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Introduction About MACPHYLLINE SR TABLET

MACPHYLLINE SR TABLET contains Acebrophylline which belongs to the group of medicines called Anti-asthmatic drugs. It is used in the management of asthma and chronic obstructive pulmonary disease (COPD). It can also be used to manage inflammation of the airways (such as bronchitis)

Before taking MACPHYLLINE SR TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have fits, stomach ulcers, viral infections, hypertension or hyperthyroidism as a precaution.

MACPHYLLINE SR TABLET is not recommended for use in pregnant women. It should be used in breastfeeding women only if it is considered necessary by the physician.

The most common side effects of taking MACPHYLLINE SR TABLET are epigastric pain, stomach discomfort, nausea, vomiting, dizziness, drowsiness, diarrhea and constipation. Consult your doctor if any of these side effects trouble you.

Uses Of MACPHYLLINE SR TABLET

It is used to manage and prevent:

Asthma & COPD
Bronchitis (inflammation of the airways)

How MACPHYLLINE SR TABLET Works

MACPHYLLINE SR TABLET is a bronchodilator with anti-inflammatory properties. It blocks the release of certain chemicals (such as phosphodiesterase) in the respiratory tract that triggers airway inflammation, swelling and narrowing. As a result, it widens the airways, and reduces airway inflammation. It also loosens the mucus accumulated in the airways which allows the air to pass through more freely through the airways and makes breathing easier.

How to use MACPHYLLINE SR TABLET

Take MACPHYLLINE SR TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy depending upon your age, body weight and disease condition.

Do not stop taking MACPHYLLINE SR TABLET once your symptoms subside without consulting your doctor.

Side Effects Of MACPHYLLINE SR TABLET

Common Side Effects of MACPHYLLINE SR TABLET:

stomach pain or discomfort, heartburn, loss of appetite
transient nausea, dizziness
vomiting, diarrhoea, constipation
drowsiness
skin rash or itching
breathing difficulties
nasal inflammation

Warning & Precautions

Pregnancy

Contraindicated

MACPHYLLINE SR TABLET is not recommended for use in pregnancy. Therefore, consult your doctor before taking it.

Breastfeeding

Consult your doctor

It is not known whether MACPHYLLINE SR TABLET can pass through breast milk. Therefore, it should be used in breastfeeding women only if considered necessary by the physician.

Driving and Using Machines

Use with Caution

MACPHYLLINE SR TABLET usually does not affect your ability to drive or operate any machinery. However, do not drive or handle any heavy tools or machines if you feel dizzy or drowsy after taking MACPHYLLINE SR TABLET.

Kidney

Consult your doctor

MACPHYLLINE SR TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.

Liver

Consult your doctor

MACPHYLLINE SR TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with hepatic dysfunction. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take MACPHYLLINE SR TABLET if you are allergic to Acebrophylline or to any other methylxanthines (such as theophylline, doxophylline).

Heart Disease

Consult your doctor

MACPHYLLINE SR TABLET is not recommended for use in patients suffering from myocardial infarction or arrythmias. It should be used with caution in patients with heart failure or any other heart problems. Therefore, consult your doctor before taking it.

Use In Pediatrics

Consult your doctor

MACPHYLLINE SR TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.

Use In Geriatrics

Use with Caution

MACPHYLLINE SR TABLET should be used with caution in the elderly patients. Therefore, consult your doctor before taking it.

Others

MACPHYLLINE SR TABLET is not recommended for use if you:

have hypotension (low blood pressure)
have fluid and electrolyte imbalance

Before taking MACPHYLLINE SR TABLET, inform your doctor if you:

have chronic alcoholism (addiction to alcohol)
have any viral infections
have an over-active thyroid gland
have hypertension (high blood pressure)
have ulcers in the stomach and/or intestines
have fits (seizures)

Interactions

Before taking MACPHYLLINE SR TABLET, inform your doctor if you are taking any of the following medicines such as:

Anti-gout agents (Ex. allopurinol)
H2 blockers (Ex. cimetidine)
Antibiotics (Ex. ciprofloxacin, erythromycin, doxycycline, amoxicillin)
Corticosteroids (Ex. prednisolone)
Calcium channel blockers (Ex. diltiazem, verapamil)
Diuretics (Ex. frusemide)
Adrenergic and dopaminergic cardiac stimulants (Ex. isoprenaline)
Oral contraceptives (Ex. ethinylestradiol)
Benzimidazoles (Ex. thiabendazole)

Overdosage:

If you or anyone else accidentally took more of MACPHYLLINE SR TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms include nausea, vomiting, upper stomach pain, restlessness, fits, fast heart rate and hyperactivity.

Synopsis

Drug	:	Acebrophylline
Pharmacological Category	:	Methylxanthines
Therapeutic Indication	:	Asthma, COPD, Bronchitis
Dosage Forms	:	Tablet, Capsule, Powder, Syrup

More Information

FAQs About MACPHYLLINE SR TABLET

Q: How MACPHYLLINE SR TABLET works?

A: MACPHYLLINE SR TABLET widens the airways and reduces airway inflammation. It also loosens the mucus accumulated in the airways which allows the air to pass through more freely through the airways and makes breathing easier.

Q: What is the use of MACPHYLLINE SR TABLET?

A: It is used to manage asthma, COPD and bronchitis (inflammation of the airways).

Q: Can I take MACPHYLLINE SR TABLET daily?

A: MACPHYLLINE SR TABLET is generally prescribed as one or two doses per day. However, your doctor will decide the number of doses per day depending upon your age, body weight and disease condition.

Q: How long does it take for MACPHYLLINE SR TABLET to start working?

A: MACPHYLLINE SR TABLET may start working within 2 hours of oral administration. However, it may take 2 weeks for the medicine to show improvements in your condition. Therefore, take the medicine regularly as informed by your doctor without fail to achieve better results.

Q: Is MACPHYLLINE SR TABLET effective?

A: Yes. It effectively controls the symptoms of asthma, COPD and bronchitis, by blocking the release of certain chemicals (phosphodiesterase) in the respiratory tract that triggers the allergic and inflammatory response. It also loosens the mucus and manages the narrowing of the airway tract which makes breathing easier.

Q: What will happen if I consume a high dose of MACPHYLLINE SR TABLET than prescribed by my doctor?

A: Do not consume a higher dose of MACPHYLLINE SR TABLET than the one prescribed by your doctor, as it may lead to unwanted side effects. Your doctor will decide the correct dose for you, depending on your age and disease condition. If the prescribed dose, is not working for you, consult your doctor for advice.

Q: Is MACPHYLLINE SR TABLET safe?

A: MACPHYLLINE SR TABLET is considered safe at doses prescribed by the physician. However, it may cause few side effects such as epigastric pain, stomach discomfort, nausea, vomiting, dizziness, drowsiness, diarrhea and constipation in some individuals

Q: What should I do if I forgot to take a dose of MACPHYLLINE SR TABLET?

A: If you forgot to take a dose of the medicine, take it as soon as possible. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of the medicine, to compensate the missed dose.

Q: Will taking a higher dose of MACPHYLLINE SR TABLET be more effective?

A: No. Do not take a higher dose of the medicine than prescribed by your doctor, as it could lead to toxicity. Always consume the dose prescribed by your doctor. If you feel that the prescribed dose is not working for you, consult your doctor for advice.

Q: Can the use of MACPHYLLINE SR TABLET make me feel dizzy?

A: MACPHYLLINE SR TABLET may cause dizziness in some individuals. If you experience dizziness, try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness.

Q: Can MACPHYLLINE SR TABLET be used in children?

A: No. MACPHYLLINE SR TABLET is not recommended for use in children and adolescents (aged below 18 years).

Q: Can MACPHYLLINE SR TABLET be used on an asthma attack?

A: No. MACPHYLLINE SR TABLET is only used to manage or manage the symptoms of asthma. If your asthma or breathing gets worse suddenly, contact your doctor immediately or go to the hospital straight away to avoid further exacerbation of the attack.

Q: Can I stop using MACPHYLLINE SR TABLET once my symptoms subside?

A: No. Continue to use MACPHYLLINE SR TABLET as long as your doctor prescribes it to you. Do not stop using this medicine or reduce the dose suddenly without consulting your doctor as it may make it less effective.

References

1. KD. Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 224.

2. Sumit Roy Tapadar, Maumita Das, Arunabha Datta Chaudhuri, Santanu Basak, and Anil Baran Singha Mahapatra. The Effect of Acebrophylline vs Sustained Release Theophylline in Patients of COPD- A Comparative Study. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. September 2014. [Accessed on 9th January 2023] click here

3. Cipla Ltd. Mucophylin Capsules (Acebrophylline). [Revised in November 2013] [Accessed on 27th December 2022] click here

4. Central Drugs Standard Control Organization. Acebrophylline capsules 100mg. May 2008. Acebrophylline SR Tablet 200 mg. November 2010. [Accessed on 9th January 2023] click here

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Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Rajnikant - MBBS, MD (Physiology)

Last updated on 20 Nov 2024 | 12:29 PM(IST)