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Introduction About LOX 2% JELLY

LOX 2% Jelly is a topical anesthetic gel containing Lidocaine (Lignocaine) 2% as its active ingredient. It is commonly used by healthcare professionals to numb skin and mucous membranes, helping to reduce discomfort during minor surgical, dental and diagnostic procedures. LOX 2% Jelly provides fast-acting numbness at the site of application. Its smooth gel formula ensures easy and precise application, making it a preferred choice for both healthcare professionals and patients needing localized pain relief.

The primary use of LOX 2% Jelly is to numb the skin or mucous membranes, helping to ease pain and discomfort associated with procedures such as suturing, catheter insertion, endoscopy, dental work and minor surgeries. It is also indicated for managing pain from skin irritation, burns, scratches, insect bites, abrasions and sunburn. Additionally, it may be used for conditions like hemorrhoids, anal fissures, and to support pain management in urethritis or during endotracheal intubation. LOX 2% Jelly contains Lignocaine (Lidocaine) 2%, which works by blocking nerve signals to prevent the transmission of pain sensations, providing targeted relief within 3–5 minutes of application.

Precautions include washing hands before and after use, avoiding application to broken or infected skin, and not allowing the jelly to come into contact with eyes, nose, or mouth. Important warnings include not using more than recommended, seeking medical advice if side effects persist, and consulting a doctor before use if you have underlying health conditions or are taking other medications. LOX 2% Jelly is generally not recommended for children unless specifically directed by a healthcare provider, as safety and effectiveness have not been established in this age group

For pregnant or breastfeeding women, LOX 2% Jelly should only be used if clearly needed and under medical supervision. Common side effects may include mild burning, itching, redness, or irritation at the application site, which usually resolve on their own. However, persistent or severe reactions should be reported to a healthcare professional immediately.

Uses Of LOX 2% JELLY

Numbs skin or mucous membranes for pain relief
Used before minor surgeries and dental procedures
Reduces discomfort during catheterization and endoscopy
Relieves pain, itching and burning from skin irritation, burns, rashes, bites and eczema
Helps manage pain from hemorrhoids, anal fissures or vaginal/rectal irritation

Benefits of LOX 2% JELLY

Reduces Pain and Discomfort in Medical Procedures

LOX 2% Jelly is formulated to help minimize pain and discomfort experienced during various medical procedures. Its active ingredient, lidocaine, works quickly to block nerve signals in the area where it is applied, allowing patients to feel less pain and discomfort. This makes it a trusted option for both healthcare providers and patients seeking relief before and during minor medical interventions.

Fast-Acting Relief for Skin Irritation and Minor Injuries

For those dealing with skin irritation, minor burns, scratches, or insect bites, LOX 2% Jelly offers rapid relief. Its fast-acting formula helps to numb the affected area, reducing sensations of pain, itching, and burning almost immediately after application. This makes it a practical choice for managing everyday skin discomforts at home or in clinical settings.

Supports Comfort During Catheterization and Endoscopy

LOX 2% Jelly is often used to enhance patient comfort during sensitive procedures such as catheter insertion and endoscopy. By numbing the area beforehand, it helps reduce the discomfort associated with these medical interventions, making the process smoother and more comfortable for patients.

Provides Temporary Numbing for Hemorrhoids and Anal Fissures

Individuals suffering from hemorrhoids or anal fissures can benefit from the temporary numbing effect of LOX 2% Jelly. Its gentle application helps to relieve pain and discomfort in these sensitive areas, providing much-needed relief and supporting overall comfort during recovery.

Promotes Patient Comfort During Dental and Minor Surgical Procedures

Dentists and surgeons frequently use LOX 2% Jelly to promote patient comfort before dental work or minor surgeries. By numbing the specific area where the procedure will take place, it helps patients feel more at ease, reducing anxiety and discomfort throughout the process.

Easy-to-Apply Smooth Gel Formula

LOX 2% Jelly features a smooth, non-greasy gel formula that is easy to apply and absorbs quickly. Its consistency ensures precise application to the affected area, making it a convenient choice for both healthcare professionals and individuals managing minor discomfort at home.

How LOX 2% JELLY Works

How LOX 2% Jelly Numbs the Skin and Mucous Membranes

LOX 2% Jelly works temporarily numbing the area where it is applied. When spread over the skin or mucous membranes, it penetrates the surface and interacts with local nerve endings. The lidocaine molecules block the nerve signals responsible for transmitting pain, resulting in a localized loss of sensation and reduced discomfort

Understanding Nerve Signal Blockade by LOX 2% Jelly

The key to LOX 2% Jelly’s action lies in its ability to block nerve signals at the site of application. Lidocaine, the active component, binds to sodium channels in the nerve cell membranes. This binding prevents sodium ions from entering the nerve cells, which is essential for the initiation and propagation of nerve impulses. As a result, pain signals are unable to travel to the brain, and the applied area feels numb

Preventing Pain Transmission with LOX 2% Jelly

By stabilizing the neuronal membrane and inhibiting the ionic fluxes necessary for nerve impulse generation, LOX 2% Jelly prevents pain signals from being transmitted. This means that sensations of pain, itching, or burning are not relayed to the brain, providing effective and targeted relief for the use

Fast-Acting Effect of LOX 2% Jelly

LOX 2% Jelly is known for its rapid onset of action. Typically, the numbing effect begins within 3 to 5 minutes after application, making it a practical choice for quick pain relief during medical procedures or for managing minor skin discomfort. Its fast-acting nature is due to lidocaine’s ability to quickly reach and block nerve endings at the site of application.

How to use LOX 2% JELLY

How to Use LOX 2% Jelly: Step-by-Step Guide

Wash your hands thoroughly before application.
Clean and dry the area where you plan to apply the jelly.
Apply a thin layer of LOX 2% Jelly to the affected area using a clean fingertip or applicator.
Gently rub the jelly into the skin until fully absorbed.
Wash your hands after application, unless your hands are the area being treated.
Use only as directed by your doctor or healthcare provider.

Recommended Dosage and Frequency for LOX 2% Jelly

Apply LOX 2% Jelly to the affected area up to 3–4 times daily, or as advised by your doctor.
Use only the amount recommended for your specific condition.
Do not apply more frequently or in larger amounts than prescribed.
Consult your doctor if you do not experience relief after 2–4 weeks of use.

Where and How to Apply LOX 2% Jelly

Apply directly to clean, dry, intact skin or mucous membranes, as directed by your doctor.
Common application sites include the anus, vagina, skin around wounds, mouth, throat, or nose (for medical procedures like catheterization or endoscopy).
Do not apply to broken, infected, or irritated skin unless instructed by a healthcare professional.
Avoid application to the face, eyes, eyelids, mouth, or nose unless specifically directed.

Important Directions for Safe Application

Use LOX 2% Jelly externally only.
Do not cover the treated area with airtight dressings (like bandages) unless advised by your doctor.
If the jelly accidentally comes into contact with your eyes, rinse immediately with plenty of water.
Discard any unused portion after initial use if required by your healthcare provider.

What if I forgot to take LOX 2% JELLY

If you miss a scheduled application, use LOX 2% Jelly as soon as you remember.
If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
Do not double the dose to make up for a missed application.
If unsure, consult your doctor or healthcare provider for guidance.

Overdose

Overusing LOX 2% Jelly or applying more than recommended can increase the risk of side effects.
Signs of overdose may include dizziness, drowsiness, numbness or tingling elsewhere in the body, blurred vision, or difficulty breathing.
If you suspect an overdose or experience unusual symptoms, stop using the jelly immediately.
Rinse the area with water if possible and seek medical attention right away.
Store LOX 2% Jelly out of reach of children to prevent accidental ingestion.
Always use LOX 2% Jelly as directed by your doctor or healthcare provider.

Side Effects Of LOX 2% JELLY

The most common side effects of LOX 2% Jelly include:

Redness, rash, burning and itching at the site of application
Mild irritation or discomfort in the area where the gel is applied.
Swelling or flushing of the skin at the application site

When to Seek Medical Attention?

If you experience any of the following serious side effects while using LOX 2% Jelly, seek medical attention immediately:

Severe skin reactions: Such as intense burning, blistering, or peeling of the skin at the application site
Unusual numbness or tingling in areas beyond the application site.

Warning & Precautions

Pregnancy

Consult your doctor

LOX 2% Jelly is generally considered safe during pregnancy. Animal studies show minimal risks to fetal development, but human data is limited. Use only under medical supervision

Breastfeeding

Consult your doctor

Lidocaine in LOX 2% Jelly is likely safe while breastfeeding. Only trace amounts may pass into breast milk, posing negligible risk to the infant. Wash hands after application and avoid contact with breasts/nipples

Driving and Using Machines

Use with Caution

No significant impairment is expected when used as directed. However, avoid driving if experiencing side effects like dizziness, drowsiness, or blurred vision

Liver

Use with Caution

Use with caution in liver disease (e.g., cirrhosis). Impaired metabolism may increase systemic absorption and toxicity risk. Monitor for symptoms like dizziness or confusion

Allergy

Contraindicated

Do not use LOX 2% Jelly if you are allergic to Lignocaine or any other ingredients of this medicine.

Heart Disease

Use with Caution

LOX 2% Jelly should be used with caution in patients with bradycardia or impaired cardiovascular function and severe shock or heart rhythm disorders.

Use In Pediatrics

Contraindicated

LOX 2% Jelly is not recommended for children. Safety and efficacy are unestablished in this age group

Use In Geriatrics

Use with Caution

LOX 2% Jelly should be used with caution in patients aged above 65 years. Higher susceptibility to side effects like dizziness or confusion requires dosage adjustments

Who should not take [GBNKEYWORD

Individuals with a history of methemoglobinemia (a blood disorder that reduces oxygen delivery to tissues) should not use LOX 2% Jelly unless specifically advised by a healthcare provider

Safety Advice

Avoid contact with eyes, nose, or mouth. If accidental contact occurs, rinse thoroughly with water immediately
Do not apply to open wounds, cuts, broken, infected, or severely traumatized skin or mucous membranes unless specifically directed by your doctor
Do not use on large areas of skin or for prolonged periods unless advised by a healthcare professional
Do not use airtight dressings (like bandages) over the treated area unless instructed by your doctor, as this may increase the risk of side effects

1. LOX 2% Jelly vs. Benzocaine Gel for Pain Relief

Aspect	LOX 2% Jelly	Benzocaine Gel
Active Ingredient	Lidocaine 2%	Benzocaine (varies, typically 10–20%)
Mechanism of Action	Blocks sodium channels to prevent nerve signals	Numbs the area by blocking nerve signals
Onset of Action	2–5 minutes	1–3 minutes
Duration of Relief	~20–30 minutes	~15–20 minutes
Common Use Cases	Minor procedures, dental anesthesia, wounds	Oral ulcers, sore gums, minor mouth pain
Effectiveness	Stronger and longer-lasting for deep numbing	Mild numbing, mainly surface-level pain
Prescription	Often requires prescription	Often available OTC

2. Which works faster—LOX 2% Jelly or clove gel?

Aspect	LOX 2% Jelly	Clove Gel
Active Ingredient	Lidocaine 2%	Eugenol (from clove oil)
Onset of Action	2–5 minutes	5–10 minutes
Duration of Relief	~20–30 minutes	~15–30 minutes
Potency	Medical-grade anesthetic	Natural numbing, less potent
Use in Dentistry	Common for procedures like scaling	Used traditionally for toothache relief

3. Is LOX 2% Jelly more effective than herbal gels for minor surgery?

Aspect	LOX 2% Jelly	Herbal Gels
Active Ingredient	Lidocaine 2%	Plant-based (e.g., aloe vera, clove, turmeric)
Purpose	Local anesthetic for surgical/nonsurgical use	Soothing, mild anti-inflammatory effects
Effectiveness	Clinically proven for pain and anesthesia	Variable; typically not strong enough
Use in Minor Surgery	Widely used in medical/dental settings	Rarely used; not reliable for anesthesia
Onset & Duration	Quick onset, reliable numbing for ~30 minutes	Slower onset, limited duration

Drug - Drug interaction

LOX 2% Jelly a local anesthetic that can interact with several medications. These interactions may affect how the drug works or increase the risk of side effects, especially if lidocaine is absorbed systemically.

1. Tramadol

Interaction: Increases risk of central nervous system (CNS) depression (drowsiness, dizziness) or seizures.
Management: Avoid concurrent use if possible. If both are needed, monitor closely for neurological symptoms.

2. Sodium Nitrate or Prilocaine

Interaction: Increases risk of methemoglobinemia (a condition where blood can’t carry oxygen efficiently).
Management: Avoid combining these drugs. Use alternative anesthetics if possible.

3. Antiarrhythmic Drugs (e.g., Amiodarone)

Interaction: Additive effects on heart rhythm, increasing risk of bradycardia or arrhythmias.
Management: Use with extreme caution. Monitor heart function (ECG, vital signs) closely.

Drug - Food interaction

Eating or Drinking After Oral/Throat Application

Interaction: If LOX 2% Jelly is applied in the mouth or throat, numbness can make swallowing difficult and increase the risk of choking, especially with hot foods or drinks
Management: Avoid eating, drinking or chewing gum for at least 1 hour after application to these areas, or until normal sensation returns

FAQs About LOX 2% JELLY

Q: What is LOX 2% Jelly used for?

A: LOX 2% Jelly is a local anesthetic used to numb skin or mucous membranes and reduce pain or discomfort from minor cuts, burns, insect bites, skin abrasions, and medical procedures. It is also used for pain relief in conditions like hemorrhoids, anal fissures, and post-herpetic neuralgia.

Q: Is LOX 2% Jelly good for dental procedures?

A: Yes, LOX 2% Jelly is used to numb oral tissues before dental injections or minor procedures. It helps reduce pain and discomfort during needle insertions or other manipulations. While it may not be as effective as higher concentration topical anesthetics in some cases, it is widely used and generally well-tolerated.

Q: Can LOX 2% Jelly be used for catheterization?

A: Yes, LOX 2% Jelly is commonly used to numb the urethra before catheter insertion, making the procedure less painful. It is applied topically to the area to provide local anesthesia and reduce discomfort during catheterization.

Q: Does LOX 2% Jelly prevent nerve impulses?

A: Yes, LOX 2% Jelly contains lidocaine, which blocks sodium channels in nerve membranes. This prevents the initiation and conduction of nerve impulses, resulting in local numbness and pain relief.

Q: How quickly does LOX 2% Jelly work?

A: LOX 2% Jelly typically starts working within 3–5 minutes after application, providing local numbness and pain relief. The onset of action is fast, making it suitable for use before medical or dental procedures.

Q: Why is LOX 2% Jelly used before medical procedures?

A: LOX 2% Jelly is used before medical procedures to numb the skin or mucous membranes, reducing pain and discomfort. It allows patients to tolerate procedures like catheterization, endoscopy, or minor surgeries more comfortably.

Q: How does LOX 2% Jelly reduce pain and discomfort?

A: LOX 2% Jelly contains lidocaine, which blocks pain signals by inhibiting sodium channels in nerve cells. This prevents the transmission of pain impulses to the brain, resulting in temporary numbness and pain relief in the treated area.

Q: How much LOX 2% Jelly should I apply?

A: Apply a thin layer of LOX 2% Jelly to the affected area using a clean applicator or gloved finger. The exact amount depends on the procedure and the area to be numbed—always follow your healthcare provider’s instructions.

Q: Can I use LOX 2% Jelly on broken skin?

A: Generally, LOX 2% Jelly should not be applied to broken, infected, or severely traumatized skin unless specifically directed by a doctor, as this may increase the risk of systemic absorption and side effects.

Q: Is LOX 2% Jelly safe for sensitive areas?

A: LOX 2% Jelly is considered safe for sensitive areas such as mucous membranes (mouth, urethra, rectum) when used as directed by a healthcare professional. However, avoid contact with eyes and follow instructions carefully.

Q: How to apply LOX 2% Jelly for hemorrhoids?

A: For hemorrhoids, apply a thin layer of LOX 2% Jelly to the affected area using a clean applicator or gloved finger. Rub gently until absorbed. Do not insert deep into the anal canal unless advised by your doctor.

Q: Can LOX 2% Jelly be used for insect bites?

A: Yes, LOX 2% Jelly can be used to relieve pain and itching from minor insect bites. Apply a thin layer to the affected area as needed. If you experience severe swelling, redness, or signs of infection, consult your doctor. Avoid using the jelly on large or multiple bites unless advised by your healthcare provider. Use only as directed for best results.

References

1. KD. Tripathi. Drugs acting on peripheral (somatic) nervous system. Essentials of medical pharmacology. 8th Edition. 2019. Page – 392.

2. Sandy M Hopper, Franz E Babl, Michelle McCarthy, Chasari Tancharoen, Katherine J Lee and Ed Oakley. A double blind, randomised placebo-controlled trial of topical 2% viscous lidocaine in improving oral intake in children with painful infectious mouth conditions. BMC Paediatrics. November 2011. [Accessed on 19th June 2025]

3. Akron. Lidocaine Hydrochloride Oral Topical Solution, USP (Viscous) 2%. Dailymed.com. [Revised in July 2022]. [Accessed on 19th June 2025]

4. Lannett Company., Inc. Lidocaine Hydrochloride Oral Topical Solution, USP 4%. Dailymed.com. [Revised in November 2019]. [Accessed on 19th June 2025]

5. Pharma science Inc. PRESCRIBING INFORMATION. pms-LIDOCAINE VISCOUS 2% Lidocaine Hydrochloride Oral Topical Solution, USP. [Revised in April 2016]. [Accessed on 19th June 2025]

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Abdul Rahman Danish - MBBS, MD (Anesthesia)

Last updated on 19 Jun 2025 | 02:57 PM(IST)