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Introduction About CORALAN 7.5MG TABLET

CORALAN 7.5MG TABLET contains Ivabradine which belongs to the group of medicines called Hyperpolarization-activated cyclic nucleotide-gated channel blockers. CORALAN 7.5MG TABLET is used to manage symptomatic stable angina pectoris (chest pain) in adult patients who are intolerant/incapable to take heart medicines (such as beta blockers) and whose heart rate is over/equal to 70 beats per minute.

It is also used to manage chronic heart failure in adult patients whose heart rate is over/equal to 75 beats per minute which are used as a combination therapy with beta-blockers or in adult patients who are contraindicated to use beta blockers.

CORALAN 7.5MG TABLET is not recommended for use in patients allergic to ivabradine. It is also not recommended for use in patients suffering from very low blood pressure, heart problems (such as unstable angina, cardiogenic shock), severe kidney disease, and/or severe liver disease.

Before taking CORALAN 7.5MG TABLET, inform your doctor if you have mild to moderate low blood pressure, chronic eye retinal disease, recent stroke (cerebral attack), heart rhythm disorders (such as irregular heartbeat, palpitation, increase in chest pain), and/or moderate liver disease.

CORALAN 7.5MG TABLET is generally not recommended for use in pregnant and breast-feeding women which is also not recommended for use in children and adolescents (aged below 18 years). The medicine is advised to be used with caution in elderly patients (aged above 65 years) after consulting the doctor.

The most common side effects of taking CORALAN 7.5MG TABLET are brief moments of increased brightness (due to sudden changes in light intensity), slow heart rate, uncontrolled blood pressure, headache, dizziness, and/or blurred vision. Consult your doctor if any of these symptoms worsen.

Uses Of CORALAN 7.5MG TABLET

Symptomatic stable angina pectoris (chest pain) in adult patients (with heart rate above/equal to 70 beats/minute)
Chronic heart failure in adult patients (with heart rate above/equal to 75 beats/minute)

How CORALAN 7.5MG TABLET Works

CORALAN 7.5MG TABLET works by reducing the heart rate which leads to low oxygen requirement of the heart resulting in improved blood supply throughout the body (with each hear beat) thus providing relief from angina pectoris and managing the occurrence of chronic heart failure in affected individuals.

How to use CORALAN 7.5MG TABLET

Tablet:

Take CORALAN 7.5MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending on your age, body weight and disease condition.

Orally Disintegrating Tablet:

Take CORALAN 7.5MG TABLET as advised by your physician. Place CORALAN 7.5MG TABLET inside your mouth and allow it to dissolve completely. Do not swallow or chew the medicine.. Your physician will decide the correct dose and duration for you depending on your age, body weight and disease condition.

Side Effects Of CORALAN 7.5MG TABLET

Common

brief moments of increased brightness (due to sudden changes in light intensity)
slow heart rate
signs of atrial fibrillation (irregular rapid contraction of heart) such as chest pain, pounding heartbeat, tiredness
uncontrolled blood pressure
headache, dizziness, blurred vision

Uncommon

racing heartbeat
nausea, constipation, diarrhoea, abdominal pain
sudden internal/external spinning sensation
difficulty breathing
muscle spasms
skin rash
signs of angioedema such as swollen face, tongue/throat, difficulty in breathing/swallowing
low blood pressure, fainting, tiredness, weakness
double vision, impaired vision

Rare

red itchy welts, itching, skin reddening
feeling unwell

How To Manage Side Effects

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom does not improve.

Dizziness:

Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.

Nausea:

Try to take CORALAN 7.5MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.

Constipation:

Try to eat high-fibre foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor to receive alternate managements for constipation.

Diarrhoea:

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhoea. Consult your doctor and inform them if the symptom gets worse.

Warning & Precautions

Pregnancy

CORALAN 7.5MG TABLET is not recommended for use during pregnancy and in women planning for pregnancy. Women of childbearing potential should use reliable contraceptive measures while taking CORALAN 7.5MG TABLET. Consult your doctor before taking the medicine.

Breastfeeding

CORALAN 7.5MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking the medicine.

Driving and Using Machines

Do not drive or operate any machines after taking CORALAN 7.5MG TABLET since it may cause temporary blindness (due to sudden changes in light intensity) which may after your ability to concentrate while driving or operating machines.

Kidney

CORALAN 7.5MG TABLET should be used with caution in patients with severe kidney disease. Consult your doctor before taking the medicine.

Liver

CORALAN 7.5MG TABLET is not recommended for use in patients with severe liver disease. It should be used with caution in patients with moderate liver disease. Consult your doctor before taking the medicine.

Allergy

Do not take CORALAN 7.5MG TABLET if you are allergic to ivabradine, and/or any other ingredients of this medicine.

Heart Disease

CORALAN 7.5MG TABLET is not recommended for use in patients with heart problems such as slow resting heart rate (beats below 70/minute), cardiogenic shock, heart rhythm disorders (such as sick sinus syndrome, sino-atrial block, heart block), heavy heart attack, and/or severe heart failure. It should be used with caution in patients with other heart rhythm disorders (such as irregular heartbeat, palpitation, increase in chest pain), sustained atrial fibrillation, long QT syndrome, slow heartbeat (associated with signs such as tiredness, dizziness, shortness of breath), and/or bundle branch block (type of severe heart failure). Consult your doctor before taking the medicine.

Others

CORALAN 7.5MG TABLET is not recommended for use if you:

suffer from very low blood pressure
have unstable angina (a severe form of chest pain)

Before taking CORALAN 7.5MG TABLET, inform your doctor if you:

had a recent stroke (cerebral attack)
suffer from mild to moderate low blood pressure (after change in antihypertensive management)
have chronic eye retinal disease

Use in Paediatrics:

CORALAN 7.5MG TABLET is generally not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before taking the medicine.

Use in Geriatrics:

CORALAN 7.5MG TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking the medicine.

Interactions

A.Drug - Drug interactions:

Before taking CORALAN 7.5MG TABLET, inform your doctor if you are taking any of the following medicine:

medicines used to manage fungal infections (Ex. fluconazole, ketoconazole, itraconazole)
rifampicin (medicine used to manage tuberculosis)
barbiturates (medicines used for difficulty sleeping or epilepsy)
phenytoin (used for epilepsy)
hypericum perforatum/St John’s Wort (herbal medicines used for depression)
medicines used to manage heart rhythm disorders (Ex. quinidine, disopyramide, sotalol, ibutilide, amiodarone)
bepridil (medicine used to manage angina pectoris)
medicines to manage anxiety, schizophrenia or other psychoses (Ex. pimozide, ziprasidone, sertindole)
medicines used to manage malaria (Ex. mefloquine,halofantrine)
intravenous erythromycin (medicine used to manage bacterial infections in different parts of the body)
pentamidine (medicine used in the management of pneumocystis pneumonia, leishmaniasis, trypanosomiasis)
cisapride (used for acid reflux)
diuretics (medicines used to manage oedema, high blood pressure) Ex. furosemide, hydrochlorothiazide, indapamide
clarithromycin, josamycin, telithromycin,erythromycin (medicines used for bacterial infections)
nelfinavir, ritonavir (medicines used to manage HIV infections)
nefazodone (medicine used to manage depression)
diltiazem, verapamil (medicines used to manage high blood pressure/angina pectoris)

B.Drug -Food interaction:

Avoid drinking grapefruit juice while taking CORALAN 7.5MG TABLET as it may alter the effect of the medicine.

Overdosage:

If you or anyone else accidentally take too much of CORALAN 7.5MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are breathlessness and tiredness.

Synopsis

Drug	:	Ivabradine
Pharmacological Category	:	Hyperpolarization-activated cyclic nucleotide-gated channel blockers
Therapeutic Indication	:	Symptomatic stable angina, Chronic Heart failure
Dosage Forms	:	Tablet

More Information

Keep CORALAN 7.5MG TABLET out of the sight and reach of children
Store at room temperature

FAQs About CORALAN 7.5MG TABLET

What is CORALAN 7.5MG TABLET used for?

CORALAN 7.5MG TABLET is used to manage symptomatic stable angina pectoris (chest pain) in adult patients who are intolerant/incapable to take heart medicines (such as beta blockers) which is also used to manage chronic heart failure in adult patients whose heart rate is over/equal to 75 beats per minute.

How CORALAN 7.5MG TABLET works?

What are the most common side effects of taking CORALAN 7.5MG TABLET?

How to take CORALAN 7.5MG TABLET?

Take CORALAN 7.5MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

CanCORALAN 7.5MG TABLET be used in pregnant women?

No, CORALAN 7.5MG TABLET is not recommended for use during pregnancy and in women planning for pregnancy as it may cause harm to the foetus. Women of childbearing potential should use reliable contraceptives while on management with CORALAN 7.5MG TABLET. Consult your doctor before taking the medicine.

References

1. K.D.Tripathi. Antianginal and Other Anti-ischaemic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 554.

2. Mirembe Reed; Connor C. Kerndt; Diala Nicolas. Ivabradine. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. [Revised in May 2022] [Accessed on 14th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK507783/

3. Lupin Limited. IVABRAD OD 10MG, IVABRAD OD 15MG. [Accessed on 14th May 2022] https://www.lupin.com/our-products/product-finder/?searchkey=Ivabradine

4. Alniche Life Sciences Pvt. Ltd. Ivaniche. [Accessed on 14th May 2022] https://www.alniche.com/cardiac-diabetes-care/

5. Noucor Health S.A. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 14th May 2022] https://www.medicines.org.uk/emc/files/pil.9104.pdf

Useful Diagnostic Tests

Electrocardiogram
Stress test
Coronary angiography

Author Details

Written By Dr. K .AZEEM HUSSAIN - B.D.S

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 22 Oct 2022 | 09:41 AM(IST)