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Introduction About PCM INJECTION

PCM INJECTION contains Paracetamol which belongs to the group of medicines called Analgesics and Antipyretics. It is used for short-term management of moderate pain (especially after surgery) and fever when administered by the intravenous route is clinically justified.

Before receiving PCM INJECTION, inform your doctor if you have heart, lung, liver or kidney problems or if you suffer from alcoholism or alcohol abuse, malnourishment and severely low blood volume due to dehydration or blood loss.

PCM INJECTION should be used with caution in pregnant and breastfeeding women only if clearly advised by the doctor. PCM INJECTION should be used with caution in children and elderly patients.

The most common side effects of receiving PCM INJECTION are nausea, vomiting, headache, sleep problems and itching. Inform your doctor if any of these side effect worsens.

Uses Of PCM INJECTION

For short-term management of moderate pain (especially after surgery) and fever

How PCM INJECTION Works

PCM INJECTION relieves pain by increasing the pain threshold by inhibiting certain enzymes (COX-1 and COX-2) involved in the synthesis of chemicals responsible for inducing pain (prostaglandins). It reduces fever by directly acting on heat-regulating centers in the brain, resulting in vessel relaxation, sweating and loss of body heat.

How to use PCM INJECTION

PCM INJECTION will be given to you only by a doctor or a nurse into the vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you based on your age, body weight and disease condition.

Side Effects Of PCM INJECTION

Common

nausea, vomiting, constipation
headache
sleep problems
itching

Rare

feeling generally unwell
drop in blood pressure
abnormal levels of liver enzymes

Inform your doctor immediately if you experience any of the following side effects while receiving PCM INJECTION:

serious allergic reaction or skin rash

How To Manage Side Effects

Constipation

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and drink plenty of water. If this does not help, inform your doctor to receive alternate management for constipation.

Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress-free. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the symptom does not improve.

Nausea And Vomiting

Stick to simple meals while receiving this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.

Warning & Precautions

Pregnancy

Monitoring required

PCM INJECTION should be used with caution in pregnant women only if considered clearly necessary. Your doctor may use the lowest possible dose to reduce the pain and fever only for shorter duration in pregnant women. Consult your doctor before receiving it.

Breastfeeding

Monitoring required

PCM INJECTION can be used in breastfeeding women only if considered clearly necessary. Consult your doctor before receiving it.

Alcohol

Consult your doctor

PCM INJECTION should be used with caution in patients with alcoholism or those who suffer from alcohol abuse.

Kidney

Use with Caution

PCM INJECTION should be used with caution in patients with kidney disease. Consult your doctor before receiving it.

Liver

Consult your doctor

PCM INJECTION is not recommended for use in patients with severe liver disease. It should be used with caution in patients with liver disease. Consult your doctor before receiving it.

Allergy

Contraindicated

Do not receive PCM INJECTION if you are allergic to Paracetamol, propacetamol or any other ingredients of this medicine.

Lungs

Contraindicated

Repeated use of PCM INJECTION is not recommended for use in patients with lung disease. Consult your doctor before receiving it.

Use In Pediatrics

Use with Caution

PCM INJECTION should be used with caution in children and your child’s doctor may adjust the dose depending upon the child’s age and body weight. Consult your child’s doctor for advice before administration of PCM INJECTION.

Use In Geriatrics

Use with Caution

PCM INJECTION should be used with caution in elderly patients. Consult your doctor before receiving it.

Others

PCM INJECTION is not recommended for use if you:

have anaemia

Before receiving PCM INJECTION, inform your doctor if you:

have severe hypovolemia (low blood volume due to dehydration or blood loss)
have chronic malnutrition

Interactions

A. Drug-Drug interactions:

Before receiving PCM INJECTION, inform your doctor if you are taking any of the following medicines:

other medicines containing paracetamol or propacetamol
probenecid (used to manage gout)
medicines used for blood thinning (Ex. warfarin)

Overdosage:

PCM INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms such as nausea, vomiting, anorexia (eating disorder), paleness, stomach pain and a risk of liver injury.

Synopsis

Drug	:	Paracetamol
Pharmacological Category	:	Para aminophenol derivative
Therapeutic Indication	:	Pain, Fever
Dosage Forms	:	Tablet, Dispersible tablet, Drops, Syrup, Oral suspension, Liquid, Oral solution, Suppositories, Infusion, Injection

More Information

Storage

Store below 25°C

FAQs About PCM INJECTION

Q: What is PCM INJECTION used for?

A: PCM INJECTION is used for short-term management of moderate pain (especially after surgery) and fever and when administered by the intravenous route is clinically justified. Consult your doctor for advice before administration of PCM INJECTION.

Q: What should I tell my doctor before receiving PCM INJECTION?

A: Patients receiving PCM INJECTION must inform their doctor about pre-existing conditions like heart, lung, liver or kidney problems, alcoholism, malnourishment or dehydration. Patients should also inform the doctor if they are pregnant, breastfeeding or allergic to anything. Inform your doctor if you experience any unusual symptoms during management with this medicine.

Q: Can PCM INJECTION be used during pregnancy?

A: PCM INJECTION should be used with caution in pregnant women only if clearly advised by the doctor. Your doctor may use the lowest possible dose to reduce the pain and fever only for a shorter duration in pregnant women. Consult your doctor before receiving PCM INJECTION.

Q: How does PCM INJECTION work?

A: PCM INJECTION relieves pain by increasing the pain threshold by inhibiting certain enzymes (COX-1 and COX-2) involved in the synthesis of chemicals responsible for inducing pain (prostaglandins). It reduces fever by directly acting on heat-regulating centers in the brain, resulting in vessel relaxation, sweating and loss of body heat.

Q: Is PCM INJECTION safe to use in patients with liver disease?

A: PCM INJECTION is not recommended for use in patients with severe liver disease. It should be used with caution in patients with liver disease. Your doctor may monitor your liver function test before and during management with this medicine to manage the risk of liver damage. Consult your doctor before receiving PCM INJECTION.

References

1. Tilo Grosser, Emer Smyth and Garret A. FitzGerald. Anti-inflammatory, Antipyretic and Analgesic agents; Pharmacotherapy of gout. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page-693.

2. KD. Tripathi. NSAIDs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh edition. 2013. Page-206.

3. Ulderico Freo, Chiara Ruocco, Alessandra Valerio, Irene Scagnol and Enzo Nisoli. Paracetamol: A Review of Guideline Recommendations. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. August 2021. [Accessed on 16th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347233/

4. Olivier Malaise, Olivier Bruyere and Jean-Yves Reginster. Intravenous paracetamol: A review of efficacy and safety in therapeutic use. ResearchGate. November 2007. [Accessed on 16th August 2022] https://www.researchgate.net/publication/247872458_Intravenous_paracetamol_A_review_of_efficacy_and_safety_in_therapeutic_use

5. Altan Pharmaceutical. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 16th August 2022] https://www.medicines.org.uk/emc/files/pil.13649.pdf

6. B. Braun Medical Inc. U.S. Food & Drug Administration. [Revised in February 2021] [Accessed on 16th August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/204957s000lbl.pdf

7. Therapeutic Pharmaceuticals. Aeknil injection (Paracetamol). [Revised in May 2016] [Accessed on 16th August 2022] https://aeknil.com/pi/aekinj.pdf

8. Central Drugs Standard Control Organization (CDSCO). Paracetamol. [Accessed on 16th August 2022] https://cdscoonline.gov.in/CDSCO/Drugs

Useful Diagnostic Tests

Complete blood count
Liver function test

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 17 Aug 2024 | 05:36 PM(IST)