness
- mild itchy rash (round-red patches), hive-like swollen areas on forearms, legs, palms, hands or feet
- other severe skin reactions such as changes in skin colour, bumps on the skin, blistering, pustules, peeling, redness, pain, itching, scaling
- fever, chills, headache, body pains, sore throat or other signs of an infection or bruise easily
- inflammation of the large intestine (colon) with diarrhoea sometimes containing blood, pain and fever
- yellowing of the skin or the whites of the eyes, severe diarrhoea with bleeding, blisters, redness or bruising of the skin, darker urine or paler stools
- anaemia
- interstitial nephritis
- weakness, weight loss, malaise
- difficulty in hearing
- decrease in white blood cell count and red blood cell count or platelet count
How To Manage Side Effects
Nausea or Vomiting:
Receive this medicine with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for managing diarrhea. Contact your doctor if the symptom did not improve.
Stomach pain:
Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.
Flatulence:
Eat smaller and frequent meals. Eat and exercise regularly. If the symptom does not improve, contact your doctor.
Skin rash:
Avoid hot showers because hot water can further irritate your skin. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Contact your doctor if the symptoms did not resolve.
Warning & Precautions
Pregnancy
There are no adequate and well-controlled studies in pregnant women, AMPILOX C 500MG INJECTION should be used during pregnancy only if clearly needed. . Contact your doctor before receiving.
Breastfeeding
AMPILOX C 500MG INJECTION may excrete in trace amounts in human milk. Safety has not been established in lactating mothers. Consult your doctor before receiving it.
Driving and Using Machines
AMPILOX C 500MG INJECTION has no adverse effects on the ability to drive or operate machinery. Consult your doctor before receiving it.
Kidney
AMPILOX C 500MG INJECTION should be used with caution in patients with kidney disease. Contact your doctor before receiving.
Liver
AMPILOX C 500MG INJECTION should be used with caution in patients with liver disease. Contact your doctor before receiving.
Allergy
Do not receive AMPILOX C 500MG INJECTION if you are allergic to Ampicillin, Cloxacillin or beta-lactam antibiotics (Ex. penicillins, cephalosporins) or to other ingredients of this medicine.
Others
Before receiving AMPILOX C 500MG INJECTION, inform your doctor if you:
- have glandular fever and/or leukaemia
- have blood related disorder/disease
- have diabetes
- have HIV infections
- have low immunity
- are on low salt diet
Use in pediatrics:
Experience in premature and new born infants is limited. Cautious administration of the AMPILOX C 500MG INJECTION to such patients and frequent evaluation of organ system function is recommended. Contact your doctor before receiving.
Use in geriatrics:
AMPILOX C 500MG INJECTION should be used with caution in elderly patients (aged 65 years and above). Contact your doctor before receiving.
Interactions
A. Drug-Drug interactions:
Inform your physician, if you are taking,
- medicines used to manage gout (Ex. probenecid, allopurinol)
- methotrexate (used for rheumatoid arthritis, psoriasis or cancer)
- medicines used to manage pregnancy (Ex. oral contraceptives)
- medicines used to manage bacterial infections (Ex. amikacin, gentamycin, chloramphenicol, erythromycin, sulphonamides and tetracyclines)
- acetylsalicylic acid (medicine used to manage blood clots)
Overdosage:
AMPILOX C 500MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms like nausea, vomiting and diarrhea or neurotoxic symptoms like limb weakness or numbness, loss of memory, loss of vision, headache in very high doses in patients with kidney problems.
Synopsis
| Drug | : | Ampicillin, Cloxacillin |
| Pharmacological Category | : | Penicillin Antibiotics |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Tablet, Capsule, Injection, Syrup, Drops, Dry syrup, Captab |
More Information
- Keep out of reach of children
- Store at room temperature
FAQs About AMPILOX C 500MG INJECTION
How AMPILOX C 500MG INJECTION is given?
AMPILOX C 500MG INJECTION will be given to you only by a doctor or a nurse into a vein or muscle as an intravenous injection or infusion or intramuscular injection. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Does AMPILOX C 500MG INJECTION cause diarrhea?
Yes. AMPILOX C 500MG INJECTION it may cause diarrhea. Contact your doctor before receiving the medicine.
What precautions do I need to follow while receiving AMPILOX C 500MG INJECTION?
Patients receiving AMPILOX C 500MG INJECTION must inform their doctor about their pre-existing disease conditions like kidney or liver problems, meningitis, history of allergic reactions before (skin rash, itching) malnourishment, low immunity, diabetes, HIV infection, convulsions, blood related disorder. Contact your doctor before receiving.
Does AMPILOX C 500MG INJECTION cause liver damage?
Yes. AMPILOX C 500MG INJECTION may cause liver damage. Contact your doctor if you experience any unusual symptoms such as yellowish discoloration of skin and whites of eye (jaundice), change in urine and stool colour.
How AMPILOX C 500MG INJECTION works?
AMPILOX C 500MG INJECTION is a combination of Ampicillin and cloxacillin where ampicillin (has a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. It acts through the inhibition of cell wall mucopeptide biosynthesis during the stage of active multiplication.) Cloxacillin manages bacteria from reproducing, which allows your body to fight only the existing bacteria.
References
1. KD. Tripathi. Beta-Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page-722 to 723.
2. Ampicillin and Cloxacillin. GlaxoSmithKline. [Revised on October 2014] [Accessed on 24th May 2022] https://www.drugs.com/uk/ampiclox-injection-500mg-leaflet.html
3. Ampicillin and Cloxacillin. Torrent pharmaceuticals Ltd. [Revised on April 2020] [Accessed on 24th May 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2906.pdf
4. Ampicillin and Cloxacillin. Wellona pharma. [Accessed on 24th May 2022] https://wellonapharma.com/product/finished/ampicillin-and-cloxacillin-injection
5. Ampicillin and Cloxacillin. Advacarepharma USA. [Accessed on 24th May 2022] https://www.advacarepharma.com/en/pharmaceuticals/ampicillin-cloxacillin-powder-for-injection
6. Ampicillin and Cloxacillin. Mims.com. [Accessed on 24th May 2022] https://www.mims.com/india/drug/info/ampicillin%20+%20cloxacillin?mtype=generic
Useful Diagnostic Tests
- Complete blood count
- Peripheral smear examination
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