ORNOF SUSPENSION 60ML
Netmeds First Membership
INTRODUCTION
ORNOF is a combination of Ornidazole and Ofloxacin which belongs to the group of medicines called Antibiotics. ORNOF is used in children to treat various bacterial infections involving the blood (such as septicemia), brain (such as meningitis), lungs (such as pneumonia, bronchitis), ear and nose (such as sinusitis), urinary tract (such as cystitis), genital infections (including both the male and female genital organs), wound (post-operative infections) and stomach (such as peritonitis).
ORNOF is also used as prophylaxis to prevent bacterial infections during surgical interventions (particularly involving the colon and in gynaecological operations).
Before initiating the treatment with ORNOF to your child, your child’s doctor may recommend your child to take relevant medical tests to understand the existing condition and to properly use this medicine.
Before giving ORNOF to your child, inform your child’s doctor if your child have heart disease (such as irregular heartbeat, valve disorder, poor heart function), kidney diseases (such as kidney failure or kidney injury), inflammation of the intestine, fits/seizure, autoimmune disease (such as multiple sclerosis), weak tendons (tendonitis, tendon rupture, rotator cuff), liver disease, psychiatric illness or emotional imbalances.
ORNOF is not recommended for use in pregnant or breastfeeding women and elderly individuals as it is used only in children.
The common side effects of taking ORNOF are nausea, vomiting, diarrhea, headache, itching and changes in taste sensation. Consult your child’s doctor immediately if any of the side effects worsen during or after treatment with ORNOF.
USES OF ORNOF
To treat bacterial infections in children such as:
- lungs infections (Ex. pneumonia, bronchitis)
- sinus infections
- urinary tract infections
- meningitis
- septicemia
- peritonitis
- post-operative wound infections
- genital infections (both the male and female genital organs)
- prophylaxis during surgical interventions (particularly involving the colon and in gynaecological operations)
HOW ORNOF WORKS
ORNOF is a combination of Ornidazole and Ofloxacin where Ornidazole kills parasites and bacteria that live in the absence of oxygen by generating harmful molecule which damages the DNA of the parasites and bacteria and ofloxacin is a quinolone antibiotic that kills bacteria by inhibiting the synthesis of bacterial DNA, hence ORNOF helps to treat various infections.
DIRECTIONS FOR USE
Give ORNOF to your child as advised by the physician. Use a measuring cup to properly measure the dose. Your child’s doctor will decide the correct dose, duration and frequency of ORNOF for your child depending on child’s age, body weight and disease condition.
SIDE EFFECTS OF ORNOF
COMMON
- headache, dizziness
- nausea, vomiting
- diarrhea
- itching
- sleep problems
- external genital itching
- vaginal inflammation
- changes in taste sensation
UNCOMMON
- stomach pain or discomfort
- dry mouth
- loss of appetite
- fungal infection
- agitation, restlessness
- burning or irritation of the eye
- cough and inflamed sore nose or throat
- spinning sensation of the head (vertigo)
RARE
- fast heartbeat
- drowsiness
- confusion, nightmare
- decrease in blood sugar levels
- depression or hallucination (feeling or hearing things not there)
- changes in sensation of smell
- shortness of breath or wheezing
- excessive sweating
- feeling faint, lightheadedness due to low blood pressure
- hives
- rash with pimples
- pain or swelling around joints (tendonitis)
- excessive sweating, hot flushes
Stop giving ORNOF to your child and contact doctor immediately if your child experiences any of the following side effects:
- severe allergic reactions (such as skin rash, itching, swelling of the face, lips, tongue and other parts of the body, difficulty in breathing or wheezing, blisters on the skin, sore throat, fever, headache)
- painful skin rashes with blisters and peeling or scaling of the skin in conditions such as steven-johnson syndrome and toxic epidural necrolysis
- abnormal heartbeat
- changes in behavior, psychosis, depression, hallucination, disorientation or fainting
- impaired vision or hearing
- severe fever, body chills or muscle pain
- swelling or rupture of tendons
- numbness or tingling sensation of the skin
- abnormal bleeding
- abnormal body movements like fits or seizure
- severe loose stools or diarrhea
- difficulty in passing urine or urine discoloration
- loss of consciousness
- abnormal body sugar level
- pain, burning, numbness and/or weakness especially in the feet and legs or hands and arms (which indicates nerve damage)
- stomach pain, itching, dark urine or yellowish discoloration of the skin and in the white part of the eye (jaundice)
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Follow simple meal plan for your child while administering ORNOF. Avoid giving foods that are oily, fried or spicy foods. Do not let your child to lie down or sleep immediately after eating. Consult child’s doctor if the symptom does not improve.
Headache:
Apply hot or cold-water bag on your child’s head. Advise your child to take rest in a quiet room. Massage child’s scalp or head with mild pressure for relieving effect. Consult child’s doctor if the symptom does not improve.
Diarrhea:
Advise your child to drink plenty of water and stay hydrated. Avoid giving your child a high-fat diet or spicy foods. Try to avoid giving any medicine on your own to your child to treat diarrhea. Consult child’s doctor if the symptom gets worse.
Dry mouth:
Tell your child to sip water regularly and other sugar free liquids. Advise them not to use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Consult child’s doctor if the symptom gets worse.
WARNING & PRECAUTIONS
PREGNANCY
ORNOF is not recommended for use in pregnant women as it is used only in children.
BREASTFEEDING
ORNOF is not recommended for use in breast-feeding women as it is used only in children.
DRIVING AND USING MACHINES
Do not let your child ride bicycles or drive other vehicles or operate any tools after taking ORNOF if your child feel dizzy, tired, sleepy, temporary loss of consciousness, less alert, spinning sensation of the head (vertigo), impaired vision, shivering, abnormal body movements and seizure/fits. Consult your child’s doctor for advice before administration of ORNOF.
KIDNEY
ORNOF should be administered with caution in children with kidney disease or problems. Consult your child’s doctor for advice before administration of ORNOF.
LIVER
ORNOF should be administered with caution in children with liver disease. Consult your child’s doctor for advice before administration of ORNOF.
ALLERGY
Do not give ORNOF to your child if they are allergic to Ofloxacin or Ornidazole. Also, inform child’s doctor if your child is allergic to other quinolone antibiotics such as ciprofloxacin, norfloxacin.
HEART DISEASE
ORNOF should be administered with caution in children with leaking heart valves (heart valve regurgitation), endocarditis (infection of the heart), irregular or slow heartbeat, family history of prolonged QT interval, weak heart (heart failure), family history of heart attack (myocardial infarction). Consult your child’s doctor for advice before administration of ORNOF.
OTHERS
ORNOF is not recommended for use, if your child:
- has epilepsy or at risk of fits
- has any pre-exisiting central nervous system (CNS) disorders
- has history of inflammation and swelling of the tendons (tendonitis) especially after the treatment with quinolone antibiotics such as ciprofloxacin, norfloxacin or nadifloxacin
- is suffering from or have a family history of glucose-6-phosphate dehydrogenase deficiency (an inherited disorder that affects the red blood cells)
Before giving ORNOF to your child, inform child’s doctor if your child:
- has enlargement or bulge of a large blood vessel (aortic aneurysm or large vessel peripheral aneurysm)
- has experienced a previous episode of aortic dissection (a tear in the aorta wall)
- has a family history of aortic aneurysm or aortic dissection
- has other risk factors or predisposing conditions (Ex. connective tissue disorders such as marfan syndrome or ehlers- danlos syndrome, turner syndrome, sjogren’s syndrome (an inflammatory autoimmune disease)
- has vascular disorders such as takayasu arteritis, giant cell arteritis, behcet’s disease and high blood pressure or atherosclerosis, arthritis
- has or ever had a history of mental illness
- has salt imbalance in the blood (especially low level of potassium or magnesium in the blood)
- has illness of the nervous system called myasthenia gravis (muscle weakness)
- has diabetic or suffer from low blood sugar
- has due to urine tests for porphyrin (a pigment in the blood) or for opiates (strong painkillers)
Use in pediatrics:
ORNOF can be used in children. Consult your child’s doctor for advice before administration of ORNOF to your child.
Use in geriatrics:
ORNOF is not recommended for use in elderly individuals as it is used only in children.
INTERACTIONS
A. Drug-Drug interactions:
Before giving ORNOF to your child, inform to child’s doctor if your child is taking or receiving any of the following medicines:
- antipsychotics such as olanzapine, clozapine (used to treat psychosis)
- cyclosporin (used to prevent organ rejection after transplant)
- quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide, pentoxifylline (used to treat irregular heart rhythm)
- lithium or tricyclic antidepressants such as clomipramine, amitriptyline (used to treat depression)
- macrolides such as erythromycin, clarithromycin, azithromycin (used to treat bacterial infection)
- vecuronium bromide (used to relax muscles)
- phenytoin, phenobarbital (used to treat epilepsy)
- didanosine (used in the treatment of HIV infection)
- furosemide (used to treat body fluid retention)
- sucralfate, cimetidine (used to treat stomach ulcer)
- antacids containing magnesium or aluminium (used for indigestion)
- corticosteroids such as prednisolone, dexamethasone (used to treat inflammation)
- non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or diclofenac (used to pain and inflammation)
- theophylline (used to treat asthma)
- insulin, glibenclamide (used to treat diabetes)
- probenecid (used to treat gout)
- methotrexate (used for rheumatism)
- warfarin, acenocoumarin, phenprocoumon (used to treat or prevent blood clot)
- medicines or dietary supplements that contain iron (for anemia) or zinc
- herbal medicines
Overdosage:
If your child or anyone else accidentally takes too much of ORNOF, consult your child’s doctor immediately or visit the nearby hospital. Overdosage symptoms of ORNOF include confusion, dizziness, loss of consciousness, seizure or fit and nausea.
SYNOPSIS
| Drug | : | Ornidazole and Ofloxacin |
| Pharmacological Category | : | Nitroimidazole and Fluoroquinolones |
| Therapeutic Indication | : | Various bacterial infections in children |
| Dosage Forms | : | Tablet, Capsule, Infusion, Injection, Syrup, Oral Suspension |
MORE INFORMATION
- Keep ORNOF out of reach from children
- Store ORNOF at room temperature
FAQs ABOUT ORNOF
Does ORNOF cause diarrhea?
Yes, ORNOF may cause side effects like diarrhea in children. Advise your child to drink plenty of water and stay hydrated. Avoid giving your child a high-fat diet or spicy foods. Try to avoid giving any medicine on your own to your child to treat diarrhea. Consult child’s doctor if the symptom gets worse during or after treatment with ORNOF.
Is ORNOF safe to use in children with heart problems?
ORNOF should be administered with caution in children with leaking heart valves (heart valve regurgitation), endocarditis (infection of the heart), irregular or slow heartbeat, family history of prolonged QT interval, weak heart (heart failure), family history of heart attack (myocardial infarction). Consult your child’s doctor for advice before administration of ORNOF.
Can ORNOF be used in children with kidney problems?
ORNOF should be administered with caution in children with kidney disease or problems. Your child’s doctor may monitor the child’s kidney function test before and during treatment with ORNOF to prevent any unusual effects or kidney damage. Consult your child’s doctor for advice before administration of ORNOF.
How does ORNOF work?
ORNOF is a combination of Ornidazole and Ofloxacin where Ornidazole kills parasites and bacteria that live in the absence of oxygen by generating harmful molecule which damages the DNA of the parasites and bacteria and ofloxacin is a quinolone antibiotic that kills bacteria by inhibiting the synthesis of bacterial DNA, hence helps to treat various infections.
What are the common side effects of ORNOF?
The common side effects of taking ORNOF are nausea, vomiting, diarrhea, headache, itching, sleep problems and changes in taste sensation. Consult your child’s doctor immediately if any of the side effects worsen during or after treatment with ORNOF.
REFERENCES
1. KD. Tripathi. Antimicrobial drugs, antiamoebic and other antiprotozoal drugs. Essentials of medical pharmacology. 8th Edition. 2019. Page – 763 & 897.
2. A. Soni, M. Chaudhary, A. Tamta, R. Sehgal, S.M. Shrivastava and V.K. Dwivedi. Science Alert. Therapeutic Efficacy of Ofloxacin and Ornidazole vs Mebatic: Toxicity Profile and Antioxidant Defense Study. [Revised in 2009] [Accessed on 3rd May 2022] https://scialert.net/fulltext/?doi=jp.2009.79.86
3. David G. Bailey, George Dresser and J. Malcolm O. Arnold, MB. National Library of Medicine (NIH). Grapefruit–medication interactions: Forbidden fruit or avoidable consequences. [Revised in 18th October 2018] [Accessed on 3rd May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589309/
4. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG). National Library of Medicine (NIH). Using medication: Using antibiotics correctly and avoiding resistance. [Revised in 13th December 2013] [Accessed on 3rd May 2022] https://www.ncbi.nlm.nih.gov/books/NBK361005
5. Shalina Healthcare. Shalflod (Ofloxacin 50 mg and Ornidazole 125 mg) Suspension. [Accessed on 3rd May 2022] https://www.shalina.com/wp-content/uploads/2018/09/shalflodgroup.pdf
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- Liver function test
- Kidney function test
- Bacterial Culture sensitivity test
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 27 Oct 2022 | 05:47 PM(IST)