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Introduction About POTRATE 10MG TABLET

POTRATE 10MG TABLET contains Potassium citrate which belongs to the group of medicines known as Urinary alkalinizers. It is used in management of renal tubular acidosis (accumulation of acids due to decreased kidney functions) with calcium stones, uric acid lithiasis (uric acid stone formation) with or without calcium stones, hypocitraturic calcium oxalate nephrolithiasis (calcium oxalate stones) of any cause.

POTRATE 10MG TABLET is not recommended for use in patients with chronic kidney disease, heart disease such as heart failure or severe myocardial damage, uncontrolled diabetes mellitus, acute dehydration, adrenal insufficiency, delayed gastric emptying, extensive tissue breakdown, oesophageal compression, intestinal obstruction or narrowing, peptic ulcer disease, active urinary tract infection. Consult your doctor before taking it.

POTRATE 10MG TABLET should be used with caution in patients with heart block. Consult your doctor before taking it.

POTRATE 10MG TABLET is generally not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking it. POTRATE 10MG TABLET should be used in breast feeding women only if clearly necessary. Consult your doctor before taking it.

The safety and effectiveness of POTRATE 10MG TABLET in children have not been established. Consult your doctor before taking. Contact your doctor if the symptoms got worse.

Uses Of POTRATE 10MG TABLET

Used to manage:

Renal tubular acidosis (accumulation of acids due to decreased kidney functions) with calcium stones
Hypocitraturic calcium oxalate nephrolithiasis (calcium oxalate stones) of any cause
Uric acid lithiasis (uric acid stone formation) with or without calcium stones

How POTRATE 10MG TABLET Works

POTRATE 10MG TABLET works by increasing urinary PH (alkaline) and raises urinary citrate by stopping its clearance. It also increases the urinary potassium and also reduces urinary calcium levels in some patients. Thus the changes induced by POTRATE 10MG TABLET produces urine that is less prone to formation of stones (calcium oxalate, calcium phosphate and uric acid). POTRATE 10MG TABLET also decreases calcium ion concentration by forming complex and the rise in urinary pH also increases the ionization of uric acid to the more soluble urate ion.

How to use POTRATE 10MG TABLET

Take POTRATE 10MG TABLET as advised by your doctor. Do not crush or chew the medicine while consuming it with water.

Your doctor will decide the correct dosage and duration for you depending upon your age, body weight and disease condition.

Side Effects Of POTRATE 10MG TABLET

Rare

Stop taking POTRATE 10MG TABLET and immediately contact your doctor if experience any of following side effects:

symptoms of bowel perforation and obstruction are severe vomiting, abdominal pain or gastrointestinal bleeding

Warning & Precautions

Pregnancy

It is not known whether POTRATE 10MG TABLET cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Hence it should be given to a pregnant woman only if clearly needed. Consult your doctor before taking it.

Breastfeeding

POTRATE 10MG TABLET should be used in breast feeding women only if necessary. Consult your doctor before taking it.

Kidney

POTRATE 10MG TABLET is not recommended for use in patients with chronic kidney disease. Consult your doctor before taking.

Allergy

Do not take POTRATE 10MG TABLET if you are allergic to Potassium citrate or to any ingredients of this medicine.

Heart Disease

POTRATE 10MG TABLET should be avoided in patients with heart disease such as heart failure or severe myocardial damage and should be used with caution in patients with heart block. Consult your doctor before taking.

Others

POTRATE 10MG TABLET is not indicated for use if you have:

hyperkalaemia (increased potassium levels)
uncontrolled diabetes mellitus
acute dehydration
strenuous physical exercise in unconditioned individuals
adrenal insufficiency
extensive tissue breakdown
delayed gastric emptying
oesophageal compression
intestinal obstruction or narrowing
peptic ulcer disease
active urinary tract infection

Before taking POTRATE 10MG TABLET, you must inform your doctor if you have:

gastrointestinal failure

Use in pediatrics:

The safety and effectiveness of POTRATE 10MG TABLET for use in children have not been established. Consult your doctor before taking.

Interactions

A. Drug- Drug interaction

Before taking POTRATE 10MG TABLET, inform your doctor if you are taking any of the following medicine:

aliskiren, potassium sparing diuretics (medicine used in the management of increased blood pressure, oedema, kidney disorders) such as spironolactone, eplerenone, amiloride
medicines used for high blood pressure (captopril, enalapril, lisinopril and angiotensin receptor blockers like losartan)
nonsteroidal anti-inflammatory drugs (used to manage pain such as indomethacin)
digoxin (medicine used for heart failure)
heparin (medicine used to manage blood from clotting)
beta blockers (medicines used to decrease blood pressure) such as atenolol, metoprolol, propranolol
medicines that decrease gastrointestinal emptying time ex. anticholinergics such as dicyclomine (used for irritable bowel syndrome)

B. Drug- food interactions:

Avoid taking foods with high level of potassium such as almonds, apricots, bananas, beans, cantaloupe, carrot juice, figs, grapefruit, halibut, milk, oat bran, potato (with skin), tuna, salmon, spinach when consuming POTRATE 10MG TABLET.

Overdosage:

If you or anyone else accidentally takes too much of POTRATE 10MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea, vomiting, diarrhoea, abdominal cramps, muscle paralysis, paraesthesia, lack of reflexes, fits, respiratory paralysis, ECG changes, hypotension and shock, bundle-branch block, ventricular arrhythmias, ventricular fibrillation, cardiovascular collapse or cardiac arrest.

Synopsis

Drug	:	Potassium citrate
Pharmacological Category	:	Urinary alkalinizer
Therapeutic Indication	:	Renal Tubular Acidosis (RTA) with Calcium Stones, Hypocitraturic Calcium Oxalate Nephrolithiasis of any Cause, Uric Acid Lithiasis with or without Calcium Stones
Dosage Forms	:	Tablet

More Information

Keep POTRATE 10MG TABLET out of reach of children
Store POTRATE 10MG TABLET below 25°C

FAQs About POTRATE 10MG TABLET

What are the uses of POTRATE 10MG TABLET?

POTRATE 10MG TABLET is used in management of renal tubular acidosis (accumulation of acids due to decreased kidney function) with calcium stones, uric acid lithiasis (uric acid stone formation) with or without calcium stones, hypocitraturic calcium oxalate nephrolithiasis (calcium oxalate stones) of any cause.

In what conditions POTRATE 10MG TABLET must avoid?

What is the best way to consume POTRATE 10MG TABLET?

POTRATE 10MG TABLET must be consumed with meals or after meals to reduce the side effects. Consult your doctor before taking the medicine.

What foods need to be avoided while taking POTRATE 10MG TABLET?

Avoid consumption of foods with high level of potassium such as almonds, apricots, bananas, beans, cantaloupe, carrot juice, figs, grapefruit, halibut, milk, oat bran, potato (with skin), tuna, salmon, spinach.

References

1. Barbara G. Wells, Joseph T. Dipiro, Terry L. Schwinghammer, Cecily V. Dipiro. Renal disorders. Pharmacotherapy Handbook. 9th edition. 2015. Page- 774.

2. Sean C Sweetman. Electrolytes. Martindale: The Complete Drug Reference. 36th edition. 2009. Page- 1675.

3. Nancy S. Krieger, John R. Asplin, Kevin K. Frick, Ignacio Granja, Christopher D. Culbertson, Adeline Ng, Marc D. Grynpas, and David A. Bushinsky. Effect of Potassium Citrate on Calcium Phosphate Stones in a Model of Hypercalciuria. Journal of American Society of Nephrology. December 2015. [Accessed on August 9th 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657843/

4. MISSION PHARMACAL COMPANY. U.S. Food & Drug Administration. [Revised in December 2009] [Accessed on August 8th 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019071s012lbl.pdf

5. ANI Pharmaceuticals, Inc. Potassium Citrate. [Revised in January 2022] [Accessed on August 8th 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2fb31727-68b1-4183-947d-00e08bf99987

6. Mission Pharmacal Company. Potassium Citrate. [Revised in August 2010] [Accessed on August 8th 2022] https://www.paladin-labs.com/our_products/Urocit_K_en.pdf

Useful Diagnostic Tests

Serum potassium
BUN (Blood Urea Nitrogen)
Complete blood count
ECG

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Pushpraj Singh - MBBS

Last updated on 28 Sep 2022 | 07:16 PM(IST)