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HomeMedicineBacterial InfectionsORNOF INFUSION 100ML
ORNOF INFUSION 100ML - Bacterial Infections-Qui
  • ORNOF INFUSION 100ML - Bacterial Infections-Qui
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ORNOF INFUSION 100ML - Bacterial Infections-Qui
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Aristo Pharmaceuticals Pvt Ltd

ORNOF INFUSION 100ML

Bacterial Infections
MRP ₹98.50 (Inclusive of all taxes)
New Reduced MRP as per revised GST benefit.
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    INTRODUCTION

    ORNOF is a combination of Ornidazole and Ofloxacin which belongs to the group of medicines called Antibiotics. It is used for the treatment of urinary tract diseases, respiratory diseases, skin diseases, soft tissue disease and sexually transmitted diseases.

    Your doctor might want you to take certain blood tests prior to the treatment with ORNOF to understand the existing condition. Avoid consumption of alcohol while receiving ORNOF as it may cause severe side effects.

    ORNOF is not recommended for use in patients with epilepsy, past history of tendinitis, peripheral neuropathy, history of myasthenia gravis, suspected gonococcal infection and rare hereditary disorders of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.

    Before receiving ORNOF, inform your doctor if you have impaired kidney or liver function, heart diseases (such as heart attack or failure, slow heart rate) sclerosis, previous tendon disorders such as rheumatoid arthritis, pelvic inflammatory disease, diabetes, history of psychotic disorder or have schedule for any laboratory test.

    ORNOF is not recommended to use among women who are pregnant or breastfeeding. It is not recommended for use in children and growing adolescents and it should be used with caution in elderly patients particularly with impaired renal function.

    The most common side effects of receiving ORNOF are inflammation of a vein (phlebitis) and infusion-site reaction (such as pain, reddening). Inform your doctor if any of these side effect worsens.

    USES OF ORNOF

    Used for the treatment of:

    • Urinary tract diseases
    • Respiratory diseases
    • Skin diseases
    • Soft tissue diseases
    • Sexually transmitted diseases

    HOW ORNOF WORKS

    ORNOF is a combination of Ornidazole and Ofloxacin where Ornidazole kills parasites and bacteria that live in the absence of oxygen by generating harmful molecule which damages the DNA of the parasites and bacteria and ofloxacin is a quinolone antibiotic that kills bacteria by inhibiting the synthesis of bacterial DNA, hence helps to treat various infections.

    DIRECTIONS FOR USE

    ORNOF will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

    SIDE EFFECTS OF ORNOF

    COMMON

    • inflammation of a vein (phlebitis)
    • infusion-site reaction (such as pain, reddening)

    UNCOMMON

    • agitation, sleep disorder, insomnia
    • dizziness, headache
    • eye irritation
    • vertigo (spinning sensation)
    • cough, common cold
    • abdominal pain, diarrhoea, nausea, vomiting
    • itching, rash

    RARE

    • loss of appetite
    • anxiety, nightmares
    • depression
    • sleepiness
    • tingling or prickling sensation in arms, legs or feet
    • altered taste or smell
    • visual disturbance
    • fast heart rate, low blood pressure
    • shortness of breath, bronchospasm
    • inflammation of digestive tract (enterocolitis)
    • hot flushes
    • excess sweating
    • pustular rash
    • tendonitis

    Inform your doctor immediately if you experience any of the following side effects while receiving ORNOF:

    • serious adverse reactions (such as tendinitis and tendon rupture, peripheral neuropathy and CNS effects)
    • pain, burning, tingling or numbness sensation, weakness or other alterations in sensations, including light touch, pain, temperature, position sense and vibratory sensation and/or motor strength
    • central nervous system stimulation such as (tremors, restlessness, lightheadedness, confusion and hallucinations)
    • anaphylactic and anaphylactoid reactions
    • convulsive seizures

    HOW TO MANAGE SIDE EFFECTS

    Headache:

    Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the symptom does not improve.

    Stomach pain:

    Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. If the symptom gets worse inform your doctor.

    Nausea or vomiting:

    Stick to simple meals while receiving this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.

    Diarrhea:

    Drink lots of fluids such as water to keep yourself hydrated. Avoid eating fried and greasy foods. Inform your doctor if the symptom does not improve.

    WARNING & PRECAUTIONS

    PREGNANCY

    ORNOF is not recommended for use in pregnant women or women planning to have a baby. Consult your doctor before receiving ORNOF.

    BREASTFEEDING

    ORNOF is not recommended for use in breastfeeding women. Consult your doctor before receiving ORNOF.

    DRIVING AND USING MACHINES

    Do not drive or operate any machines while receiving ORNOF as you may feel sleepy, impairment of skills, dizziness and visual disturbances.

    ALCOHOL

    Avoid consumption of alcohol while receiving ORNOF as it can cause severe side effects. Consult your doctor before receiving ORNOF.

    KIDNEY

    ORNOF should be used with caution in patients with impaired kidney function. Consult your doctor before receiving ORNOF.

    LIVER

    ORNOF should be used with caution in patients with impaired liver function. Consult your doctor before receiving ORNOF.

    ALLERGY

    Do not receive ORNOF if you are allergic to Ornidazole, Ofloxacin or any of the other ingredients of this medicine.

    LUNGS

    ORNOF should be used with caution in patients with surgical history of lung transplant. Consult your doctor before receiving ORNOF.

    HEART DISEASE

    ORNOF should be used with caution in patients with cardiac diseases such as heart attack or failure, slow heart rate and congenital long QT syndrome as it might increase the risk factor for prolongation of the QT interval. Consult your doctor before receiving ORNOF.

    OTHERS

    ORNOF is not recommended for use if you have:

    • epilepsy or with a lowered seizure threshold
    • past history of tendinitis
    • latent or actual defects in glucose-6-phosphate dehydrogenase activity
    • peripheral neuropathy
    • history of myasthenia gravis
    • suspected gonococcal infection
    • rare hereditary disorders of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption

    Before receiving ORNOF, inform your doctor if you have:

    • sclerosis
    • known or suspected CNS disorders such as severe cerebral arteriosclerosis, epilepsy and other factors that predispose to seizures
    • previous tendon disorders such as rheumatoid arthritis
    • pelvic inflammatory disease
    • history of psychotic disorder or in patients with psychiatric disease
    • diabetes
    • any scheduled laboratory test to be given
    • uncorrected electrolyte imbalance such as low potassium or magnesium levels in the blood

    Use in pediatrics:

    ORNOF is not recommended for use in children and growing adolescents. Consult your child’s doctor for advice.

    Use in geriatrics:

    ORNOF should be used with caution in elderly patients particularly with impaired kidney function. Consult your doctor before receiving ORNOF.

    INTERACTIONS

    A. Drug-Drug interactions:

    Before receiving ORNOF, inform your doctor if you are taking any of the following medicines:

    • Class IA and III anti-arrhythmics such procainamide, disopyramide, amiodarone, sotalol (used to treat arrhythmia)
    • tricyclic antidepressants such as amitriptyline, nortriptyline (used to treat depression)
    • macrolide antibiotics such as azithromycin, clarithromycin (used to treat bacterial infections)
    • antipsychotics such as risperidone, quetiapine (used to treat schizophrenia)
    • anticoagulants such as heparin or warfarin (used to prevent or treat blood clots)
    • theophylline (used to treat asthma)
    • fenbufen or other nonsteroidal anti-inflammatory drugs such as ibuprofen (used to inflammation in osteoarthritis)
    • glibenclamide (used to treat diabetes)
    • probenecid (used to treat gout)
    • cimetidine (used to treat stomach ulcers)
    • furosemide (used to treat fluid retention)
    • methotrexate (used to treat certain forms of cancer)

    B. Drug - Food interactions:

    Avoid milk and dairy products while on treatment with ORNOF.

    Overdosage:

    ORNOF will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely to cause an overdose. However, consult your doctor or nurse if you experience any unusual symptoms such as CNS symptoms (confusion, dizziness, impairment of consciousness and seizures), increased QT interval, gastrointestinal reactions such as nausea and mucosal erosions.

    SYNOPSIS

    Drug :   Ornidazole and Ofloxacin
    Pharmacological Category :   Nitroimidazole and Fluoroquinolones
    Therapeutic Indication :   Various bacterial infections
    Dosage Forms :   Tablet, Capsule, Infusion, Injection, Syrup, Oral Suspension

    MORE INFORMATION

    • Store at a temperature, not more than 30°C

    FAQs ABOUT ORNOF

    What is ORNOF and what it is used for?

    ORNOF is a combination of Ornidazole and Ofloxacin which belongs to the group of medicines called Antibiotics. It is used for the treatment of urinary tract diseases, respiratory diseases, skin diseases, soft tissue disease and sexually transmitted diseases.

    How does ORNOF work?

    ORNOF is a combination of Ornidazole and Ofloxacin where Ornidazole kills parasites and bacteria that live in the absence of oxygen by generating harmful molecule which damages the DNA of the parasites and bacteria and ofloxacin is a quinolone antibiotic that kills bacteria by inhibiting the synthesis of bacterial DNA, hence helps to treat various infections.

    Is it safe to use ORNOF during pregnancy?

    ORNOF is not recommended for use in pregnant women or women planning to have a baby. Consult your doctor for advice to select a suitable alternative to treat the specific infection.

    Can ORNOF be used in patients with heart problems?

    ORNOF should be used with caution in patients with cardiac diseases such as heart attack or failure, slow heart rate and congenital long QT syndrome as it might increase the risk factor for prolongation of the QT interval. Consult your doctor before receiving it.

    How is ORNOF administered?

    ORNOF will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

    REFERENCES

    1. KD. Tripathi. Antiamoebic and Other Antiprotozoal Drugs, Sulfonamides, Cotrimoxazole and Quinolones. Seventh edition. 2013. Page – 839, 713
    2. Dr Avinash Shankar, Dr Amresh Shankar and Dr Anuradha Shankar. Rationale of Ornidazole and Ofloxacin in Management of Diarrhoea. International Journal of Clinical Chemistry and Laboratory Medicine. 2018 [Accessed on 10th October 2022] https://www.arcjournals.org/pdfs/ijcclm/v4-i3/4.pdf
    3. Nikhil Bush , Vishal Sharma , K Chandrahasan , Amol N Patil. Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge. National library of medicine, National center for biotechnology information. Pubmed.gov 2020. [Accessed on 10th October 2022] https://pubmed.ncbi.nlm.nih.gov/32984191/
    4. GM Global. Acioflo O Infusion (Ornidazole and Ofloxacin). [Accessed on 10th October 2022] https://gm-global.in/products/infusions/acioflo-o/
    5. Medley Pharmaceuticals Ltd. O2 Infusion (Ornidazole and Ofloxacin). [Accessed on 10th October 2022] https://www.medleylab.com/product/nutrakare/anti-diarrhoeal.html
    6. Ciplamed. Oflox IV Infusion (Ofloxacin). [Revised in January 2019] [Accessed on 10th October 2022] https://www.ciplamed.com/content/oflox-iv-infusion
    7. Swisschem. Ornidachem-IV infusion (Ornidazole). [Accessed on 10th October 2022] https://www.swisschem.in/product/ornidachem-iv/

    USEFUL DIAGNOSTIC TESTS

    • Complete blood count
    • Kidney function test

    AUTHOR DETAILS

    Written By Dr. R. Dinesh John Rajkumar, Pharm.D
    Last updated on 22 Oct 2022 | 04:12 PM(IST)

    Lab updated