INTRODUCTION

A BEC 300MG contains Abacavir which belongs to a group of anti-retroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs). It is indicated to treat HIV (human immunodeficiency virus) infection. This medicine reduces the amount of virus in your body, and keeps it at a low level and also increases the CD4 cell count in your blood. CD4 cells are a type of white blood cell which is essential in helping your body to fight infection. Abacavir is a guanosine analogue which is a clinically potent anti-retroviral which leads to rapid reduction in plasma HIV-RNA count and rapid rise in CD4 cell count.

Always take this A BEC 300MG exactly as prescribed by your doctor. Before taking this medicine, tell your doctor if you have liver, kidney or heart problems. It is not recommended during pregnant and breastfeeding. Your doctor will prescribe the right dose depends on your child’s age and body weight. The common side effects are hypersensitivity reactions such as skin rash, nausea, vomiting, abdominal pain and diarrhea.

USES OF A BEC 300MG

• Treats HIV (Human Immunodeficiency Virus) infection

HOW A BEC 300MG WORKS

A BEC 300MG is a guanosine analogue which is phosphorylated to carbovir triphosphate. This interferes with HIV viral RNA-dependent DNA polymerase resulting in inhibition of viral replication. It works by decreasing the amount of HIV in blood.

DIRECTIONS FOR USE

Always take this A BEC 300MG exactly as your doctor has told you. Swallow as a whole, with a glass of water and do not crush or chew. It can be taken with or without food.

SIDE EFFECTS OF A BEC 300MG

HOW TO MANAGE SIDE EFFECTS

Nausea:

Stick to simple normal meals and do not eat rich or spicy foods.

Diarrhoea:

Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, or sweet foods.

WARNING & PRECAUTIONS

INTERACTIONS

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• rifampicin (used to treat bacterial infections)
• phenobarbital or phenytoin (used to treat epilepsy)
• methadone (used as a heroin substitute)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT A BEC 300MG

How does A BEC 300MG work?

It interferes with an enzyme called reverse transcriptase (RT), which is used by HIV-infected cells to make new viruses.

What is the toxicity of A BEC 300MG?

The most common symptoms of hypersensitivity reactions are fever, rash, nausea, vomiting, diarrhea or abdominal pain and tiredness.

What if I forget to take a dose of A BEC 300MG?

If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose. Do not double the dose to make up for the missed one.

REFERENCES

1. KD Tripathi MD.  Antimicrobial drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 808.

2. Flexner C. Antiretroviral Agents and Treatment of HIV Infection. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. Page - 1635-1637.

3. Safrin S. Antiviral Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 856-857.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 1-2.

5. Mario Cruciani, Carlo Mengoli, Marina Malena, Giovanni Serpelloni, Saverio G. Parisi, Graeme Moyle, Oliviero Bosco. Virological efficacy of abacavir: systematic review and meta-analysis: Journal of Antimicrobial chemotherapy. Volume 69, Issue 12, December 2014; [Accessed Jan 9, 2021] https://academic.oup.com/jac/article/69/12/3169/818477

6. Mylan, Potters Bar (UK). Pharmadox Healthcare Limited. Electronic Medicines Compendium (EMC); [Revised Oct, 2019] [Accessed Jan 9, 2021] https://www.medicines.org.uk/emc/files/pil.9079.pdf

7. GlaxoSmithKline. ViiV Healthcare. 1998; U.S. Food & Drug Administration; [Revised March, 2012] [Accessed Jan 9, 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020977s024,020978s028lbl.pdf

USEFUL DIAGNOSTIC TESTS

• HIV 1 & 2, Ab Western Blot
• HIV 1 And 2 Antibody - Chromatography
• HIV 1 And 2 Antibody - ELISA