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Introduction About CAFIRATE ORAL 20MG SOLUTION

CAFIRATE ORAL 20MG SOLUTION contains Caffeine which belongs to the group of medicines called CNS stimulants. It is used to manage primary apnea (episodes of interrupted breathing) in premature babies. Primary apnea in premature babies happens due to immature development of baby’s breathing centers.

CAFIRATE ORAL 20MG SOLUTION has been shown to reduce the number of episodes of interrupted breathing in premature newborns babies. It can also be used to manage bronchopulmonary dysplasia (airway damage) among premature babies.

Before CAFIRATE ORAL 20MG SOLUTION is administered, inform your doctor if you child has any liver, kidney or heart problems. You must also inform your doctor if your child suffers from seizure disorders, slow weight gain or frequent regurgitation (spitting up of milk or food) as a precaution.

If you are the mother of the premature infant who receives the management, you must not drink coffee or take foods which has high caffeine content. This is because the caffeine taken by the breastfeeding mother may pass through the breast milk to the nursing premature infant who is already receiving caffeine therapy and may lead to an overdosage. The most common side effect of CAFIRATE ORAL 20MG SOLUTION is fast or irregular heart rate. Consult your doctor if it worsens.

Uses Of CAFIRATE ORAL 20MG SOLUTION

Manage primary apnea (episodes of interrupted breathing) in premature babies
Manage and manages bronchopulmonary dysplasia (airway damage) in premature babies

How CAFIRATE ORAL 20MG SOLUTION Works

CAFIRATE ORAL 20MG SOLUTION is a CNS stimulant. It works by stimulating a part of the brain that controls breathing. As a result, the brain transfers a lot of breathing signals to the lungs which makes the lungs breathe more deeper and faster. It also increases the number of breathing cycles, manages the airway damage and reduces the need for mechanical ventilation.

How to use CAFIRATE ORAL 20MG SOLUTION

CAFIRATE ORAL 20MG SOLUTION will be administered orally (via gastric feeding tube) to your child only by a doctor or a nurse.

Your doctor will decide the correct dose and duration of therapy for your child based on their gestational age, body weight and health condition.

Side Effects Of CAFIRATE ORAL 20MG SOLUTION

Common

Fast or irregular heart rate
Increased blood sugar levels

Contact your doctor immediately if you notice any of the following side effects in your child after CAFIRATE ORAL 20MG SOLUTION is administered:

Severe bloody stools
Fits
Blood infections (sepsis)
Allergic reactions (such as skin rash, itching, redness, swelling of the face, lips, tongue or threating and breathing difficulties)

Warning & Precautions

Breastfeeding

Contraindicated

Kidney

Use with Caution

CAFIRATE ORAL 20MG SOLUTION should be used with caution in babies with kidney problems. Therefore, inform your doctor as a precaution.

Liver

Use with Caution

CAFIRATE ORAL 20MG SOLUTION should be used with caution in babies with liver problems. Therefore, inform your doctor as a precaution.

Allergy

Contraindicated

If your child is allergic to caffeine, kindly inform your doctor before CAFIRATE ORAL 20MG SOLUTION is administered to the child.

Heart Disease

Use with Caution

CAFIRATE ORAL 20MG SOLUTION should be used with caution in babies with heart problems (such as irregular heart rate). Therefore, inform your doctor as a precaution.

Use In Pediatrics

Safe

CAFIRATE ORAL 20MG SOLUTION can be used in premature infants born between 28-33 gestation weeks (7-8 months of pregnancy) under careful medical supervision.

Others

Before CAFIRATE ORAL 20MG SOLUTION is administered to the baby, kindly inform the doctor if your baby suffers from any of the following conditions:

fits
frequent regurgitation (spitting up of milk or food)
increased urination
slow or reduced weight gain or food intake
increased caffeine intake by the mother before the baby is delivered
use of antiepileptic medicines by the mother during her pregnancy

Interactions

A. Drug-Drug interactions:

Before CAFIRATE ORAL 20MG SOLUTION is administered to the child, kindly inform the doctor if your child is given any of the following medicines as a precaution:

other medicines that help in breathing (Ex. theophylline, doxapram)
medicines used to control fits (such as phenobarbitone or phenytoin) taken by the mother during pregnancy before delivering the baby
ketoconazole (a medicine used to manage fungal infections)
medicines used to manage stomach ulcers (such as omeprazole, pantoprazole, rabeprazole, ranitidine, famotidine, cimetidine, etc.)

Overdosage:

CAFIRATE ORAL 20MG SOLUTION will be administered only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor if you notice fits or any other side effects in your child.

Synopsis

Drug	:	Caffeine
Pharmacological Category	:	Methylxanthines
Therapeutic Indication	:	Apnea of prematurity in infants
Dosage Forms	:	Tablet, Injection, Oral solution, Suspension

More Information

Keep CAFIRATE ORAL 20MG SOLUTION out of reach of children
Store CAFIRATE ORAL 20MG SOLUTION at room temperature

FAQs About CAFIRATE ORAL 20MG SOLUTION

Q: What is the use of CAFIRATE ORAL 20MG SOLUTION?

A: CAFIRATE ORAL 20MG SOLUTION is used to manage primary apnea (episodes of interrupted breathing) in premature babies. It can also be used to manage bronchopulmonary dysplasia (airway damage) among premature babies.

Q: How CAFIRATE ORAL 20MG SOLUTION helps in breathing problems?

A: CAFIRATE ORAL 20MG SOLUTION is a CNS stimulant. It works by stimulating a part of the brain that controls breathing. As a result, the brain transfers a lot of breathing signals to the lungs which makes the lungs breathe more deeper and faster. It also increases the number of breathing cycles, manages the airway damage and reduces the need for mechanical ventilation.

Q: Is CAFIRATE ORAL 20MG SOLUTION safe for use in children?

A: CAFIRATE ORAL 20MG SOLUTION can be used in premature infants born between 28-33 gestation weeks (7-8 months of pregnancy) under careful medical supervision.

Q: Why newborn babies suffer from apnea?

A: Primary apnea in premature babies happens due to immature development of baby’s breathing centers.

Q: What are the side effects of CAFIRATE ORAL 20MG SOLUTION?

A: The most common side effect of CAFIRATE ORAL 20MG SOLUTION is fast or irregular heart rate. Consult your doctor if it worsens.

Q: Is CAFIRATE ORAL 20MG SOLUTION effective?

A: CAFIRATE ORAL 20MG SOLUTION effectively improves breathing among infants suffering from apnea of prematurity. It works by stimulating a part of the brain that controls breathing. It also increases the number of breathing cycles, manages the airway damage and reduces the need for mechanical ventilation.

References

1. KD. Tripathi. Drugs for Cough and Bronchial asthma. CNS Stimulants and Cognition Enhancers. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 224, 227& 488.

2. Justin Evans; John R. Richards; Amanda S. Battisti. Caffeine. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2022. [Accessed on 25th March 2023] https://www.ncbi.nlm.nih.gov/books/NBK519490/

3. Macarthys Laboratories Limited. Caffeine Citrate Oral solution. Electronic Medicines Compendium [Revised in July 2018] [Accessed on 25th March 2023] https://www.medicines.org.uk/emc/files/pil.5145.pdf

4. American Regent, Inc. Caffeine Citrate Injection, Solution. Dailymed.com. [Revised in September 2020]. [Accessed on 25th March 2023] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d17e3be5-514f-454a-8347-d804cd5ec37f

5. Central Drugs Standard Control Organization. Caffeine Citrate Oral Solution. July 2009. [Accessed on 25th March 2023] https://cdscoonline.gov.in/CDSCO/Drugs

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Rajnikant - MBBS, MD (Physiology)

Last updated on 27 Mar 2023 | 05:47 PM(IST)

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