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Introduction About REVOFER 500MG INJECTION

Revofer 500mg Injection contains Ferric carboxymaltose which belongs to the group of medicines called Iron replacement medicines. It is used to correct iron deficiency anemia. Iron deficiency anaemia is a condition in which the body lacks enough amount of iron, which is essential for the transport of oxygen in the body.

Revofer 500mg Injection 10ml should be used under careful medical supervision. It will be given to you only by a doctor or a nurse into the vein as injection or infusion. Your doctor will decide the correct dose and duration of therapy for you based on your health condition.

Before receiving Revofer 500mg Injection inform your doctor if you have any liver problems or chronic kidney diseases. You must inform your doctor if you have asthma, rheumatoid arthritis, eczema or other allergies, any systemic infections, low levels of phosphate in the blood or high blood pressure as a precaution.

Revofer 500mg Injection is not recommended for use if you have anaemia not caused by iron deficiency, iron overload disorder or if you are allergic to ferric carboxymaltose or any other parenteral iron preparations.

Inform your doctor before receiving Revofer 500mg Injection 10ml if you are pregnant or breastfeeding as a precaution.

The most common side effects of receiving Revofer 500mg Injection 10ml may include headache, dizziness, flushing, high blood pressure, nausea and injection or infusion site reactions. Consult your physician if any of the symptom worsens.

Uses Of REVOFER 500MG INJECTION

Manage iron deficiency anaemia

How REVOFER 500MG INJECTION Works

Revofer 500mg Injection contains iron in the form of Ferric carboxymaltose. Iron is an essential micronutrient that gives the red blood cells the reddish brown colour and the capacity to transport oxygen. It improves oxygen levels in the body and corrects tiredness, weakness and shortness of breath caused due to anemia.

How to use REVOFER 500MG INJECTION

REVOFER 500MG INJECTION 10ml will be given to you only by a doctor or a nurse into a vein as an intravenous injection or infusion. Your physician will decide the correct dose and duration for you depending upon your age, body weight and severity of the condition.

Side Effects Of REVOFER 500MG INJECTION

Common

headache
dizziness
flushing
high blood pressure
nausea
injection/infusion site reactions
low levels of phosphorous in the blood

Uncommon

numbness, prickling or tingling sensation of the skin
change in taste sensation
vomiting
indigestion, stomach pain, constipation, diarrhoea
pain in the arms or the legs
muscle spasms
swelling of the hands and feet, and chills

Rare

inflammation of the vein
anxiety
wheezing

Contact your doctor immediately if you experience any of the following side effects after receiving Revofer 500mg:

symptoms of serious allergic reaction or kounis syndrome (such as rashes, itching, swelling of the face, lips, mouth, tongue, throat or body causing difficulty in breathing or wheezing and chest pain)
severe or life-threatening allergic reactions called anaphylactic reactions which can be associated with heart, circulation problems (low blood pressure) and loss of consciousness
sign of a decrease in blood phosphorus causing softening of bones (osteomalacia) symptoms include worsening of tiredness, muscle or bone pain (pain in arms or legs, joints or back) and may lead to fractures

How To Manage Side Effects

Constipation

Managing constipation often involves simple lifestyle changes. Increase fiber intake by incorporating more fruits, vegetables, and whole grains into your diet. Staying hydrated is essential, so drink plenty of water throughout the day. Regular physical activity can stimulate bowel movements and promote digestive health. Establishing a consistent daily routine for meals and bathroom breaks may help regulate bowel habits. Over-the-counter fiber supplements or stool softeners can be considered, but it's advisable to consult a healthcare professional before using them regularly. If constipation persists or is accompanied by other concerning symptoms, seek medical advice for a more thorough evaluation and personalized guidance.

Dizziness Or Drowsiness

Managing dizziness involves identifying and addressing its underlying causes. If dizziness is mild and associated with dehydration, ensure adequate fluid intake. Avoid sudden changes in position, such as standing up too quickly, to minimize the risk of orthostatic hypotension. If caused by low blood sugar, eating a balanced meal may help. Relaxation techniques, like deep breathing, can be beneficial for stress-induced dizziness. Adequate rest and regular sleep patterns contribute to overall balance. In case of persistent or severe dizziness, it's crucial to consult with a healthcare professional to rule out more serious underlying conditions and receive appropriate> management.

Headache

Managing a headache often involves a combination of lifestyle adjustments and over-the-counter remedies. Begin by ensuring proper hydration, as dehydration can contribute to headaches. Relaxation techniques, such as deep breathing or meditation, may help alleviate stress-related headaches. Adequate rest and maintaining regular sleep patterns are crucial. Over-the-counter pain relievers like acetaminophen, ibuprofen, or aspirin can provide relief, but it's essential to follow recommended dosages. Applying a cold or warm compress to the forehead or neck may also offer comfort. If headaches persist or become severe, it's advisable to consult a healthcare professional for a comprehensive assessment and personalized guidance.

Warning & Precautions

Pregnancy

Consult your doctor

There is limited data from the use of REVOFER 500MG INJECTION in pregnant women. Therefore, inform your doctor before receiving REVOFER 500MG INJECTION if you are pregnant or think you may be pregnant.

Breastfeeding

Consult your doctor

It is unlikely that REVOFER 500MG INJECTION represents a risk to the nursing child. However, consult your doctor for advice before receiving it.

Driving and Using Machines

Use with Caution

REVOFER INJECTION is unlikely to impair the ability to drive or operate machines.

Kidney

Use with Caution

REVOFER INJECTION should be used with caution in patients with chronic kidney disease who are dependent of haemodialysis> management. Therefore, consult your doctor before receiving it.

Liver

Use with Caution

REVOFER INJECTION should be used with caution in patients with liver diseases. Therefore, consult your doctor before receiving it.

Allergy

Contraindicated

Do not receive REVOFER 500MG INJECTION if you are allergic to ferric carboxymaltose or any of the other ingredients of this medicine or if you have experienced serious allergic reactions to other injectable iron preparations.

Lungs

Use with Caution

REVOFER 500MG INJECTION should be used with caution in patients with severe asthma. Therefore, consult your doctor before receiving it.

Use In Pediatrics

Contraindicated

REVOFER 500MG INJECTION is not recommended for use in infants aged below 1 year. Consult your child’s doctor for advice to manage the condition.

Use In Geriatrics

Use with Caution

REVOFER 500MG INJECTION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.

Others

REVOFER INJECTION is not recommended for use if you have:

anaemia not caused by iron deficiency
iron overload (too much iron in your body) or disturbances in the utilisation of iron

Before receiving REVOFER INJECTION inform your doctor if you have:

systemic lupus erythematosus
rheumatoid arthritis
eczema or other allergies
an infection
low levels of phosphate in the blood
high blood pressure

Interactions

A. Drug-Drug interactions:

Before receiving REVOFER INJECTION, inform your doctor if you are using or have recently taken any other medicines including prescription, non-prescription medicines and vitamins or herbal supplements.

oral iron preparations such as ferrous ascorbate, ferrous sulphate, ferric citrate (used to manage or manage low levels of iron in the body)

Overdosage:

REVOFER 500MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

Synopsis

Drug	:	Ferric carboxymaltose
Pharmacological Category	:	Iron replacement medicines
Therapeutic Indication	:	Iron Deficiency Anemia (IDA)
Dosage Forms	:	Injection

More Information

Keep Inj Revofer out of reach in children
Store Inj Revofer at room temperature

FAQs About REVOFER 500MG INJECTION

Q: What is the use of REVOFER 500MG INJECTION?

A: REVOFER 500MG INJECTION is used in the management of iron deficiency anaemia. Consult your doctor before using it.

Q: How does REVOFER 500MG INJECTION work?

A: REVOFER 500MG INJECTION contains iron (III) hydroxide complexed with a carbohydrate polymer called carboxymaltose, which is capable of releasing iron. The iron released from the complex helps in the synthesis of haemoglobin and increases the red blood cell count. As a result, it manages iron-deficiency anaemia.

Q: Is REVOFER 500MG INJECTION safe to use in patients with kidney problems?

A: REVOFER 500MG INJECTION should be used with caution in patients with chronic kidney disease who are dependent on haemodialysis management. Consult your doctor before using REVOFER 500MG INJECTION.

Q: Who should avoid taking REVOFER 500MG INJECTION?

A: REVOFER 500MG INJECTION is not recommended for use in patients with evidence of iron overload or disturbances in the utilization of iron, anaemia not caused by iron deficiency, known allergies to ferric carboxymaltose, or serious allergies to other parenteral iron products.

Q: Is REVOFER 500MG INJECTION safe to use with elderly patients?

A: REVOFER 500MG INJECTION should be used with caution in elderly patients (aged 65 years or older). Your doctor may monitor you carefully during administration and at a certain time after administration of REVOFER 500MG INJECTION. Consult your doctor before using it.

Q: Can REVOFER 500MG INJECTION be used during pregnancy?

A: [GNKEYWORD] should be used with caution in pregnant women only if clearly advised by your doctor. Inform your doctor if you are pregnant, think you may be pregnant, or are planning to have a baby. Consult your doctor before using REVOFER 500MG INJECTION.

Q: Can REVOFER 500MG INJECTION interact with other medications?

A: Yes, REVOFER 500MG INJECTION can interact with other medications, including certain antibiotics, antifungals, antidepressants, and medications that affect heart rhythm. It's crucial to inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting REVOFER 500MG INJECTION therapy to avoid potential interactions.

Q: How often do I need to take REVOFER 500MG INJECTION?

A: The frequency of REVOFER 500MG INJECTION will depend on your specific condition and management plan. Your healthcare provider will determine the appropriate dosing schedule for you.

Q: What should I do if I miss a dose of REVOFER 500MG INJECTION?

A: It's crucial to follow your healthcare provider's instructions regarding management. If you miss a dose, contact your healthcare provider for guidance.

Q: What are the side effects of taking REVOFER 500MG INJECTION?

A: The most common side effects of taking REVOFER 500MG INJECTION may include headache, dizziness, flushing, high blood pressure, and nausea. Consult your physician if any of the symptoms worsen.

Q: What precautions must be taken while using REVOFER 500MG INJECTION?

A: Before taking REVOFER 500MG INJECTION, inform your doctor if you have liver, kidney disease, severe asthma, systemic lupus erythematosus, rheumatoid arthritis, eczema or other allergies, infections, low levels of phosphate in the blood, or high blood pressure.

Q: If a higher dose of REVOFER 500MG INJECTION is administered, will I get faster results?

A: No. Do not take more than the recommended dose of REVOFER 500MG INJECTION, as it may increase the risk of unwanted side effects. Your doctor will decide the correct dose and duration depending on age, body weight, and disease conditions.

References

1. KD. Tripathi. Haematinics and Erythropoietin. Essentials of medical pharmacology. Seventh edition. 2013. Page – 605.

2. Joao Ricardo Friedrischa and Rodolfo Delfini Cancadob. Intravenous ferric carboxymaltose for the treatment of iron deficiency anemia. NIH. National Library of Medicine, National Center for Biotechnology Information. PMC PubMed Central. October 2015. [Accessed on 1st July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678908/

3. American Regent, Inc. Safety and Tolerability of Ferric Carboxymaltose (FCM) Versus Standard of Care in Treating Iron Deficiency Anemia. NIH. U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in February 2018] [Accessed on 1st July 2022] https://clinicaltrials.gov/ct2/show/NCT00703937

4. Vifor France. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 1st July 2022] https://www.medicines.org.uk/emc/files/pil.5910.pdf

5. Vifor (International) Inc. U.S. Food & Drug Administration. [Revised in April 2021] [Accessed on 1st July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/203565s014lbl.pdf

Useful Diagnostic Tests

Ferritin
Iron Serum
Total Iron Binding Capacity
Transferrin Saturation
Complete blood count

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Shruthi Raikar - BDS

Last updated on 27 Mar 2024 | 05:57 PM(IST)