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Introduction About JANUMET XR CP 100/1000MG TABLET

JANUMET XR CP 100/1000MG TABLET is used to control blood sugar levels in patients with type II diabetes mellitus, along with proper diet and exercise. It is a combination of Metformin and Sitagliptin, which belongs to the group of medicines called Antidiabetic agents.

Before taking JANUMET XR CP 100/1000MG TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have high blood cholesterol levels, severe systemic infections, or are severely dehydrated due to excessive vomiting or diarrhea recently. During therapy with JANUMET XR CP 100/1000MG TABLET, your doctor might regularly monitor your blood sugar levels and kidney functions to avoid the risk of unwanted side effects. You may asked to make certain lifestyle changes, such as following a healthy diet, regular physical exercise, and quitting alcohol consumption, to achieve better results.

JANUMET XR CP 100/1000MG TABLET is not recommended for use in patients with severe, uncontrollable diabetes. It is also not suitable for use in patients with alcoholism, shock, or problems with breathing or blood circulation. Consult your doctor before taking JANUMET XR CP 100/1000MG TABLET if you are pregnant or breastfeeding. The most common side effects of taking JANUMET XR CP 100/1000MG TABLET are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in the mouth, sore throat, stuffy nose, and joint pain. Consult your doctor if they bother you.

Uses Of JANUMET XR CP 100/1000MG TABLET

Used to manage type II diabetes mellitus

How JANUMET XR CP 100/1000MG TABLET Works

JANUMET XR CP 100/1000MG TABLET is an antidiabetic medicine. It contains two medicines, namely metformin and sitagliptin. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells utilize more of the circulating blood glucose. Additionally, it can stop glucose production by the liver and reduce its absorption in the body. Sitagliptin inhibits DPP-4 which leads to increased levels of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide(GIP), decreased levels of glucagon, and a stronger insulin response to glucose.

How to use JANUMET XR CP 100/1000MG TABLET

Take JANUMET XR CP 100/1000MG TABLET, preferably after meals or as advised by your physician
Swallow the medicine with a glass of water. Do not crush or chew the medicine
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition
Do not stop taking unless your doctor advises you to stop

Side Effects Of JANUMET XR CP 100/1000MG TABLET

Common side effects of JANUMET XR CP 100/1000MG TABLET:

hypoglycemia (low blood sugar)
flatulence, diarrhea, constipation, stomach pain, and loss of appetite
swelling of the hands and legs (edema)
metallic taste
drowsiness, dizziness
dry mouth

Stop taking and consult your doctor immediately if you experience any of the following side effects:

serious allergic reaction (such as hives, swelling of the face, lips, tongue, or throat causing difficulty breathing or swallowing)
severe blistering of the skin (signs of an allergic skin reaction called bullous pemphigoid)
signs of pancreatitis (severe and persistent pain in the stomach areas that might reach through to your back with or without nausea and vomiting)
signs of lactic acidosis (cold hands or feet, dizziness or lightheadedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)

Warning & Precautions

Pregnancy

Contraindicated

JANUMET XR CP 100/1000MG TABLET is not recommended for use by pregnant women. Therefore, inform your doctor before taking this medicine if you are pregnant, think you may be pregnant, or are planning to have a baby.

Breastfeeding

Contraindicated

JANUMET XR CP 100/1000MG TABLET is not recommended for use by breastfeeding women.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy after taking JANUMET XR CP 100/1000MG TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking JANUMET XR CP 100/1000MG TABLET, as it may increase the risk of unwanted side effects.

Kidney

Contraindicated

JANUMET XR CP 100/1000MG TABLET is not recommended for use in patients with severely reduced kidney functions.

Liver

Consult your doctor

JANUMET XR CP 100/1000MG TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with gallstones.

Allergy

Contraindicated

Do not take JANUMET XR CP 100/1000MG TABLET if you are allergic to metformin or sitagliptin or any other ingredients of this medicine.

Heart Disease

Contraindicated

JANUMET XR CP 100/1000MG TABLET is not recommended for use in patients with severe heart problems (such as acute heart failure or a recent heart attack).

Use In Pediatrics

Contraindicated

JANUMET XR CP 100/1000MG TABLET is not recommended for use in children and adolescents (aged below 18 years).

Use In Geriatrics

Use with Caution

JANUMET XR CP 100/1000MG TABLET should be used with caution in elderly patients (aged above 65 years).

Others

It is not recommended for use if you:

have severe, uncontrollable diabetes
have nausea, vomiting, diarrhea, or rapid weight loss
have lactic acidosis or ketoacidosis (a buildup of lactic acid or ketones in the body)
are dehydrated
have any severe systemic infection
have shock or problems in blood circulation
have problems in breathing
are an alcoholic
are scheduled for any X-rays in the upcoming days

Before taking the medicine, inform your doctor if you:

have or ever had pancreatitis (inflammation of the pancreas)
have alcohol dependence
have high blood lipid levels
have type I diabetes mellitus (insulin-dependent diabetes)
are about to have a major surgery
are fasting
are malnourished, starved, on an irregular diet, or feeling weak
perform extreme muscle exercises
have a vitamin B12 deficiency

Interactions

A. Drug-Drug interactions:

Before taking JANUMET XR CP 100/1000MG TABLET, inform your doctor if you are taking any of the following medicines, such as:

Anti-diabetics (Ex. glimepiride, glyburide, gliclazide, teneligliptin, rosiglitazone, pioglitazone)
iodine contrast medium
Bronchodilators (Ex. salbutamol or terbutaline)
corticosteroids Ex. hydrocortisone, prednisolone)
diuretics (Ex. furosemide, hydrochlorothiazide)
NSAID’s (Ex. ibuprofen and celecoxib)
Antihypertensives (Ex. atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, and telmisartan)
alcohol-containing medicines (such as cough syrups)
H2 blockers (Ex. cimetidine)
Anti-viral agents (Ex. dolutegravir)
Anti-Anginal agents (Ex. ranolazine)
Antibiotics (Ex. trimethoprim)
Cardiac glycosides (Ex. digoxin)

Overdosage:

If you or anyone else accidentally took more JANUMET XR CP 100/1000MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are feeling cold or uncomfortable, severe nausea or vomiting, stomach pain, unexplained weight loss, muscular cramps, and fast breathing.

Synopsis

Drug	:	Metformin, Sitagliptin
Pharmacological Category	:	Biguanides, DPP-4 Inhibitors
Therapeutic Indication	:	Type II diabetes mellitus
Dosage Forms	:	Tablet, Capsule, Combi pack

More Information

FAQs About JANUMET XR CP 100/1000MG TABLET

Q: What is JANUMET XR CP 100/1000MG TABLET used for?

A: It is an antidiabetic medicine used as an adjunct to diet and exercise to control blood sugar levels in patients with type II diabetes mellitus.

Q: How and when to take JANUMET XR CP 100/1000MG TABLET?

A: Take JANUMET XR CP 100/1000MG TABLET, preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.

Q: How long should I take JANUMET XR CP 100/1000MG TABLET?

A: You need to take as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Q: What is the best time to take JANUMET XR CP 100/1000MG TABLET?

A: It must be taken with meals to avoid gastrointestinal side effects.

Q: What should I do if I forget to take a dose of JANUMET XR CP 100/1000MG TABLET?

A: If you forgot to take a dose of JANUMET XR CP 100/1000MG TABLET, take it as soon as you remember. However, if it is time for the next dose, skip the missed dose and take the next one regularly.

Q: What are the most common side effects of taking JANUMET XR CP 100/1000MG TABLET?

A: The most common side effects are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in the mouth, sore throat, stuffy nose, and joint pain.

Q: Can I stop taking JANUMET XR CP 100/1000MG TABLET without consulting your doctor?

A: No. You should not stop taking JANUMET XR CP 100/1000MG TABLET without consulting your doctor because it may lead to a reversal of symptoms.

Q: Will taking a higher dose of JANUMET XR CP 100/1000MG TABLET be more effective?

A: No, taking a higher dose will not be effective; rather, it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: What precautions do I need to follow while taking JANUMET XR CP 100/1000MG TABLET?

A: Before taking JANUMET XR CP 100/1000MG TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have high blood cholesterol levels, severe systemic infections, or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results.

Q: Can I take medication for high blood pressure along with JANUMET XR CP 100/1000MG TABLET?

A: It is not advisable to take medicines to control blood pressure while taking JANUMET XR CP 100/1000MG TABLET without consulting your doctor.

Q: What should I do if I experience low blood sugar after taking JANUMET XR CP 100/1000MG TABLET?

A: Low blood sugar is a common side effect. If you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness, or an irregular heartbeat), consume a sugary snack or sugar drink immediately.

Q: Can JANUMET XR CP 100/1000MG TABLET be taken with insulin?

A: Co-administration of JANUMET XR CP 100/1000MG TABLET with insulin is considered risky as it increases the chance of hypoglycemia (decreased blood sugar levels.

Q: Can JANUMET XR CP 100/1000MG TABLET be used in pregnant women?

A: No. it is not recommended for use by pregnant women.

Q: How much JANUMET XR CP 100/1000MG TABLET should I take?

A: It should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body condition, and severity of the disease.

Q: Can JANUMET XR CP 100/1000MG TABLET cause constipation?

A: Yes. Constipation is a common side effect. Eat plenty of fiber-rich foods, such as fresh fruits, vegetables, and cereals, as well as drink plenty of water and exercise more regularly when taking this medicine.

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page-274 & 275.

2. Erin L. St. Onge, Shannon Miller and Elizabeth Clements. Sitagliptin/Metformin (Janumet) as Combination Therapy in the Treatment of Type-2 Diabetes Mellitus. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2012. [Accessed on 19th January 2024] click here

3. Chitrabhanu Ballav and Stephen C.L. Gough. Safety and Efficacy of Sitagliptin-Metformin in Fixed Combination for the Treatment of Type 2 Diabetes Mellitus. Libertas Academica. 2013. [Accessed on 19th January 2024] click here

4. Merck Sharp & Dohme (UK) Limited. Electronic Medicines Compendium (EMC) [Revised in February 2022] [Accessed on 19th January 2024] click here

5. Merck & Co., Inc. JANUMET® (sitagliptin and metformin hydrochloride) tablets, for oral use. [Revised in July 2022] [Accessed on 19th January 2024] click here

6. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 19th January 2024] click here

7. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 19th January 2024] click here

8. Organon Pharma (UK) Limited. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 19th January 2024] click here

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Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 18 Nov 2024 | 12:26 PM(IST)