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Drug Information

What is Epalrestat used for?

Epalrestat tablet is used for the treatment of diabetic neuropathy.

Epalrestat may also be prescribed for other conditions as determined by the doctor.

How does Epalrestat work?

Epalrestat belongs to the class of drugs called aldose reductase enzyme inhibitors. The drug acts by inhibiting the action of certain enzymes and reduces the accumulation of sorbitol, which is responsible for nerve damage. Thus, it helps in reducing the complications of diabetes.

How to take Epalrestat?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Take Epalrestat tablet as prescribed by your doctor.

  • Swallow the tablet Do not crush or chew the tablet. Take the drug without food.

If you miss a dose of Epalrestat, please take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

What are the drugs that interact with Epalrestat?

Consult your doctor for potential drug interactions.

What are the side effects of Epalrestat?

The following are the most common side effects of Epalrestat:

  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Headache
  • Oedema

The following are the severe side effects and you may require immediate medical attention:

  • High blood pressure
  • Kidney dysfunction

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while taking Epalrestat?

  • Avoid taking the medicine if you are allergic to Epalrestat or similar drugs.
  • Avoid consumption of alcohol as it may alter the absorption of Epalrestat.
  • Do not drive or operate heavy machinery if Epalrestat causes dizziness or blurred vision.
  • Avoid Epalrestat during pregnancy or breastfeeding because the safe use of the drug is not yet established.
  • Do not stop taking the medication abruptly unless instructed by the doctor. Stopping the medication suddenly may cause the illness to return.
  • Do not exceed the dose prescribed by the doctor.

You are advised not to take Epalrestat if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking Epalrestat?

  • Tell your doctor if you have any history of heart, liver or kidney diseases.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.

Frequently Asked Questions about Epalrestat

  1. How should Epalrestat be stored?
  2. Epalrestat should be stored at room temperature away from heat, light and moisture.

  3. What is the adult dose of Epalrestat for treating diabetic neuropathy?
  4. The adult dose of Epalrestat for treating diabetic neuropathy is 50 mg three times a day. However, please consult your doctor for dose-related queries.

  5. Is it safe to alter the dose of Epalrestat?
  6. No. it is not advised to alter the dose of Epalrestat without doctor’s consent.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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