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Introduction About XIDORIN 5 TABLET

XIDORIN 5 TABLET contains Midodrine which belongs to the group of medicines called Alpha -1 Selective Adrenergic Receptor Agonist. It is used to manage low blood pressure (hypotension) in adults. Symptoms of low blood pressure include blurred or fading vision, dizziness or light-headedness, fainting, feeling sick, difficult in concentrating.

Midodrine acts on the blood vessels via the sympathetic nervous system (part of nervous system that cause increase in heart rate, blood pressure, breathing rate, and dilatation of pupil) to correct imbalances of blood distribution, such as preventing too much blood pooling in the legs when standing up which may cause low blood pressure. Your doctor may regularly monitor the blood pressure when you are lying down and when you are standing up as there may be a risk of your blood pressure rising when you lie down (Ex. at night).

XIDORIN 5 TABLET is not recommended for use in patients having severe heart disease.XIDORIN 5 TABLET should be used with caution in patient having severe kidney disease, liver problems. Consult your doctor for advice before takingXIDORIN 5 TABLET, if you are pregnant or breast-feeding.XIDORIN 5 TABLET is not recommended for use in children and adolescents below the age of 18 years. The most common side effects of takingXIDORIN 5 TABLET are increased blood pressure when lying down, headache, nausea (feeling sick), vomiting, heartburn. Consult your doctor if the symptom worsens.

Uses Of XIDORIN 5 TABLET

Used to manage certain severe forms of low blood pressure in adults by increasing the blood pressure

How XIDORIN 5 TABLET Works

XIDORIN 5 TABLET acts on the blood vessels via the sympathetic nervous system (part of nervous system that cause increase in heart rate, blood pressure, breathing rate, and dilatation of pupil) to correct the imbalances of blood distribution, such as preventing too much blood pooling in the legs when standing up which may cause low blood pressure.

How to use XIDORIN 5 TABLET

TakeXIDORIN 5 TABLET as advised by your physician. Swallow this medicine, do not crush, or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of XIDORIN 5 TABLET

Common

Pain when urinating
Tingling and itching
Increased blood pressure when lying down
Headache
Nausea (feeling sick), vomiting
Heartburn
Inflammation of the lining inside the mouth
Flushing
Rash
Chills
Difficulty in urinating

Uncommon

Sleep disturbances including difficulty sleeping
Restlessness
Agitation (state of anxiety), irritability
Slowed heart rate
Urge to urinate

Rare

Rapid, irregular or fast heartbeat
Chest pain
Signs of increased liver enzymes such stomach pain, dark urine, fatigue (feeling tired), itching, jaundice (yellowing of your skin or eyes)
Dizziness or light headedness
Stroke
Visual disturbances

How To Manage Side Effects

Dizziness Or Drowsiness

When you feel dizzy, lie or sit down immediately. If you're experiencing a severe episode of vertigo, lie in a dark and quite place with eyes closed. Driving should be avoided, if you experience frequent dizziness without warning. Talk to your doctor if the symptom worsens.

Headache

Apply hot or cold-water bag on your head. Try taking rest in a quiet and dark room. Massage with mild pressure on scalp or head.

Nausea And Vomiting

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks, and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Consult your doctor if your symptom does not improve.

Warning & Precautions

Pregnancy

Contraindicated

XIDORIN 5 TABLET is not recommended for use in pregnant. Consult your doctor before takingXIDORIN 5 TABLET.

Breastfeeding

Contraindicated

XIDORIN 5 TABLET is not recommended for use during breast-feeding. Discuss with your doctor before takingXIDORIN 5 TABLET.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy or lightheaded after takingXIDORIN 5 TABLET. Consult your doctor before takingXIDORIN 5 TABLET.

Kidney

Contraindicated

XIDORIN 5 TABLET is not recommended for use in patients with severe kidney disease. Consult your doctor before takingXIDORIN 5 TABLET.

Liver

Use with Caution

XIDORIN 5 TABLET should be used with caution in patients having liver impairment. Consult your doctor before takingXIDORIN 5 TABLET.

Allergy

Contraindicated

XIDORIN 5 TABLET is not recommended for use if you are allergic to Midodrine.

Heart Disease

Contraindicated

XIDORIN 5 TABLET is not recommended for use in patients with severe heart disease including slow pulse, heart attack, heart failure, heart rhythm disorders, widening of the aorta (aortic aneurysm) or other cardiovascular diseases and also in patients with high blood pressure, or a form of low blood pressure known as vasovagal hypotension. Consult your doctor before takingXIDORIN 5 TABLET.

Use In Pediatrics

Contraindicated

XIDORIN 5 TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before takingXIDORIN 5 TABLET.

Use In Geriatrics

Use with Caution

XIDORIN 5 TABLET is used with caution in patients above 60 years of age. Usually the management is initiated with the lowest dose and gradually increased depending upon the clinical condition of the patient. Consult your doctor before takingXIDORIN 5 TABLET.

Others

XIDORIN 5 TABLET is not recommended for use if you have:

Difficulty in urinating
Have elevated pressure in the eye (glaucoma) or poor vision because of diabetes
Hyperthyroidism (overactive thyroid gland)
Hormonal disorders caused by a tumour in the adrenal medulla (pheochromocytoma)
Enlarged prostate

Before takingXIDORIN 5 TABLET, inform your doctor if you have:

Serious disorder of the nervous system (autonomic nervous system disorders)
Problems with blood circulation
Disease of the prostate

Interactions

A. Drug-Drug interactions:

Reserpine and guanethidine (medicines used to reduce high blood pressure)
Antihistamines like cetirizine, chlorpheniramine (used to manage allergies)
Hormones for the thyroid like thyroxine
Tricyclic antidepressants like clomipramine, amoxapine, amitriptyline and MAO-inhibitors such as selegiline, isocarboxazid, phenelzine, (both used to manage depression)
Vasoconstrictors like epinephrine, dopamine, phenyl epinephrine (medicines that narrow blood vessels)
Sympathomimetic agents such as ephedrine, isoproterenol, metaproterenol, (medicines that have a stimulating effect on certain parts of the nervous system)
Prazosin and phentolamine (medicines used to manage heart disease
Digitalis preparations such as digitoxin, digoxin (medicines used to manage heart disease)
Fludrocortisone acetate (medicine used to reduce inflammation)
Perphenazine (medicine used to manage mental or mood disorders)
Amiodarone (medicine used to manage irregular heartbeat)
Metoclopramide (medicine used to prevent vomiting)

Overdosage:

If you or anyone else accidentally take too much ofXIDORIN 5 TABLET, consult your doctor immediately or visit the nearby hospital. The most common symptoms of overdose are high blood pressure (hypertension), slow heart rate (bradycardia), difficulty urinating and feeling of coldness.

Synopsis

Drug	:	Midodrine
Pharmacological Category	:	Alpha -1 Selective Adrenergic Receptor Agonist
Therapeutic Indication	:	Low blood pressure
Dosage Forms	:	Tablet

More Information

Storage

KeepXIDORIN 5 TABLET out of reach of children
Store at room temperature

FAQs About XIDORIN 5 TABLET

Q: CanXIDORIN 5 TABLET cause heart palpitations?

A: Yes,XIDORIN 5 TABLET may cause irregular and fast heartbeat as it is one of the side effects of this medicine. This may result in the risk of falling down. Other symptoms include blurred vision, weakness, or tiredness, feeling sick. Consult your doctor immediately if you experience any abnormal heartbeat or signs of abnormal heartbeat (such as chest pain, dizziness, fainting).

Q: How doesXIDORIN 5 TABLET works?

A: XIDORIN 5 TABLET acts on the blood vessels via the sympathetic nervous system (part of nervous system that cause increase in heart rate, blood pressure, breathing rate, and dilatation of pupil) to correct the imbalances of blood distribution, such as preventing too much blood pooling in the legs when standing up which may cause low blood pressure.

Q: Is it safe to useXIDORIN 5 TABLET in older patients?

A: Yes, but it should be used with caution in elderly with regular monitoring of blood pressure levels and your doctor may monitor your vital organs as it may cause damage to liver, kidney, and heart.

Q: What happens if I stop takingXIDORIN 5 TABLET?

A: Do not stop takingXIDORIN 5 TABLET without talking to your doctor first. Stopping this medicine suddenly can cause your blood pressure to fall and may increase the risk of blurred vision, dizziness, fainting or death.

Q: Who should not takeXIDORIN 5 TABLET?

A: You should not useXIDORIN 5 TABLET if you have severe heart disease, overactive thyroid, an adrenal gland tumour, kidney disease, heart disease, liver disease, painful urination, or if your blood pressure is high even while lying down. Consult your doctor immediately if you experience any unusual effects.

References

1. Goodman and Gillman’s. the pharmacological basis of therapeutics. 12th edition. Adrenergic Agonist and Antagonist. Page- 295-297.

2. William Smith, Hong Wan, David Much, Antoine G. Robinson and Patrick Martin. Clinical benefit of midodrine hydrochloride in symptomatic orthostatic hypotension: a phase 4, double-blind, placebo-controlled, randomized, tilt-table study. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. July 2016. [Accessed 20th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951503/

3. Achuthan Sourianarayanane, MD, MRCP, David S. Barnes, MD and Arthur J. McCullough, MD. Beneficial Effect of Midodrine in Hypotensive Cirrhotic Patients with Refractory Ascites. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. February 2011. [Accessed 20th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061020/

4. Tiofarma B.V. Health Products Regulatory Authority (HPRA). [Revised in August 2021] [Accessed 20th May 2022] http://www.hpra.ie/img/uploaded/swedocuments/56f4c194-cebb-4cee-b24e-b8ce367e433c.pdf

5. MIAS Pharma Limited. Electronic Medicines Compendium (EMC). [Revised in April 2021] [Accessed 20th May 2022] https://www.medicines.org.uk/emc/files/pil.12496.pdf

6. Shire US Inc. U.S. Food & Drug Administration. [Revised in January 2017] [Accessed 20th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/019815s010lbl.pdf

Useful Diagnostic Tests

Kidney function test

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Venkatesh Poludasu - MBBS

Last updated on 11 Jul 2024 | 12:10 PM(IST)