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INTRODUCTION
ABMAC TABLET contains Acebrophylline, desloratadine and montelukast that help in improving breathing difficulties associated with various conditions like asthma, hay fever and allergic rhinitis. These conditions trigger an allergic reaction like narrowing of the airway passages like bronchi which in turn leads to difficulty in breathing and chest pain.
ABMAC TABLET relaxes the airways, thereby removing the obstruction in the respiratory system and facilitating easy breathing. It also relieves various skin reactions such as itch and rash.
ABMAC TABLET is not recommended in patients suffering from various kidney disorders, liver disorders, and heart disorders like an irregular heartbeat (arrhythmia) and chest pain due to an insufficient supply of blood to the heart muscles (myocardial infarction).
ABMAC TABLET is not recommended for use by children below the age of 15 years. It is recommended to consult a doctor before taking it, as only he can decide the required dosage of ABMAC TABLET based on body mass, age, and the condition of the infection. The most common side effects reported with the use of ABMAC TABLET are diarrhoea, nausea, and vomiting. Consult your doctor if any of your symptoms get worse.
USES OF ABMAC TABLET
- Treat breathlessness and wheezing caused due to an obstruction in the lungs (chronic obstructive pulmonary disease)
- Treat breathlessness and chest pain occurring due to the narrowing of the tubes called bronchi (bronchial asthma)
- Treat inflammation of bronchi (bronchitis)
- Treat the inflammation of the nasal passages characterized by sneezing, runny or itchy nose, itchy palate and eyes, in adults and adolescents of 12 years of age and older due to allergy (Allergic Rhinitis) ( Ex. Hay fever or allergy to dust mites)
- Relieve the dry, itchy skin associated with Hives/ Urticaria
- Prevent exercise-related breathlessness due to the narrowing of airways
HOW ABMAC TABLET WORKS
ABMAC TABLET contains acebrophylline, desloratadine, and montelukast. Acebrophylline is a bronchodilator that helps in relaxing the muscles of the bronchi, thus widening the lumen (bronchodilator) and regulating mucous production and clearance, thus resulting in relief from inflammation (anti-inflammatory property), which provides relief from breathing difficulties.
Desloratadine is a tricyclic antihistamine that helps to control various allergic reactions and also does not make you feel sleepy or drowsy. Montelukast blocks the action of various allergy-producing chemicals in the body (leukotrienes), which provides relief and improves the symptoms of asthma and/or hay fever and/or seasonal allergies like wheezing and breathing difficulty by preventing the narrowing and swelling of lung airways.
Thus, together, these medicines present in ABMAC TABLET help in improving breathing difficulties associated with various causes.
DIRECTIONS FOR USE
Take ABMAC TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It is recommended to take medicine thirty to sixty minutes before or after food. Your doctor will determine the correct dose and duration for you depending on your age, body weight, and disease condition.
SIDE EFFECTS OF ABMAC TABLET
COMMON
- frequent passing of loose stools (diarrhoea)
- feeling sick (nausea)
- pain and/or discomfort in the abdomen
- loss of appetite
- constipation
- outward swelling in the abdomen (abdominal distension)
- development of itch and rash on the skin along (urticaria)
- burning of the heart (heartburn)
- bleeding of the oesophagus
- inflammation of nasal passages
- drowsiness
- difficulty in breathing
- infection in the upper respiratory tract comprising the trachea, bronchi
- decrease in the count of white blood cells (leukocytosis)
- fatigue
- dry mouth
- headache
- increased temperature of the body (fever)
UNCOMMON
- allergic reaction comprising of swelling of face and/or lips and/or tongue and/or throat leading to difficulty in swallowing and breathing
- agitation, depression, anxiety, aggression and other moods/behaviour-related changes
- dream abnormalities like nightmares, sleepwalking and troubled sleep
- fits (seizures)
- feeling dizzy and drowsy
- feeling numbness
- dry mouth
- digestive issues like indigestion
- bleeding from the nose
- skin issues like the development of rash and bruises
- pain in muscles and joints
- cramps in muscles
- feeling of tiredness and weakness
- feeling sick
- dry mouth
RARE
- headache
- feeling of numbness in the arm
- difficulty in sleeping (insomnia)
- increase in the rate of heartbeat (tachycardia)
- fatigue
- increase in blood pressure (hypertension)
- decrease in blood pressure (hypotension)
- excretion of protein in the urine (albuminuria)
- excretion of glucose in urine (glycosuria)
- increase in the sugar levels of blood (hyperglycemia)
- increase in the tendency to bleed (frequent bleeding)
- feeling of the heart beating fast (palpitations)
- rapid jerking of muscles (tremors)
- disturbance in attention and memory loss and other behavior and mood-related changes
Stop taking ABMAC TABLET and consult your doctor immediately if you experience any of the following:
- chills and fever
- allergic reactions like difficulty in breathing, wheezing, itching, hives and swelling
- symptoms of asthma get worse
- development of flu-like symptoms
- numbness of arms and/or legs
HOW TO MANAGE SIDE EFFECTS
Constipation
Eat healthy meals that are rich in fiber. Try to incorporate leafy green vegetables and whole grains into your diet. Take an adequate amount of water. Consult your doctor if it persists for a long time or worsens with time.
Diarrhea
Stick to simple meals. Consume less rich or spicy foods. To compensate for the loss of water and minerals, consume an oral rehydration solution. Stay hydrated. Consult your doctor if it persists for a long time or worsens with time.
Headache
Stay hydrated and get as much rest as you can. Stay away from harsh lights and loud sounds. Apply a pain-relieving balm to your forehead and/or take aspirin or acetaminophen. If the headache persists or worsens, consult your doctor.
Nausea And Vomiting
Stick to simple meals. Consume less rich or spicy foods. Stay hydrated. Consult your doctor if it persists for a long time or worsens with time.
Tiredness
Drink plenty of fluids and electrolytes and eat a balanced diet with an increased frequency of meals. Try to do regular, minimal exercise and follow a proper sleep schedule. If the symptom does not improve, consult your doctor about it.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedABMAC TABLET is not recommended for use in pregnant women or those who are planning pregnancy. Consult your doctor before taking ABMAC TABLET.
BREASTFEEDING
ContraindicatedABMAC TABLET is not recommended for use in nursing women due to a lack of safety data. Consult your doctor before taking ABMAC TABLET.
DRIVING AND USING MACHINES
Use with CautionABMAC TABLET does not affect your ability to drive or use machinery.
ALCOHOL
ContraindicatedABMAC TABLET is not recommended to be taken along with alcohol as it may lead to an increase in the severity of side effects like fainting and dizziness.
KIDNEY
ContraindicatedABMAC TABLET is not recommended for patients suffering from any disorder of kidney. Consult your doctor before taking ABMAC TABLET.
LIVER
ContraindicatedABMAC TABLET is not recommended for patients suffering from any disorder of the liver. Consult your doctor before taking ABMAC TABLET.
ALLERGY
ContraindicatedDo not take ABMAC TABLET if you are allergic to acebrophylline and/or theophylline and/or any other xanthine derivative and/or desloratadine and/or montelukast and/or any other constituent of ABMAC TABLET.
LUNGS
Use with CautionABMAC TABLET is to be used with caution in patients suffering from asthma. Consult your doctor before taking ABMAC TABLET.
HEART DISEASE
ContraindicatedABMAC TABLET is not recommended in patients suffering from pain in the chest due to insufficient oxygen supply to muscles of the heart (Acute Myocardial Infarction) and/or irregular heartbeat (arrhythmia) and/or low blood pressure. Consult your doctor before taking ABMAC TABLET.
USE IN PEDIATRICS
ContraindicatedABMAC TABLET is not recommended to be taken by children less than the age of 15 years. Consult your doctor before using ABMAC TABLET.
OTHERS
ABMAC TABLET is not recommended for use if you:
- are allergic to acebrophylline and/or theophylline and/or any other xanthine derivative and/or desloratadine and/or montelukast and/or any other constituent of this medicine
- are suffering from chest pain due to a shortage of oxygen to the heart (acute myocardial infarction)
- are suffering from low blood pressure and irregular heartbeats (arrhythmia)
- are suffering from the disorder of kidney and liver
Before taking ABMAC TABLET, inform your doctor if you:
- have dysfunctional kidney
- had/have medical and/or family history of seizures
- have/had a diagnosis of any kind of sugar intolerance
INTERACTIONS
A. Drug-Drug Interactions:
Before taking ABMAC TABLET, inform your doctor if you are taking any of the following medicine:
- medicines to treat gout (ex. allopurinol)
- medicines to treat ulcers (ex. cimetidine)
- medicines to relieve inflammatory disorders (corticosteroids)
- medicines to treat infections (ex, ciprofloxacin, erythromycin, amoxicillin, doxycycline)
- medications to treat parasitic (pinworm) infection (ex. thiabendazole)
- medicines to treat heart disorders (ex. diltiazem, verapamil, isoprenaline, frusemide)
- oral medicines for contraception (ex. estrogen)
- medicines to treat epilepsy (ex. phenobarbital, phenytoin)
- medicines used to treat various infections like tuberculosis (ex. rifampicin)
- medicines used to treat increased bad lipids in plasma (ex. gemfibrozil)
Overdosage:
If you or anyone else accidentally take too much of ABMAC TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are
nausea, severe vomiting, pain in the stomach and blood in vomiting (haematemesis). If abdominal pain persists for a long time, it may indicate inflammation of the pancreas (Pancreatitis). Other symptoms include restlessness, increased tonicity of muscles (hypertonia), exaggerated limb reflexes and convulsions. Increased tendency to sleep and increased thirst can also be experienced on overdosage with ABMAC TABLET.
SYNOPSIS
| Drug | : | Acebrophylline, Desloratadine, Montelukast |
| Pharmacological Category | : | Bronchodilators, Tricyclic antihistamine, Leukotriene receptor Antagonist |
| Therapeutic Indication | : | Difficulty in breathing |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep ABMAC TABLET out of reach from children
- Keep ABMAC TABLET safe from light and humidity
- Store at below 25° Celsius
FAQs ABOUT ABMAC TABLET
Q: What is ABMAC TABLET used for?
A: ABMAC TABLET is used to provide relief from the symptoms associated with various conditions like asthma, hay fever, and allergic rhinitis. These conditions trigger allergic reactions like narrowing of the airway passages like the bronchi, which in turn lead to difficulty breathing and chest pain. ABMAC TABLET relaxes the airways, thereby removing the obstruction in the respiratory system and facilitating easy breathing.
Q: Can I drive after taking ABMAC TABLET?
A: Yes, you can drive after taking ABMAC TABLET as it does not affect your ability to drive or use machinery. However, it is advised that you consult your doctor first.
Q: Can I take ABMAC TABLET during pregnancy?
A: Pregnant women or women planning to become pregnant should avoid using ABMAC TABLET. Make sure to consult your doctor before taking ABMAC TABLET.
Q: How do I take ABMAC TABLET?
A: Take ABMAC TABLET as advised by your physician. Take ABMAC TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It is recommended to take medicine thirty to sixty minutes before or after food. Your doctor will determine the correct dose and duration for you depending upon your age, body weight, and disease condition.
Q: Can ABMAC TABLET be taken by children?
A: ABMAC TABLET is not recommended to be taken by children younger than 15 years old. Consult your doctor before using ABMAC TABLET. It is recommended to consult a doctor before taking it, as only he can decide the required dosage of ABMAC TABLET based on body mass, age, and the condition of the infection.
Q: How should I store ABMAC TABLET?
A: ABMAC TABLET should be stored away from light and at a temperature below 250 °C. Also, ABMAC TABLET must be kept out of the reach of children.
Q: Can I take alcohol after taking ABMAC TABLET?
A: No, it is recommended to avoid drinking alcohol while taking and/or after taking ABMAC TABLET because it might make you dizzy.
REFERENCES
1. KD Tripathi Drugs for Cough and Bronchial Asthma Essentials of medical pharmacology. Seventh edition Page- 218.
2. KD Tripathi. Histamine and Antihistaminics. Essentials of medical pharmacology. Seventh edition Page 159.
3. Ciebiada, M., Górska-Ciebiada, M., DuBuske, L.M. and Górski, P., 2006. Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis. Annals of allergy, asthma & immunology. [Revised in November 2006] [Accessed on 8th August 2022] https://pubmed.ncbi.nlm.nih.gov/17165277/
4. Nettis, E., Colanardi, M.C., Paradiso, M.T. and Ferrannini, A., 2004. Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double-blind, placebo-controlled study. Clinical & Experimental Allergy. [Revised in 2004] [Accessed on 8th August 2022] https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.616.47&rep=rep1&type=pdf
5. Agliati, G., 1995. Acebrophylline in the treatment of chronic obstructive pulmonary disease. Current therapeutic research. [Revised in February 1995] [Accessed on 8th August 2022] https://www.sciencedirect.com/science/article/abs/pii/0011393X95850422
6. Ciplamed Acebrophyllin. [Last Reviewed in November 2013] [Accessed on 8th August 2022] https://www.ciplamed.com/content/mucophylin-capsules#:~:text=In%20healthy%20volunteers%2C%20given%20200,acetic%20acid%20after%201%20hour
7. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 8th August 2022] https://www.medicines.org.uk/emc/files/pil.12005.pdf
8. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 8th August 2022] https://www.medicines.org.uk/emc/files/pil.1243.pdf
9. Steris Healthcare. [Published on 28th April 2021] [Accessed on 8th August 2022] https://www.sterisindia.com/latest-update/-montelukast-acebr/4977
10. Divine Saviour. [Accessed on 8th August 2022] https://divinesavior.in/products-list.php?cat=20&ptype=Respiratory#prettyPhoto
USEFUL DIAGNOSTIC TESTS
- Liver Function Test
- Kidney Function Test
- Complete Blood Count
AUTHOR DETAILS
Written By Dr. Dhivakaran R, BDS
Last updated on 28 Feb 2023 | 03:20 PM(IST)
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