ZOMELIS MET 50/500mg Tablet 15's

Introduction About ZOMELIS MET 500MG TABLET

ZOMELIS MET 50/500mg Tablet is a combination of Vildagliptin and Metformin. It is used to help manage high blood sugar levels in adults with type 2 diabetes mellitus. This medicine belongs to the class of antidiabetic agents. Vildagliptin helps increase insulin secretion and reduce glucose production, while Metformin lowers liver glucose production and enhances insulin sensitivity.

ZOMELIS MET 50/500mg Tablet can be prescribed either alone or in combination with other diabetes medications. For optimal results, all diabetes managements work best when paired with a healthy diet and regular physical activity. Your prescribed dose will depend on your specific condition, blood sugar levels, and any other medications you may be taking. Taking the medication with meals can help minimize the risk of an upset stomach. It is important to take it consistently at the same time every day to maximize its effectiveness and not to stop taking it unless advised by your doctor. This medicine helps control your blood sugar levels and reduces the risk of serious complications in the future. Maintaining the diet and exercise plan recommended by your doctor is crucial while on this medication, as your lifestyle plays a significant role in managing diabetes.

Common side effects include nausea, headache, gastroesophageal reflux disease, diarrhea, stomach pain, loss of appetite, metallic taste, joint pain, tiredness, constipation and swollen hands, ankles, or feet (oedema). Low blood sugar level (hypoglycemia) is also a possible side effect if you are also taking other diabetes medicines like insulin or sulfonylurea, so you need to know how to recognize and deal with it.

This medicine may not be suitable for everyone. Before starting it, inform your doctor if you have a history of kidney, liver, or heart problems, problems with your pancreas, or if you consume alcohol frequently. If you are pregnant or breastfeeding, consult your doctor before taking this medication. Other medicines may interact with Zomelis Met 50/500mg Tablet, so be sure to let your doctor know about all the medications you are currently taking. Avoid alcohol, as it can lower your blood sugar levels. Your doctor will monitor your kidney function and blood sugar levels before and during management.

Uses Of ZOMELIS MET 500MG TABLET

• Type 2 diabetes mellitus

Benefits of ZOMELIS MET 500MG TABLET

01) Dual-action control of blood sugar in type 2 diabetes:
ZOMELIS MET 50/500mg combines Vildagliptin and Metformin, offering a synergistic effect that enhances insulin secretion and reduces glucose production, helping maintain better glycemic control in adults with type 2 diabetes.

02) Enhances insulin sensitivity and reduces liver glucose output:
Metformin works by improving the body's response to insulin and reducing the amount of sugar produced by the liver, supporting more stable blood glucose levels throughout the day.

03) Promotes better post-meal glucose control:
Vildagliptin increases levels of incretin hormones, which help regulate insulin and glucagon after meals. This helps to reduce sharp spikes in blood sugar following food intake.

04) Low risk of weight gain and hypoglycemia when used as directed:
Unlike some other diabetes medications, this combination typically does not lead to weight gain and has a lower risk of causing low blood sugar when taken correctly, especially when not combined with insulin or sulfonylureas.

05) Twice-daily dosing with meals for improved gastrointestinal tolerance:
Taking the tablet with meals helps reduce the chances of stomach upset, a common issue with Metformin, while also improving drug absorption and effectiveness.

06) Supports long-term diabetes management and complication prevention:
By effectively lowering and maintaining blood sugar levels, ZOMELIS MET helps to reduce long-term complications of diabetes such as nerve damage, kidney issues, and cardiovascular diseases.

07) Suitable for combination therapy with other antidiabetic agents:
Can be safely used alongside other oral antidiabetic medicines or insulin under medical supervision, providing flexibility in managing more advanced stages of type 2 diabetes.

08) Backed by regular monitoring to ensure safe and effective use:
Doctors typically monitor kidney function and blood sugar levels during management to ensure the medicine remains safe and effective for long-term use.

How ZOMELIS MET 500MG TABLET Works

ZOMELIS MET 50/500mg Tablet contains two antidiabetic agents such as Vildagliptin (a DPP-4 inhibitor) and Metformin (a biguanide) that work together to manage blood sugar levels in adults with type 2 diabetes mellitus. This dual-action approach targets different aspects of glucose regulation in the body.

Mechanism of Action of Vildagliptin:

Vildagliptin works by inhibiting the enzyme DPP-4, which increases the levels of incretin hormones (GLP-1 and GIP). These hormones help the pancreas release more insulin after meals and reduce the amount of glucagon produced, thus lowering blood sugar levels.

Role of Metformin in Glucose Regulation:

Metformin reduces the production of glucose in the liver (hepatic gluconeogenesis) and improves the body's response to insulin. It also helps slow the absorption of glucose from the intestines, supporting steady blood sugar control throughout the day.

Dual Mechanism: How Vildagliptin and Metformin Work Together:

This combination improves both insulin secretion (via Vildagliptin) and insulin action (via Metformin). Vildagliptin enhances insulin release in response to meals, while Metformin ensures that the body’s cells respond more effectively to insulin and produce less glucose.

Why the Combination of DPP-4 Inhibitor and Biguanide is Effective:

By addressing both insulin deficiency and insulin resistance — two key issues in type 2 diabetes — this combination provides a more comprehensive blood sugar-lowering effect than either drug alone. It also lowers the risk of complications without causing significant weight gain or hypoglycemia when used properly.

How the Body Responds to ZOMELIS MET 50/500mg:

After oral intake, Metformin is absorbed and starts working on the liver’s glucose production, while Vildagliptin increases incretin levels, which regulate insulin and glucagon in response to meals. This coordinated action helps keep blood sugar levels within a healthy range, especially after eating.

How to use ZOMELIS MET 500MG TABLET

Always take ZOMELIS MET 50/500mg Tablet exactly as prescribed by your doctor. Do not exceed the recommended dose. Follow your doctor’s instructions carefully to achieve the best results and reduce the risk of side effects.

Recommended Dosage of ZOMELIS MET 50/500mg Tablet:

The dosage of ZOMELIS MET will depend on your blood sugar levels, medical history, and response to management. Your doctor may start with a lower dose and adjust it as needed to maintain optimal blood glucose control.

How to Take ZOMELIS MET Correctly:

• Take the tablet with meals to reduce the risk of stomach upset.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• It is usually taken twice a day, preferably with breakfast and dinner.

Timing and Frequency of ZOMELIS MET Dosage:

• Take the tablet at the same time each day to maintain consistent levels in your body.
• Regular dosing helps improve blood sugar control and reduces the chance of missed doses.

Important Precautions While Using ZOMELIS MET:

• Do not skip meals while taking this medicine, as it may increase the risk of low blood sugar (especially if taken with insulin or sulfonylureas).
• Avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis and affect blood sugar levels.
• Inform your doctor about any history of kidney, liver, or heart problems.
• Pregnant or breastfeeding women should consult their doctor before use.

What if I forgot to take ZOMELIS MET 500MG TABLET

• If you miss a dose, take it as soon as you remember, with food.
• If it is almost time for your next dose, skip the missed dose, do not double up to make up for it.
• Return to your regular dosing schedule

Monitoring and Follow-Up:

• Regular blood sugar checks and periodic kidney function tests may be recommended during management.
• Keep all follow-up appointments and inform your doctor of any unusual symptoms.

Side Effects Of ZOMELIS MET 500MG TABLET

Like all medicines, ZOMELIS MET 50/500mg Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking ZOMELIS MET 50/500mg Tablet are:

• Nausea
• Headache
• Gastroesophageal reflux disease
• Diarrhea
• Stomach pain
• Loss of appetite
• Metallic taste
• Joint pain
• Tiredness
• Constipation
• Swollen hands, ankles, or feet (oedema)

When To Seek Medical Attention?

• Signs of lactic acidosis such as deep or rapid breathing, severe drowsiness, muscle pain or cramping, stomach pain with nausea or vomiting, or feeling cold in hands and feet
• Signs of a severe allergic reaction such as swelling of the face, lips, tongue, or throat, difficulty breathing; rash; or itching
• Symptoms of pancreatitis including severe upper abdominal pain (may radiate to the back), nausea, and vomiting
• Signs of liver problems such as yellowing of the skin or eyes (jaundice), dark urine, or unusual fatigue
• Symptoms of low blood sugar (hypoglycemia) if taken with insulin or sulfonylureas, such as shakiness, sweating, confusion, blurred vision, dizziness, or fainting
• Unexplained fatigue, fast breathing, or irregular heartbeat, which could indicate a serious metabolic imbalance

How To Manage Side Effects

Diarrhea

• Drink Fluids: Drink clear fluids such as water, broths, and oral rehydration solutions (ORS).
• Electrolytes: If you are losing a lot of fluids (for example, from frequent diarrhea), consider drinking an electrolyte solution to help replenish lost minerals like potassium and sodium.
• BRAT Diet: Try to take Bananas, Rice (white rice), Apple sauce and Toast (plain, without butter) to control diarrhoea management.
• Avoid Certain Foods: While recovering avoid the following food items such as fatty, greasy, or fried foods, spicy foods, dairy products (especially if you have a temporary lactose intolerance), caffeinated drinks and alcohol and artificial sweeteners like sorbitol.
• Over-the-Counter Medications: You can take over-the-counter anti-diarrheal medications such as loperamide, Bismuth subsalicylate if appropriate for you. Follow the recommended dosage.

Headache

• Stay Hydrated – Drink plenty of water to reduce dehydration, which can worsen headaches.
• Rest in a Quiet, Dark Room – Avoid bright lights and loud noises to ease headache discomfort.
• Use a Cold or Warm Compress – Apply a cold pack to your forehead or a warm compress to the neck for relief.
• Practice Deep Breathing – Relaxation techniques like deep breathing or meditation can help reduce headache severity.
• Avoid Caffeine and Alcohol – These can trigger or worsen headaches.
• Limit Screen Time – Reduce exposure to screens if headaches are triggered by eye strain.
• Massage Your Temples and Neck – Gentle massages can help relieve tension headaches.
• Take Over-the-Counter Pain Relievers – If needed, mild painkillers like paracetamol (if approved by your doctor) can help.

Nausea And Vomiting

• Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.
• Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.
• Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger)
• Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors.

Warning & Precautions

Pregnancy

Monitoring required

ZOMELIS MET 50/500mg Tablet is not recommended during pregnancy unless clearly advised by your doctor. Limited human data are available, and animal studies suggest potential risk to the unborn baby. Consult your doctor before taking this medication.

Breastfeeding

Contraindicated

ZOMELIS MET 50/500mg Tablet is not recommended during breastfeeding, as both Vildagliptin and Metformin may pass into breast milk and affect the nursing infant. Consult your doctor before taking this medication.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you experience dizziness or fatigue or blurred vision after taking it.

Alcohol

Consult your doctor

Avoid alcohol while taking this medicine, as it can increase the risk of lactic acidosis and cause unpredictable blood sugar levels.

Kidney

Consult your doctor

ZOMELIS MET 50/500mg Tablet is not recommended in patients with severe kidney function and should be used with caution in patients with other kidney problems. Consult your doctor before taking this medication.

Liver

Consult your doctor

ZOMELIS MET 50/500mg Tablet is not recommended in patients with severe liver problems and should be used with caution in patients with other liver problems. Consult your doctor before taking this medication.

Allergy

Contraindicated

Do not take ZOMELIS MET 50/500mg Tablet if you are allergic (hypersensitive) to Metformin or Vildagliptin or any other ingredients of this medicine.

Heart Disease

Contraindicated

ZOMELIS MET 50/500mg Tablet is not recommended in patients who recently had a heart attack or heart failure or any signs of heart problems such as serious blood circulation problems or difficulty breathing. Consult your doctor before taking this medication.

Use In Pediatrics

Contraindicated

ZOMELIS MET 50/500mg Tablet is not recommended for use in children and adolescents less than 18 years of age due to a lack of safety and effectiveness. Consult a pediatrician before giving this medication in children.

Use In Geriatrics

Use with Caution

ZOMELIS MET 50/500mg Tablet should be used with caution in elderly patients above 65 years of age, especially in patients with impaired kidney function. Your doctor will adjust the dose depending on kidney function, and your kidney function will be monitored regularly.

Other Warnings for ZOMELIS MET 500MG TABLET

Before taking this medicine, inform your doctor if you have:

• pancreatic disease
• Vitamin B12 deficiency
• Malnutrition with adrenal or pituitary insufficiency

Who should not take [GBNKEYWORD

ZOMELIS MET 50/500mg Tablet is not recommended for use if you have:

• Type 1 diabetes mellitus
• Uncontrolled diabetes
• Severe infection or seriously dehydrated
• are going to have a contrast x-ray (a specific type of x-ray involving an injectable dye)

Drug - Drug interaction

Inform your physician if you are taking any of the following medications before starting ZOMELIS MET 50/500mg Tablet:

1. Sulfonylureas or Insulin (e.g., Glimepiride, Insulin Glargine)

• Interaction: May enhance the blood sugar-lowering effect of Metformin and Vildagliptin.
• Effects: Increased risk of hypoglycemia (low blood sugar).
• Management: Monitor blood sugar levels closely. Dose adjustment of sulfonylurea or insulin may be necessary.

2. Diuretics (e.g., Furosemide, Hydrochlorothiazide)

• Interaction: May reduce Metformin's effectiveness and increase the risk of lactic acidosis due to dehydration.
• Effects: Altered blood sugar control; risk of electrolyte imbalance or kidney dysfunction.
• Management: Monitor kidney function and hydration status; use with caution.

3. ACE Inhibitors (e.g., Enalapril, Ramipril)

• Interaction: May increase the glucose-lowering effect of Metformin.
• Effects: Risk of hypoglycemia, especially in elderly patients.
• Management: Monitor blood sugar levels when starting or adjusting ACE inhibitor therapy.

4. Beta-Blockers (e.g., Metoprolol, Propranolol)

• Interaction: May mask symptoms of hypoglycemia, such as rapid heartbeat.
• Effects: Delayed recognition and treatment of low blood sugar.
• Management: Educate patients on alternative signs of hypoglycemia (e.g., sweating, dizziness).

5. Contrast Agents for Imaging Procedures (e.g., Iodinated contrast dyes)

• Interaction: When combined with Metformin, may increase the risk of lactic acidosis.
• Effects: Acute kidney injury, especially in patients with existing renal impairment.
• Management: Temporarily discontinue Metformin before the procedure and restart only after kidney function is confirmed to be normal.

6. Rifampicin or Phenytoin

• Interaction: May reduce the effectiveness of Vildagliptin.
• Effects: Possible rise in blood sugar levels.
• Management: Monitor blood glucose closely and adjust dose if needed.

Drug - Food interaction

1. Alcohol

• Interaction: Alcohol can potentiate the effect of Metformin on lactate metabolism.
• Effects: Increased risk of lactic acidosis, especially in individuals with liver or kidney problems or those who drink heavily.
• Management: Avoid alcohol completely or consume only in moderation with physician approval.

2. High-Fat Meals

• Interaction: May delay the absorption of Metformin slightly.
• Effects: Minimal clinical impact, but could influence gastrointestinal tolerance.
• Management: Take ZOMELIS MET with meals to reduce gastrointestinal side effects, preferably with meals of moderate fat content.

3. Foods Rich in Simple Sugars (e.g., sweets, sugary drinks)

• Interaction: Can counteract the blood sugar-lowering effect of the medication.
• Effects: Poor glycemic control, increased risk of hyperglycemia.
• Management: Follow a diabetes-friendly diet low in refined sugars and high in fiber as advised by your doctor.

4. Grapefruit Juice (Cautionary)

• Interaction: While not strongly established, grapefruit juice can affect the metabolism of many oral drugs.
• Effects: Potential alteration in drug levels.
• Management: Use with caution and consult your doctor before regular consumption.

Synopsis

More Information

A. Diet & Exercise considerations while taking ZOMELIS MET 50/500mg Tablet?

B. What are some practical ways you can improve your overall diabetes control on a daily basis?

FAQs About ZOMELIS MET 500MG TABLET

References

1. KD Tripathi MD. Hormones and related drugs. Essentials of Medical Pharmacology. Seventh edition. New Delhi, May 2013. Page-274.

2. Paresh Ved and Samrat Shah. Evaluation of vildagliptin and fixed dose combination of vildagliptin and metformin on glycemic control and insulin dose over 3 months in patients with type 2 diabetes mellitus. March 2012. [Accessed on 13th June 2025]  

3. Serge Halimi, Anja Schweizer, Biljana Minic, James Foley and Sylvie Dejage. Combination treatment in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet. March 2008. [Accessed on 13th June 2025]  

4. Novartis Pharma GmbH. Electronic Medicines Compendium (EMC) [Revised in August 2021] [Accessed on 13th June 2025]  

5. Cipla Ltd. VYSOV-M Tablets (Vildagliptin + Metformin hydrochloride). [Revised in July 2020] [Accessed on 13th June 2025]  

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 14 Jun 2025 | 11:23 AM(IST)