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Introduction About INVOKANA 100MG TABLET

INVOKANA 100MG TABLET contains Canagliflozin which belongs to the group of medicines called Anti-diabetic drugs. It is used to manage type 2 diabetes mellitus along with diet and exercise in adults. It is also used to reduce the risk of heart disease and slow down worsening of kidney function in patients with type 2 diabetes mellitus.

Type 2 diabetes is a condition in which your body fails to make enough insulin and the insulin that your body produces does not work as well as it is expected to. Symptoms include increased thirst, urination and hunger, blurry vision, numbness in hands or feet or tiredness.

INVOKANA 100MG TABLET is not recommended for use in patients who are on kidney dialysis and with type-1 diabetes. It should be used with caution in patients with low blood pressure, severe liver, kidney and heart disease, stroke. Consult your doctor before taking it.

INVOKANA 100MG TABLET is not recommended for use in pregnant and breast-feeding women. Consult your doctor before taking it.

INVOKANA 100MG TABLET is not recommended for use in children and adolescents (under 18 years of age). It should be used with caution in elderly patients aged above 75 years of age. Consult your doctor before taking it.

The most common side effects of taking INVOKANA 100MG TABLET are vaginal yeast infection, rash or redness of the penis or foreskin, changes in urination, constipation, nausea and feeling thirsty. Contact your doctor if any of the symptoms worsen.

Uses Of INVOKANA 100MG TABLET

It is used in adults:

To manage type -2 diabetes mellitus
To reduce the risk of heart disease
To slow down worsening of kidney function

How INVOKANA 100MG TABLET Works

INVOKANA 100MG TABLET works by increasing the removal of glucose from the body in the form of urine. This reduces the amount of glucose in your blood and can help manage heart disease and slow down worsening of kidney function in patients with type 2 diabetes mellitus.

How to use INVOKANA 100MG TABLET

Take INVOKANA 100MG TABLET as advised by your physician. It can be taken with or without food. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Do not stop taking INVOKANA 100MG TABLET unless your doctor advice you to stop. Otherwise, it may lead to increase in blood sugar levels.

Side Effects Of INVOKANA 100MG TABLET

Serious

Stop taking INVOKANA 100MG TABLET and consult your doctor immediately if you experience any of the following side effects:

severe allergic reaction (swelling of the face, lips, mouth, tongue or throat that may cause difficulty in breathing or swallowing)
signs and symptoms of diabetic ketoacidosis such as rapid weight loss, nausea, vomiting, stomach pain, too much thirst, breathlessness, confusion, unusual sleepiness or tiredness, a sweet-smelling breath, a sweet or metallic taste in your mouth or a different odour to your urine or sweat
signs and symptoms of necrotising fasciitis of the perineum or Fournier’s gangrene include pain, tenderness, redness or swelling of the genitals or the area between the genitals and the anus with fever or feeling generally unwell
signs of dehydration (loss of too much fluid from your body) are light-headed or dizzy, fainting, very dry or sticky mouth, feeling very thirsty, feeling very weak or tired, passing little or no urine, fast heartbeat
signs of low blood sugar are blurred vision, tingling lips, trembling, sweating, pale looking, change in mood or feeling anxious or confused
signs of a severe infection of the urinary tract include fever and/or chills, burning sensation while urination, pain in your back or side and blood in urine

Common

vaginal yeast infection
rash or redness of the penis or foreskin
changes in urination (more frequent urination or in larger amounts, urgent need to urinate, need to urinate at night)
constipation, nausea
feeling thirsty

Uncommon

blood in urine
rash or red skin with itching, raised bumps, oozing fluid or blisters, hives
bone fracture
kidney failure (due to loss of excessive fluid)
lower limb amputations (especially of the toe) usually if you are at high risk of heart disease
phimosis (problems in pulling back the foreskin around the tip of the penis)
skin reactions after exposure to sunlight

How To Manage Side Effects

Constipation

Eat plenty of fiber rich foods like fresh fruits, vegetables, cereals and drink ample amount of water. Exercise more regularly. If you still feel constipated, contact your doctor.

Nausea And Vomiting

Take INVOKANA 100MG TABLET, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea did not improve.

Skin rash Or Itching

Avoid hot bath because hot water can irritate your skin further. Do not scratch the affected area. Use sunscreen and wear protective clothing while going outside. Use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if your rashes worsen.

Warning & Precautions

Pregnancy

Contraindicated

INVOKANA 100MG TABLET is not recommended for use in pregnant women. Consult your doctor before taking INVOKANA 100MG TABLET.

Breastfeeding

Contraindicated

INVOKANA 100MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking INVOKANA 100MG TABLET.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizziness or lightheadedness after taking INVOKANA 100MG TABLET.

Alcohol

Contraindicated

Avoid Consumption of alcohol while taking INVOKANA 100MG TABLET as it may increase the risk of diabetic ketoacidosis (complication of diabetes), so consult your doctor before taking INVOKANA 100MG TABLET.

Kidney

Consult your doctor

INVOKANA 100MG TABLET is not recommended for use in patients who are on kidney dialysis. It should be used with caution in patients with kidney disease. Consult your doctor before taking INVOKANA 100MG TABLET.

Liver

Use with Caution

INVOKANA 100MG TABLET should be used with caution in patients with severe liver disease. Consult your doctor before taking INVOKANA 100MG TABLET.

Allergy

Contraindicated

Do not take INVOKANA 100MG TABLET if you are allergic to Canagliflozin or any of the other ingredients of this medicine.

Heart Disease

Use with Caution

INVOKANA 100MG TABLET should be used with caution in patients with low blood pressure and serious heart disease. Consult your doctor before taking INVOKANA 100MG TABLET.

Use In Pediatrics

Contraindicated

INVOKANA 100MG TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking INVOKANA 100MG TABLET.

Use In Geriatrics

Use with Caution

INVOKANA 100MG TABLET should be used with caution in elderly patients aged above 75 years of age due to increased risk of dehydration. Consult your doctor before taking INVOKANA 100MG TABLET.

Others

INVOKANA 100MG TABLET is not recommended for use if you:

have type 1 diabetes (insulin dependent diabetes)

Before taking INVOKANA 100MG TABLET, inform your doctor if you:

have diabetic ketoacidosis (a complication of diabetes with high blood sugar, rapid weight loss, nausea or vomiting)
have stroke
have had a lower limb amputation
have had blocked or narrowed blood vessels, usually in your leg
have damage to the nerves (neuropathy) in your leg
have had diabetic foot ulcers or sores
have had had problems with your pancreas or surgery on your pancreas
have wounds, discolouration of feet or having any tenderness or pain in your feet
have signs of a genital yeast infection (irritation, itching, unusual discharge or odour)
have a severe infection of the urinary tract with fever
have intolerance to lactose or other sugars
are going to have surgery

Interactions

A. Drug-Drug interactions:

Before taking INVOKANA 100MG TABLET, inform your doctor if you are taking any of the following medicine:

medicines used to lower blood pressure Ex. diuretics such as furosemide, chlorthalidone
insulin or sulfonylureas (medicines used to manage high blood sugar levels) Ex. glimepiride glipizide
St. John’s wort (used to manage depression)
medicines used to control seizures (Ex. carbamazepine, phenytoin or phenobarbital)
medicines used to manage HIV infection (Ex. efavirenz or ritonavir)
rifampicin (used to manage tuberculosis)
cholestyramine (used to reduce blood cholesterol levels in the blood)
medicines used to manage heart problems (Ex. digoxin or digitoxin)
dabigatran (medicine that lowers the risk of blood clot formation)

Overdosage:

If you or anyone else accidentally take too much of INVOKANA 100MG TABLET, consult your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Canagliflozin
Pharmacological Category	:	Sodium Glucose Cotransporter-2 Inhibitor
Therapeutic Indication	:	Type- 2 Diabetes mellitus
Dosage Forms	:	Tablet

More Information

Keep INVOKANA 100MG TABLET out of reach of children
store INVOKANA 100MG TABLET below 30°C

FAQs About INVOKANA 100MG TABLET

Q: Does INVOKANA 100MG TABLET cause dehydration?

A: Yes, INVOKANA 100MG TABLET may cause dehydration (loss of too much fluid from your body) especially in elderly people (aged 75 and over) and people with kidney problems and people taking water tablets (diuretics). Signs of dehydration are light-headed or dizzy, fainting, very dry or sticky mouth, feeling very thirsty, feeling very weak or tired, passing little or no urine, fast heartbeat. Contact your doctor immediately if you experience any signs of dehydration.

Q: Does INVOKANA 100MG TABLET protect heart?

A: INVOKANA 100MG TABLET works by increasing the removal of glucose from the body in the form of urine. This reduces the amount of glucose in your blood and can help manage heart disease and slow down worsening of kidney function in patients with type 2 diabetes mellitus. Contact your doctor before taking INVOKANA 100MG TABLET.

Q: Can INVOKANA 100MG TABLET be used in children?

A: No. INVOKANA 100MG TABLET is used for adults and not recommended for children and adolescents below 18 years of age. Your doctor will decide the correct dose or select a suitable alternative therapy for your child.

Q: Is INVOKANA 100MG TABLET safe in pregnancy and breastfeeding?

A: INVOKANA 100MG TABLET is not recommended for use during pregnancy and breastfeeding. If you are pregnant, think you may be pregnant or are planning to get pregnant, ask your doctor before taking INVOKANA 100MG TABLET.

Q: When is the best time to take INVOKANA 100MG TABLET?

A: Take INVOKANA 100MG TABLET as advised by your physician. It is best to take your tablet before the first meal of the day. Try to take it at the same time each day. This will help you remember to take INVOKANA 100MG TABLET.

Q: What happens if I stop taking INVOKANA 100MG TABLET?

A: Take INVOKANA 100MG TABLET as advised by your doctor. Do not stop taking INVOKANA 100MG TABLET unless your doctor advice you to stop. Otherwise, it may lead to increase in blood sugar.

Q: What precautions do I need to follow while taking INVOKANA 100MG TABLET?

A: It is important to check your feet regularly and adhere to any other advice regarding foot care and adequate hydration given by your doctor. You should tell your doctor immediately if you notice any wounds or discolouration or if you experience any tenderness or pain in your feet. To control your diabetes, you still need to follow the advice about diet and exercise from your doctor. If you are following a diabetic weight control diet, continue to follow it while you are taking INVOKANA 100MG TABLET.

Q: How long does it take for INVOKANA 100MG TABLET to work?

A: Take INVOKANA 100MG TABLET according to the doctor’s advice. INVOKANA 100MG TABLET starts to work quickly and blood sugar levels should begin to decline in the first week or two after you start taking this medication. Contact your doctor if your symptoms did not improve.

Q: Can INVOKANA 100MG TABLET cause hypoglycemia?

A: Yes. INVOKANA 100MG TABLET may cause hypoglycemia (low blood sugar levels). Signs of low blood sugar are blurred vision, tingling lips, trembling, sweating, pale looking, change in mood or feeling anxious or confused. In such case, have a fruit juice, glucose tablets or soft drinks, honey or sugary candy. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack or drink and check the blood sugar again. Contact your doctor immediately if your symptoms worsen.

References

1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Diabetes Mellitus. Pharmacotherapy Handbook. Ninth edition. 2015. Page- 161.

2. Kaushal S, Singh H, Thangaraju P, Singh J. Canagliflozin: A Novel SGLT2 Inhibitor for Type 2 Diabetes Mellitus. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. March 2014. [Accessed on 26th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978932/

3. Jakher H, Chang TI, Tan M, Mahaffey KW. Canagliflozin review - safety and efficacy profile in patients with T2DM. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. February 2019. [Accessed on 26th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363491

4. Janssen-Cilag SpA. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 26th April 2022] https://www.medicines.org.uk/emc/files/pil.11409.pdf

5. Canagliflozin. Invokana. [Accessed on 26th April 2022] https://www.invokana.com/about-invokana

6. Drugbank. Canagliflozin. [Accessed on 26th April 2022] https://go.drugbank.com/drugs/DB08907

Useful Diagnostic Tests

Glucose-Fasting Blood
Glucose-Postprandial Blood
Glycosylated Hemoglobin
Urine test for glucose
Kidney Function Test

Author Details

Written By Dr. R. Dinesh John Rajkumar - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 21 Oct 2023 | 04:10 PM(IST)