ZOONOVAC Vaccine 1's
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Introduction About ZOONOVAC VACCINE
ZOONOVAC VACCINE contains Rabies Virus which belongs to the group of medicines called Vaccines. It is used to manage rabies before exposure to rabies virus (pre-exposure prophylaxis) or after exposure to rabies virus (post-exposure prophylaxis) in all age groups. Rabies is an infection that can be transmitted when a person is bitten, scratched or even just licked by an infected animal.
ZOONOVAC VACCINE is not recommended for use if you have an acute illness with a high fever. ZOONOVAC VACCINE should be used with caution in patients who has history of allergy (such as asthma, hay fever). Consult your doctor before receiving it.
ZOONOVAC VACCINE can be used in pregnant and breast-feeding women who have had or are likely to have contact with the virus and also used for pre-exposure prophylaxis. Consult your doctor before receiving it.
The most common side effects of receiving ZOONOVAC VACCINE are headache, dizziness, rash, hives, general discomfort, fatigue, weakness and fever. Contact your doctor if any of the symptoms worsen.
Uses Of ZOONOVAC VACCINE
- To manage rabies
How ZOONOVAC VACCINE Works
ZOONOVAC VACCINE contains a rabies virus that has been killed, which stimulates the immune system (the body's natural defence system) to form antibodies against rabies viruses. These antibodies protect from infections or diseases caused by the rabies virus.
How to use ZOONOVAC VACCINE
ZOONOVAC VACCINE will be given to you only by a doctor or a nurse into a muscle as an injection into a muscle (usually in the upper arm or in small children, into the muscle of the thigh). Your doctor will decide the correct dose and duration for you depending upon your age, body weight, previous vaccination status and disease condition. Do not administer the medicine into the buttocks, under the skin or into a blood vessel.
Side Effects Of ZOONOVAC VACCINE
Common
- headache, dizziness
- rash, hives
- general discomfort
- fatigue, weakness
- fever
- swollen glands
- decreased appetite
- nausea, vomiting, diarrhoea, stomach pain
- muscle pain, joint pain
- pain, redness, swelling, itching or bruising at the site of injection
- hardness of the skin at the site of injection
Rare
- tingling sensations
- sweating, chills
Stop receiving ZOONOVAC VACCINE and contact your doctor if you experience any of the following side effects:
- signs of anaphylactic reactions (serious allergic reactions) such as shock (severe drop of blood pressure), itching, skin rash, swelling of face and/or neck, breathing difficulties, bluish discoloration of the tongue or lips, low blood pressure, rapid heart rate, weak pulse, skin coldness, dizziness and fainting
How To Manage Side Effects
Headache:
Rest and relax. Drink plenty of fluids such as water or ORS (Oral Rehydrating Solution) and apply a pain-relieving balm on the head if necessary. Contact your doctor if your headache did not improve.
Nausea and vomiting:
Receive ZOONOVAC VACCINE, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting did not improve.
Stomach pain:
Try to have smaller meals but take them frequently. Keep a heating pad on your stomach. Do not self-manage and contact your doctor if the stomach pain did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Contact your doctor if your dizziness did not improve.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Do not take any medicine on your own to manage diarrhoea. Contact your doctor if your diarrhoea did not improve.
Skin rash:
Avoid hot baths because hot water can irritate your skin further. Do not scratch the affected area. Use sunscreen and wear protective clothing while going outside. Use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if the rashes worsen.
Warning & Precautions
Pregnancy
ZOONOVAC VACCINE can be used in pregnant women who have had or are likely to have contact with the virus and also used for pre-exposure prophylaxis (before exposure to rabies virus). Consult your doctor before receiving ZOONOVAC VACCINE.
Breastfeeding
ZOONOVAC VACCINE can be used in breast feeding women who have had or are likely to have contact with the virus and also used for pre-exposure prophylaxis (before exposure to rabies virus). Consult your doctor before receiving ZOONOVAC VACCINE.
Allergy
ZOONOVAC VACCINE is not recommended for use if you are allergic to the rabies vaccine or beta propiolactone or any of the other ingredients of this medicine.
Lungs
ZOONOVAC VACCINE should be used with caution in patients who has a history of allergy (such as asthma). Consult your doctor before receiving ZOONOVAC VACCINE.
Others
ZOONOVAC VACCINE is not recommended for use if you:
- have an acute illness with a high fever that requires management
Before receiving ZOONOVAC VACCINE, inform your doctor if you:
- have history of any other reactions to the vaccine
- have any blood disorders that makes you bruise or bleed easily such as haemophilia or thrombocytopenia
- have poor immunity status
- have/has a severe allergy to egg or egg products or to polygeline, latex
- have/has a severe allergy to the antibiotics like neomycin, chlortetracycline or amphotericin B
- fainted with a previous injection of ZOONOVAC VACCINE
- has a history of allergies (such as hay fever)
Use in Paediatrics
ZOONOVAC VACCINE should be used with caution in children (below 1 year). Consult your doctor before receiving ZOONOVAC VACCINE.
Interactions
A. Drug-Drug Interactions:
Before receiving ZOONOVAC VACCINE, inform your doctor, if you are taking any of the following medicine:
- immunosuppressants (medicines that lower the body’s immune responses) such as corticosteroids Ex. dexamethasone, beclomethasone
Overdosage:
ZOONOVAC VACCINE will be given to you only by a doctor or nurse in a hospital and so it is unlikely to receive an overdose. However, if you experience any unusual symptoms, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Rabies Vaccine |
| Pharmacological Category | : | Vaccine |
| Therapeutic Indication | : | Prevent Rabies |
| Dosage Forms | : | Injection |
More Information
- Keep ZOONOVAC VACCINE out of the sight and reach of children
- Store ZOONOVAC VACCINE in a refrigerator (at 2°C to 8°C)
FAQs About ZOONOVAC VACCINE
Can I take other vaccines with ZOONOVAC VACCINE?
ZOONOVAC VACCINE can be given at the same time as other inactivated vaccines. A different injection site will be used for each type of vaccine. Consult your doctor before receiving ZOONOVAC VACCINE.
Can I receive ZOONOVAC VACCINE with fever?
ZOONOVAC VACCINE is generally not recommended for use in people who are ill, with a high temperature or acute infection, the vaccination will be postponed until you or your child have recovered. Your doctor may still decide to give the vaccine even if this applies to you or your child. This is because rabies is a serious disease.
What side effects are seen with ZOONOVAC VACCINE?
The most common side effects of receiving ZOONOVAC VACCINE are headache, dizziness, rash, hives, general discomfort, fatigue, weakness and fever. Contact your doctor if any of the symptoms worsen.
Who should avoid using ZOONOVAC VACCINE?
ZOONOVAC VACCINE is not recommended for use if you have an acute illness with a high fever that requires management or are allergic to rabies vaccine or beta propiolactone or any of the other ingredients of this medicine. Consult your doctor before receiving ZOONOVAC VACCINE.
How frequent should I receive ZOONOVAC VACCINE?
The pre-exposure immunisation course consists of 3 injections at Day 0, Day 7 and either Day 21 or Day 28. If you are at high risk of exposure to rabies, your doctor will assess the need and plan further booster injections in line with official guidance. Post-exposure prophylaxis should be initiated as early as possible after suspected rabies exposure. Proper wound care must be done immediately or as early as possible after exposure. It must be before administration of rabies vaccine or rabies antibodies. Vaccine should be administered on Day 0, Day 3, Day 7, Day 14 and Day 28 for Post-exposure prophylaxis.
References
1. KD. Tripathi. Vaccines And Sera. Essentials of medical pharmacology. Seventh edition. 2013. Page – 922.
2. Huang G, Liu H, Cao Q, Liu B, Pan H, Fu C. Safety of post-exposure rabies prophylaxis during pregnancy. NIH National Library of Medicine, National Center for Biotechnology Information. January 2013. [Accessed on 13th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667934/
3. Bethesda (MD). Rabies Vaccine. Drugs and Lactation Database (LactMed): National Institute of Child Health and Human Development. June 2020. [Accessed on 13th August 2022] https://www.ncbi.nlm.nih.gov/books/NBK501090/
4. Bavarian Nordic A/S. Electronic Medicines Compendium (EMC). [Revised in February 2021] [Accessed on 13th August 2022] https://www.medicines.org.uk/emc/files/pil.2502.pdf
5. Sanofi Pasteur. Electronic Medicines Compendium (EMC). [Revised in November 2020] [Accessed on 13th August 2022].
Useful Diagnostic Tests
- Fluorescent antibody test (FAT)
- Reverse transcriptase- polymerase chain reaction (RT-PCR)
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