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Drug Information

What is Nicoumalone used for?

Nicoumalone is used for the treatment and prevention of harmful blood clots in the body.

Nicoumalone may also be prescribed for other conditions as determined by the doctor.

How does Nicoumalone work?

Nicoumalone belongs to the class of drugs called anti-coagulants. This drug acts by inhibiting certain enzymes in the liver and blocking the synthesis of the clotting factors. Thus, it helps in preventing the formation of harmful blood clots.

How to take Nicoumalone ?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Take Nicoumalone as prescribed by your doctor.

Swallow the tablet whole. Do not crush or chew the tablet. Take Nicoumalone tablets with or without food.

If you miss a dose of Nicoumalone, take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

The overdose symptoms of Nicoumalone include the following:

  • Haemorrhage
  • Haematemesis
  • Haemoptysis
  • Haematuria
  • Gastrointestinal haemorrhage
  • Hypotension
  • Abdominal pain

You must seek immediate medical care if you experience any of the above symptoms.

What are the drugs that interact with Nicoumalone?

Drugs that interact with Nicoumalone include the following:

  • Acetaminophen
  • Allopurinol
  • Chloramphenicol
  • Ciprofloxacin
  • Danazol
  • Erythromycin
  • Fenofibrate
  • Fluorouracil
  • Fluoxetine
  • Glucagon
  • Griseofulvin
  • Gemfibrozil
  • Heparin
  • Imatinib
  • Ibuprofen
  • Heparin
  • Omeprazole
  • Phenytoin
  • Propafenone
  • Quinidine
  • Rifamycin
  • Sulfinpyrazone
  • Tamoxifen
  • Toremifene
  • Zafirlukast

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Nicoumalone?

The following are the most common side effects of Nicoumalone:

  • Nausea
  • Vomiting
  • Diarrhoea
  • Dark urine
  • Black coloured stools
  • Fainting
  • Loss of appetite
  • Confusion
  • Stomach pain

The following are the severe side effects and you may require immediate medical attention:

  • Persistent nosebleeds
  • Prolonged menstrual flow
  • Unusual vaginal bleeding
  • Easy bruising
  • Unusual dizziness
  • Fast heartbeat

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions Nicoumalone?

  • Avoid using the medicine if you are allergic to Nicoumalone or similar drugs.
  • Avoid consumption of alcohol as it may increase the risk of stomach bleeding.
  • Avoid Nicoumalone during pregnancy or breastfeeding as the safe use of the drug is not yet established.
  • Do not stop using the medication abruptly unless instructed by the doctor. Stopping the medication suddenly may cause the illness to return.
  • Be cautious while taking Nicoumalone if you have any kidney or liver impairment.
  • Keep the medication out of reach of children.

You are advised not to take Nicoumalone if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking Nicoumalone?                        

  • Tell your doctor if you have any history of blood disorders, bleeding problems, alcohol abuse, high blood pressure, severe injury, severe diabetes, cancer, congestive heart failure, inflammatory disease, thyroid disorders, intestinal absorption problems, dementia and genetic disorders.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • Notify your doctor if you are pregnant or breastfeeding.

Frequently Asked Questions about Nicoumalone

  1. How should Nicoumalone be stored?
  2. Store Nicoumalone tablets at room temperature (15 – 30OC). Protect from light, heat, and moisture.

  3. Is it safe to use Nicoumalone in elderly?
  4. Nicoumalone should be used with caution in elderly. Consult your doctor before using the drug.

  5. Can I stop taking Nicoumalone if I am feeling better?
  6. No, it is not advised to discontinue the use of Nicoumalone. Abrupt discontinuation may cause the illness to return.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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