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Introduction About LEEZOLE VG CAPSULE

LEEZOLE VG CAPSULE is a combination of Clindamycin and Clotrimazole which belongs to the group of medicines called Antibiotics and Antifungal agents respectively. It is used to manage vaginal (genital) infections (Ex. vaginal candidiasis, bacterial vaginosis and mixed vaginal infections). It can also be used to cleanse the genital tract prior to any gynecological procedures.

LEEZOLE VG CAPSULE is meant for intravaginal use only. Carefully insert the medicine deep into the vagina as far as possible. Wash your hands before and after inserting the medicine. Closely follow the dose-related instructions given by your doctor to achieve better results. Skipping doses in between the therapy or stopping the therapy without consulting your doctor may not result in adequate infection control.

While using LEEZOLE VG CAPSULE, do not engage in vaginal intercourse or use any vaginal products (such as tampons or douches). Before using LEEZOLE VG CAPSULE inform your doctor if you have any stomach problems (such as colitis). You must also inform your doctor if you are pregnant or breastfeeding or currently having periods before using LEEZOLE VG CAPSULE as a precaution.

LEEZOLE VG CAPSULE is generally safe and well tolerated with fewer side effects like mild vaginal itching or irritation, vaginal discharge and mild diarrhea. Consult your doctor if they trouble you.

Uses Of LEEZOLE VG CAPSULE

Manage vaginal (genital) infections
Cleanses genital tract prior to gynaecological procedures

How LEEZOLE VG CAPSULE Works

LEEZOLE VG CAPSULE is effective in managing both bacterial and fungal genital infections. It works by killing the susceptible microorganism that causes infection within the body. It contains two medicines namely clindamycin and clotrimazole.

Clindamycin is an antibacterial agent. It blocks the production of certain bacterial proteins which is essential for the bacteria to survival. This action manages the further growth and multiplication of bacteria within the body

Clotrimazole is an antifungal agent. It blocks the production of certain chemicals (ergosterol) within the fungal cell which is essential for its survival. This action kills the susceptible fungi and manages the further spread of infection.

How to use LEEZOLE VG CAPSULE

Use LEEZOLE VG CAPSULE as directed by your physician. It is for intravaginal use only. Lie down on your back and place your legs wide apart. Carefully insert the medicine deep into the vagina. Do not move faster, run or stand immediately after inserting the medicine.

Wash your hands before and after inserting the medicine. Do not use this medicine while on your monthly periods. Your doctor will decide the correct dose and duration of therapy for you based on your age, body weight and health condition.

Do not stop using this medicine without consulting your doctor as it may not completely manage your infection.

Side Effects Of LEEZOLE VG CAPSULE

Common

mild vaginal itching, irritation or burning sensation
vaginal discharge
mild diarrhea

Rare

Stop using LEEZOLE VG CAPSULE and contact your doctor immediately if you experience any of the following side effects:

signs of allergic reactions (such as skin rash, itching, swelling of face, mouth, tongue and throat causing difficulty in breathing)
worsening of vaginal conditions (including severe vaginal pain, itching and discharge)
severe stomach pain and/or bloody stools
severe skin rash with raised lumps, hives and blistering

Warning & Precautions

Pregnancy

There are no adequate studies regarding the use of LEEZOLE VG CAPSULE in pregnant women. Therefore, it should be used in pregnant women only if it is considered necessary by the physician. Consult your doctor for advice before using it.

Breastfeeding

LEEZOLE VG CAPSULE should be used with caution among breastfeeding women. Therefore, consult your doctor before using it.

Allergy

Do not use LEEZOLE VG CAPSULE if you are allergic to clindamycin or to clotrimazole.

Others

LEEZOLE VG CAPSULE is not recommended for use if you:

have a history of stomach conditions (such as regional enteritis, ulcerative colitis)

Before using LEEZOLE VG CAPSULE, inform your doctor if you:

have a habit of using tampons or douches
are currently on your monthly periods

Use in Paediatrics:

Consult your doctor before using this medicine in children (aged below 18 years).

Use in Geriatrics:

Consult your doctor before using this medicine in case of elderly patients (aged 65 years or above).

Interactions

A. Drug-Drug interactions:

Before using LEEZOLE VG CAPSULE, inform your doctor if you are taking any of the following medicines such as:

Other antibiotics (such as erythromycin)
Other antifungal agents (such as Amphotericin-B and nystatin)

Overdosage:

If you or anyone else accidentally swallowed the medicine, consult your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Clindamycin, Clotrimazole
Pharmacological Category	:	Lincosamide Antibiotics, Azole Antifungals
Therapeutic Indication	:	Genital infections
Dosage Forms	:	Vaginal Suppositories, Pessarie, Vaginal Capsule, Vaginal Tablet, Gel, Cream

More Information

Keep LEEZOLE VG CAPSULE out of reach from children
Store LEEZOLE VG CAPSULE at room temperature

FAQs About LEEZOLE VG CAPSULE

Q: What is the use of LEEZOLE VG CAPSULE?

A: LEEZOLE VG CAPSULE is used to manage vaginal (genital) infections (Ex. vaginal candidiasis, bacterial vaginosis and mixed vaginal infections). It can also be used to cleanse the genital tract prior to any gynecological procedures.

Q: How LEEZOLE VG CAPSULE works?

A: LEEZOLE VG CAPSULE works by killing the susceptible microorganism that causes infection within the body. It is effective in managing both bacterial and fungal genital infections.

Q: How to use LEEZOLE VG CAPSULE?

LEEZOLE VG CAPSULE is for intravaginal use only. Lie down on your back and place your legs wide apart. Carefully insert the medicine deep into the vagina. Do not move faster, run or stand immediately after inserting the medicine. Wash your hands before and after inserting the medicine.

Q: How long should I use LEEZOLE VG CAPSULE?

A: Generally, management with LEEZOLE VG CAPSULE may last for 3 consecutive days. Therefore, you need to use LEEZOLE VG CAPSULE for the stipulated duration prescribed by your doctor. Failing to do so may not result in adequate infection control.

Q: What shall I do if I forgot to use LEEZOLE VG CAPSULE?

A: If you forgot to use LEEZOLE VG CAPSULE, use it as soon as you remember. However, if it is time for the next application, skip the missed one and take the next dose. Do not insert too many medicines to compensate the missed doses.

Q: Is LEEZOLE VG CAPSULE safe?

A: LEEZOLE VG CAPSULE is safe at doses prescribed by the physician. Therefore, do not alter the dose of LEEZOLE VG CAPSULE without consulting your doctor.

Q: Can I stop using LEEZOLE VG CAPSULE without consulting your doctor?

A: No. You should not stop using LEEZOLE VG CAPSULE without consulting your doctor as it may reduce its effectiveness. Therefore, use LEEZOLE VG CAPSULE for the stipulated duration recommended by your doctor to achieve maximum results.

Q: Can LEEZOLE VG CAPSULE be used in pregnant women?

A: LEEZOLE VG CAPSULE should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor before using it.

Q: What are the side effects of using LEEZOLE VG CAPSULE?

A: In some patients, LEEZOLE VG CAPSULE may cause mild vaginal itching or irritation, vaginal discharge and mild diarrhea. Consult your doctor if they trouble you.

References

1. KD. Tripathi. Macrolide and other Antibacterial antibiotics. Antifungal drugs. Essentials of Medical Pharmacology. 7th edition. 2013. Page – 756, 763, & 792.

2. Manish Maladkar, Shrikant Patil, Suvarcha Sood. A Clinical Experience to Assess Safety and Efficacy of Fixed Dose Combination of Clindamycin and Clotrimazole in the Treatment of Patients With Mixed Bacterial and Fungal Vaginosis. Journal of Clinical Gyenocology and Obstetrics. June 2015. [Accessed on 13th January 2023]. https://www.jcgo.org/index.php/jcgo/article/view/331/183

3. Tillomed Laboratories Ltd. Clotrimazole 500mg Vaginal Tablet (Clotrimazole). Electronic Medicines Compendium. [Revised in December 2020]. [Accessed on 13th January 2023]. https://www.medicines.org.uk/emc/files/pil.11464.pdf

4. Syscan CL. Torrent Pharmaceutical Ltd. [Revised in June 2014]. [Accessed on 13th January 2023]. https://www.torrentian.com/pisheet/Upload/PI_Sheet/1550.pdf

5. Leeford Healthcare Pvt Ltd. Leezole-VG. [Accessed on 13th January 2023]. https://www.leeford.in/product/504/leezole-vg

6. Syscan CL. Torrent Pharmaceuticals Ltd. [Accessed on 13th January 2023]. https://www.mims.com/india/drug/info/syscan-cl

7. Hetero Healthcare Ltd. Imidil C Vaginal suppository. [Accessed on 13th January 2023]. https://www.heterohealthcare.com/imidil-c-vaginal-suppository

8. Softgel Healthcare Pvt Ltd. Clindamycin 100mg and Clotrimazole 100mg soft gelatin vaginal suppositories. [Accessed on 13th January 2023]. https://www.nafdac.gov.ng/wp-content/uploads/Files/SMPC/a_v5/SmPC-CLINDA-CLOTROMAZOLE.pdf

Useful Diagnostic Tests

Complete Blood count

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Pushpraj Singh - MBBS

Last updated on 13 Jan 2023 | 05:15 PM(IST)