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Introduction About MEROPACE 500 INJECTION

MEROPACE 500 INJECTION contains Meropenem which belongs to the group of medicines known as Antibiotics. It is used to manage various bacterial infections such as pneumonia (including community acquired pneumonia and nosocomial pneumonia), urinary tract infections, intra-abdominal infections, gynaecological infections such as endometritis and pelvic inflammatory disease, skin and skin structure infections, meningitis and septicaemia. It is also indicated for empiric management, for presumed infections in adult patients with febrile neutropenia, used as monotherapy or in combination with anti-viral or anti-fungal agents. MEROPACE 500 INJECTION is also used in the management of neutropenic patients with fever that is suspected to be due to a bacterial infection and bacterial infection of the blood.

During the management, your doctor may do blood tests from time to time. MEROPACE 500 INJECTION should be used with caution in patients with liver problems, kidney problems, and diarrhea. MEROPACE 500 INJECTION is generally not recommended in patients with gastrointestinal problems and hypersensitivity reactions. Consult your doctor before receiving if you are pregnant or breastfeeding women.

MEROPACE 500 INJECTION should be used with caution in children over 3 months old and in geriatric patients. The common side effects of MEROPACE 500 INJECTION are abdominal pain, nausea, vomiting, diarrhea, headache, skin rash, itchy skin, pain, and inflammation. Consult your doctor if the above symptom does not improve.

Uses Of MEROPACE 500 INJECTION

Used to manage bacterial infections such as:

Pneumonia (including community acquired pneumonia and nosocomial pneumonia)
Urinary tract infections
Intra-abdominal infections
Gynaecological infections such as endometritis and pelvic inflammatory disease
Skin and skin structure infections
Meningitis
Septicaemia

How MEROPACE 500 INJECTION Works

MEROPACE 500 INJECTION is a broad-spectrum carbapenem antibiotic which is active against gram-positive and gram-negative bacteria. It exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.

How to use MEROPACE 500 INJECTION

MEROPACE 500 INJECTION will be administered intravenously only by a doctor or a nurse. Your doctor will administer the correct dose and duration for you depending on your age, body weight, and severity of the infection.

Side Effects Of MEROPACE 500 INJECTION

Common

Abdominal pain
Nausea
Vomiting
Diarrhea
Headache
Skin rash, itchy skin
Pain and inflammation
Increased platelets in the blood
Change in blood tests

Uncommon

Tingling feeling (pins and needles)
Infections of the mouth or the vagina are caused by a fungus (thrush)
Diarrhea with bowel inflammation
Sore veins
Frequent infections, high temperature, and sore throat
Sudden beginning of a severe rash or blistering or peeling skin (may be associated with a high fever and joint pains)

Rare

Fits (seizures)
Acute disorientation and confusion

Contact your doctor immediately if you experience any of the following side effects after receiving MEROPACE 500 INJECTION:

Severe allergic reaction (severe rash, itching, or hives on the skin, swelling of the face, lips, tongue, or other parts of the body, shortness of breath, wheezing, or trouble breathing)
Serious skin reactions (serious hypersensitivity reactions involving fever, skin rash, changes in the blood tests, severe red scaly rash, skin bumps that contain pus, blisters or peeling of the skin, severe skin rashes appearing as reddish circular patches often with central blisters on the trunk, skin peeling, ulcers of mouth, throat, nose, genitals, and eyes)
Being breathlessness when you do not expect it and red or brown urine (may be a sign of damage to red blood cells)

How To Manage Side Effects

Diarrhea

Drink more fluids like water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own for diarrhea without consulting your doctor.

Headache

Rest and relax. Drink more fluids like water and apply a pain-relieving balm on the head if needed. Do not consume alcohol. If the symptom does not improve, contact your doctor.

Nausea And Vomiting

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods.

Stomach Pain

Try to rest and relax. Eat and drink slowly or try to have lesser and more frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.

Warning & Precautions

Pregnancy

Monitoring required

MEROPACE 500 INJECTION should not be used in pregnancy unless the benefit justifies the potential risk to the foetus. Consult your doctor before receiving.

Breastfeeding

Monitoring required

MEROPACE 500 INJECTION should not be used in breast-feeding women unless the benefit justifies the potential risk to the baby. Consult your doctor before receiving.

Driving and Using Machines

Use with Caution

There is no data available, but it is anticipated that MEROPACE 500 INJECTION will not affect the ability to drive and use machines.

Kidney

Use with Caution

MEROPACE 500 INJECTION should be taken with caution in patients with kidney problems. If needed dose will be adjusted accordingly. Consult your doctor before receiving.

Liver

Use with Caution

MEROPACE 500 INJECTION should be used with caution in patients with liver problems. Consult your doctor before receiving.

Allergy

Contraindicated

Do not receive MEROPACE 500 INJECTION if you are allergic to Meropenem, antibiotics such as penicillins, cephalosporins, or carbapenems or to any ingredients of this medicine.

Use In Pediatrics

Contraindicated

MEROPACE 500 INJECTION is not recommended to use in children below 3 months. Your doctor will administer the right dose depends on your child’s age, body weight and severity of the infection for children above 3 months. Consult your doctor for advice before receiving MEROPACE 500 INJECTION.

Use In Geriatrics

Use with Caution

MEROPACE 500 INJECTION should be used with caution in elderly patients. Consult your physician for advice before receiving MEROPACE 500 INJECTION.

Others

MEROPACE 500 INJECTION is not recommended if you have or had:

A history of gastro-intestinal problems like colitis
Hypersensitivity reactions

Before receiving MEROPACE 500 INJECTION, inform your doctor if you have or had:

Severe diarrhoea

Interactions

A. Drug-Drug interactions:

Before receiving MEROPACE 500 INJECTION inform your doctor if you are taking any of the following medicine:

Medicine used for the management of gout (Ex. probenecid)
Medicines used to manage epilepsy (Ex. valproic acid, sodium valproate, valpromide)
Medicines used to manage or manage blood clots (Ex. warfarin)

Overdosage:

MEROPACE 500 INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your physician or nurse if you experience any unusual symptoms.

Synopsis

Drug	:	Meropenem
Pharmacological Category	:	Carbapenem Antibiotics
Therapeutic Indication	:	Bacterial infections
Dosage Forms	:	Injection

More Information

Storage

Keep out of reach of children
Store below 25°C

FAQs About MEROPACE 500 INJECTION

Q: Can MEROPACE 500 INJECTION be used in children?

A: MEROPACE 500 INJECTION is generally not recommended to use in children below 3 months and it should be used with caution in children 3 months and older. Your doctor will administer the right dose depends on your child’s age, body weight and severity of the infection.

Q: Can I stop receiving MEROPACE 500 INJECTION if I feel my condition improved?

A: No. You should not stop receiving the management even when you feel your condition improved. Stopping the management may bring back the infection or you may develop resistance to MEROPACE 500 INJECTION.

Q: What are the common side effects of MEROPACE 500 INJECTION?

A: The common side effects of MEROPACE 500 INJECTION are abdominal pain, nausea, vomiting, diarrhea, headache, skin rash, itchy skin, pain, and inflammation. Consult your doctor if the above symptom does not improve.

Q: Is it safe to receive MEROPACE 500 INJECTION during pregnancy and lactating?

A: MEROPACE 500 INJECTION should not be used during pregnancy and lactating unless the benefit justifies the potential risk to the foetus. Consult your doctor before receiving.

Q: Can I use MEROPACE 500 INJECTION in patients having epilepsy?

A: Before using MEROPACE 500 INJECTION, consult your doctor regarding epilepsy as the medicines used for the management of epilepsy may interfere with the effects of MEROPACE 500 INJECTION.

References

1. KD Tripathi MD. Beta-Lactam Antibiotics. Essentials of Medical Pharmacology 8th edition. Page-731.

2. Nadine A. Steffens MSc Student, Estevan S. Zimmermann PhD, Sabrina M. Nichelle Pharmacist, Natália Brucker PhD. Meropenem use and therapeutic drug monitoring in clinical practice: a literature review. Journal of Clinical Pharmacy and Therapeutics. [February 2021] [Accessed on 9th August 2022] https://onlinelibrary.wiley.com/doi/10.1111/jcpt.13369

3. Dunia Al-Hadithic, Ibrahim Al-Zakwania, Abdullah Balkhairb, Yousuf M. Al Suleimania. Evaluation of appropriateness of meropenem prescribing at a tertiary care hospital: A retrospective study in Oman. International Journal of Infectious Diseases. April 2020 [Accessed on 9th August 2022] https://www.ijidonline.com/action/showPdf?pii=S1201-9712%2820%2930261-7

4. Ranbaxy (UK) Limited. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 9th August 2022] https://www.medicines.org.uk/emc/files/pil.10969.pdf

5. Hikma Farmacêutica (Portugal) S.A. Health Products Regulatory Authority. [Revised in July 2020] [Accessed on 9th August 2022] https://www.hpra.ie/img/uploaded/swedocuments/ddaeebf5-c979-4bcf-994a-c46bc0c6c818.pdf

6. AstraZeneca Pharmaceuticals LP. US Food and Drug Administration [Revised in June 2010] [Accessed on 9th August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050706s022lbl.pdf

7. Sanofi India Limited. M-Nem injection [Revised in April 2021] [Accessed on 9th August 2022] https://www.sanofi.in/dam/jcr:a6c7055f-427d-4e19-a6f6-81c37423e3ff/M-Nem%20PI%20_New.pdf

8. Zeventus Healthcare Limited. [Accessed on 9th August 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=83

Useful Diagnostic Tests

Complete blood tests

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Salem Gill - MBBS

Last updated on 24 Jul 2024 | 12:11 PM(IST)