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Introduction About TRULICITY 1.5MG INJECTION(PFS)

TRULICITY 1.5MG INJECTION(PFS) contains Dulaglutide which belongs to a group of medicines called Incretin mimetics. It is used to manage type II diabetes mellitus along with diet and exercise. Type 2 diabetes is a condition in which body does not make enough insulin, and the insulin that your body produces does not work as well as it should. When this happens, sugar (glucose) builds up in blood.

GLP-1 makes your pancreas to produce more insulin after you eat and helps in maintaining blood glucose levels in the normal range. It helps the pancreas to release the right amount of insulin when blood sugar levels are high. Insulin helps in moving sugar from the blood into other body tissues where it is used for energy.

Always use this medicine as advised by your doctor. It is not recommended for the children and adolescents under 18 years of age. It is not recommended for use in patients with severe stomach or intestinal problems. Do not take TRULICITY 1.5MG INJECTION(PFS) if you are pregnant or breast-feeding women or if you are trying to become pregnant. Consult your doctor for advice.

The most common side effects are nausea, diarrhoea, vomiting, decreased appetite and indigestion. Consult your doctor if any of the above side effects worsen or persists for a longer duration.

Uses Of TRULICITY 1.5MG INJECTION(PFS)

Used to manage type II diabetes mellitus along with diet and exercise

How TRULICITY 1.5MG INJECTION(PFS) Works

TRULICITY 1.5MG INJECTION(PFS) activates GLP-1 receptor, a membrane-bound cell-surface receptor coupled to adenylyl cyclase in the pancreatic beta cells. GLP-1 makes your pancreas to produce more insulin after you eat and helps in maintaining blood glucose levels in the normal range. It helps the pancreas to release the right amount of insulin when blood sugar levels are high. Insulin helps in moving sugar from the blood into other body tissues where it is used for energy.

How to use TRULICITY 1.5MG INJECTION(PFS)

TRULICITY 1.5MG INJECTION(PFS) will be given to you only by a doctor or a nurse into under the skin (subcutaneous injection) of your stomach area (abdomen) or upper leg (thigh).

Side Effects Of TRULICITY 1.5MG INJECTION(PFS)

Common

low blood sugar
nausea and vomiting
diarrhea
abdominal (stomach) pain
feeling less hungry (decreased appetite)
indigestion
constipation
stomach bloating

Stop receiving TRULICITY 1.5MG INJECTION(PFS) and contact your doctor immediately if you experience any of the following side effects:

anaphylactic reactions, angioedema (symptoms are rashes, itching and rapid swelling of the tissues of the neck, face, mouth or throat, hives and difficulties breathing)

How To Manage Side Effects

Diarrhea

Drink lot of fluid, such as water or squash, to avoid dehydration. Do not take any other medicines without consulting your doctor.

Headache

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

Warning & Precautions

Pregnancy

Monitoring required

TRULICITY 1.5MG INJECTION(PFS) is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

Breastfeeding

Monitoring required

TRULICITY 1.5MG INJECTION(PFS) is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you have signs of low blood sugar (hypoglycaemia) while taking TRULICITY 1.5MG INJECTION(PFS).

Alcohol

Contraindicated

Consumption of alcohol is not recommended during management with this medicine.

Kidney

Use with Caution

TRULICITY 1.5MG INJECTION(PFS) should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.

Liver

Use with Caution

TRULICITY 1.5MG INJECTION(PFS) should be taken with caution in patients with severe liver disease. Consult your doctor for advice.

Allergy

Contraindicated

Do not use TRULICITY 1.5MG INJECTION(PFS) if you are allergic to Dulaglutide or any other ingredients of this medicine.

Others

TRULICITY 1.5MG INJECTION(PFS) is not recommended for use if you:

or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC)
have severe stomach or intestinal problems

Interactions

Before taking TRULICITY 1.5MG INJECTION(PFS) inform your doctor if you are taking prescription, non-prescription medicines or herbal supplements.

Synopsis

Drug	:	Dulaglutide
Pharmacological Category	:	Glucagon-like Peptide-1 Agonists (GLP-1 Agonist)
Therapeutic Indication	:	Type II Diabetes mellitus
Dosage Forms	:	Injection, Prefilled syringe

More Information

Keep TRULICITY 1.5MG INJECTION(PFS) out of reach of children
Store TRULICITY 1.5MG INJECTION(PFS) at temperature 2-8°C

FAQs About TRULICITY 1.5MG INJECTION(PFS)

Q: Can TRULICITY 1.5MG INJECTION(PFS) be used in pregnant women?

A: TRULICITY 1.5MG INJECTION(PFS) is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

Q: How long can you stay on TRULICITY 1.5MG INJECTION(PFS)?

A: TRULICITY 1.5MG INJECTION(PFS) may take this medicine up to 5 weeks to start lowering your blood glucose levels but the maximum effect will not be seen for 3-6 months. Consult your doctor for advice.

Q: What is TRULICITY 1.5MG INJECTION(PFS) made of?

A: TRULICITY 1.5MG INJECTION(PFS) is novel glucagon-like peptide-1 agonist (GLP-1) and biologic drug consisting of the dipeptidyl peptidase-IV-protected GLP-1 analogue covalently linked to human IgG4-Fc heavy chain by a small peptide linker.

Q: Can TRULICITY 1.5MG INJECTION(PFS) be used to manage type 1 diabetes?

A: No TRULICITY 1.5MG INJECTION(PFS) should not be used in patients with type 1 diabetes mellitus or for sdiabetic ketoacidosis.

Q: What should I avoid while using TRULICITY 1.5MG INJECTION(PFS)?

A: Avoid fried or fatty foods and foods high in sugar while using this medicine to reduce the risk of nausea and vomiting. Eat slowly and eat smaller meals that are light and bland.

Q: What to monitor while using TRULICITY 1.5MG INJECTION(PFS)?

A: Always monitor renal function in patients with renal impairment experiencing severe gastrointestinal reactions. Observe for signs and symptoms of pancreatitis. And also monitor for progression of diabetic retinopathy in patients with a history of diabetic retinopathy.

Q: Does TRULICITY 1.5MG INJECTION(PFS) reduce liver fat?

A: This medicine significantly reduces LFC and improves GGT levels in participants with NAFLD. There were non-significant reductions in PFC, liver stiffness, serum AST and serum ALT.

Q: Is TRULICITY 1.5MG INJECTION(PFS) short or long acting?

A: TRULICITY 1.5MG INJECTION(PFS) is a long-acting agonist which can maintain an appropriate agonist level in plasma throughout the 24 hours of the day.

Q: Does TRULICITY 1.5MG INJECTION(PFS) cause hair loss?

A: No. It does not cause hair loss from using the medicine. Hair loss was not a side effect seen in studies of TRULICITY 1.5MG INJECTION(PFS).

Q: How quickly does TRULICITY 1.5MG INJECTION(PFS) work?

A: TRULICITY 1.5MG INJECTION(PFS) starts working shortly after you start using it. However, it may take several weeks to a month to see the full effects of this medicine.

References

1. Celeste B Burness, Lesley J Scott; Dulaglutide: A Review in Type 2 Diabetes; [Published on Dec 2015] [Accessed on 18th December 2023] https://pubmed.ncbi.nlm.nih.gov/26423061/

2. Eli Lilly and Company; Trulicity (dulaglutide) for the Treatment of Type 2 Diabetes [Published on 2014] [Accessed on 18th December 2023] https://www.clinicaltrialsarena.com/projects/trulicity-type-2-diabetes/

3. Eli Lilly and Company Indianapolis, IN 46285, USA; U.S. Food & Drug Administration; [Revised on Jan 2017] [Accessed on 18th December 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/125469s007s008lbl.pdf

4. Eli Lilly Italia S.p.A.,Via Gramsci 731/733, 50019, Sesto Fiorentino, Firenze (FI), Italy; Electronic Medicines Compendium (EMC); [Revised on Oct 2019] [Accessed on 18th December 2023] https://www.medicines.org.uk/emc/files/pil.3634.pdf

Useful Diagnostic Tests

Blood Glucose Fasting (FBS)
Random Blood Sugar (RBS)
Post Prandial Blood Sugar (PPBS)
Glucose-Fasting Urine
Insulin-Fasting
Insulin Postprandial (PP)

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 12 Jan 2024 | 12:07 PM(IST)