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Introduction About ZPAC 260MG INJECTION
ZPAC 260MG INJECTION contains Paclitaxel which belongs to a group of anti-cancer medicines called Taxanes. ZPAC 260MG INJECTION is used to manage ovarian and breast cancer as a first line of therapy and as a second line of management when platinum containing medicines (such as cisplatin) or anthracyclines are insufficient to manage the disease in affected individuals.
ZPAC 260MG INJECTION is also used to manage advanced NSCLC (non-small cell lung cancer) when surgery/radiation therapy is not suitable. The medicine is also indicated for use to manage AIDS-related Kaposi’s sarcoma when other managements (such as anthracyclines) are insufficient to manage the disease in affected individuals.
ZPAC 260MG INJECTION is not recommended for use in patients allergic to paclitaxel and polyoxyethylated castor oil. It is also not recommended for use in patients with few white blood cells count and serious & uncontrolled infection. The medicine is also not used in patients suffering from severe liver disease.
Before receiving ZPAC 260MG INJECTION, inform your doctor if you had previously received radiation to your chest and/or suffering from thrombocytopenia (low platelet count)/acute infections (such as herpes zoster, chickenpox, herpes), kidney problems (such as chronic kidney disease), liver problems (such as mild/moderate hepatic impairment) and/or heart problems (such as severe coronary artery disease, myocardial infarction and arrhythmias).
ZPAC 260MG INJECTION is not recommended for use during pregnancy. Women of child-bearing potential should use effective contraception method while receiving ZPAC 260MG INJECTION which should be continued for next-6 months after completing the management. The medicine is also not recommended for use in breastfeeding women.
ZPAC 260MG INJECTION is also not recommended for use in children and adolescents (aged below 18 years). The medicine can be used with caution in elderly patients (aged above 65 years) after consulting the doctor.
The most common side effects of receiving ZPAC 260MG INJECTION are minor allergic reactions (such as flushing, rash, itching), shortness of breath, sore throat/mouth ulcers, diarrhea, nausea, vomiting and/or loss of hair. Consult your doctor if any of these symptoms worsen.
Uses Of ZPAC 260MG INJECTION
- Manage ovarian and breast cancer.
- Manage advanced NSCLC (non-small cell lung cancer)
- Manage AIDS-related Kaposi’s sarcoma in affected individuals.
How ZPAC 260MG INJECTION Works
ZPAC 260MG INJECTION works by interfering with the microtubule structures in the cell (substance which aids cancer cells to divide and multiply) thus inhibiting the growth of cancer cells and managing its spread in affected individuals.
How to use ZPAC 260MG INJECTION
ZPAC 260MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of ZPAC 260MG INJECTION
Common
- minor allergic reactions such as flushing, rash and/or itching
- infections such as upper respiratory infection, urinary tract infection
- shortness of breath
- sore throat/mouth ulcers, sore and red mouth
- diarrhea, nausea, vomiting
- loss of hair
- pain in the muscles, cramps, joints
- fever, severe chills, headache, dizziness, tiredness, looking pale
- bleeding, bruising more easily than normal
- signs of peripheral neuropathy such as numbness, tingling/weakness in arms and legs
- temporary mild nail change and skin changes
- reactions at injection sites such as localized swelling, pain and/or redness of the skin.
Uncommon
- septic shock (severe drop in blood pressure) due to infections
- racing heartbeat, rapid beating of the heart, respiratory distress, heart attack, heart block
- fatigue, sweating, fainting, significant allergic reactions, phlebitis (inflammation of a vein), swelling of the face, lips, mouth, tongue and/or throat
- back pain, chest pain, pain around hands and feet, chills, abdominal pain.
Rare
- febrile neutropenia (type of fever) due to low white blood cell count associated with fever and increased risk of infection
- motor neuropathy (disease that affects your body’s motor nerves)
- pulmonary embolism (blockade of lung artery), lung fibrosis (damaged/scarred lung tissue), interstitial pneumonia (scarring of lung tissue), pleural effusion (build of fluid between lungs and chest)
- bowel obstruction, bowel perforation, inflammation of colon, inflammation of the pancreas (pancreatitis)
- skin redness
- peritonitis (inflammation of abdominal layer)
- fever, dehydration, weakness
- anaphylactic reactions (life threatening allergic reaction).
How To Manage Side Effects
Diarrhea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea. Consult your doctor and inform them if the symptom gets worse.
Nausea and vomiting:
Try to receive ZPAC 260MG INJECTION with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if symptom gets worse.
Headache:
If ZPAC 260MG INJECTION causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving ZPAC 260MG INJECTION. If it lasts more than a week or severe, inform your doctor.
Dizziness:
Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.
Tiredness:
Make sure you take rest and drink plenty of fluids. Avoid or limit the consumption of alcohol. Try to receive ZPAC 260MG INJECTION at a time when you can sit down (or lie down) when the symptoms are at their worst. Avoid driving or using tools or machinery until you feel well.
Warning & Precautions
Pregnancy
ZPAC 260MG INJECTION is generally not recommended for use in pregnant women. Women with child-bearing potential should use effective contraception method while receiving ZPAC 260MG INJECTION which should be continued for next-6 months after completing the> management. Consult your doctor before receiving ZPAC 260MG INJECTION.
Breastfeeding
ZPAC 260MG INJECTION is not recommended for use in breastfeeding women as it is not known whether the medicine pass through breast milk. Consult your doctor before receiving the medicine.
Driving and Using Machines
Do not drive or use heavy machines if you feel dizzy/tired after receiving ZPAC 260MG INJECTION.
Alcohol
Avoid consumption of alcohol while receiving ZPAC 260MG INJECTION since it may cause harmful effects to the patient.
Kidney
ZPAC 260MG INJECTION should be used with caution in patient with chronic kidney disease. Consult your doctor before receiving ZPAC 260MG INJECTION.
Liver
ZPAC 260MG INJECTION is not recommended for use in patients with severe hepatic impairment. It should be used with caution in patients with mild to moderate hepatic impairment. Consult your doctor before receiving the medicine.
Allergy
Do not receive ZPAC 260MG INJECTION if you are allergic to paclitaxel, polyoxyethylated castor oil and/or any other ingredients of this medicine.
Heart Disease
ZPAC 260MG INJECTION should be used with caution in patients with heart conduction problems, severe coronary artery disease, myocardial infarction and arrhythmias. Consult your doctor before receiving the medicine.
Others
ZPAC 260MG INJECTION is not recommended for use if you:
- have too few white blood cells count
- have serious and uncontrolled infection.
Before receiving ZPAC 260MG INJECTION, inform your doctor if you:
- have signs of bone marrow suppression such as fever, sever chills, sore throat and/or mouth ulcers
- had previous radiation to your chest
- have signs of mucositis such as sore/red mouth
- suffer from thrombocytopenia (low platelet count)
- suffer from acute infections (such as herpes zoster, chickenpox, herpes).
Use in Pediatrics:
ZPAC 260MG INJECTION is not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before receiving the medicine.
Use in Geriatrics:
ZPAC 260MG INJECTION should be used with caution in elderly patients (aged above 65 years). Consult your doctor before receiving the medicine.
Interactions
A. Drug - Drug interactions:
Before receiving ZPAC 260MG INJECTION, inform your doctor if you are taking any of the following medicine:
- erythromycin, rifampicin (medicines used to manage infections)
- ketoconazole (used for fungal infections)
- fluoxetine (used to stabilize mood)
- carbamazepine, phenytoin (used to manage seizures/epilepsy)
- gemfibrozil (used to lower blood lipid levels)
- cimetidine (used for heartburn/stomach ulcers)
- ritonavir, saquinavir, indinavir, nelfinavir, efavirenz, nevirapine (used to manage HIV and AIDS)
- clopidogrel (used to manage blood clots)
- verapamil, quinidine (used to manage irregular heart rhythms)
- diazepam (used to manage anxiety, muscle spasm, seizures)
- cyclosporine (used to manage rejection of transplanted organ)
- cisplatin (used for testicular cancer)
- cimetidine (used to manage gastroesophageal reflux disease)
- ranitidine (used for indigestion, gastroesophageal reflux disease and manage stomach ulcers)
- dexamethasone (used for inflammation, severe allergies)
- diphenhydramine (used to manage short term sleep problems).
Overdosage:
ZPAC 260MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Paclitaxel |
| Pharmacological Category | : | Antineoplastic agents |
| Therapeutic Indication | : | Ovarian cancer, Breast cancer, Kaposi sarcoma, Non-small cell lung cancer (NSCLC) |
| Dosage Forms | : | Injection |
More Information
- Keep ZPAC 260MG INJECTION out of reach of children
- Do not store ZPAC 260MG INJECTION above 25°C
FAQs About ZPAC 260MG INJECTION
What is ZPAC 260MG INJECTION used for?
ZPAC 260MG INJECTION is used to manage ovarian and breast cancer as a first line of therapy and as a second line of management when platinum containing medicines (such as cisplatin) or anthracyclines are insufficient to manage the disease. It is also used to manage advanced NSCLC (non-small cell lung cancer) and AIDS-related Kaposi’s sarcoma in affected individuals.
How ZPAC 260MG INJECTION works?
ZPAC 260MG INJECTION works by interfering with the microtubule structures in the cell (substance which aids cancer cells to divide and multiply) thus inhibiting the growth of cancer cells and managing its spread in affected individuals.
What are the most common side effects of receiving ZPAC 260MG INJECTION?
The most common side effects of receiving ZPAC 260MG INJECTION are minor allergic reactions (such as flushing, rash, itching), shortness of breath, sore throat/mouth ulcers, diarrhea, nausea, vomiting and/or loss of hair. Consult your doctor if any of these symptoms worsen.
How to administer ZPAC 260MG INJECTION?
ZPAC 260MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Can ZPAC 260MG INJECTION be used in pregnant women?
No, ZPAC 260MG INJECTION is not recommended for use in pregnant women. Women with child-bearing potential should use effective contraception method while receiving ZPAC 260MG INJECTION which should be continued for next-6 months after completing the management. Consult your doctor before receiving ZPAC 260MG INJECTION.
References
1. KD. Tripathi. Anticancer drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page –865.
2. Maela C. Farrar; Tibb F. Jacobs. Paclitaxel. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. [Revised in May 2022] [Accessed on 7th October 2021] https://www.ncbi.nlm.nih.gov/books/NBK536917
3. Kyohei Kanematsu, Hironori Tsujimoto,∗ Shinsuke Nomura, Hiroyuki Horiguchi, Nozomi Ito, Kenji Yamazaki, Shuichi Hiraki, Suefumi Aosasa, Junji Yamamoto and Kazuo Hase. Weekly paclitaxel therapy for gastric cancer in patients with renal dysfunction: A case report. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in September 2016] [Accessed on 7th October 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021784/
4. Denise A Yardley. Taxanes in the elderly patient with metastatic breast cancer. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in September 2015] [Accessed on 7th October 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567240/
5. Fresenius Kabi India Pvt. Ltd. Paclitaxel. [Accessed on 7th October 2021] https://www.fresenius-kabi.com/in/products/paclitaxel
6. Dr. Reddy's Laboratories Ltd. Mitotax Inj. 250mg. [Accessed on 7th October 2021] https://www.drreddys.com/russia-en/products/product-list/m/mitotax-inj-250-mg/
7. Intas Pharmaceuticals Ltd. CYTAX-200. [Accessed on 7th October 2021] https://www.intaspharma.com/products/
8. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in December 2019] [Accessed on 7th October 2021] https://www.medicines.org.uk/emc/files/pil.6076.pdf
Useful Diagnostic Tests
- Mammogram
- CA-125 blood test
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