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Introduction About ANGIPLAT 2.5MG CAPSULE

ANGIPLAT 2.5MG CAPSULE contains Nitroglycerine that belongs to the group of medicines called Vasodilators. It is used for the management of angina pectoris due to coronary artery disease.

Angina is a type of chest pain which is caused by reduced blood flow to the heart as a result of coronary artery disease. Symptoms are feeling the pressure, squeezing, heaviness, tightness or pain in the chest or heavy weight lying on the chest.

Along with ANGIPLAT 2.5MG CAPSULE your doctor may advise you to make certain lifestyle changes such as quitting alcohol and smoking, eating a healthy diet, managing weight and improving your sleep pattern.

ANGIPLAT 2.5MG CAPSULE is not recommended for use in patients having heart diseases (hypertrophic obstructive cardiomyopathy), anaemia, raised pressure in the head, raised pressure in the eye (glaucoma), or are taking medicines to manage erectile dysfunction (sildenafil, vardenafil, tadalafil.

ANGIPLAT 2.5MG CAPSULE should be used with caution in patients having liver or kidney diseases, underactive thyroid gland, low body temperature, malnourishment, abnormally low levels of oxygen in the blood, very low blood pressure, low blood volume, disease of the blood vessels supplying the brain, or conditions that lower blood volume in the heart.

ANGIPLAT 2.5MG CAPSULE should be used with caution in pregnant and breastfeeding women. Take your doctor’s advice before taking medicine. ANGIPLAT 2.5MG CAPSULE is not recommended for use in children. ANGIPLAT 2.5MG CAPSULE should be used with caution in elderly patients.

The most common side effects of taking ANGIPLAT 2.5MG CAPSULE are throbbing headache, spinning sensation, dizziness, drowsiness and lack of energy. Consult your doctor if the symptoms worsen or doesn’t improve.

Uses Of ANGIPLAT 2.5MG CAPSULE

It is used for the management of angina pectoris due to coronary artery disease

How ANGIPLAT 2.5MG CAPSULE Works

ANGIPLAT 2.5MG CAPSULE causes relaxation of smooth muscles within blood vessels which leads to relaxation and widening of blood vessels. This improves blood supply to the heart muscles. As a result, it helps to relieve chest pain and blood pressure.

How to use ANGIPLAT 2.5MG CAPSULE

Always use ANGIPLAT 2.5MG CAPSULE exactly as prescribed by your doctor.

For Tablet, Capsule: Swallow ANGIPLAT 2.5MG CAPSULE with a glass of water. Do not crush or chew the medicine.

For Sublingual Tablet: Place ANGIPLAT 2.5MG CAPSULE inside your mouth, below the tongue and allow it to dissolve completely. Do not swallow or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and severity of the disease condition. Continue to take ANGIPLAT 2.5MG CAPSULE for the stipulated duration prescribed by your doctor to achieve better results.

Side Effects Of ANGIPLAT 2.5MG CAPSULE

Common

throbbing headache
spinning sensation
fall in blood pressure when seated or standing up
dizziness, drowsiness
lack of energy

Uncommon

fainting
facial flushing
nausea, vomiting
localised burning sensation
tongue blistering
circulatory collapse

Rare

restlessness
heartburn
bad breath, red, itchy, or flaky skin, skin rash

Stop taking ANGIPLAT 2.5MG CAPSULE and contact your doctor immediately if you experience any of the following side effects:

worsening of angina symptoms, chest pain
signs of hypoxaemia (low levels of oxygen in the blood) (difficulty breathing, increased rate of breathing)
signs of methemoglobinemia (breathing problems, tiredness, headache)
difficulty breathing, bluish discolouration of the lips, fingers or toes (cyanosis)
rapid or slowed heartbeat
blindness in one eye
cerebral ischaemia (impaired blood flow to the brain) which may cause weakness in one leg or arm or weakness in one entire side of the body
difficulty speaking, slurred speech
loss of coordination, loss of consciousness
allergic skin reactions

How To Manage Side Effects

Nausea:

Take this medicine with or after meals. Stick to simple meals while taking this medicine. Avoid eating rich or spicy food. Do not consume any medication by yourself. Take your doctor’s advice if the nausea doesn’t improve or worsen.

Headache:

Try to take rest and do not involve yourself in exertive activities. Rest in a quiet and dark room. Apply a pain-relieving balm on your forehead. Take your doctor’s advice if headache doesn’t improve

Vomiting:

Drink clear or ice-cold drinks. Eat bland, light foods and avoid fried, oily, or sweet foods. Avoid carbonated drinks. Take your doctor’s advice if vomiting doesn’t improve.

Dizziness:

Lie, or sit down immediately when you feel dizzy. If you're feeling severe episodes of spinning(vertigo), lie in a dark and quiet place with your eyes closed. Try to avoid vehicle driving. Take your doctor’s advice if dizziness doesn’t improve.

Drowsiness:

Take adequate sleep. Do not involve in rigorous activities. Do not interfere with your sleep cycle. Talk to your doctor if the drowsiness doesn’t improve.

Warning & Precautions

Pregnancy

ANGIPLAT 2.5MG CAPSULE should be used with caution in pregnant women. Consult your doctor before taking ANGIPLAT 2.5MG CAPSULE.

Breastfeeding

ANGIPLAT 2.5MG CAPSULE should be used with caution in breastfeeding women. Consult your doctor before taking ANGIPLAT 2.5MG CAPSULE.

Driving and Using Machines

Do not drive or operate any machines if you feel dizzy after taking ANGIPLAT 2.5MG CAPSULE.

Alcohol

Avoid consumption of alcohol during the management with ANGIPLAT 2.5MG CAPSULE as it may increase some effects of the medicine.

Kidney

ANGIPLAT 2.5MG CAPSULE should be taken with caution in patients with severe kidney disease. Consult your doctor before taking it.

Liver

ANGIPLAT 2.5MG CAPSULE should be used with caution in patients with severe liver disease. Consult your doctor before taking it.

Allergy

Do not take ANGIPLAT 2.5MG CAPSULE if you are allergic to Nitroglycerine or any other components of this medicine.

Heart Disease

ANGIPLAT 2.5MG CAPSULE is not recommended for use in patients having heart diseases such as hypertrophic obstructive cardiomyopathy (thickening of heart muscles). ANGIPLAT 2.5MG CAPSULE should be used with caution in patients having other heart diseases such as having had a recent heart attack, narrowing of heart valves, inflammation of the heart, heart failure or fluid build-up around the heart. Consult your doctor before taking ANGIPLAT 2.5MG CAPSULE.

Others

ANGIPLAT 2.5MG CAPSULE is not recommended for use if you:

have anaemia
have raised pressure in the head (including that caused by accident)
bleeding on the brain (pain in eyes, changes in vision, bad headache behind the eyes)
raised pressure in the eye

Before taking ANGIPLAT 2.5MG CAPSULE inform your doctor if you have:

underactive thyroid gland
low body temperature
malnutrition (poor nutrition due to digestion problems or imbalanced diet)
abnormally decreased levels of oxygen in the blood
severely low blood pressure
low blood volume
conditions that lower the blood volume in the heart
cerebrovascular diseases (diseases affecting the blood vessels supplying the brain)

Use in paediatrics:

ANGIPLAT 2.5MG CAPSULE is not recommended for use in children. Ask for the advice of your child’s doctor before giving it to your child.

Use in geriatrics:

ANGIPLAT 2.5MG CAPSULE should be used with caution in elderly patients. Ask for your doctor’s advice before taking the medicine.

Interactions

A. Drug-Drug interactions:

Before taking ANGIPLAT 2.5MG CAPSULE, inform your doctor if you are taking any of the following medicine:

medicines for erectile dysfunction (male impotence) (Ex. sildenafil, vardenafil, tadalafil)
medicines used to manage paracetamol overdose (Ex. n-acetylcysteine)
medicines for migraine (Ex. ergotamine)
other nitrates used to manage heart diseases (Ex. isosorbide dinitrate, isosorbide mononitrate, disopyramide), high blood pressure (Ex. ramipril, atorvastatin)
medicines used for thinning your blood and managing blood clots (Ex. warfarin)
medicines used to manage Parkinson’s disease (Ex. apomorphine)
medicines used to manage stomach ulcers (Ex. propantheline)
medicines used to manage anxiety and depression (Ex. amitriptyline, isocarboxazid)

Overdosage:

If you or anyone else uses too much of ANGIPLAT 2.5MG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage of ANGIPLAT 2.5MG CAPSULE may include nausea, low blood pressure, restlessness, fainting, blue colouration of the skin, methaemoglobin in the blood, breathing difficulties, lack of oxygen in tissues, slow heartbeat or mental illness.

Synopsis

Drug	:	Nitroglycerin (Glyceryl Trinitrate)
Pharmacological Category	:	Vasodilators
Therapeutic Indication	:	Angina pectoris
Dosage Forms	:	Tablet, Capsule, Sublingual Tablet, Injection, Patch, Spray

More Information

Keep ANGIPLAT 2.5MG CAPSULE out of reach in children
Store ANGIPLAT 2.5MG CAPSULE at room temperature below 25°C

FAQs About ANGIPLAT 2.5MG CAPSULE

Why is ANGIPLAT 2.5MG CAPSULE prescribed?

ANGIPLAT 2.5MG CAPSULE is used to manage angina pectoris due to coronary artery disease. Angina is a type of chest pain which is caused by reduced blood flow to the heart as a result of coronary artery disease. Symptoms are feeling the pressure, squeezing, heaviness, tightness or pain in the chest or heavy weight lying on the chest.

Can ANGIPLAT 2.5MG CAPSULE be used in elderly patients?

ANGIPLAT 2.5MG CAPSULE should be used with caution in elderly patients. Take the medicines sat down to reduce possible low blood pressure or fainting. Your doctor may change the dose to suit your condition. If you notice that ANGIPLAT 2.5MG CAPSULE is not working as well at relieving pain as they have done, contact your doctor.

How to use ANGIPLAT 2.5MG CAPSULE?

Always use ANGIPLAT 2.5MG CAPSULE exactly as prescribed by your doctor.

For Tablet, Capsule: Swallow ANGIPLAT 2.5MG CAPSULE with a glass of water. Do not crush or chew the medicine.

For Sublingual Tablet: Place ANGIPLAT 2.5MG CAPSULE inside your mouth, below the tongue and allow it to dissolve completely. Do not swallow or chew the medicine.

Can ANGIPLAT 2.5MG CAPSULE cause headache?

Yes. ANGIPLAT 2.5MG CAPSULE can cause throbbing headache. If it happens, try to take rest and do not involve yourself in exertive activities. Rest in a quiet and dark room. Apply a pain-relieving balm on your forehead. Do not consume any medication without consulting a doctor. Take your doctor’s advice if headache doesn’t improve

Is it safe to consume alcohol while being managed with ANGIPLAT 2.5MG CAPSULE?

You are advised not to drink alcohol with ANGIPLAT 2.5MG CAPSULE, as some of the effects of this medicine are increased such as dizziness. If you have a habit of drinking alcohol, take your doctor’s advice before taking ANGIPLAT 2.5MG CAPSULE.

Can ANGIPLAT 2.5MG CAPSULE affect my ability to drive?

As ANGIPLAT 2.5MG CAPSULE can cause dizziness, you should make sure you are not affected before driving or operating machinery, especially if taken with alcohol. Do not drive or operate any machines if you feel dizzy after taking ANGIPLAT 2.5MG CAPSULE. You can resume doing your activities after you feel normal again.

References

1. KD. Tripathi. Antianginal and Other Anti-ischaemic Drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page – 588, 589.

2. Panel Donald, P.PageN, Aubrey Carson Clarence, A.Buhr, Paul E.Flinn, Clyde E, Wells Margaret, T.Randall. Stability Study of Nitroglycerin Sublingual Tablets. Science Direct. January 2016. [Accessed 10th October 2022] https://www.sciencedirect.com/science/article/abs/pii/S0022354915400085

3. T Winsor, H J Berger. Oral nitroglycerin as a prophylactic antianginal drug: clinical, physiologic, and statistical evidence of efficacy based on a three-phase experimental design. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November 1975. [Accessed 10th October 2022] https://pubmed.ncbi.nlm.nih.gov/811102/

4. W Schneider, M Kaltenbach, B Stahl, W D Bussmann. Anti-anginal efficacy of oral nitroglycerin. A clinical double-blind study with dose-effect relationships. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. August 1984. [Accessed 10th October 2022] https://pubmed.ncbi.nlm.nih.gov/6430666/

5. Kyle H. Kim, Connor C. Kerndt, Ghufran Adnan, Derek J. Schaller. Statpearls. Nitroglycerin. NIH National Library of Medicine, National center for biotechnology information. November 202. [Accessed on 8th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK482382/

6. Accord. Electronic Medicines Compendium (EMC); [Revised on October 2019] [Accessed 10th October 2022] https://www.medicines.org.uk/emc/files/pil.5827.pdf

7. Torrent Pharmaceuticals Ltd. Vasovin XL (Nitroglycerine). [Revised in February 2022]. [Accessed 10th October 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1790.pdf

8. Leeford Healthcare. Caditril 6.4 (Nitroglycerine). [Accessed 10th October 2022] https://www.leeford.in/product/568/caditril-64

9. Leeford Healthcare. Caditril 2.6 (Nitroglycerine). [Accessed 10th October 2022] https://www.leeford.in/product/568/caditril-64

Useful Diagnostic Tests

ECG (electrocardiogram)
Kidney Function Tests
Liver Function Tests
Chest Xray

Author Details

Written By Dr. Priyanka Goel - BDS

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 25 Jan 2023 | 12:03 PM(IST)