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Introduction About XSULIN R 40IU INJECTION

XSULIN R 40IU INJECTION contains Human Insulin which belongs to the group of medicines called Antidiabetic agents. It improves glycemic control in patients with diabetes mellitus (both type I and type II). It helps your body to make utilize of the circulating blood glucose by transporting the circulating glucose from the blood into the muscles and fat tissues.

Talk to your doctor before starting therapy with XSULIN R 40IU INJECTION if you have any liver, kidney or heart problems. You must also inform your doctor if you have a history of stroke, any infection in the recent days, perform intense exercise or planning to go abroad (as the mealtime and injection timings may vary) as a precaution.

Do not use this medicine if you have hypoglycemia (low blood sugar levels). Consult your doctor before using this medicine if you are pregnant or breastfeeding. Along with the management, carefully follow the instructions given by your doctor regarding the mealtime and exercise (such as how often and how much to do).

Carefully follow the instructions given by the doctor in case of self-administration. Do not mix or change your insulin unless your doctor tells you to do so.

The most common side effects of receiving XSULIN R 40IU INJECTION are low blood sugar levels, pain, redness, itching, swelling or thickening at the injection site, lump formation under the skin and swelling of body parts. Consult your doctor if any of these side effect troubles you.

Uses Of XSULIN R 40IU INJECTION

Improves glycaemic control in patients with diabetes mellitus (both type I and type II)

How XSULIN R 40IU INJECTION Works

XSULIN R 40IU INJECTION helps your body to make utilise of the circulating blood glucose. It helps in the transport of glucose from the blood into the muscles and fat tissues. It also stops the production of glucose by the liver. As a result, it controls blood sugar levels and improve glycemic control in patients with diabetes mellitus.

How to use XSULIN R 40IU INJECTION

Use XSULIN R 40IU INJECTION exactly as advised by your doctor.

For Injections: Injections (supplied as vials or ampoules) must be administered only a doctor or a nurse into the vein (intravenously) or beneath the skin (subcutaneously). Your doctor will decide correct dose, frequency of administration and the injection site depending upon your age, body weight and health condition.

For Pre-filled syringe or insulin pens:

Inject this medicine exactly as instructed by your doctor. It should be injected beneath the skin (subcutaneously). Carefully follow the instructions provided by your doctor if you are administering it by yourself.

Prior to the administration, rotate the device well for 10 times between your palms and invert 10 times, until the liquid forms a uniform mixture
Do not shake the medicine vigorously, as it may form a froth
Insert a fresh needle before injection. Make sure that the medicine does not contain any lumps or air bubbles in it
After injecting the medicine, remove the needle from the pen and dispose it immediately
Do not share your needle or disposable pens or pre-filled syringe with anyone to avoid the risk of spreading infections
Dispose the pen or pre-filled syringe, once it is empty
Avoid repeatedly injecting the medicine at the same site to manage skin damage. Instead, the injection site should be rotated. Make sure to consult your doctor before changing the injection site as a precaution.

XSULIN R 40IU INJECTION should not be mixed with any other insulins before use. Do not stop therapy with XSULIN R 40IU INJECTION without consulting your doctor.

Side Effects Of XSULIN R 40IU INJECTION

Common

Injection site reactions (such as pain, redness, itching or swelling)
Lipodystrophy (shrinkage of fat tissues beneath the skin)
Lumps under the skin
Edema (swelling of face, hands and legs)
Low blood sugar levels (signs include tiredness, hunger, nausea, headache, nervousness, cold sweats, fast heartbeat)

Consult your doctor immediately if you experience any of the following side effects:

signs of heart failure (such as shortness of breath, chest pain, swelling of body parts, sudden weight gain)
serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)

How To Manage Side Effects

Hypoglycemia

Managing hypoglycemia, or low blood sugar, involves prompt action to raise blood glucose levels and manage complications. When experiencing hypoglycemia, individuals should quickly consume a source of rapidly-absorbed carbohydrates, such as glucose tablets, fruit juice, or regular soda. Waiting for about 15 minutes and rechecking blood sugar levels is crucial to ensure they rise to a safe range. If hypoglycemia persists, additional carbohydrate intake may be necessary. Once blood sugar levels stabilize, a small snack containing both carbohydrates and protein can help sustain them. Regular monitoring and consultation with a healthcare professional are essential for developing a personalized plan to manage hypoglycemia effectively. In severe cases, emergency assistance may be required.

Injection Site Reactions

Managing injection site reactions is essential for individuals who regularly administer injections. To alleviate discomfort and minimize potential issues, it is crucial to follow proper injection techniques. Rotate injection sites to manage overuse of a single area, allowing tissues to heal. Use a clean, sterile needle and syringe for each injection. Apply an ice pack to the injection site before and after administration to reduce pain and swelling. If redness, swelling, or irritation persists, consult a healthcare professional for guidance. It is essential to report any severe or persistent reactions to ensure appropriate adjustments to the injection routine and to manage potential complications.

Warning & Precautions

Pregnancy

Consult your doctor

Consult your doctor before undergoing therapy with XSULIN R 40IU INJECTION if you are pregnant, think you may be pregnant or planning to have a baby.

Breastfeeding

Consult your doctor

Consult your doctor before undergoing therapy with XSULIN R 40IU INJECTION if you are breastfeeding.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if your ability is affected by XSULIN R 40IU INJECTION.

Alcohol

Consult your doctor

Avoid consumption of alcohol while undergoing therapy with XSULIN R 40IU INJECTION as it may make this medicine less effective.

Kidney

Use with Caution

XSULIN R 40IU INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before administration.

Liver

Use with Caution

XSULIN R 40IU INJECTION should be used with caution in patients with liver problems. Therefore, consult your doctor before administration.

Allergy

Contraindicated

Talk to your doctor before receiving XSULIN R 40IU INJECTION if you are allergic to Human insulin or to any other insulin types.

Heart Disease

Use with Caution

XSULIN R 40IU INJECTION should be used with caution in patients with heart problems. Therefore, consult your doctor before administration.

Use In Pediatrics

Monitoring required

XSULIN R 40IU INJECTION should be used in children and in adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor before administration.

Use In Geriatrics

Use with Caution

XSULIN R 40IU INJECTION should be used with caution among the elderly patients (aged 65 years or above). Therefore, consult your doctor before administration.

Others

XSULIN R 40IU INJECTION is not recommended for use if you:

have or at risk of developing hypoglycaemia (low blood sugar levels)

Talk to your doctor before receiving XSULIN R 40IU INJECTION if you:

have diabetes that is well controlled by the current insulin therapy
recently became ill or had any infections
perform intense exercise or physical activity
are planning to go abroad (as mealtime and injection timings may get changed)
have a history of stroke

Interactions

A. Drug-Drug interactions:

Before XSULIN R 40IU INJECTION is administered, inform your doctor if you are taking any of the following medicines such as:

Other antidiabetic agents (Ex. glimepiride, glyburide, gliclazide, rosiglitazone, pioglitazone)
Anti-asthmatic agents (Ex. salbutamol or terbutaline)
corticosteroids (used to manage pain and inflammation) Ex. hydrocortisone, prednisolone
thyroid hormones (such as thyroxine, levothyroxine)
thiazide diuretics (Ex. hydrochlorothiazide, chlorothiazide)
pain killers (such as aspirin)
Antihypertensive agents (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
growth hormone (used to increase growth)
octreotide (used to manage diarrhea)
lanreotide (a medicine used to manage abnormal body growth)
danazol (a medicine for uterine problems)
antidepressants (such as moclobemide, isocarboxazid, phenelzine, selegiline, tranylcypromine)

Overdosage:

If you or anyone else accidentally took more XSULIN R 40IU INJECTION, consult your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Human Insulin
Pharmacological Category	:	Insulin Preparations
Therapeutic Indication	:	Diabetes mellitus
Dosage Forms	:	Injection, Cartridge, Disposable pen

More Information

Keep XSULIN R 40IU INJECTION out of the sight and reach of children
Before use: Store XSULIN R 40IU INJECTION in the refrigerator (between 2-8?)
In Use: Store at room temperature after opening for up to 28 days

FAQs About XSULIN R 40IU INJECTION

Q: What is XSULIN R 40IU INJECTION used for?

A: XSULIN R 40IU INJECTION improves glycemic control in patients with diabetes mellitus (both type I and type II). It helps your body to make utilize of the circulating blood glucose by transporting the circulating glucose from the blood into the muscles and fat tissues.

Q: How XSULIN R 40IU INJECTION should be administered?

A: XSULIN R 40IU INJECTION should be administered beneath the skin or into the vein. Do not inject it in your vein in case if you are administering this medicine on your own.

Q: How long should I take XSULIN R 40IU INJECTION?

A: You need to take XSULIN R 40IU INJECTION as long as your doctor prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: What to do if I forgot to take a dose of XSULIN R 40IU INJECTION?

A: If you forgot to take a dose of XSULIN R 40IU INJECTION, take it as soon as you remember. However, if it is time for the next dose of XSULIN R 40IU INJECTION, skip the missed dose and take the next one regularly. Do not take a double dose of XSULIN R 40IU INJECTION to compensate the missed ones.

Q: What are the most common side effects of taking XSULIN R 40IU INJECTION?

A: The most common side effects of receiving XSULIN R 40IU INJECTION are low blood sugar levels, pain, redness, itching, swelling or thickening at the injection site, lump formation under the skin and swelling of body parts. Consult your doctor if any of these side effect troubles you.

Q: Can I stop therapy with XSULIN R 40IU INJECTION without consulting your doctor?

A: No. You should not stop therapy with XSULIN R 40IU INJECTION without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using XSULIN R 40IU INJECTION, consult your doctor for advice.

Q: Will taking a higher dose of XSULIN R 40IU INJECTION be more effective?

A: No, taking a higher dose of XSULIN R 40IU INJECTION will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: Can I take medication for high blood pressure along with XSULIN R 40IU INJECTION?

A: It is not advisable to take medicines to control blood pressure while taking XSULIN R 40IU INJECTION without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive medications along with XSULIN R 40IU INJECTION as they have known interactions with XSULIN R 40IU INJECTION.

Q: Can XSULIN R 40IU INJECTION be used in pregnant women?

A: Consult your doctor before undergoing therapy with XSULIN R 40IU INJECTION if you are pregnant, think you may be pregnant or planning to have a baby.

Q: How much XSULIN R 40IU INJECTION should I take?

A: XSULIN R 40IU INJECTION should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.

References

1. KD. Tripathi. Insulin, Oral hypoglycaemic drugs and glucagon. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 264.

2. Cesar Munguia; Ricardo Correa. Regular Insulin. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2022. [Accessed on 23rd January 2024] https://www.ncbi.nlm.nih.gov/books/NBK553094/

3. Eli Lilly Nederland B.V. HUMULIN® I (Isophane) KwikPen® 100 IU/ml suspension for injection (Insulin human). Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 23rd January 2024] https://www.medicines.org.uk/emc/files/pil.8194.pdf

4. Eli Lilly and Company. HUMULIN R- insulin human injection, solution. Dailymed.com. [Revised in June 2022] [Accessed on 23rd January 2024] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b519bd83-038c-4ec5-a231-a51ec5cc291f

5. Biocon Ltd. Insugen-R 100 IU. [Revised in May 2012] [Accessed on 23rd January 2024] https://www.biocon.com/docs/prescribing_information/diabetology/insugenr100iu_pi.pdf

6. Biocon Ltd. Insugen-R 40 IU. [Revised in December 2019] [Accessed on 23rd January 2024] https://www.biocon.com/docs/domestic-market-pi/metabolics/INSUGEN%20R%2040%20IU%20%20PI.pdf

Useful Diagnostic Tests

HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
Blood Glucose Fasting (FBS)
Insulin-Fasting
Netmeds Diabetic Checkup
Advance Diabetes Monitoring (Senior Female)
Jaanch Diabetic Profile Basic

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 31 Jan 2024 | 03:15 PM(IST)