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Introduction About ZYROVA F10 TABLET
ZYROVA F10 TABLET is used to manage hyperlipidemia in addition to proper diet, exercise, and lifestyle changes. It is a combination of Rosuvastatin and Fenofibrate which belongs to the group of medicines called Anti-lipidemic agents. It helps to reduce the levels of bad cholesterol (VLDL and LDL) and triglycerides in the body by modulating the actions of certain enzymes that are involved in lipid metabolism. By reducing lipid levels in the blood, ZYROVA F10 TABLET can also be used to manage the risk of heart attack, stroke, atherosclerosis and other circulatory disorders.
Along with the management, follow the diet, exercise and lifestyle changes instructed by your doctor to achieve better results. Avoid drinking large amount of alcohol while taking ZYROVA F10 TABLET. If you are diabetic, work on the blood sugar levels and keep them under control. Before taking ZYROVA F10 TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have thyroid problems, diabetes, high blood pressure or a family history of muscle disorders. ZYROVA F10 TABLET is not recommended for use in patients with severe liver or kidney problems. It is also not suitable for use in patients with severe repetitive unexplained muscle pain or in patients who had recently taken an antibiotic called Fusidic acid to manage bacterial infections.
Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with ZYROVA F10 TABLET. During management with the medicine, your doctor will periodically monitor liver functions, kidney functions, blood sugar levels, muscle functions and blood cholesterol levels to avoid the risk of unwanted side effects. The most common side effects are headache, constipation, bloating, muscle pain and liver problems. You must also inform your doctor if you experience severe unexplained muscle pain or weakness with fever, weakness or reddish-brown urine after taking the medicine.
Uses Of ZYROVA F10 TABLET
It is used to manage:
- hyperlipidemia (high blood lipid levels)
- heart attack, stroke or atherosclerosis
How ZYROVA F10 TABLET Works
ZYROVA F10 TABLET is a combination of Fenofibrate and Rosuvastatin which helps to reduces the levels of bad cholesterol (VLDL and LDL) and triglycerides in the body by modulating the actions of certain enzymes that are involved in lipid metabolism (such as HMG-CoA reductase and lipoprotein lipase). Additionally, it can also reduce the amount of cholesterol absorbed in the body. By lowering the blood lipid levels, it helps to manage fat deposition within the blood vessels and reduces the chances of heart attack, stroke, atherosclerosis or other circulatory problems.
How to use ZYROVA F10 TABLET
- Take the medicine as directed by the physician
- It is taken preferably after meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine
- Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
- Do not stop taking ZYROVA F10 TABLET without consulting the doctor
Side Effects Of ZYROVA F10 TABLET
Common side effects of ZYROVA F10 TABLET:
- headache
- dizziness
- stomach pain, constipation, nausea, diarrhea, flatulence
- muscle pain
- weakness
- increased blood sugar levels
- skin redness and itching
Stop taking ZYROVA F10 TABLET and consult your doctor immediately if you experience any of the following side effects:
- severe allergic skin reactions (skin rash, itching, skin redness with blisters or peeling of the skin, swelling in the mouth, which may be associated with high fever and joint pains)
- unexplained muscle pain or weakness, especially if accompanied by fever, weakness or reddish-brown urine
- lupus-like disease syndrome characterized by rash, muscle pain, joint disorders, pain and swelling
- severe stomach pain due to inflammation of pancreas
- signs of blood clots in the body (chest pain, shortness of breath, pain, redness and swelling in the legs)
Warning & Precautions
Pregnancy
ContraindicatedZYROVA F10 TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Women of childbearing potential must use a suitable contraception to avoid pregnancy while undergoing therapy with this medicine.
Breastfeeding
ContraindicatedZYROVA F10 TABLET is not recommended for use in breast-feeding women.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected by this medicine.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking ZYROVA F10 TABLET as it may reduce the effectiveness of this medicine.
Kidney
Consult your doctorZYROVA F10 TABLET is not recommended for use in patients with moderate to severe kidney problems. It should be used with caution in patients with other mild kidney problems.
Liver
Consult your doctorZYROVA F10 TABLET is not recommended for use in patients with severe liver or gall bladder problems. It should be used with caution in patients with other liver problems.
Allergy
ContraindicatedDo not take ZYROVA F10 TABLET if you are allergic to Rosuvastatin or Fenofibrate or any other ingredients of this medicine.
Lungs
Use with CautionZYROVA F10 TABLET should be used with caution in patients with respiratory failure. It should be used with caution in patients with respiratory diseases.
Use In Pediatrics
ContraindicatedZYROVA F10 TABLET is not recommended for use in children and adolescents (aged below 18 years).
Use In Geriatrics
Use with CautionZYROVA F10 TABLET should be used with caution in elderly patients.
Others
It is not recommended for use if you:
- have repeated or unexplainable muscle cramps or pain
- have inflammation of the pancreas
- have problems in thyroid gland (underactive thyroid)
- have a family history of muscular disorder
- previously had any muscle problems while taking similar type of lipid-lowering medicines
Before taking ZYROVA F10 TABLET, inform your doctor if you:
- have diabetes (type I or type II)
- are obese
- have high blood pressure
- have blood problems
Interactions
A. Drug-Drug Interactions:
Before taking ZYROVA F10 TABLET inform to your doctor if you are taking any of the following medicines such as:
- Antibiotics (Ex. actinomycin, regorafenib, erythromycin, fusidic acid)
- Immunosuppressants (Ex. cyclosporin)
- Anticoagulants (Ex. warfarin, acenocoumarol, clopidogrel)
- Anti-viral agents (Ex. lamivudine, stavudine, ritonavir, dasabuvir, sofosbuvir, velpatasvir, voxilaprevir, lopinavir, atazanavir)
- Estrogen hormone (Ex. ethinylestradiol)
- Anti-diabetics (Ex. rosiglitazone, pioglitazone)
- Bile acid sequestrants (Ex. cholestyramine, colesevelam)
- Anti-arrhythmic agents (Ex. amiodarone)
- Antifungals (Ex. nystatin, amphotericin, ketoconazole)
- Anticonvulsants (Ex. carbamazepine, phenobarbital, phenytoin, primidone)
- Antidepressants (Ex. amitriptyline, amoxapine)
- Anti-gout agents (Ex. colchicine)
- Antacids (Ex. aluminium hydroxide)
B. Drug- Food Interactions:
Avoid drinking grapefruit juice while taking ZYROVA F10 TABLET as it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally took more ZYROVA F10 TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Rosuvastatin, Fenofibrate |
| Pharmacological Category | : | HMG-CoA reductase inhibitors, Lipoprotein Lipase Activators |
| Therapeutic Indication | : | Manage hyperlipidemia, Heart attack, stroke or atherosclerosis |
| Dosage Forms | : | Tablet, Capsule |
More Information
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FAQs About ZYROVA F10 TABLET
Q: What are the uses of ZYROVA F10 TABLET?
A: ZYROVA F10 TABLET is used to control elevated blood cholesterol levels in addition to proper diet, exercise and lifestyle changes. By reducing lipid levels in the blood, ZYROVA F10 TABLET can also be used to manage the risk of heart attack, stroke, atherosclerosis and other circulatory disorders.
Q: Can the use of ZYROVA F10 TABLET cause diabetes?
A: ZYROVA F10 TABLET may increase the blood sugar levels in some patients. This is most predominantly seen in patients who already have diabetes along with obesity and/or hypertension.
Q: What is the best time to take ZYROVA F10 TABLET?
A: Take as advised by your physician. Your doctor will decide the best time for you to take ZYROVA F10 TABLET.
Q: What are the side effects of taking ZYROVA F10 TABLET?
A: The most common side effects are pain in joints and muscles, gastrointestinal problems such as constipation, diarrhoea, indigestion or nausea and headache.
Q: Can I consume alcohol along with ZYROVA F10 TABLET?
A: It is advisable to avoid alcohol consumption while taking ZYROVA F10 TABLET to achieve maximum benefits.
Q: Can the use of ZYROVA F10 TABLET make me feel more tired?
A: Yes. The use of ZYROVA F10 TABLET can make you feel more tired, because it acts by reducing the supply of energy to the muscles present in the body. However, you may also feel tired due to other reasons such as severe liver damage. Consult your doctor if you experience excessive tiredness with muscle pain.
Q: Who should not take ZYROVA F10 TABLET?
A: It is not recommended for use in patients with severe liver or kidney problems. It is also not suitable for use in patients having muscle problems. If you are pregnant or breastfeeding consult your doctor before taking ZYROVA F10 TABLET. Before taking the medicine, inform your doctor if you have diabetes or any heart problems. Do not take this medicine if you are undergoing therapy with antibiotics such as fusidic acid.
Q: What are the dietary restrictions that I need to follow while taking ZYROVA F10 TABLET?
A: While taking ZYROVA F10 TABLET, follow a low-cholesterol diet as instructed by your doctor and avoid excessive alcohol intake. Avoid eating oil rich or deep-fried foods. Limit your sugar intake by avoid eating biscuits, cakes, soft drinks or pastries. Stick to a simple nutritious diet.
Q: What should I do if I forget to take a dose of ZYROVA F10 TABLET?
A: If you forget to take a dose, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of ZYROVA F10 TABLET to compensate the missed dose.
Q: Can I stop taking ZYROVA F10 TABLET once my blood cholesterol level is controlled?
A: Do not stop taking this medicine without consulting your doctor, as it could once again increase your blood cholesterol levels. It can only control your blood cholesterol levels and cannot manage them completely, therefore, it is important to take this medicine until your doctor advises you to stop.
Q: Can I take ZYROVA F10 TABLET if I am diabetic?
A: ZYROVA F10 TABLET may increase blood sugar levels in some patients. This is most predominantly seen in patients who already have diabetes along with obesity and/or hypertension.
Q: Does ZYROVA F10 TABLET cause muscle pain?
A: ZYROVA F10 TABLET may cause a rare but serious side effect of unexplained muscle pain or weakness called rhabdomyolysis. It might be an early sign of a potentially serious muscle degradation. Also, talk to your doctor before taking ZYROVA F10 TABLET if you already have weak muscles or have a family history of any muscle disorders.
Q: How long should I take ZYROVA F10 TABLET to manage high cholesterol?
A: You should take ZYROVA F10 TABLET as long as your doctor advises you to take. Because ZYROVA F10 TABLET will only help you in managing your cholesterol levels and cannot completely manage them. If you stop using this medicine, your cholesterol levels may raise once again.
Q: Can ZYROVA F10 TABLET be taken by pregnant or breast-feeding women?
A: It is not recommended for use in pregnant or breast-feeding women. Women of childbearing age must use a reliable contraceptive method to avoid pregnancy while undergoing therapy with this medicine. However, if you accidentally become pregnant while taking this medicine, stop taking it and consult your doctor immediately.
References
1. KD. Tripathi. Hypolipidemic Drugs and Plasma Expanders. Essentials of medical pharmacology. Seventh edition. Page- 637 & 639.
2. Gursharan Sidhu; Jayson Tripp. Fenofibrate. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. March 2022. [Accessed on 13th October 2022] click here
3. Paul N Durrington, Jaakko Tuomilehto, Andreas Hamann, David Kallend, Karen Smith. Rosuvastatin and fenofibrate alone and in combination in type 2 diabetes patients with combined hyperlipidaemia. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. May 2004. [Accessed on 13th October 2022] click here
4. Zentiva K.S. Electronic Medicines Compendium (EMC). [Revised in June 2022] [Accessed on 13th October 2022] click here
5. Genus Pharmaceuticals. Electronic Medicines Compendium (EMC). [Revised in October 2020] [Accessed on 13th October 2022] click here
6. Accord. Electronic Medicines Compendium (EMC). [Revised in April 2021] [Accessed on 13th October 2022] click here
7. Cipla Ltd. ROSULIP-F Tablets (Rosuvastatin + Fenofibrate). Ciplamed.com. [Revised in December 2015] [Accessed on 13th October 2022] click here
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