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Introduction About XYLOCAINE NF CREAM

XYLOCAINE NF CREAM is a combination of Lignocaine and Nifedipine, which belongs to the group of medicines called Local anaesthetics and Calcium channel blockers. It is used to relieve pain and relax muscles during the management or examination of anal fissures, thrombosed external haemorrhoids, post-haemorrhoidectomy, anal sphincter hypertonia, etc.

An anal fissure is a small cut or tear in the delicate lining of the anus that occurs when passing hard or large stools, causing pain and bleeding during bowel movements. Sometimes the pain caused by the anal fissure leads to contraction of the muscle that controls bowel movements and frequent bowel movements.

Before applying XYLOCAINE NF CREAM, inform your doctor if you have severely injured mucosa, inflammation of the areas in the rectum, diabetes, liver or kidney cardiac insufficiency, etc. Pregnant (especially during the first trimester) and breastfeeding women should use XYLOCAINE NF CREAM with caution.

XYLOCAINE NF CREAM is not recommended for use in children and adolescents (below 18 years of age) and should be used with caution in elderly patients. Consult your doctor before applying. The common side effects of XYLOCAINE NF CREAM are pain, burning sensations, itching, hyperemia and bleeding. Consult your doctor if any of the symptoms worsen.

Uses Of XYLOCAINE NF CREAM

Relieves pain and relaxes muscles during the management or examination of anal fissure, thrombosed external haemorrhoids, post haemorrhoidectomy, anal sphincter hypertonia

How XYLOCAINE NF CREAM Works

Lignocaine is a local anaesthetic that numbs the area where you have applied it by stopping nerves from sending pain signals to the brain. Nifedipine is a calcium channel blocker that relaxes the muscles in the anal opening. This collective action is useful for relieving pain and healing anal fissures.

How to use XYLOCAINE NF CREAM

Apply XYLOCAINE NF CREAM as advised by your physician. It is for rectal use only. Wash your hands before use and if possible, use a finger covering, such as a plastic wrap, cling film, a finger cot or a disposable glove. Apply the medicine to the anal region as advised by your doctor. Your doctor will determine the correct dose and duration of management for you based on your age and the severity of your existing condition.

Side Effects Of XYLOCAINE NF CREAM

Common

pain
burning sensation
itching
hyperaemia
bleeding

How To Manage Side Effects

Itching:

Wash the area around the anus carefully daily with plain water or mild soap to keep it clean and dry. Avoid irritants and do not wear tight underwear. If there is no improvement, please consult your doctor for advice.

Warning & Precautions

Pregnancy

Use with Caution

XYLOCAINE NF CREAM should be used with caution in pregnant women (especially during the first trimester). Consult your doctor before applying it.

Breastfeeding

Use with Caution

XYLOCAINE NF CREAM should be used with caution in breastfeeding women. Consult your doctor before applying it.

Driving and Using Machines

Safe

No effects that could influence the capacity to drive and operate machinery are therefore foreseeable.

Kidney

Use with Caution

XYLOCAINE NF CREAM should be used with caution in patients with renal insufficiency. Consult your doctor before applying it.

Liver

Use with Caution

XYLOCAINE NF CREAM should be used with caution in patients with hepatic insufficiency. Consult your doctor before applying it.

Allergy

Contraindicated

Do not apply XYLOCAINE NF CREAM if you are allergic to Lidocaine or Nifedipine.

Heart Disease

Contraindicated

XYLOCAINE NF CREAM is not recommended for use in patients with cardiac insufficiency. Consult your doctor before applying it.

Use In Pediatrics

Use with Caution

XYLOCAINE NF CREAM should be used with caution in children and adolescents (below 18 years of age). Consult your doctor for advice.

Use In Geriatrics

Use with Caution

XYLOCAINE NF CREAM should be used with caution in elderly patients. Consult your doctor for advice.

Others

XYLOCAINE NF CREAM is not recommended for use if you:

have severe hypotension

Before applying XYLOCAINE NF CREAM, inform your doctor if you:

have severely injured mucosa and phlogosis (inflammation)
have diabetes

Interactions

A. Drug-Drug interactions:

Before applying XYLOCAINE NF CREAM, inform your doctor if you are taking any of the following medicine:

medicines used to lower blood pressure [Ex. propranolol]
cimetidine (a medicine used to manage stomach acidity and peptic ulcers)
digoxin (a medicine used to manage heart problems)

Overdosage:

If you or anyone else have accidentally applied too much of XYLOCAINE NF CREAM, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are light-headedness, dizziness, ringing sensation in the ears, decrease in blood pressure, altered heart rate, etc.

Synopsis

Drug	:	Lignocaine (Lidocaine), Nifedipine
Pharmacological Category	:	Local anaesthetics, Calcium channel blockers
Therapeutic Indication	:	Relieves pain and relaxes muscles during the management or examination of anal fissure, thrombosed external haemorrhoids, post haemorrhoidectomy, anal sphincter hypertonia
Dosage Forms	:	Cream, Gel

More Information

Keep XYLOCAINE NF CREAM out of reach from children
Store at room temperature

FAQs About XYLOCAINE NF CREAM

Q: What are the precautions to be followed while applying XYLOCAINE NF CREAM?

A: XYLOCAINE NF CREAM for rectal use should be used with caution in patients with severely injured mucosa and phlogosis (inflammation), diabetic patients or those with hepatic and/or renal insufficiency, elderly patients or in patients being managed with antihypertensive drugs. If your symptoms worsen, please contact your doctor immediately.

Q: Can we apply XYLOCAINE NF CREAM for pregnant women?

A: In pregnant women (especially during the first trimester), XYLOCAINE NF CREAM should be used with caution. Consult your doctor before applying XYLOCAINE NF CREAM.

Q: Can spicy food cause fissures?

A: No. Spicy foods do not cause fissures. But they can irritate the fissures and worsen your symptoms. Therefore, it is advised that you avoid spicy foods if you are facing issues with your fissures.

Q: How long does the fissure take to heal?

A: Fissures usually heal within a few weeks. But if they persist for longer than 4 to 6 weeks, they are termed chronic fissures. Please consult your doctor without delay if you have been noticing fissures for longer than 4 weeks.

References

1. KD Tripathi. Antiarrhythmic Drugs & Antianginal and Other Anti-ischaemic Drugs. Essentials of medical pharmacology. Seventh 7th edition. 2013. Page – 530 & 549.

2. Rasha Kadim Albayati, Adel Musa Al-Rekabi, Nahedh R. Alammar, Adel Musa Al-Rekabi. Topical combination of Nifedipine with Lidocaine for Anal Fissure Treatment, Indian Journal of Public Health Research and Development, March 2019. [Accessed on 8th June 2022] https://www.researchgate.net/profile/Hayder-Fawzi/publication/331625528_Topical_Combination_of_Nifedipine_with_Lidocaine_for_Anal_Fissure_Treatment/links/5c8830f9a6fdcc38174f9438/Topical-Combination-of-Nifedipine-with-Lidocaine-for-Anal-Fissure-Treatment.pdf

3. Pasquale Perrotti, Patrizia Dominici, Enzo Grossi, Carmine Antropoli, Guglielmo Giannotti, Maria Cusato, Mario Regazzi, Renata Cerutti. NIH National Library of Medicine, National center for Biotechnology Information. Pharmacokinetics of anorectal nifedipine and lidocaine (lignocaine) ointment following haemorrhoidectomy: an open-label, single-dose, phase IV clinical study, 2009. [Accessed on 8th June 2022] https://pubmed.ncbi.nlm.nih.gov/19301938/

4. NEW FA DEM Farmaceutici e Chimici S.r.l., Lignocaine and Nifedipine. [Revised in June 2020] [Accessed on 8th June 2022] https://myhealthbox.eu/en/view/3527457/e00dfb867aba2b7b0df8d941eba051ac/leaflet

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS

Last updated on 25 Mar 2023 | 02:21 PM(IST)

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