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Introduction About LACOSMART 50 TABLET

LACOSMART 50 TABLET contains lacosamide a compound used to support individuals managing certain neurological conditions. This tablet belongs to a group of medicines known as functional central nervous system (CNS) agents. It is commonly offered as part of long-term care plans under specialist guidance. It works by interacting with voltage-gated sodium channels in the brain helping to regulate irregular nerve signal activity.

This tablet is generally recommended for patients with uncontrolled nerve signal disturbances or those requiring additional support in managing abnormal brain activity patterns. It may be considered in both adults and adolescents depending on the clinical basis. LACOSMART 50 TABLET is ideally taken orally with water either with or without food and at the same time daily for consistency. The exact dose and frequency are to be determined by a medical professional based on individual patient response.

Before initiating LACOSMART 50 TABLET , it is important to discuss all current medications, existing medical conditions, and any history of liver, kidney or heart rhythm issues. Caution is advised during pregnancy or breastfeeding and use in such cases is only recommended if clearly advised by a healthcare provider. It is also important not to abruptly discontinue the tablet without medical supervision, as this may affect the body’s neuronal balance.

Commonly observed side effects may include dizziness, fatigue, blurred vision, nausea and coordination difficulties. Most of these are mild and temporary, but patients are encouraged to report any persistent or unusual symptoms. It is essential to follow prescribed instructions carefully and attend regular check-ups to monitor progress.

Uses Of LACOSMART 50 TABLET

Helps regulate nerve signal activity (in the management of partial onset seizures)
Supports balanced brain function

Benefits of LACOSMART 50 TABLET

LACOSMART 50 TABLET and Brain Signal Regulation

LACOSMART 50 TABLET plays a role in supporting the normal flow of electrical signals in the brain. Our brain works by sending tiny electrical messages between nerve cells (neurons). Sometimes, these signals can become too fast or irregular. LACOSMART 50 TABLET helps by interacting with specific channels in brain cells called voltage-gated sodium channels, which are important for controlling nerve activity.

By helping to stabilize these signals, LACOSMART 50 TABLET may assist in keeping the brain’s communication system more balanced. This support can be especially helpful in cases where individuals experience sudden changes in nerve activity. While it does not work instantly, regular use as advised by a doctor can promote better nerve signal control over time.

How LACOSMART 50 TABLET supports brain function

The brain’s ability to process thoughts, movements and sensations depends on how well its nerve cells communicate. LACOSMART 50 TABLET is used in situations where this communication may be disrupted due to overactive nerve signals. Lacosamide supports the slow inactivation of sodium channels which helps prevent excessive electrical firing between neurons.

This controlled response helps the brain maintain a steady rhythm in how it sends and receives signals. For many people, this can lead to better focus, reduced nervous system disruptions and improved participation in daily routines. However, results can vary and should always be monitored by a healthcare professional to ensure it fits the individual's care plan.

How LACOSMART 50 TABLET Works

Mechanism of LACOSMART 50 TABLET in neuronal activity

LACOSMART 50 TABLET helps support balanced nerve cell activity in the brain. Nerve cells communicate by sending electrical signals and sometimes these signals can become too frequent or irregular. LACOSMART 50 TABLET works by gently regulating this nerve activity, helping to maintain a steady flow of electrical messages. This action supports the brain’s ability to function smoothly and respond appropriately to various signals.

By promoting stability in how nerve cells send signals, LACOSMART 50 TABLET contributes to maintaining clearer communication between neurons. This balanced activity may help individuals maintain better neurological function as part of their overall care plan.

LACOSMART 50 TABLET and Sodium Channel Modulation

A key way LACOSMART 50 TABLET supports nerve activity is through its effect on sodium channels which are tiny gateways on nerve cells that control the movement of electrical impulses. LACOSMART 50 TABLET specifically enhances the “slow inactivation” of these voltage-gated sodium channels. This means it helps prevent nerve cells from firing excessively or too quickly, promoting more controlled and steady nerve signal transmission.

This modulation of sodium channels is important because it helps maintain the natural rhythm of nerve signals, reducing the chances of sudden spikes or disruptions. Through this action, LACOSMART 50 TABLET supports a more balanced and stable nervous system function, which is essential for everyday brain and nerve health.

How to use LACOSMART 50 TABLET

Recommended Dosage for LACOSMART 50 TABLET

Dosage is determined by your healthcare provider based on individual needs.
Commonly prescribed as 1 or 2 tablets per day
The dose may be gradually increased or adjusted for optimal effect.
Do not change your dose without consulting your doctor.
Follow the exact schedule provided by your healthcare professional.

LACOSMART 50 TABLET Administration Tips

Take LACOSMART 50 TABLET with a full glass of water.
Swallow tablets whole; do not crush or chew.
Take at the same time(s) each day to maintain even levels in your body.
Keep a daily routine or use reminders to avoid missed doses.

Can I take LACOSMART 50 TABLET with food?

Yes, LACOSMART 50 TABLET can be taken with or without food.
Taking it with food may help reduce mild stomach discomfort in some people.
Consistency is key—try to take it the same way (with or without food) every day.
Avoid alcohol while taking LACOSMART 50 TABLET unless your doctor approves.

What if I forgot to take LACOSMART 50 TABLET

If you forget to take a dose of LACOSMART 50 TABLET take it as soon as you remember. However, if it is close to the time for your next scheduled dose, it’s best to skip the missed one and continue with your regular dosing routine. Do not take two doses at once to make up for the missed tablet, as this could lead to unwanted side effects. Missing doses occasionally may reduce the consistency of nerve signal support so it’s a good idea to take your tablet at the same time every day. If you often miss doses or are unsure what to do, speak with your healthcare provider for advice.

Overdose

Taking more than the prescribed amount of LACOSMART 50 TABLET can cause serious side effects such as dizziness, nausea, loss of coordination or irregular heartbeat. In case of accidental or intentional overconsumption, immediate medical attention is strongly advised. Do not try to adjust the dosage on your own. Always follow your doctor’s instructions carefully and keep the medication in a safe place away from children to avoid accidental intake. Immediately seek medical advice in case of overdosage to reduce the risk of complications

Side Effects Of LACOSMART 50 TABLET

Common side effects of LACOSMART 50 TABLET

headache
nausea
double or blurred vision
myoclonic seizures (short jerks of a muscle or group of muscles)
difficulties in coordinating movements or walking
problems in keeping balance, tremors (shaking), tingling (paresthesia) or muscle spasms, falling easily and getting bruises
troubles with memory, confusion
rapid and uncontrollable movements of the eyes (nystagmus)
vomiting, dry mouth, constipation, indigestion, excessive gas in the stomach or bowel, diarrhea
reduced sensitivity or feeling, difficulty in articulating words, disturbance in attention
noise in the ear such as buzzing, ringing or whistling
irritability, trouble sleeping, depression
sleepiness, tiredness or weakness (asthenia)
itching, rash
runny nose, fever, sore throat, eating less than usual (in children)

When to Seek Medical Attention?

Stop taking LACOSMART 50 TABLET and contact your doctor immediately if you experience any of the following side effects:

symptoms of abnormal heartbeat (such as rapid, irregular or slow heartbeat, palpitations, shortness of breath, feeling lightheaded, fainting)

How To Manage Side Effects

Headache

Stay hydrated and avoid skipping meals.
Rest in a quiet, dark place to reduce discomfort.
Limit screen time and take regular breaks.
Use a mild pain reliever like paracetamol if needed (with medical advice).
Ensure regular sleep and manage stress levels.

Nausea And Vomiting

Drink clear fluids slowly to stay hydrated.
Eat small, bland meals (such as toast or crackers).
Avoid strong smells and spicy or greasy foods.
Sit upright after eating to aid digestion.
Take anti-nausea medicine only if recommended by your doctor

LACOSMART 50 TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.

Other Warnings for LACOSMART 50 TABLET

Before taking LACOSMART 50 TABLET, inform your doctor if you have:

self-harming thoughts
often dizzy or fall over

Safety Advice

Precautions to Follow While Taking LACOSMART 50 TABLET

Before starting LACOSMART 50 TABLET, it is important to inform your doctor about any existing health conditions such as heart rhythm issues, liver or kidney problems or if you are taking any other medications. Individuals with a history of dizziness or imbalance should take extra care as LACOSMART 50 TABLET may cause unsteadiness especially at the beginning of use.

Make sure to follow the prescribed dose and avoid changing the dosage without medical advice. If you are scheduled for any surgery or medical procedure inform your healthcare provider that you are using this medicine. Also, regular follow-ups may be advised to monitor your body's response particularly if you are taking other medicines alongside LACOSMART 50 TABLET.

Things to Avoid While Taking LACOSMART 50 TABLET

Avoid driving or using heavy machinery until you know how the medicine affects you. It may cause dizziness or blurred vision in some individuals.
Do not consume alcohol, as it may worsen drowsiness, reduce alertness, and increase the risk of coordination problems.
Avoid stopping the medicine suddenly unless advised by your doctor, as this may affect your health stability.
Avoid combining with other central nervous system-active medicines (such as sleep aids or sedatives) without medical consultation.
Skip grapefruit or citrus-heavy diets in excess as they may interfere with how certain medications are processed.

Diet and Lifestyle Advice

Following healthy diet and lifestyle practices while using LACOSMART 50 TABLET can support overall well-being and help maintain consistency in your routine. Although LACOSMART 50 TABLET does not require specific dietary restrictions, mindful habits can improve your daily functioning and reduce discomfort.

Balanced Diet for Better Tolerance

Eat regular, balanced meals to maintain stable energy levels.
If LACOSMART 50 TABLET causes mild nausea or stomach upset, try taking it after food.
Stay hydrated throughout the day-drink plenty of water unless advised otherwise.
Include fiber-rich foods (like vegetables, whole grains, fruits) if you experience constipation.

Lifestyle Tips for Stability

Establish a daily medicine routine: Take LACOSMART 50 TABLET at the same time each day to help form a habit.
Ensure adequate sleep: Maintain regular sleep-wake cycles, as poor sleep may affect your daily function.
Avoid sudden posture changes: Stand up slowly from sitting or lying down to reduce dizziness.
Practice light activity or walking: Can support balance and help reduce fatigue.
Stress management: Gentle exercises like yoga, breathing techniques, or journaling can promote calmness.

Drug - Drug interaction

LACOSMART 50 TABLET may interact with certain other medicines that affect how it works in the body. These interactions can influence the activity level of lacosamide or increase the chance of side effects. Informing your doctor about all medications you take — including prescription, over-the-counter, herbal or supplements — is important to help manage these risks.

1. Medications That Affect the Central Nervous System (CNS)

Interaction: Combining LACOSMART 50 TABLET with sedatives, anti-anxiety medicines, or sleep aids (e.g., diazepam, clonazepam) may cause increased drowsiness, dizziness, or trouble concentrating.
Management: Use caution when performing tasks that require alertness. Your doctor may adjust the dosage of either medicine.

2. Other Anti-Seizure Medicines

Interaction: Drugs like carbamazepine or phenytoin may either increase or decrease LACOSMART 50 TABLET effectiveness. In some cases, LACOSMART 50 TABLET may slightly increase the levels of these medicines too.
Management: Your healthcare provider may monitor blood levels of these drugs and adjust doses accordingly to maintain stability.

3. Heart Rhythm Medicines (e.g., beta-blockers, antiarrhythmics)

Interaction: LACOSMART 50 TABLET can affect electrical conduction in the heart. Taking it along with medicines like metoprolol, amiodarone, or digoxin may raise the risk of irregular heart rhythms.
Management: ECG monitoring may be required in certain patients, especially those with heart-related issues or elderly individuals.

4. Enzyme-Inducing Drugs (e.g., rifampin, St. John's Wort)

Interaction: These can lower LACOSMART 50 TABLET levels in the blood, potentially making it less effective.
Management: Your doctor may consider dose adjustments or alternative therapies if needed.

Drug - Food interaction

1. Alcohol

Interaction: Alcohol can enhance the sedative and dizziness-related side effects of LACOSMART 50 TABLET, affecting concentration, coordination, and reaction time.
Management: Avoid or limit alcohol while using LACOSMART 50 TABLET. Speak to your doctor about alcohol use during your treatment course.

2. Caffeinated Beverages (Coffee, Energy Drinks)

Interaction: While not a direct interaction excess caffeine may interfere with sleep or increase nervousness, which can overlap with or worsen certain medicine-related effects.
Management: Moderate your intake of caffeine-rich drinks, especially if you experience restlessness or poor sleep while on LACOSMART 50 TABLET.

3. Grapefruit and Citrus Juices

Interaction: Though not confirmed as a major issue with Lacosamide, grapefruit juice is known to affect the liver enzymes responsible for processing many medications.
Management: It is advisable to avoid large quantities of grapefruit juice unless cleared by your doctor, especially if taking multiple medicines.

Synopsis

Drug	:	Lacosamide
Pharmacological Category	:	Antiepileptics
Therapeutic Indication	:	Epilepsy
Dosage Forms	:	Tablet, Injection, Syrup

More Information

Comparison: LACOSMART 50 TABLET Vs Lacoset XR 100 mg

Feature	LACOSMART 50 TABLET	Lacoset XR 100 mg
Active Ingredient	Lacosamide	Lacosamide
Formulation	Immediate-release tablet	Extended-release tablet
Indications	Partial-onset seizures	Partial-onset seizures
Dosage Frequency	Twice daily (usually)	Once daily
Onset of Action	Rapid	Slower due to extended release
Side Effects	Dizziness, headache, nausea	Similar to LACOSMART 50 TABLET but with smoother plasma levels
Cost	Generally more affordable	Slightly higher than immediate-release
Availability	Widely available	Less commonly available
Use in Special Populations	Requires monitoring in cardiac patients	Same as immediate-release

FAQs About LACOSMART 50 TABLET

Q: What Is LACOSMART 50 TABLET Used For?

A: LACOSMART 50 TABLET contains lacosamide, which is used to treat partial-onset seizures in individuals aged 4 years and older. It can be prescribed alone or alongside other medications to help control seizures.

Q: Is LACOSMART 50 TABLET a cure for epilepsy?

A: No, LACOSMART 50 TABLET is not a cure. It helps manage and reduce the frequency of seizures but does not eliminate the underlying condition. Continuous use as prescribed is necessary for effective seizure control.

Q: Can LACOSMART 50 TABLET be used alone or with other medications?

A: LACOSMART 50 TABLET can be used as monotherapy or in combination with other antiepileptic drugs, depending on the patient's condition and the doctor's recommendation.

Q: Is LACOSMART 50 TABLET habit-forming?

A: While rare, some cases have reported a potential for dependency. Patients with a history of substance abuse should use LACOSMART 50 TABLET cautiously and under strict medical supervision.

Q: How should I take LACOSMART 50 TABLET?

A: Take LACOSMART 50 TABLET exactly as prescribed by your doctor, usually twice daily, approximately 12 hours apart. Swallow the tablet whole with water, with or without food.

Q: Can I stop taking LACOSMART 50 TABLET suddenly?

A: No, do not stop taking LACOSMART 50 TABLET abruptly without consulting your doctor, as it may increase the risk of seizures. Your doctor will guide you on how to taper the dose safely.

Q: Can LACOSMART 50 TABLET be taken with food?

A: Yes, LACOSMART 50 TABLET can be taken with or without food. Taking it with food may help reduce stomach discomfort.

Q: Are there serious side effects I should be aware of?

A: Yes, serious side effects can include irregular heartbeat, fainting, allergic reactions, and mood changes. Seek immediate medical attention if you experience these

Q: Can LACOSMART 50 TABLET cause mood changes or depression?

A: Some patients may experience mood swings, depression, or suicidal thoughts. It's crucial to monitor any behavioral changes and inform your doctor promptly.

Q: Can LACOSMART 50 TABLET be used during pregnancy?

A: LACOSMART 50 TABLET should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Discuss with your doctor if you're pregnant or planning to become pregnant.

Q: Does LACOSMART 50 TABLET affect heart rhythm?

A: Yes, LACOSMART 50 TABLET can cause PR interval prolongation, leading to irregular heartbeats. Patients with cardiac conditions should use it cautiously.

Q: Does LACOSMART 50 TABLET affect vision?

A: Yes, blurred or double vision has been reported. If you experience visual disturbances, consult your healthcare provider.

References

1. Misty D. Smith, Cameron S. Metcalf and Karen S. Wilcox. Pharmacotherapy of the Epilepsies. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018 Page – 303-326.

2. Liyan Hou, Bingjie Peng, Defu Zhang, Jingjing Yang, Ying Wang, Li Tong, Sheng Li, Qingshan Wang and Jie Zhao. Clinical Efficacy and Safety of Lacosamide as an Adjunctive Treatment in Adults with Refractory Epilepsy. Frontiers in neurology. December 2021 [Accessed on 2nd August 2025]

3. Jon Allard, William Henley, Brendan Mclean, Sunil Ram, Manny Bagary, Rohit Shankar. Lacosamide in the general population and in people with intellectual disability: Similar responses. European Journal of Epilepsy. March 2020. [Accessed on 2nd August 2025]

4. G. L. Krauss. Lacosamide for the treatment of epilepsy. Taylor and Francis online. June 2011 [Accessed on 2nd August 2025]

5. UCB Pharma Limited. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 2nd August 2025]

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 05 Aug 2025 | 09:54 AM(IST)