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INTRODUCTION
ACMETEL CH TABLET is a combination of Chlorthalidone and Telmisartan which belongs to the group of medicines called Diuretics and Angiotensin II receptor blockers, respectively. It is used to treat essential hypertension (high blood pressure) in affected individuals when monotherapy with chlorthalidone or telmisartan becomes inadequate to control the condition.
It is also used as initial therapy in patients who are indicated for multiple drug therapy to control high blood pressure.
ACMETEL CH TABLET is not recommended for use in patients allergic to chlorthalidone, telmisartan, and/or any sulphonamide-derived medicines. It is also not recommended for use in patients suffering from anuria (failure of kidneys to produce urine) and severe liver impairment.
Before taking ACMETEL CH TABLET, inform your doctor if you have liver problems (such as mild to moderate hepatic impairment), kidney problems (such as decreased renal function, severe renal impairment, nephrogenic diabetes insipidus), and/or heart problems (such as congestive heart failure).
ACMETEL CH TABLET is not recommended for use during pregnancy and in women planning for pregnancy. It is also not recommended for use in breastfeeding women since it passes through breast milk.
ACMETEL CH TABLET should be used with caution in children and adolescents (aged 6 to 18 years) and in elders (aged 65 years and above). Consult your doctor before taking this medicine.
The most common side effects of taking ACMETEL CH TABLET are back pain, sore throat, nausea, abdominal pain, indigestion, diarrhoea, and/or headache. Consult your doctor if any of these symptoms worsen.
USES OF ACMETEL CH TABLET
- Treats hypertension to lower blood pressure
HOW ACMETEL CH TABLET WORKS
ACMETEL CH TABLET helps to lower blood pressure, where telmisartan works by blocking angiotensin (a hormone responsible for regulating blood pressure and maintaining fluid balance in the body) which leads to relaxation of blood vessels and chlorthalidone works by removing extra water and certain electrolytes from the body which leads to relaxation of blood pressure and improved blood flow thus reducing high blood pressure in affected individuals.
DIRECTIONS FOR USE
Take ACMETEL CH TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF ACMETEL CH TABLET
COMMON
- signs of upper respiratory tract infection such as cough, sore throat, runny nose
- back pain
- sinusitis (sinus infection), pharyngitis (sore throat)
- nausea, abdominal pain, indigestion, diarrhoea
- influenza-like symptoms such as cough, sore throat, headaches
- swelling of legs, muscle aches and pain
- headache, dizziness, feeling weak
- coughing
- high blood pressure
- chest pain
- sign of low potassium levels in the blood such as constipation, weakness, muscle damage
- signs of hyperuricemia (excess uric acid in the blood) such as nausea, vomiting, colicky pain
- red itchy welts, itchy skin
- impotence
UNCOMMON
- increased sweating, flushing
- allergy, fever, leg pain, general discomfort
- racing heartbeat, fast heartbeat
- sleeplessness, drowsiness, spinning/burning/pickling sensation, involuntary muscle contractions, numbness
- dry mouth
- flatulence, constipation, gastritis (inflammation of the stomach), piles, stomach flu, enteritis, acid reflux, nonspecific gastrointestinal disorders
- toothache
- gout (inflammation of joints), high cholesterol, diabetes mellitus
- joint pain, leg cramps
- anxiety, depression, nervousness
- fungal infection, abscess, middle ear infection
- asthma, bronchitis (inflammation of lungs), stuffy nose, shortness of breath, nosebleed
- inflammation of the skin, rash
- inflammation of urinary bladder
- abnormal vision, pink eye, ringing in the ear, earache
RARE
- signs of rhabdomyolysis (condition marked by the breakdown of muscle) such as muscle cramps, feeling tired/weak
- signs of hypercalcemia (high calcium level in blood) such as stomach upset, nausea, vomiting
- hypercalcaemia (elevated calcium levels in the blood)
- glycosuria (excess sugar in urine)
- worsening of diabetic metabolic rate
- photosensitization
- jaundice (a condition causing yellowish discolouration of skin and eyes)
- irregular heartbeat
- blood abnormalities (such as thrombocytopenia, leucopenia, agranulocytosis and eosinophilia)
- pulmonary oedema (respiratory disorder)
- allergic interstitial nephritis (kidney disorder)
Stop taking ACMETEL CH TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of hypokalaemia (low potassium level in blood) such as muscular weakness, racing heartbeat, extreme tiredness
- oligohydramnios (disorder of amniotic fluid resulting in decreased amniotic fluid volume)
HOW TO MANAGE SIDE EFFECTS
Nausea/vomiting:
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods.
Constipation:
Try to eat high-fibre foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor to receive alternate treatments for constipation.
Diarrhoea:
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
Headache:
If ACMETEL CH TABLET causes a headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking ACMETEL CH TABLET. If it lasts more than a week or is severe, inform your doctor.
Dizziness:
Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.
Itchy Skin:
Try to pat or tap your skin instead of scratching it. Hold a damp towel to cool your skin. Wear loose clothing and avoid tight clothes or clothes made from wool or synthetic fabrics. Avoid using perfumed soaps, deodorants or moisturizers and use a skin softener regularly.
WARNING & PRECAUTIONS
PREGNANCY
ACMETEL CH TABLET is generally not recommended for use during pregnancy unless it is considered clearly necessary. Treatment with ACMETEL CH TABLET should be discontinued if you get pregnant. Consult your doctor before taking the medicine.
BREASTFEEDING
ACMETEL CH TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking the medicine.
KIDNEY
ACMETEL CH TABLET should be used with caution in patients undergoing haemodialysis and in patients with kidney problems such as decreased renal function, severe renal impairment, and nephrogenic diabetes insipidus. Consult your doctor before taking the medicine.
LIVER
ACMETEL CH TABLET is not recommended for use in patients with severe liver impairment. It should be taken with caution in patients with liver disease such as mild to moderate hepatic impairment. Consult your doctor before the medicine.
ALLERGY
Do not take ACMETEL CH TABLET if you are allergic to chlorthalidone, telmisartan, any sulphonamide-derived medicines, and/or any other ingredients of this medicine.
HEART DISEASE
ACMETEL CH TABLET should be used with caution in patients with heart diseases such as congestive heart failure. Consult your doctor before taking the medicine.
OTHERS
ACMETEL CH TABLET is not recommended for use if you:
- have anuria (failure of kidneys to produce urine).
Use in Paediatrics:
ACMETEL CH TABLET should be used with caution in children and adolescents (aged 6 to 18 years). Consult your doctor before taking the medicine.
Use in Geriatrics:
ACMETEL CH TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking the medicine.
INTERACTIONS
A. Drug - Drug interactions:
Before taking ACMETEL CH TABLET, inform your doctor if you are taking any of the following medicine
- aliskiren, ramipiril, guanethidine, methyldopa (medicines used to treat high blood pressure)
- digoxin (medicine used to treat heart failure)
- lithium (medicine used to treat mood disorders)
- non-steroidal anti-inflammatory agents (medicines used treat pain and inflammation) such as selective COX-2 inhibitors (Ex. celecoxib), indometacin
- anti-diabetics (medicines used to treat high blood sugar) Ex. metformin, glibenclamide, insulin
- anti-cholinergic agents (medicines used to treat nerve disorders) Ex. atropine, biperiden
- calcium salts (used to treat calcium deficiency)
- vitamin D (used to treat Vitamin D deficiency)
- cyclosporin (medicine used to prevent organ transplant rejection)
- other antihypertensive drugs (medicines used to treat hypertension) such as β-blockers (acebutolol, atenolol), vasodilators (Ex. benazepril, lisinopril), calcium antagonists (amlodipine, diltiazem), ACE inhibitors (benazepril, captopril)
- cholestyramine (used to lower high cholesterol levels in the blood)
- corticosteroids (medicines used to treat inflammation) Ex. prednisolone
- beta-2 agonists (used to treat asthma, bronchitis) Ex. salbutamol, terbutaline
- amphotericin (used to treat serious and life-threatening fungal infection)
- carbenoxolone (used to treat acid peptic disease)
- digitalis (used to treat heart conditions)
- allopurinol (used to the lower uric acid levels in blood)
- amantadine (used to treat Parkinson’s disease)
- diazoxide (used to manage symptoms of low blood sugar)
- cytotoxic agents (medicines used to prevent cancer cells from division and metastases) Ex. cyclophosphamide, methotrexate
B. Drug - Food interaction:
Avoid having very strict low-salt diet while taking ACMETEL CH TABLET since it may cause undesirable effects.
Overdosage:
If you or anyone else accidentally take too much of ACMETEL CH TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are low blood pressure, dizziness, fast heart rate, slow heart rate, nausea, sleeplessness, hypovolaemia (low blood volume), and electrolyte imbalances (associated with an irregular heartbeat and muscle spasms).
SYNOPSIS
| Drug | : | Chlorthalidone, Telmisartan |
| Pharmacological Category | : | Diuretics, Angiotensin II receptor blockers |
| Therapeutic Indication | : | Hypertension |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep ACMETEL CH TABLET out of reach of children
- Store the medicine in a cool, dry place away from the light
FAQs ABOUT ACMETEL CH TABLET
What is ACMETEL CH TABLET used for?
ACMETEL CH TABLET is used to treat essential hypertension (high blood pressure) in affected individuals when monotherapy with chlorthalidone or telmisartan becomes inadequate to control the condition.
How does ACMETEL CH TABLET works?
ACMETEL CH TABLET helps to lower blood pressure, whereas telmisartan works by blocking angiotensin (a hormone responsible for regulating blood pressure and maintaining fluid balance in the body) which leads to the relaxation of blood vessels and chlorthalidone works by removing extra water and certain electrolytes from the body which leads to relaxation of blood pressure and improved blood flow thus reducing high blood pressure in affected individuals.
How ACMETEL CH TABLET is taken?
Take ACMETEL CH TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
What are the side effects of ACMETEL CH TABLET?
The most common side effects of taking ACMETEL CH TABLET are back pain, sore throat, nausea, abdominal pain, indigestion, diarrhoea, and/or headache. Consult your doctor if any of these symptoms worsen.
What happens if you take more ACMETEL CH TABLET than the required dose?
If you or anyone else accidentally take too much of ACMETEL CH TABLET, consult your doctor immediately or visit the nearby hospital. Overdose symptoms are low blood pressure, dizziness, fast heart rate, slow heart rate, nausea, sleeplessness, hypovolaemia (low blood volume), and electrolyte imbalances (associated with irregular heartbeat and muscle spasms).
REFERENCES
1. KD Tripathi. Drugs Affecting Renin - Angiotensin System & Plasma Kinins and Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 507,559
2. Suresh V Sagarad, Sudha Biradar Kerure, Chaitanya Kumar S, and Ramakrishna MR. Sagarad Kerure SB, Kumar S C, Mr R. The Antihypertensive Efficacy of Chlorthalidone and Telmisartan in Indian Hypertensive Patients who were Uncontrolled with Hydrochlorothiazide and Telmisartan Combination – A prospective and an open label study. NIH National Library of Medicine. National center for biotechnology Information. February 2013. [Accessed on 10th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644445/
3. Mary M. Stephens, Beth A. Fox, and Lisa Maxwell. Therapeutic Options for the Treatment of Hypertension in Children and Adolescents. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. February 2012. [Accessed on 10th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296488/
4. Steris Healthcare PVT Ltd. Telmistrum CH 6.25. [Accessed on 10th October 2022] https://www.sterisindia.com/latest-update/telmisartan-chlo/1402
5. Wonset Healthcare. TELVOK CH 20. [Accessed on 10th October 2022] https://wonset.co.in/products
6. Ciplamed. CRESAR CT Tablets. [Revised in February 2018] [Accessed on 10th October 2022] https://ciplamed.com/content/cresar-ct-tablets
7. Ipca Laboratories Ltd. CDT Tablet. [Accessed on 10th October 2022] https://www.ipca.com/pharmaceutical-formulations-manufacturers-india/
USEFUL DIAGNOSTIC TESTS
- Blood pressure test
VIDEOS
Chlorthalidone+Telmisartan Tablet - Drug Information
Chlorthalidone+Telmisartan Tablet : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
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