Uses of Metformin+Sitagliptin

The combination of Metformin and Sitagliptin is used to control blood sugar levels in patients with type II diabetes mellitus along with proper diet and exercise.  

Therapeutic Category

Metformin: Antidiabetic agents (Biguanides)  

Sitagliptin: Antidiabetic agents (Dipeptidyl peptidase 4 (DPP-4) inhibitor) 

How Metformin+Sitagliptin works

Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose. Additionally, it can stop glucose production by the liver and reduces its absorption in the body.

Sitagliptin controls blood sugar levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that reduces insulin secretion in the body. Collectively, it controls blood sugar levels and improve glycemic control in patients with type II diabetes.

Common side effects of Metformin+Sitagliptin

• hypoglycemia (low blood sugar)
• nausea, vomiting
• flatulence, diarrhea, constipation, stomach pain, loss of appetite
• swelling of hands and legs (edema)
• upper respiratory infections
• stuffy nose, sore throat
• joint pain, pain in arms or legs
• metallic taste

When to consult your doctor

Consult your doctor:

• In case of accidental overdosage
• If you experience serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
• If you experience severe blistering of the skin (signs of an allergic skin reaction called bullous pemphigoid)
• If you experience signs of pancreatitis (such as severe and persistent pain in the stomach areas which might reach through to your back with or without nausea and vomiting)
• If you experience signs of lactic acidosis (such as cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)

Health Tips for Metformin+Sitagliptin

• Maintain a balanced diet that includes whole foods such as fruits, vegetables, whole grains, lean meats and healthy fats. To assist maintain blood sugar levels, keep track of your carbohydrate intake. Try taking foods with a low glycemic index, as they have a slower impact on blood sugar levels
• Stay hydrated by drinking plenty of water throughout the day. Hydration is important for kidney function and general health
• Exercise on a regular basis can assist increase insulin sensitivity and blood sugar control. Aim for a combination of aerobic and strength training, as prescribed by your doctor
• Monitor your blood sugar levels on a regular basis, as directed by your doctor. Keeping track of your levels will help you understand how your body reacts to the medicine and can help you make dietary decisions
• Evaluate your feet on a regular basis for any signs of blisters, sores, or cuts. Diabetes patients must take special care of their feet
• Avoid drinking alcohol as it can affect blood sugar levels and interact with your medications
• Meditation and deep breathing exercises are all effective stress-reduction approaches. Stress management has been shown to improve blood sugar levels
• Take Metformin+Sitagliptin exactly as directed by your doctor. Follow the specified dosage and regimen. Do not change the dosage or discontinue the medicine without first consulting your doctor