Amaryl MV 2mg Tablet 15'S

Introduction About AMARYL MV 2MG TABLET

What is Amaryl MV 2mg Tablet?

Amaryl MV 2mg Tablet is a prescription oral medication used to manage type 2 diabetes mellitus in adults. It contains three active ingredients Glimepiride, Metformin and Voglibose. This combination helps regulate blood sugar levels by stimulating insulin secretion, reducing glucose production, and slowing carbohydrate absorption.

Glimepiride stimulates the pancreas to release more insulin. Metformin reduces sugar production in the liver and improves insulin sensitivity. Voglibose slows the digestion and absorption of carbohydrates from the intestine, preventing blood sugar spikes after meals.

Take Amaryl MV 2mg Tablet as prescribed by your healthcare provider, usually with meals to reduce gastrointestinal side effects. Swallow the tablet whole with water and do not crush or chew. Regular blood glucose monitoring is recommended to adjust the dose as necessary.

Before taking Amaryl MV 2mg Tablet, inform your doctor if you have kidney, liver, or heart problems. Discuss any history of lactic acidosis or ketoacidosis. Pregnant and breastfeeding women should consult their physician before use. Avoid alcohol consumption while taking this medication.

The possible side effects are hypoglycemia (low blood sugar levels), nausea, vomiting, diarrhea, stomach pain, headache and changes in taste sensation. Store in a cool, dry place below 30°C. Keep out of reach of children.

Uses Of AMARYL MV 2MG TABLET

• Management of Type 2 diabetes mellitus when diet and exercise alone are insufficient
• Improvement of glycemic control
• Manage complications related to uncontrolled diabetes such as neuropathy, kidney damage, and cardiovascular diseases

Benefits of AMARYL MV 2MG TABLET

How does Amaryl MV benefit type 2 diabetes patients?

Amaryl MV 2mg Tablet offers multiple benefits for patients managing type 2 diabetes:

• It effectively lowers blood glucose by combining three mechanisms: Glimepiride stimulates pancreatic insulin release, Metformin reduces hepatic glucose production and improves insulin sensitivity, and Voglibose delays carbohydrate absorption from the intestine. This triple-action helps maintain stable blood sugar levels throughout the day.
• The medication aids in controlling hyperglycemia, reducing the risk of acute and chronic complications related to diabetes, such as kidney damage, nerve neuropathy, and cardiovascular diseases.
• Amaryl MV is suitable for adults whose blood sugar levels are not well controlled by diet, exercise, or single-agent therapies. It supports better glycemic control when used alongside lifestyle changes, improving overall disease management.
• Taken once or twice daily with meals, it minimizes gastrointestinal discomfort and helps manage hypoglycemia by aligning insulin release with food intake. Regular blood glucose monitoring is recommended for safe and effective use.
• With consistent use, Amaryl MV helps patients maintain healthier blood sugar levels, improves quality of life, and reduces the risk of long-term diabetes complications, supporting better overall health outcomes

How AMARYL MV 2MG TABLET Works

Glimepiride stimulates the pancreas to release more insulin. Metformin reduces sugar production in the liver and improves insulin sensitivity. Voglibose slows the digestion and absorption of carbohydrates from the intestine, preventing blood sugar spikes after meals.

Combined Action of Ingredients in Amaryl MV 2mg Tablet

Amaryl MV 2mg Tablet combines three active ingredients Glimepiride, Metformin, and Voglibose that work through different but complementary mechanisms to provide effective blood sugar control in type 2 diabetes patients.

• Glimepiride belongs to the sulfonylurea class and works primarily by stimulating the pancreas to release more insulin. It achieves this by blocking ATP-sensitive potassium channels on pancreatic beta cells, causing a cascade that results in insulin granule exocytosis. This increased insulin helps reduce blood glucose levels by promoting glucose uptake into cells
• Metformin is a biguanide that decreases hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis, while also enhancing insulin sensitivity in muscle and fat tissues. It further helps by slowing glucose absorption from the intestine, contributing to reduced blood glucose levels without causing insulin secretion directly
• Voglibose is an alpha-glucosidase inhibitor that delays carbohydrate digestion and absorption in the gut. By inhibiting enzymes that break down complex carbohydrates into glucose, Voglibose minimizes postprandial (after-meal) blood sugar spikes, enhancing overall glycemic control

How to use AMARYL MV 2MG TABLET

Take Amaryl MV 2mg Tablet as prescribed by your healthcare provider, usually with meals to reduce gastrointestinal side effects. Swallow the tablet whole with water and do not crush or chew. Regular blood glucose monitoring is recommended to adjust the dose as necessary.

Recommended Dosage of Amaryl MV 2mg Tablet

The usual adult dosage for Amaryl MV 2mg Tablet is one tablet taken twice daily. Your doctor will determine the exact dose based on your blood sugar levels and treatment response. Dosage adjustments may be needed over time for optimal control.

Best Time to Take Amaryl MV 2mg Tablet

It is best to take Amaryl MV with or immediately before meals, ideally at the same time each day. This helps minimize gastrointestinal side effects and aligns medication with food intake to reduce the risk of hypoglycemia.

Can Amaryl MV Be Taken With Food?

Yes, Amaryl MV should be taken with meals to avoid stomach upset and ensure proper absorption of the medication. Taking it with food also helps manage low blood sugar episodes by synchronizing insulin release with food digestion.

Monitoring Blood Sugar While on Amaryl MV 2mg Tablet

Regular blood glucose monitoring is essential to assess treatment effectiveness and avoid complications like hypoglycemia. Follow your doctor’s guidance on how frequently to test your levels. Routine monitoring of kidney and liver function may also be recommended, given the medication’s metabolism pathways.

What if I forgot to take AMARYL MV 2MG TABLET

If you miss a dose, take it as soon as you remember unless it is almost time for your next scheduled dose. Do not double the dose to make up for a missed one. If unsure, consult your healthcare provider.

Overdose

If you or anyone else accidentally takes too much of Amaryl MV 2mg Tablet, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are hypoglycemia (low blood sugar), lactic acidosis, pancreatitis (inflammation of the pancreas), abdominal discomfort, and/or diarrhea.

Side Effects Of AMARYL MV 2MG TABLET

Common Side Effects of AMARYL MV 2MG TABLET

• hypoglycemia (low blood sugar levels)
• nausea
• vomiting
• diarrhea
• stomach pain
• headache
• changes in taste sensation

When to consult a doctor?

• severe hypoglycemia
• signs of lactic acidosis (lactic acid built up in the bloodstream) such as exhaustion or extreme fatigue, body weakness, diarrhea, and/or headache

How To Manage Side Effects

Hypoglycemia

Recognizing and managing hypoglycemia with Amaryl MV 2mg Tablet is crucial for patient safety. Common symptoms of hypoglycemia (low blood sugar) include dizziness, sweating, hunger, irritability, headache, trembling, rapid heartbeat, and weakness. If these symptoms occur, patients should immediately consume fast-acting carbohydrates such as glucose tablets, sugar candies, honey, or fruit juice to quickly raise blood sugar levels. Carrying a quick sugar source at all times is advised. It is important to maintain regular meals and not skip food intake while on this medication to manage glycemic episodes. Patients experiencing severe or persistent symptoms should seek immediate medical help.

Nausea And Vomiting

Gastrointestinal side effects associated with Amaryl MV 2mg Tablet often include nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These symptoms are usually mild and transient, commonly seen at the beginning of therapy as the body adjusts. Taking the medication with food can help reduce stomach upset. Drinking adequate fluids and following a balanced diet rich in fiber, with moderate fat intake, can also mitigate these side effects. Persistent or severe gastrointestinal symptoms should be reported to a healthcare professional for appropriate management.

Warning & Precautions

Pregnancy

Consult your doctor

Pregnant women should consult their physician before using Amaryl MV 2mg Tablet.

Breastfeeding

Consult your doctor

Breastfeeding women should consult their physician before using Amaryl MV 2mg Tablet.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you experience impaired alertness or reactions (due to hypoglycemia) while taking Amaryl MV 2mg Tablet.

Alcohol

Consult your doctor

Avoid alcohol consumption while taking Amaryl MV 2mg Tablet.

Kidney

Consult your doctor

Amaryl MV 2mg Tablet is not recommended in patients with severe renal failure. It should be used with caution in patients with other kidney diseases.

Liver

Consult your doctor

Amaryl MV 2mg Tablet is not recommended for use in patients with severe liver disease. It should be used with caution in patients with other liver diseases.

Allergy

Contraindicated

Do not take Amaryl MV 2mg Tablet if you are allergic to Glimepiride, Metformin, Voglibose or any other ingredients of this medicine.

Lungs

Contraindicated

Amaryl MV 2mg Tablet is not recommended for use in patients with lung problems such as acute or chronic respiratory failure.

Heart Disease

Contraindicated

Amaryl MV 2mg Tablet is not recommended in patients with heart problems such as acute or chronic cardiac failure or recent myocardial infarction.

Use In Pediatrics

Contraindicated

Amaryl MV 2mg Tablet is not recommended for use in children and adolescents (aged below 18 years) since the safety and effectiveness of the medicine are not established.

Use In Geriatrics

Use with Caution

Amaryl MV 2mg Tablet should be used with caution in elderly patients (aged 65 years and above).

Other Warnings for AMARYL MV 2MG TABLET

Before taking Amaryl MV 2mg Tablet, inform your doctor if you:

• recently had trauma
• had or scheduled for any surgery
• suffer from febrile infections, fever, and/or uncontrolled diabetes
• are undernourished and/or have irregular mealtimes or skipped meals
• suffer from an imbalance between physical exertion and carbohydrate intake
• have hypothyroidism
• have a history of laparotomy  
• suffer from chronic intestinal disease
• suffer from fever

Who should not take AMARYL MV 2MG TABLET

Amaryl MV 2mg Tablet is not recommended for use if you,

• suffer from any acute type of metabolic acidosis
• suffer from acute conditions such as dehydration, severe infection, and shock
• have severe ketosis
• had severe infections before or after the operation
• had severe trauma
• have gastrointestinal obstruction

Diet and Lifestyle Advice

What to Expect

With regular use, Amaryl MV 2mg Tablet helps lower your blood sugar by increasing insulin release, reducing sugar production in your liver, and slowing sugar absorption from your meals. It may take several weeks to notice significant improvements in your blood sugar control. Some common side effects include mild nausea, diarrhea, abdominal discomfort, or a metallic taste, especially when you start treatment. Because Amaryl MV stimulates insulin release, you may experience symptoms of low blood sugar (hypoglycemia), such as dizziness, sweating, or hunger, particularly if meals are delayed or missed. Immediate treatment of hypoglycemia with sugary foods or drinks is important.

Lifestyle Tips for Effective Diabetes Management

• Follow a Balanced Diet: Incorporate a diabetic-friendly diet rich in fiber, whole grains, vegetables, and lean proteins. Limit simple sugars and processed foods. Eating regular meals helps manage swings in blood sugar
• Stay Physically Active: Aim for moderate exercise such as walking, swimming, or cycling at least 30 minutes most days. Exercise improves insulin sensitivity and helps control blood sugar
• Regular Monitoring: Keep track of your blood sugar levels with home testing kits as recommended. This helps you and your doctor adjust your treatment plan for optimal control
• Avoid Alcohol and Smoking: Alcohol can increase the risk of hypoglycemia when on Amaryl MV. Smoking worsens diabetic complications and should be avoided.
• Stay Hydrated: Drink plenty of water to support metabolism and kidney health.
• Manage Stress: Practice stress-reducing activities like meditation, yoga, or hobbies, as stress can impact blood sugar levels.
• Attend Regular Check-ups: Routine visits to your healthcare provider for blood tests, eye exams, and kidney function tests are essential for early detection of complications

Drug - Drug interaction

Medications and Substances That Interact

1. Other Antidiabetic Medicines and Insulin: Combining Amaryl MV 2mg Tablet with other oral antidiabetic agents (such as glipizide, glyburide, or insulin) can increase the risk of hypoglycemia (low blood sugar). Dose adjustments may be required and close monitoring is advised.

 2. Antibiotics: Certain antibiotics (rifampicin, ciprofloxacin, clarithromycin, sulfacetamide, minocycline, chloramphenicol) can alter blood sugar levels or interact with the metabolism of Amaryl MV, requiring careful medical supervision.

3. Antifungals: Drugs like fluconazole, isavuconazole, and miconazole can affect the action of Amaryl MV 2mg Tablet and may require dose adjustments

4. Corticosteroids and Diuretics: Medications such as prednisolone, methylprednisolone, and furosemide (a diuretic) can interfere with blood glucose control and may increase the risk of side effects

5. Other Drug Classes: Amaryl MV 2mg Tablet can interact with anticancer drugs (cyclophosphamide, trofosfamide, vandetanib), anticonvulsants (phenytoin, fenfluramine),

antidepressants (phenelzine, selegiline), anticoagulants (warfarin), and laxatives (bisacodyl).

6. Medications for Heart Conditions: Disopyramide and certain alpha blockers (doxazosin, prazosin) may interact, affecting heart function or blood pressure.

Practical Guidance

• Always inform your healthcare provider about all medications, supplements, and herbal products you are using before starting Amaryl MV 2mg Tablet
• Monitor your blood sugar regularly, especially when starting or stopping other medicines
• Never adjust your diabetes medication on your own, consult your physician for any changes or concerns about drug interactions

Synopsis

More Information

Include data-driven comparisons with other diabetes medications, highlighting unique advantages or differentiators of Amaryl MV 2mg, supporting informed choices without subjective opinions.

• Triple Combination Advantage: Amaryl MV 2mg Tablet combines Glimepiride (stimulates insulin secretion), Metformin (reduces hepatic glucose output and improves insulin sensitivity), and Voglibose (delays carbohydrate absorption). This multi-mechanism approach offers broader glycemic control than monotherapy or dual therapies like Glimepiride-Metformin or Metformin alone, especially for patients struggling with post-prandial spikes.
• Efficacy in Glycemic Control: Studies indicate that the combination of Glimepiride and Metformin achieves comparable HbA1c reductions to newer agents like DPP-4 inhibitors but at a more affordable cost. Adding Voglibose further smoothens post-meal glucose fluctuations, which monotherapies or dual combinations may not optimize fully.
• Hypoglycemia and Weight Considerations: While sulfonylureas (Glimepiride) carry a risk of hypoglycemia and weight gain, Amaryl MV’s balanced dose with Metformin and Voglibose mitigates these effects better than higher dose sulfonylurea monotherapy. Compared to DPP-4 inhibitors, Amaryl MV may 2mg Tablet have a higher hypoglycemia risk but is often favored where cost and multi-target control are priorities.
• Cost-Effectiveness: Amaryl MV is generally more cost-effective than newer branded agents while providing robust glucose-lowering efficacy through its triple combination, making it accessible for patients requiring comprehensive control without higher therapy costs.
• Clinical Suitability: Ideal for patients with type 2 diabetes inadequately controlled on monotherapy, post-prandial hyperglycemia, or those requiring intensified treatment with a cost-effective oral option. Not suitable for type 1 diabetes or patients with severe renal/hepatic impairment.

Emphasis on Long-Term Health Benefits: Content that highlights protection against serious diabetes-related complications encourages continued adherence

• Maintains stable blood sugar levels, managing dangerous highs and lows that contribute to organ damage.
• Lowers risk of diabetes complications like kidney failure (nephropathy), nerve damage (neuropathy), blindness (retinopathy), and cardiovascular diseases (heart attack, stroke).
• Helps reduce the chances of needing amputations due to diabetes-related poor circulation and infections
• Supports overall metabolic health, improving energy, reducing fatigue, and enhancing quality of life over the long term.
• Encourages patient adherence by emphasizing that ongoing treatment, even when symptoms lessen is essential to protect vital organs and manage irreversible damage
• Aligns with clinical evidence showing improved outcomes with consistent glycemic control through combined medication and lifestyle measures

FAQs About AMARYL MV 2MG TABLET

Q: Can Amaryl MV 2mg Tablet be used during pregnancy?

A: Consult your doctor before using Amaryl MV 2mg Tablet if you are pregnant or planning to conceive.

Q: What should I do if I miss a dose of Amaryl MV 2mg Tablet?

A: Take Amaryl MV 2mg Tablet as soon as you remember unless it is almost time for your next dose. Do not double the dose.

Q: What is Amaryl MV 2mg Tablet used for?

A: Amaryl MV 2mg Tablet is used in adults to manage type 2 diabetes mellitus when diet, exercise, and single-agent or second-line therapy with two drugs are insufficient to adequately control blood sugar levels.

Q: How does Amaryl MV 2mg Tablet work?

A: Glimepiride lowers blood glucose levels by increasing the amount of insulin released by the pancreas. Metformin works by decreasing glucose production in the liver and the amount of glucose absorbed by the stomach and intestine. Voglibose works by inhibiting the alpha-glucosidase enzyme, which breaks down complex carbohydrates into simple sugars. This leads to a reduction in blood glucose levels in individuals with type 2 diabetes mellitus.

Q: What are the side-effects of Amaryl MV 2mg Tablet?

A: The most common side-effects of Amaryl MV 2mg Tablet are nausea and vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, and/or hypoglycemia (low blood sugar).

Q: How do I take Amaryl MV 2mg Tablet?

A: Take Amaryl MV 2mg Tablet as advised by your physician. It is preferably taken with meals to avoid stomach upset. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Q: What happens if Amaryl MV 2mg Tablet is taken at more than its required dosage?

A: If you or anyone else accidentally takes too much of Amaryl MV 2mg Tablet, symptoms of hypoglycemia (low blood sugar), lactic acidosis, pancreatitis (inflammation of the pancreas), abdominal discomfort, and/or diarrhea may occur.

Q: Can AMARYL MV 2MG TABLET be used in pregnancy?

A: No, Amaryl MV 2mg Tablet is not recommended for use during pregnancy since it may cause harm to the fetus.

Q: Who should not take Amaryl MV 2mg Tablet?

A: Amaryl MV 2mg Tablet is also not recommended for use in patients with acute conditions (such as dehydration or severe infection), severe ketosis, severe trauma, lung problems, heart problems and/or severe kidney or liver problems.

Q: Can Amaryl MV 2mg Tablet be used in children?

A: No, Amaryl MV 2mg Tablet is not recommended for use in children and adolescents (aged below 18 years).

References

1. KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. Seventh Edition. 2019. Page – 270, 275, 277.

2. Kalra S, Das AK, Priya G, Ghosh S, Mehrotra RN, Das S, Shah P, Bajaj S, Deshmukh V, Sanyal D, Chandrasekaran S, Khandelwal D, Joshi A, Nair T, Eliana F, Permana H, Fariduddin MD, Shrestha PK, Shrestha D, Kahandawa S, Sumanathilaka M, Shaheed A, Rahim AA, Orabi A, Al-Ani A, Hussein W, Kumar D, Shaikh K. Fixed-dose combination in management of type 2 diabetes mellitus. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. [Revised in November 2020] [Accessed on 21st November 2025]

3. Windlas Biotech Private Limited. Amaryl MV 1mg, Amaryl MV 2mg. [Revised in March 2021] [Accessed on 21st November 2025]

4. Leeford Healthcare Ltd. VOGLIMET-GM FORTE. [Accessed on 21st November 2025]

5. Ikon Remedies Pvt. Ltd. Voglicon-GM Tablets. [Accessed on 21st November 2025]

User Feedback

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (RBS)
• Post Prandial Blood Sugar (PPBS)
• Insulin-Fasting
• Insulin Postprandial (PP)
• Vital Diabetes Care
• Extended Diabetes Care
• Advance Diabetes Care
• Comprehensive Diabetes Care

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 21 Nov 2024 | 03:18 PM(IST)