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Introduction About TRIOPIL 2MG TABLET

TRIOPIL 2MG TABLET is used to manage type II diabetes mellitus when diet, exercise and management with single agent does not result in adequate sugar control. It is a combination of Glimepiride, Metformin and Pioglitazone which belongs to the group of medicines called Antidiabetic agents.

Before taking TRIOPIL 2MG TABLET, inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any eye problems, hormonal imbalance, alcoholism, or if you are malnourished, starved, on an irregular diet as a precaution. It is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis.

Along with the management, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking the medicine as it may aggravate the existing condition. The most common side effects are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness and weight gain. Consult your doctor if any of these side effect worsens.

Uses Of TRIOPIL 2MG TABLET

Used to manage type II diabetes mellitus

How TRIOPIL 2MG TABLET Works

TRIOPIL 2MG TABLET stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). It also makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, it can also reduce the glucose produced by the liver and reduces its absorption in the body.

How to use TRIOPIL 2MG TABLET

Take TRIOPIL 2MG TABLET preferably after meals or as advised by your physician
Swallow the medicine with a glass of water. Do not crush or chew the medicine
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
Do not stop taking TRIOPIL 2MG TABLET unless your doctor advice you to stop

Side Effects Of TRIOPIL 2MG TABLET

Common side effects of TRIOPIL 2MG TABLET:

hypoglycemia (low blood sugar levels)
diarrhea, stomach pain, loss of appetite, flatulence
changes in taste, metallic taste
joint pain, back pain, muscle pain

Stop taking TRIOPIL 2MG TABLET and contact your doctor immediately if you experience any of the following side effects:

signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
symptoms of heart failure (such as unusual shortness of breath or trouble in breathing, rapid increase in weight or localised swelling (oedema), especially in the ankles or legs, unusual tiredness)
signs and symptoms of bladder cancer (blood in your urine, pain while urinating or urgent need to pee)
increased risk of fractures (especially in the bones of hand, upper arm, or foot in women)
blurred vision due to swelling at the back of the eye or worsening of existing blurred vision
serious allergic reaction (hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
signs of liver problems (nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)

Warning & Precautions

Pregnancy

Consult your doctor

There are no adequate human data to determine the safety of TRIOPIL 2MG TABLET during pregnancy.

Breastfeeding

Consult your doctor

It is not known if TRIOPIL 2MG TABLET passes into human milk and if it can harm your baby. Talk to your doctor about the best way to control your blood glucose levels while breastfeeding.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if your ability is affected by TRIOPIL 2MG TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking TRIOPIL 2MG TABLET as it may increase the risk of unwanted side effects.

Kidney

Consult your doctor

TRIOPIL 2MG TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems.

Liver

Consult your doctor

TRIOPIL 2MG TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems.

Allergy

Contraindicated

Do not take TRIOPIL 2MG TABLET if you are allergic to Glimepiride, Metformin, Pioglitazone or to any other ingredients of this medicine.

Heart Disease

Consult your doctor

TRIOPIL 2MG TABLET is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems.

Use In Pediatrics

Contraindicated

TRIOPIL 2MG TABLET is not recommended for use in children and in adolescents (aged below 18 years).

Use In Geriatrics

Use with Caution

TRIOPIL 2MG TABLET should be used with caution in elderly patients (aged above 65 years).

Others

It is not recommended for use if you:

have type I diabetes mellitus (insulin dependent diabetes)
have lactic acidosis (build-up of lactic acid in the body)
have diabetic ketoacidosis
have bladder cancer
pass bloody urine

Before taking TRIOPIL 2MG TABLET, inform your doctor if you:

are recovering from any injury, operation, infections or from any form of stress
have G6PD deficiency
are on fating or malnourished, starved, on an irregular diet, or feeling weak
perform extreme physical exercises without proper carbohydrate intake
are severely dehydrated
have hormonal problems
have edema (swelling of body parts)
smoke
have special type of diabetic eye disease called macular oedema
have cysts on your ovaries (polycystic ovarian syndrome)
previously had stroke
have anemia
have any bone problems or at risk of developing bone fractures
are a premenopausal woman
have thyroid problems

Interactions

A. Drug-Drug Interactions:

Before taking TRIOPIL 2MG TABLET, inform your doctor if you are taking any of the following medicines:

Antidiabetics (Ex. teneligliptin, rosiglitazone, insulin, gliclazide)
Non-steroidal anti-inflammatory agents (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azopropazone, oxyphenbutazone)
Antibiotics (Ex. amikacin, nitrofurantoin, sulfamethoxazole, tetracyclines, chloramphenicol, ciprofloxacin, clarithromycin, Trimethoprim)
Antifungals (Ex. fluconazole, miconazole, isuvaconazole)
Anticoagulants (Ex. warfarin)
Hormone replacement therapy (Ex. testosterone)
Antidepressants (Ex. moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine, chlorpromazine, prochlorperazine, lithium)
Anti-lipidemic agents (Ex. fenofibrate, nicotinic acid, colesevelam)
Antihypertensives (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine and reserpine)
Anti-arrhythmic agent (Ex. Disopyramide)
Anti-gout agents (Ex. allopurinol, probenecid, sulfinpyrazone)
Anti-cancer agents (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib and olaparib)
Hemorrheologic agents (Ex. Pentoxifylline)
Enzyme inhibitor (Ex. tritoqualine)
Alpha blockers (Ex. prazosin, doxazosin)
Hormonal replacement therapy (Ex. estradiol)
Thiazide diuretics (Ex. hydrochlorothiazide)
Hormones (Ex. Levothyroxine)
Corticosteroids (Ex. prednisolone, betamethasone)
Bronchodilators (Ex. salbutamol, terbutaline)
Alpha- and beta-adrenergic agonists (Ex. Adrenaline)
Laxatives (Ex. lactulose, liquid paraffin)
Anticonvulsants (Ex. phenytoin, Fenfluramine)
Barbiturates (Ex. phenobarbital)
Carbonic anhydrase inhibitor (Ex. acetazolamide)
H2 blockers (Ex. Cimetidine)
Anti-TB agents (Ex. Rifampicin)
HIV integrase inhibitors (Ex. Dolutegravir)
Anti-anginal (Ex. Ranolazine)

Overdosage:

If you or anyone else accidentally took more TRIOPIL 2MG TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion). To manage this, consume any sugary food immediately. If the symptom did not improve or worsens contact your doctor immediately. Other symptoms of overdosage might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.

Synopsis

Drug	:	Glimepiride, Metformin, Pioglitazone
Pharmacological Category	:	Sulfonylureas, Biguanides, PPAR-gamma and PPAR-alpha agonist
Therapeutic Indication	:	Type II diabetes mellitus
Dosage Forms	:	Tablet

More Information

FAQs About TRIOPIL 2MG TABLET

Q: What is TRIOPIL 2MG TABLET used for?

A: TRIOPIL 2MG TABLET is an antidiabetic medicine used to manage type II diabetes mellitus when diet, exercise and management with single agent does not result in adequate response.

Q: How and when to take TRIOPIL 2MG TABLET?

A: Take TRIOPIL 2MG TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: How long should I take TRIOPIL 2MG TABLET?

A: You need to take TRIOPIL 2MG TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: What is the best time to take TRIOPIL 2MG TABLET?

A: TRIOPIL 2MG TABLET must be taken with meals to avoid gastrointestinal side effects.

Q: What to do if I forgot to take a dose of TRIOPIL 2MG TABLET?

A: If you forgot to take a dose of TRIOPIL 2MG TABLET, take it as soon as you remember. However, if it is time for the next dose of TRIOPIL 2MG TABLET, skip the missed dose and take the next one regularly.

Q: Can I stop taking TRIOPIL 2MG TABLET without consulting your doctor?

A: No. You should not stop taking TRIOPIL 2MG TABLET without consulting your doctor because it may lead to reversal of symptoms.

Q: Will taking a higher dose of TRIOPIL 2MG TABLET be more effective?

A: No, taking a higher dose of TRIOPIL 2MG TABLET will not be effective, rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: Can I take medication for high blood pressure along with TRIOPIL 2MG TABLET?

A: It is not advisable to take medicines to control blood pressure while taking TRIOPIL 2MG TABLET without consulting your doctor, as they have known interactions with TRIOPIL 2MG TABLET.

Q: How to manage the side effects of TRIOPIL 2MG TABLET?

A: Low blood sugar is a common side effect of taking TRIOPIL 2MG TABLET. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey or sugary candy. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or drink, and check the blood sugar levels once again. If your condition did not improve, consult your doctor immediately.

Q: Can TRIOPIL 2MG TABLET be taken with insulin?

A: Co-administration of TRIOPIL 2MG TABLET with insulin is considered risky as they can increase the chances of hypoglycemia (low blood sugar levels). Therefore, consult your doctor before taking it.

Q: Does TRIOPIL 2MG TABLET cause weight gain?

A: Yes. TRIOPIL 2MG TABLET may cause weight gain in some individuals. To avoid this, follow a healthy diet and regular physical activity as advised by your physician. However, if you experience any weight gain due to swelling of body parts (such as in face, legs, or hands), consult your doctor immediately.

Q: What are the side effects of taking TRIOPIL 2MG TABLET?

A: The most common side effects of taking TRIOPIL 2MG TABLET are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness and weight gain. Consult your doctor if any of these side effect worsens.

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270, 275 & 277.

2. Jeong Mi Kim, Sang Soo Kim, Jong Ho Kim, Mi Kyung Kim, Tae Nyun Kim, Soon Hee Lee, Chang Won Lee, Ja Young Park, Eun Sook Kim, Kwang Jae Lee, Young Sik Choi, Duk Kyu Kim and In Joo Kim. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2019. [Accessed on 9th January 2023] click here

3. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 9th January 2023] click here

4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 9th January 2023] click here

5. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 9th January 2023] click here

6. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2020] [Accessed on 9th January 2023] click here

7. Cipla Ltd. TRIEXER ER Tablets (Glimepiride + Pioglitazone hydrochloride + Metformin hydrochloride). Ciplamed. [Revised in September 2020] [Accessed on 9th January 2023] click here

8. Central Drugs Standard Control Organization. FDC of Glimepiride (1mg/2mg) + Pioglitazone (15mg) + Metformin (500mg E.R) Tablet. August 2005. [Accessed on 9th January 2023] click here

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Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 20 Nov 2024 | 12:08 PM(IST)