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Introduction About PENETREX KNOT KIT

PENETREX KNOT KIT is a combination of Mifepristone and Misoprostol that belongs to the group of medicines Anti-progestational steroids and Synthetic prostaglandin. It is used for the medical termination of the pregnancy no later than 63 days after the first day of your last menstrual period.

Before taking PENETREX KNOT KIT, inform your doctor if you have kidney, liver, respiratory problems, high blood pressure, high blood cholesterol levels, suffer from an illness that may affect the clotting of your blood, anaemia or malnourished.

PENETREX KNOT KIT is contraindicated if your pregnancy has not been confirmed, if the first day of your last period was more than 63 days ago, or if your doctor suspects an ectopic pregnancy, have hereditary porphyria, suffer from chronic adrenal failure.

Failure of pregnancy termination (continuing pregnancy) after taking PENETREX KNOT KIT after the first medicine (mifepristone) leads to increased risk of birth defects like facial paralysis, head, and limb malformations. Consult your doctor before taking it.

PENETREX KNOT KIT may pass into breast milk, hence stop breastfeeding once you have used the management. Consult your doctor before taking it. PENETREX KNOT KIT should not be stopped abruptly without consulting the doctor as it may lead to incomplete abortion. Avoid grapefruit juice when you are managed with PENETREX KNOT KIT.

The common side effects of PENETREX KNOT KIT are uterine contractions, lower abdominal cramps, heavy bleeding, gastrointestinal cramping, nausea, vomiting or diarrhoea. If any of these side effect get worsen, contact your doctor for advice.

Uses Of PENETREX KNOT KIT

It is used for medical termination of pregnancy no later than 63 days after the first day of your last menstrual period

How PENETREX KNOT KIT Works

PENETREX KNOT KIT contains Mifepristone blocks the action of the progesterone hormone required in women to continue the pregnancy. Misoprostol increases the uterus contraction and dilates the cervix, that results in expelling the pregnancy. Thus, the combination of Mifepristone and Misoprostol causes termination of pregnancy.

How to use PENETREX KNOT KIT

Take PENETREX KNOT KIT as advised by your physician. Check the label before use. Your doctor will decide the right dose depends on your age, body weight and disease condition.

Side Effects Of PENETREX KNOT KIT

Common

uterine contractions
lower abdominal cramps
heavy bleeding
nausea, vomiting
diarrhoea

Uncommon

infection (following abortion)
hypersensitivity reactions
skin rashes

Rare

headache
malaise (feeling unwell)
hot flushes
dizziness
chills
fever
low blood pressure
hives and skin disorders
uterine rupture
fatal toxic shock

Stop taking PENETREX KNOT KIT and contact your doctor immediately if you experience any of the following side effects:

severe abdominal pain, fainting, fast heartbeat, fever lasting more than 4 hours

How To Manage Side Effects

Diarrhea

Drink lots of fluids and water to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhoea and consult your doctor if the symptom gets worse.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.

Nausea And Vomiting

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Contact your doctor if the symptom did not improve.

Warning & Precautions

Pregnancy

Risky

There is little information on the risks to the unborn baby. Failure of pregnancy termination (continuing pregnancy) after taking PENETREX KNOT KIT after the first medicine (mifepristone) has been associated with a 3-fold increased risk of birth defects (particular facial paralysis, head and limb malformations). Consult your doctor before taking it.

Breastfeeding

Consult your doctor

PENETREX KNOT KIT may pass into breast milk hence stop breastfeeding once you have used the> management. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy after taking PENETREX KNOT KIT.

Alcohol

Contraindicated

Avoid consumption of alcohol while taking PENETREX KNOT KIT because it might make you dizzier.

Kidney

Use with Caution

PENETREX KNOT KIT should be used with caution in patients with impaired kidney function. Consult your doctor for advice before taking PENETREX KNOT KIT.

Liver

Use with Caution

PENETREX KNOT KIT should be used with caution in patients with liver diseases. Consult your doctor for advice before taking.

Allergy

Contraindicated

Do not take PENETREX KNOT KIT if you are allergic to Mifepristone, Misoprostol, or any other ingredients of the medicine.

Lungs

Contraindicated

PENETREX KNOT KIT is not recommended if you suffer from severe asthma which cannot be adequately managed with medication. Consult your doctor for advice before taking PENETREX KNOT KIT.

Heart Disease

Use with Caution

PENETREX KNOT KIT should be used with caution in patients with heart problems, high blood pressure or high blood cholesterol levels. Consult your doctor for advice before taking PENETREX KNOT KIT.

Others

PENETREX KNOT KIT is not recommended for use if:

your first day of your last period was more than 63 days ago
your doctor suspects an ectopic pregnancy
you have hereditary porphyria (disorder of the blood)
you suffer from chronic adrenal failure

Before taking PENETREX KNOT KIT, inform your doctor if you:

have undergone genital cutting or circumcision
suffer from an illness that may affect the clotting of your blood
are anaemic or malnourished

Interactions

A. Drug - Drug interactions:

Before taking PENETREX KNOT KIT, inform your doctor if you are taking any of the following medicine:

medicines used to manage asthma or inflammation (Ex. dexamethasone)
medicines used to manage fungal infection (Ex. ketoconazole, itraconazole)
antibiotics (Ex. erythromycin)
St. John’s Wort (natural remedy used to manage mild depression)
medicines used to manage seizures or epilepsy (Ex. phenytoin, phenobarbital)
medicines used to manage the body from rejecting a transplanted organ (Ex. cyclosporine, tacrolimus, sirolimus)
painkiller medicines (Ex. alfentanil, fentanyl)
medicines used to manage migraine (Ex. ergotamine, diergotamine)
medicines used to help keep the heart beating normally (Ex. quinidine)
some medicines used during general anaesthesia

B. Drug - Food interaction:

Avoid grapefruit juice when you are managed with PENETREX KNOT KIT. Consult your doctor before taking the medicine.

Overdosage:

If you or anyone else takes too much of PENETREX KNOT KIT, consult your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Mifepristone, Misoprostol
Pharmacological Category	:	Antiprogesterone steroids, Prostaglandins analogues
Therapeutic Indication	:	Medical termination of pregnancy
Dosage Forms	:	Tablet, Kit

More Information

Keep PENETREX KNOT KIT out of reach of children
Store at room temperature

FAQs About PENETREX KNOT KIT

Q: What caution is required after management with PENETREX KNOT KIT?

A: After management you should be aware that uterine bleeding usually starts 1 to 2 days after taking the medicine. The bleeding lasts 2 or 3 weeks, if the bleeding is heavy and prolonged, contact the doctor immediately.

Q: Is it possible to get pregnant immediately again after medical termination of pregnancy?

A: It is recommended that you avoid getting pregnant again soon after the termination of pregnancy. You should therefore start using a method of contraception within 3 to 9 days of taking the PENETREX KNOT KIT. Discuss with your doctor for further precautions.

Q: Do you feel pain during the management with PENETREX KNOT KIT?

A: During the management with PENETREX KNOT KIT there could be symptoms like uterine contractions, lower abdominal cramps, heavy bleeding, and discomfort. Consult your doctor if you feel unwell.

Q: What if I miss the dose of PENETREX KNOT KIT?

A: If you forget to use any part of the management, it may not be fully effective which means that your pregnancy may not be completely expelled. Consult with your doctor as you may need further management to end the pregnancy.

Q: How many days bleeding is normal after management with PENETREX KNOT KIT?

A: The bleeding usually continues a few days to two weeks and should become light after the first few days. You may also pass some blood clots or tissue or have light bleeding for longer than two weeks. Consult your doctor if there is a bleeding for a longer period.

References

1. KD. Tripathi. Prostaglandins, Leukotrienes (Eicosanoids) and Platelet Activating Factor. Essentials of medical pharmacology. Seventh edition. 2017. Page – 181.

2. Raymond EG, Shannon C, Weaver MA, Winikoff B. First-trimester medical abortion with mifepristone 200 mg and misoprostol: a systematic review. Contraception. PubMed, January 2013. [Accessed on 31st January 2023] https://pubmed.ncbi.nlm.nih.gov/22898359/

3. Medical Abortion with Mifepristone + Misoprostol (13 - 22 Weeks) National Library of Medicine. [Revised in May 2014] [Accessed on 31st January 2023] https://clinicaltrials.gov/ct2/show/NCT01768299

4. Macleods Pharma. Mifepristone, Misoprostol. [Accessed on 31st January 2023] https://www.macleodspharma.com/products/

5. Sun Pharmaceutical Industries Europe. Mifepristone, Misoprostol. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 31st January 2023] https://www.medicines.org.uk/emc/files/pil.3380.pdf

6. Danco Laboratories. Mifepristone, Misoprostol. [Revised in March 2016] [Accessed on 31st January 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020687s020lbl.pdf

7. Cipla Med. Mifepristone, Misoprostol. [Accessed on 31st January 2023] https://ciplamed-library.com/content/mtp-kit

Useful Diagnostic Tests

Complete blood test
Gynaecological diagnosis

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Venkatesh Poludasu - MBBS

Last updated on 01 Feb 2023 | 04:40 PM(IST)