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Introduction About ONDET 4 INJECTION

ONDET 4 INJECTION is used to provide relief from sensation of nausea and vomiting. It contains a medicine called Ondansetron which is an anti-emetic medicine. It reduces the nausea and vomiting sensation by blocking the vomiting centres of the brain.

Before receiving ONDET 4 INJECTION, inform your doctor if you have severe constipation, heart or liver problems, imbalance with the levels of salts in the blood, such as potassium, sodium and magnesium or if you have been scheduled for any surgery.

Consult your doctor before taking ONDET 4 INJECTION if you are pregnant or breastfeeding as a precaution.

The most common side effects of receiving ONDET 4 INJECTION includes headache, flushing and constipation. Consult your doctor if any of these above symptoms gets worse.

Uses Of ONDET 4 INJECTION

Management of nausea and vomiting

How ONDET 4 INJECTION Works

ONDET 4 INJECTION is anti-emetic medicine which works by blocking the action of serotonin, a natural substance in the body that can trigger nausea and vomiting. Specifically, it targets the 5-HT3 receptors in the brain and the gastrointestinal tract. By inhibiting these receptors, ondansetron effectively reduces the signals that lead to nausea and vomiting, providing relief to patients undergoing treatments that can induce these symptoms.

How to use ONDET 4 INJECTION

ONDET 4 INJECTION will be given to you only by a doctor or a nurse, into a vein as an intravenous infusion, or into the muscles as intramuscular injection
Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition

Side Effects Of ONDET 4 INJECTION

Common Side Effects of ONDET 4 INJECTION:

headache
flushing (feeling of warmth)
constipation
Dizziness
Diarrhea
fits (seizures)
irregular heartbeat (fast or slow)
low blood pressure
hiccups

Stop receiving ONDET 4 INJECTION and contact your doctor if you experience any of the following side effects:

sudden wheezing, chest pain or tightness
swelling of eyelids, face, lips, mouth or tongue
skin rash, red spots or lumps under your skin (hives) or anywhere on the body

Warning & Precautions

Pregnancy

Consult your doctor

Pregnant women should only use ONDET 4 INJECTION if prescribed by a doctor, after assessing the benefits and risks.

Breastfeeding

Consult your doctor

Limited data is available on the use of ondansetron during breastfeeding. While no harmful effects have been reported in breastfed infants, ondansetron is excreted in breast milk. Therefore, breastfeeding mothers should consult a doctor before using this medicine to ensure its safety for their baby.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy or uneasy after receiving ONDET 4 INJECTION.

Liver

Use with Caution

ONDET 4 INJECTION should be used with caution in patients with liver problems. Consult your doctor before receiving ONDET 4 INJECTION.

Allergy

Contraindicated

Do not take ONDET 4 INJECTION if you are allergic to ondansetron, granisetron or palonosetron or to any other ingredients of this medicine.

Heart Disease

Use with Caution

ONDET 4 INJECTION should be used with caution in patients with heart diseases such as uneven heartbeats (arrhythmias) or congestive heart failure.

Use In Pediatrics

Monitoring required

ONDET 4 INJECTION can be used in children if prescribed by the physician.

Use In Geriatrics

Monitoring required

ONDET 4 INJECTION can be used in elderly patients if prescribed by the physician.

Others

Before receiving ONDET 4 INJECTION, inform your doctor if you:

have a blockage in your gut
have constipation
have problems with the levels of salts in the blood (such as potassium, sodium and magnesium)
are intolerant to some sugars (Ex. lactose intolerance)

Interactions

A. Drug-Drug Interactions:

Before receiving ONDET 4 INJECTION, inform your doctor, if you are receiving any of the following medicine:

apomorphine (used to manage Parkinson’s disease)
Antiepileptics (Ex. phenytoin, carbamazepine)
Anti-TB agent (Ex. rifampicin)
Pain killers (such as tramadol, methadone)
Antipsychotic agents (Ex. haloperidol)
Cardiac agents (Ex. amiodarone) and/or high blood pressure (Ex. atenolol, timolol)
cancer medicines (Ex. doxorubicin, daunorubicin, monoclonal, trastuzumab)
Antibiotics (such as erythromycin, ketoconazole)
Antidepressants, Sedatives, Anxiolytics (ex. fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, venlafaxine, duloxetine escitalopram)

Overdosage:

If you or anyone else accidentally takes too much of ONDET 4 INJECTION, consult your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Ondansetron
Pharmacological Category	:	Serotonin antagonist
Therapeutic Indication	:	Nausea and Vomiting
Dosage Forms	:	Tablet, Injection, Dispersible Tablet, Syrup, Suspension, Oral strips, Lozenges, Pastille

FAQs About ONDET 4 INJECTION

Q: Is ONDET 4 INJECTION a chemo drug?

A: No, it is not a chemo drug. It belongs to a group of medicines called serotonin antagonists and used to manage side effects caused due to chemotherapy.

Q: What ONDET 4 INJECTION is used for?

A: ONDET 4 INJECTION is used to manage nausea and vomiting caused by medical managements like chemotherapy, radiotherapy or surgery.

Q: For how long should you take ONDET 4 INJECTION?

A: Your doctor will advise you on how long you should continue to take ONDET 4 INJECTION. Consult your doctor from time to time to review your management and assess your symptoms.

Q: What happens if you take more ONDET 4 INJECTION than your required dose?

A: If you or anyone else accidentally takes too much of ONDET 4 INJECTION, consult your doctor immediately or visit the nearby hospital.

Q: What side effects are seen with ONDET 4 INJECTION?

A: The most common side effects of receiving ONDET 4 INJECTION are headaches, flushing (feeling of warmth), constipation. Consult your doctor if above side effects got worse.

References

1. KD. Tripathi. Section 11, Gastrointestinal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 661.

2. LTS Lohmann Therapie-Systeme AG Lohmannstrasse. Andernach GERMANY [Revised April 2022] [Accessed on 29 September 2022] click here

3. Koland M, Sandeep V, Charyulu N. Fast Dissolving Sublingual Films of Ondansetron Hydrochloride: Effect of Additives on in vitro Drug Release and Mucosal Permeation. J Young Pharm. 2010 Jul;2(3):216-22. [Accessed on 29 September 2022] click here

4. Kumria R, Gupta V, Bansal S, Wadhwa J, Nair AB. Oral buccoadhesive films of ondansetron: Development and evaluation. Int J Pharm Investig. 2013 Apr;3(2):112-8. [Accessed on 29 September 2022] click here

5. Ondansetron Soluble Films. [Accessed on 29 September 2022] click here

6. Myoclinic. [Accessed on 29 September 2022] click here

Useful Diagnostic Tests

Complete blood count

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS

Last updated on 11 Feb 2025 | 05:01 PM(IST)