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Introduction About TRANTAS INJECTION

TRANTAS INJECTION contains Tranexamic Acid which belongs to the group of medicines called Antifibrinolytics. It is used in the management of bleeding in conditions such as heavy menstrual bleeding in women, gastrointestinal bleeding (bleeding in digestive tract, anywhere from the throat to rectum), bleeding due to thrombolytic therapy (medicine that is used to breakdown blood clots) and after having surgeries (such as ear, nose, throat, prostate gland, urinary tract, gynecological, abdominal or heart surgery) in adults and children above one year of age.

TRANTAS INJECTION is not recommended for use in patients with severe kidney impairment, blood clotting disorder or consumption coagulopathy (condition affecting the blood’s ability to clot and stop the bleeding) or history of seizures (fits). Your doctor may recommend you to take relevant tests to understand your existing condition.

Before receiving TRANTAS INJECTION, inform your doctor if you had or have blood in the urine, are at risk of having a blood clot, excessive clotting or bleeding throughout the body (disseminated intravascular coagulation).

TRANTAS INJECTION is not recommended for use in the first trimester of pregnancy and in breast-feeding women. It should be used with caution in pregnant women only if clearly advised by the doctor. TRANTAS INJECTION should be used with caution in elderly patients, especially in patients with the evidence of renal failure.

The most common side effects of receiving TRANTAS INJECTION are nausea or vomiting and diarrhea. Inform your doctor immediately if any of the side effect worsens.

Uses Of TRANTAS INJECTION

Prevent and manages bleeding in children (aged above one) and adults in conditions such as:

heavy menstrual bleeding in women
gastrointestinal bleeding
after having surgeries (such as ear, nose, throat, heart, abdominal, gynaecological and prostrate or urinary tract surgery)
bleeding due to medicine that is used to breakdown blood clots (thrombolytic therapy)

How TRANTAS INJECTION Works

TRANTAS INJECTION manages bleeding by blocking the plasminogen from binding with fibrin which results in bleeding. As a result, it manages and controls bleeding associated with various factors.

How to use TRANTAS INJECTION

TRANTAS INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous injection. Your doctor will decide the correct dose, frequency and duration for you depending upon your age, body weight and disease condition.

Side Effects Of TRANTAS INJECTION

Common

diarrhea
nausea, vomiting

Uncommon

skin rashes

Rare

Inform your doctor immediately if you experience any of the following side effects while receiving TRANTAS INJECTION:

severe allergic reaction (signs include redness of the skin and lumpy skin rashes, difficulty in breathing, swelling of face, mouth, lips or eyelids, unexplained high temperature (fever) and fainting)
swelling of the throat that causes breathing and swallowing difficulty
symptoms of a blood clot (such as swelling or pain in the legs or chest, headache, weakness of the face and limbs on one side of the body)

How To Manage Side Effects

Diarrhea

Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Inform your doctor if the symptom gets worse.

Nausea And Vomiting

Stick to simple meals while receiving this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.

Warning & Precautions

Pregnancy

Contraindicated

TRANTAS INJECTION is not recommended for use in the first trimester of pregnancy. It should be used with caution in pregnant women only if considered clearly necessary. Women of childbearing potential should use effective contraception during management with this medicine. Consult your doctor before receiving TRANTAS INJECTION.

Breastfeeding

Contraindicated

TRANTAS INJECTION is not recommended for use in breastfeeding women as it passes through breast milk. Consult your doctor for advice.

Kidney

Consult your doctor

TRANTAS INJECTION is not recommended for use in patients with severe kidney impairment. It should be used with caution in patients with mild to moderate kidney impairment. Your doctor may adjust the dose depending upon the kidney function. Consult your doctor before receiving TRANTAS INJECTION.

Liver

Use with Caution

TRANTAS INJECTION can be used with caution in patients with liver impairment. Consult your doctor before receiving TRANTAS INJECTION.

Allergy

Contraindicated

Do not receive TRANTAS INJECTION if you are allergic to Tranexamic acid or any other ingredients of this medicine.

Use In Pediatrics

Use with Caution

TRANTAS INJECTION should be used with caution in children above 1 year of age. Your child’s doctor will adjust the dose based on the bodyweight of the child. Consult child’s doctor for advice before administration of TRANTAS INJECTION.

Use In Geriatrics

Use with Caution

TRANTAS INJECTION should be used with caution in elderly patients, especially in patients with the evidence of renal failure. Consult your doctor before receiving TRANTAS INJECTION.

Others

TRANTAS INJECTION is not recommended for use if you:

have blood clotting disorder or consumption coagulopathy (condition affecting the blood’s ability to clot and stop the bleeding)
have history of seizures (fits)

Before receiving TRANTAS INJECTION, inform your physician if you:

have blood in the urine (which may lead to urinary tract obstruction)
are at risk of having a blood clot
have excessive clotting or bleeding throughout the body (disseminated intravascular coagulation)

Interactions

A. Drug-Drug interactions:

Before receiving TRANTAS INJECTION, inform your doctor if you have received or taking any of the following medicines:

ethinyl estradiol, levonorgestrel (oral contraceptives used to manage pregnancy)
thrombolytic agents such as streptokinase, reteplase, tenecteplase (medicines that manage blood clot)
antifibrinolytics such as aminocaproic acid, aprotinin (medicines that help the blood to clot)

Overdosage:

TRANTAS INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, if you experience any unusual symptoms contact your doctor immediately. Symptoms include dizziness, headache, low blood pressure and convulsions (fits).

Synopsis

Drug	:	Tranexamic Acid
Pharmacological Category	:	Antifibrinolytics
Therapeutic Indication	:	Prevent and manages bleeding in certain conditions
Dosage Forms	:	Injection, Gel, Tablet

More Information

Store at room temperature

FAQs About TRANTAS INJECTION

Q: Can TRANTAS INJECTION be used in elderly patients?

A: TRANTAS INJECTION should be used with caution in elderly patients, especially in patients with the evidence of renal failure. Consult your doctor for advice before receiving TRANTAS INJECTION.

Q: Is TRANTAS INJECTION safe to use during pregnancy?

A: TRANTAS INJECTION is not recommended for use in the first trimester of pregnancy. It should be used with caution in pregnant women only if clearly advised by the doctor. Women of childbearing potential should use effective contraception during management with this medicine. Consult your doctor before receiving TRANTAS INJECTION.

Q: Can TRANTAS INJECTION be used in patients with impaired kidney function?

A: TRANTAS INJECTION is not recommended for use in patients with severe kidney impairment. It should be used with caution in patients with mild to moderate kidney impairment. Your doctor may adjust the dose depending upon the kidney function. Consult your doctor before receiving TRANTAS INJECTION.

Q: Does TRANTAS INJECTION cause nausea?

A: Yes, TRANTAS INJECTION may cause nausea in some individuals. To manage this effect, stick to simple meals while receiving this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.

Q: How TRANTAS INJECTION is administered?

A: TRANTAS INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous injection. It should not be injected into a muscle (intramuscularly). Your doctor will decide the correct dose, frequency and duration for you depending upon your age, body weight and disease condition.

References

1. KD. Tripathi. Drugs affecting blood and blood formation. Essentials of medical pharmacology. Eighth Edition. 2019. Page – 676.

2. John M. Chauncey, Jerald S. Wieters. Tranexamic Acid. NIH. National Library of Medicine, National center for biotechnology information. [Revised in January 2022] [Accessed on 14th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK532909/

3. Johnny Cai, Jessica Ribkoff, Sven Olson, Vikram Raghunathan, Hanny Al-Samkari, Thomas G. DeLoughery, and Joseph J. Shatzel. The many roles of tranexamic acid: An overview of the clinical indications for TXA in medical and surgical patients. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. December 2019 [Accessed on 14th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023891/

4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 14th July 2022] https://www.medicines.org.uk/emc/files/pil.8953.pdf

5. Emcure Pharma UK Ltd. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 14th July 2022] https://www.medicines.org.uk/emc/product/11894/smpc

6. Medochemie Ltd. Electronic Medicines Compendium (EMC). [Revised in May 2018] [Accessed on 14th July 2022] https://www.medicines.org.uk/emc/files/pil.3374.pdf

Useful Diagnostic Tests

Complete blood count
Liver function test
Kidney function test
Bleeding Time/clotting time
Eye test

Author Details

Written By Dr. R. Dinesh John Rajkumar - Pharm.D

Reviewed For Accuracy By Dr. Venkatesh Poludasu - MBBS

Last updated on 06 Mar 2023 | 09:16 AM(IST)