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Introduction About ALKAZIP SYRUP

ALKAZIP SYRUP contains Disodium Hydrogen Citrate which belongs to the group of medicines called Urinary Alkalizers. It is used to manage the symptoms of urinary tract infections (such as low urine output, painful urination or burning sensation while passing urine) when used in combination with antibiotics.

It works by increasing your blood pH and by making your urine less acidic. Therefore, it helps in managing metabolic acidosis (low pH in blood) and hyperuricemia (high blood uric acid levels) and manage the incidence of gout and/or kidney stones caused due to high blood uric acid levels.

It corrects dehydration by replacing the lost electrolytes in the body. It also helps in managing the symptoms of inflammation in the urinary tract such as pyelitis, cystitis, urethritis and urolithiasis. ALKAZIP SYRUP must be dissolved in water before consumption.

Before taking ALKAZIP SYRUP inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have Addison’s disease, fluid retention in your body parts or lungs, hypertension or heat cramps as a precaution.

Do not take ALKAZIP SYRUP without consulting your doctor if you are pregnant or breastfeeding. The most common side effects of taking ALKAZIP SYRUP are increased urination, diarrhea and flatulence. Consult your doctor if any of these side effects troubles you.

Uses Of ALKAZIP SYRUP

Symptoms of urinary tract infections (such as low urine output, painful urination or burning sensation while passing urine)
Corrects dehydration and metabolic acidosis (low pH of the blood)
Makes the urine less acidic
Manage inflammation of kidneys, bladder and urethra
Manage high blood uric acid levels
Prevents gout and kidney stone formation

How ALKAZIP SYRUP Works

ALKAZIP SYRUP is a urinary alkalizer. It works by increasing the pH of the blood and urine. This makes your urine less acidic which helps in managing the urinary symptoms (such as painful urination, low urine output or burning sensation while passing urine) caused due to urinary tract infections or inflammation.

It also replenishes the lost electrolytes in the body and increases urine output which helps in managing dehydration and in flushing out harmful bacteria that causes urinary tract infection.

How to use ALKAZIP SYRUP

Take ALKAZIP SYRUP as advised by your physician. Dissolve the required amount of the medicine in water before consumption. Your doctor will decide the correct dose, amount of water to be used for dissolution and duration of therapy based on your age, body weight and disease condition. Do not stop taking ALKAZIP SYRUP without consulting your doctor.

Side Effects Of ALKAZIP SYRUP

Common

Nausea, vomiting
Diarrhea, stomach pain, flatulence
Increased urine output
Low potassium levels in blood on prolong use
Mood changes, tiredness, shortness of breath, muscle weakness, and irregular heartbeat

How To Manage Side Effects

Diarrhea

Drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens, contact your doctor immediately.

Nausea And Vomiting

Take ALKAZIP SYRUP with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if the symptoms are worsening.

Warning & Precautions

Pregnancy

Consult your doctor

The safety and effectiveness of ALKAZIP SYRUP have not been established in pregnant women. Therefore, it should be used in pregnant women only if considered necessary by the physician. It is strictly not recommended for use in pregnant women with toxaemia (high blood pressure during pregnancy due to infections).

Breastfeeding

Consult your doctor

The safety and effectiveness of ALKAZIP SYRUP have not been established in breastfeeding women. Therefore, it should be used in breastfeeding women only if considered necessary by the physician.

Driving and Using Machines

Safe

ALKAZIP SYRUP is unlikely to affect your ability for driving or handling any heavy tools or machines.

Kidney

Consult your doctor

ALKAZIP SYRUP is not recommended for use in patients with severe kidney problems (such as oliguria, azotemia or anuria). It should be used with caution in patients with low urine output. Therefore, consult your doctor before taking it.

Liver

Use with Caution

ALKAZIP SYRUP should be used with caution in patients with acute liver failure. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take ALKAZIP SYRUP if you are allergic to Disodium hydrogen citrate.

Lungs

Use with Caution

ALKAZIP SYRUP should be used with caution in patients with fluid accumulation in the lungs. Therefore, consult your doctor before taking it.

Heart Disease

Consult your doctor

ALKAZIP SYRUP is not recommended for use in patients with severe heart problems (such as myocardial damage). It should be used with caution in patients with heart failure or hypertension. Therefore, consult your doctor before taking it.

Use In Pediatrics

Use with Caution

ALKAZIP SYRUP should be used with caution in children and adolescents (aged 6 years or above). Therefore, consult your doctor for advice before taking it.

Use In Geriatrics

Use with Caution

ALKAZIP SYRUP should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.

Others

ALKAZIP SYRUP is not recommended for use if you:

have Addison’s disease (a disease caused due to problems in adrenal gland)
have acute dehydration or heat cramps

Before taking ALKAZIP SYRUP inform your doctor if you:

have fluid retention in your body

Interactions

A. Drug-Drug Interactions:

Before taking ALKAZIP SYRUP, inform your doctor if you are taking any of the following medicines such as:

Antacids (medicines used to manage heartburn and stomach ulcers) such as aluminium hydroxide, magnesium hydroxide
Chlorpropamide (a medicine used to manage diabetes)
Lithium (a medicine used to manage mental illnesses)
Methotrexate (a medicines used to manage cancer or rheumatoid arthritis)
Methenamine (a medicine used to manage bacterial infection)
Salicylates (used for pain relief) such as aspirin
Tetracyclines (used to manage bacterial infections) such as doxycycline
Mecamylamine (a medicine used to manage hypertension)
Flecainide, Quinidine (used to manage abnormal heart rhythm)
Sympathomimetics (such as dobutamine, dopamine, norepinephrine, epinephrine, and isoproterenol) used to stimulate body secretions, gut movements and muscle movements

Overdosage:

If you or anyone else accidentally took too much of ALKAZIP SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include stomach ulcers, diarrhea, nausea, vomiting, hyperactivity, edema and fits.

Synopsis

Drug	:	Disodium Hydrogen Citrate
Pharmacological Category	:	Urinary Alkalizer
Therapeutic Indication	:	Urinary symptoms, Metabolic Acidosis
Dosage Forms	:	Oral Solution

More Information

Keep ALKAZIP SYRUP out of reach of children
Store ALKAZIP SYRUP at room temperature

FAQs About ALKAZIP SYRUP

Q: What is the use of ALKAZIP SYRUP?

A: ALKAZIP SYRUP is used to manage the symptoms of urinary tract infections (such as low urine output, painful urination or burning sensation while passing urine) when used in combination with antibiotics. It helps in managing metabolic acidosis (low pH in blood) and hyperuricemia (high blood uric acid levels) and manage the incidence of gout and/or kidney stones caused due to high blood uric acid levels. It corrects dehydration by replacing the lost electrolytes in the body. It also helps in managing the symptoms of inflammation in the urinary tract such as pyelitis, cystitis, urethritis and urolithiasis.

Q: How ALKAZIP SYRUP works in my body?

A: ALKAZIP SYRUP is a urinary alkalizer. It works by increasing the pH of the blood and urine. This makes your urine less acidic which helps in managing the urinary symptoms (such as painful urination, low urine output or burning sensation while passing urine) caused due to urinary tract infections or inflammation. It also replenishes the lost electrolytes in the body and increases urine output which helps in managing dehydration and in flushing out harmful bacteria that causes urinary tract infection.

Q: How to take ALKAZIP SYRUP?

A: Take ALKAZIP SYRUP as advised by your physician. Dissolve the required amount of the medicine in water before consumption. Your doctor will decide the correct dose, amount of water to be used for dissolution and duration of therapy based on your age, body weight and disease condition.

Q: Is ALKAZIP SYRUP good for urinary infection?

A: Yes. ALKAZIP SYRUP helps in controlling urinary symptoms (such as painful urination, low urine output or burning sensation while passing urine) caused due to urinary tract infections or inflammation. It also increases urine output which helps in flushing out harmful bacteria that causes urinary tract infection.

Q: What are the side effects of ALKAZIP SYRUP?

A: The most common side effects of taking ALKAZIP SYRUP are increased urination, diarrhea and flatulence. Consult your doctor if any of these side effects troubles you.

Q: Can ALKAZIP SYRUP be used in children?

A: ALKAZIP SYRUP should be used with caution in children and adolescents (aged 6 years or above). Therefore, consult your doctor for advice before taking it.

Q: Can ALKAZIP SYRUP be used during breastfeeding?

A: The safety and effectiveness of ALKAZIP SYRUP have not been established in breastfeeding women. Therefore, it should be used in breastfeeding women only if considered necessary by the physician.

References

1. Disodium Sodium Citrate. Martindale: The-Complete-Drug-Reference. 36th Edition. Page – 1673.

2. Mausumi De, Amit Kumar Ghosh, Saugata Ghosh, Sudip Barua and Subhajit Paul. effect of alkalinisation of urine on the efficacy of quinolones in treatment of urinary tract infection. Jouurnal of Evidence Based Medicine and Healthcare. 2018. [Accessed on 25th March 2023] https://www.ingentaconnect.com/content/doaj/23492562/2018/00000005/00000006/art00016;jsessionid=7pq41sm06s41n.x-ic-live-02

3. Pfizer Ltd. Citralka Syrup. [Accessed on 25th March 2023] https://labeling.pfizer.com/ShowLabeling.aspx?id=14817#:~:text=Disodium%20hydrogen%20citrate%2C%20also%20known,and%20promotes%20a%20mild%20diuresis.&text=Disodium%20hydrogen%20citrate%20is%20metabolized%20after%20absorption%20to%20sodium%20bicarbonate.

4. Vibcare Pharma Pvt Ltd. Disodium Hydrogen Citrate. [Accessed on 25th March 2023] https://vibcare.co.in/disodium-hydrogencitrate/

5. MIMS.com. Disodium Hydrogen Citrate. [Accessed on 25th March 2023] https://www.mims.com/malaysia/drug/info/disodium%20hydrogen%20citrate?mtype=generic

6. Leeford Healthcare Pvt Ltd. Alkazip. [Accessed on 25th March 2023] https://www.leeford.in/product/231/alkazip

7. Orion Lifescience. (Hytra Syrup) Disodium Hydrogen Citrate 1.4 Gm Syrup. [Accessed on 25th March 2023] https://www.orionlifes.com/product/disodium-hydrogen-citrate-1-4-gm-syrup/

8. Green Cross Remedies. Urilica Syrup. [Accessed on 25th March 2023] https://greencrossindia.com/p/urilica-syrup.html

9. Winston Pharmaceuticals Ltd. RV-Alkawin. [Accessed on 25th March 2023] https://www.winstonpharma.com/rv-alkawin/

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Pushpraj Singh - MBBS

Last updated on 27 Mar 2023 | 05:48 PM(IST)