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Introduction About CONTRAPAQUE 350MG INFUSION

CONTRAPAQUE 350MG INFUSION is a radio-contrast agent used for diagnostic purposes only. It helps in diagnosing an illness by taking a clear picture of internal body parts which helps your doctor to tell if there is any abnormality in organ shape and size. It can be used for X-rays of urinary system, spine and blood vessels, including blood vessels supplying the heart, salivary gland, stomach and intestines and for scanning uterus, joints, breasts, ovaries, head and entire body (CAT scan).

CONTRAPAQUE 350MG INFUSION contains a medicine called Iohexol which is a radio contrast agent. It works by absorbing the X-rays due to its iodine content, making certain areas appear white on scans like CT or X-rays. This helps doctors clearly see blood vessels, organs, and tissues for accurate diagnosis.

Make sure to drink plenty of fluids before and after receiving CONTRAPAQUE 350MG INFUSION, especially if you have diabetes, myeloma, kidney problems, aged above 65 years or have generally poor health conditions.

Before receiving CONTRAPAQUE 350MG INFUSION inform your doctor if you have liver, kidney or heart problems. You must also inform your doctor if you are pregnant or breastfeeding or having diabetes, epilepsy, thyroid problems, cancers of bone marrow, muscle weakness, brain problems, etc as a precaution.

The most common side effects of receiving CONTRAPAQUE 350MG INFUSION are feeling hot or flushed, shortness of breath, respiratory problems, headache, nausea, vomiting, diarrhea, dizziness, Inflammation of pancreas and pain around stomach, Increased/abnormal sweating and feeling cold. Consult your doctor if any of these side effect troubles you.

Uses Of CONTRAPAQUE 350MG INFUSION

Radio-contrast agent used for diagnostic purposes
Takes a clear picture of internal body parts
Diagnosis illness, abnormality in organ shape and size
Can be used prior to X-rays of urinary system, spine and blood vessels, including blood vessels supplying the heart, salivary gland, stomach and intestines
Can be used prior to scanning uterus, joints, breasts, ovaries, head and entire body

How CONTRAPAQUE 350MG INFUSION Works

CONTRAPAQUE 350MG INFUSION contains Iohexol which is a contrast agent used in medical imaging to help doctors see blood vessels, organs, and other tissues more clearly during scans like CT or X-rays. It works by absorbing X-rays due to its iodine content, making the areas where it is injected appear white on the scan. This contrast helps to differentiate various structures in the body, aiding in accurate diagnosis.

How to use CONTRAPAQUE 350MG INFUSION

CONTRAPAQUE 350MG INFUSION will be given to you only by a doctor or a trained medical professional into your veins (as intravenous injection), into the blood vessels (as intraarterial injection), into the spine, inside joints, or other body cavities (like uterus, ovaries) or by mouth. The route of administration depends up on the organ which needs to be examined. Make sure to drink plenty of water or fluids before and after administration of CONTRAPAQUE 350MG INFUSION.

Side Effects Of CONTRAPAQUE 350MG INFUSION

Common

Feeling hot or flushed
Shortness of breath, respiratory problems (after an intraarterial injection)
Headache, nausea, vomiting, diarrhea
Inflammation of pancreas
Pain around stomach

Uncommon

Increased/abnormal sweating
Feeling cold
Dizziness/Fainting
Pain and discomfort (after an intraarterial injection)
Inflammation of the membranes that surround the brain and spinal cord

Rare

Slow rate
Fever
Irregular heartbeats, cough, stopped breathing, fever, general discomfort
Feeling weak, muscle weakness
Intolerance to bright light
Feeling abnormally tired
Skin rash and itching, skin redness, reduced eyesight
fits, pain in arms or legs, neck pain, back pain

Inform your doctor immediately if you experience any of the following side effects after receiving CONTRAPAQUE 350MG INFUSION such as:

Severe allergic reactions (such as skin rashes with severe itching, itchy spots, blisters on skin and in mouth, red/itchy eyes, cough, running nose, sneezing, wheeziness, difficulty in breathing or tightness or pain in your chest, swelling of your face, dizziness)

Signs of Encephalopathy (such as)
Thyroid disorders
A short-term decrease in formation of urine due to decreased kidney damage

How To Manage Side Effects

Nausea And Vomiting

To manage nausea and vomiting after iohexol therapy, it's recommended to stay hydrated by sipping clear fluids and eating small, bland meals. Resting in a comfortable position and avoiding strong odors can also help. If the symptoms persist or are severe, over-the-counter anti-nausea medications like ginger supplements or prescription medications might be necessary. Always consult a healthcare provider for proper guidance and if symptoms do not improve.

Warning & Precautions

Pregnancy

Monitoring required

CONTRAPAQUE 350MG INFUSION should be used in pregnancy only if the potential benefits outweigh the risks of iohexol injection. Therefore, inform your doctor before receiving CONTRAPAQUE 350MG INFUSION if you are pregnant or think you may be pregnant.

Breastfeeding

Monitoring required

CONTRAPAQUE 350MG INFUSION can be used in breastfeeding women when considered necessary by the physician. Mothers can continue breastfeeding normally after examination with this medicine.

Driving and Using Machines

Use with Caution

Do not drive or handle any heavy tools or machines if you experience dizziness or any side effect that affects your concentration after receiving CONTRAPAQUE 350MG INFUSION.

Kidney

Use with Caution

CONTRAPAQUE 350MG INFUSION should be used with caution in patients having kidney problems. Therefore, consult your doctor for advice.

Liver

Use with Caution

CONTRAPAQUE 350MG INFUSION should be used with caution in patients having liver problems. Therefore, consult your doctor for advice.

Allergy

Contraindicated

Before receiving CONTRAPAQUE 350MG INFUSION, talk to your doctor if you have any allergies to Iohexol or any other contrast agent.

Lungs

Use with Caution

CONTRAPAQUE 350MG INFUSION should be used with caution in patients suffering from asthma. Therefore, consult your doctor for advice.

Heart Disease

Use with Caution

CONTRAPAQUE 350MG INFUSION should be used with caution in patients suffering from severe cardiac disease (involving heart or blood vessels) including high blood pressure, blood clots, stroke, and arrhythmias. Therefore, consult your doctor for advice.

Use In Pediatrics

Use with Caution

CONTRAPAQUE 350MG INFUSION should be used with caution in children (aged below 18 years) specifically in infants as a precaution. Therefore, consult your doctor for advice. Make sure your child drinks plenty of water or fluids before and after examination.

Use In Geriatrics

Use with Caution

CONTRAPAQUE 350MG INFUSION should be used with extreme caution in elderly patients (aged 65 years or above). Therefore, inform your doctor if you have any pre-existing disease conditions.

Others

CONTRAPAQUE 350MG INFUSION should not be used if you:

Have severe thyroid problems

Before receiving CONTRAPAQUE 350MG INFUSION, inform your doctor if you:

Have any thyroid problems
Have ever had any allergies
Have diabetes
Have any brain disease (such as brain tumours, swelling or inflammation of the brain, problems in blood vessels supplying the brain, including blood clot or bleeding)
Have ‘myasthenia gravis’ (a condition causing severe muscle weakness)
Have phaeochromocytoma
Have homocystinuria (a condition with increased excretion of the amino acid cysteine in urine)
Have any problems with your blood or bone marrow
Have a disease of immune system
Have ever had alcohol dependence or addiction to any drugs
Have epilepsy
Have a thyroid function test in the next few weeks
Have pulmonary hypertension
Have paraproteinaemias (the presence of excessive amount of an abnormal protein in your blood)
are having any blood or urine test on the same day
have myeloma (cancer of bone marrow)

Interactions

A. Drug-Drug Interactions:

Antidiabetic agents
Cardiac agents (such as betablockers, vasoactive substances, ACE - enzyme inhibitors or angiotensin antagonists
Interleukin-2 or interferons (used for immune system diseases)
Antidepressants

Synopsis

Drug	:	Iohexol
Pharmacological Category	:	Radio-Contrast Agent
Therapeutic Indication	:	Diagnostic agent
Dosage Forms	:	Injection, Infusion

More Information

Storage

Keep CONTRAPAQUE 350MG INFUSION out of reach of children
Store below 30°C

FAQs About CONTRAPAQUE 350MG INFUSION

Q: What is CONTRAPAQUE 350MG INFUSION used for?

A: CONTRAPAQUE 350MG INFUSION is a radio-contrast agent used for diagnostic purposes only. It helps in diagnosing an illness by taking a clear picture of internal body parts which helps your doctor to tell if there is any abnormality in organ shape and size. It can be used for X-rays of urinary system, spine and blood vessels, including blood vessels supplying the heart, salivary gland, stomach and intestines and for scanning uterus, joints, breasts, ovaries, head and entire body (CAT scan).

Q: How CONTRAPAQUE 350MG INFUSION works?

A: CONTRAPAQUE 350MG INFUSION contains Iohexol which is a contrast agent used in medical imaging to help doctors see blood vessels, organs, and other tissues more clearly during scans like CT or X-rays. It works by absorbing X-rays due to its iodine content, making the areas where it is injected appear white on the scan. This contrast helps to differentiate various structures in the body, aiding in accurate diagnosis.

Q: Is CONTRAPAQUE 350MG INFUSION safe?

A: Iohexol is generally safe, but like all medical procedures, it can have side effects. Most are mild, like nausea or a warm sensation. Serious allergic reactions are rare but possible.

Q: What are the common side effects of taking CONTRAPAQUE 350MG INFUSION?

A: The most common side effects of receiving CONTRAPAQUE 350MG INFUSION are feeling hot or flushed, shortness of breath, respiratory problems, headache, nausea, vomiting, diarrhea, dizziness, Inflammation of pancreas and pain around stomach, Increased/abnormal sweating and feeling cold. Consult your doctor if any of these side effect troubles you.

Q: Can CONTRAPAQUE 350MG INFUSION be used during pregnancy?

A: CONTRAPAQUE 350MG INFUSION should be used in pregnancy only if the potential benefits outweigh the risks of iohexol injection. Therefore, inform your doctor before receiving CONTRAPAQUE 350MG INFUSION if you are pregnant or think you may be pregnant.

Q: What precautions must be taken before receiving CONTRAPAQUE 350MG INFUSION?

A: Make sure to drink plenty of fluids before and after receiving CONTRAPAQUE 350MG INFUSION, especially if you have diabetes, myeloma, kidney problems, aged above 65 years or have generally poor health conditions. Before receiving CONTRAPAQUE 350MG INFUSION inform your doctor if you have liver, kidney or heart problems. You must also inform your doctor if you are pregnant or breastfeeding or having diabetes, epilepsy, thyroid problems, cancers of bone marrow, muscle weakness, brain problems, etc as a precaution. Inform your doctor immediately if you experience any allergic reactions after receiving CONTRAPAQUE 350MG INFUSION.

Q: Which medicines should be avoided while taking CONTRAPAQUE 350MG INFUSION?

A: Before receiving CONTRAPAQUE 350MG INFUSION inform your doctor if you are taking any antidiabetic agents, heart medicines, (such as betablockers, vasoactive substances, ACE - enzyme inhibitors or angiotensin antagonists), Interleukins and interferons (used for immune system diseases) and antidepressants as a precaution.

Q: Can I take CONTRAPAQUE 350MG INFUSION when I have thyroid problems?

A: Before receiving CONTRAPAQUE 350MG INFUSION inform your doctor if you have any thyroid problems. CONTRAPAQUE 350MG INFUSION should not be used in patients with severe thyroid problems.

Q: Can I take CONTRAPAQUE 350MG INFUSION when I have cancer?

A: Before receiving CONTRAPAQUE 350MG INFUSION inform your doctor if you have cancers of bone marrow as a precaution, as your doctor will monitor your health condition more closely.

References

1. Goodman and Gilman’s: The Pharmacological Basics of Therapeutics. 12th Edition. Thyroid and Anti-thyroid Drugs. Page-1153.

2. Iohexol. ScienceDirect. Clinical Biochemistry. 2013. [Accessed on 2nd September 2024] https://www.sciencedirect.com/topics/medicine-and-dentistry/iohexol

3. Omnipaque 140 mg I/ml solution for injection. GE Healthcare Limited. EMC.UK [Revised in March 2024]. [Accessed on 2nd September 2024] https://www.hpra.ie/img/uploaded/swedocuments/92f98b2a-368a-4753-a4a9-6805045a3113.pdf

4. OMNIPAQUE injection 140 and 350 mg iodine/mL. U.S. Food and Drug Administration (USFDA). [Revised in April 2023]. [Accessed on 2nd September 2024] https://www.gehealthcare.com/-/jssmedia/8a5df56afa4f4ea78352d110b227e956.pdf

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. M N Himaja - MBBS

Last updated on 04 Sep 2024 | 10:40 AM(IST)