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Introduction About ZNPRO D CAPSULE
ZNPRO D CAPSULE is used to manage Gastro-Esophageal Reflux Disease (GERD) among patients who have not responded adequately to rabeprazole alone. It is a combination of Domperidone and Rabeprazole which belongs to the group of medicines called Dopamine Antagonists and Proton pump inhibitors respectively. It can also be used to manage peptic ulcers caused by H. pylori infection or NSAIDs use.
Along management with ZNPRO D CAPSULE, try to eat less spicy foods and drink plenty of water. Avoid smoking or alcohol consumption as it may aggravate your existing condition. Patients receiving long-term management with the medicine should be kept on regular surveillance to rule out the risk of hypomagnesaemia (decreased magnesium levels in blood) and bone fracture, predominantly in the elderly patients and in patients with other recognized risk factors.
Before taking ZNPRO D CAPSULE inform your doctor if you have any liver, kidney or heart problems. Your doctor may reduce the dose or suggest an alternative therapy. It is not recommended for use in pregnant or breastfeeding women and in children (aged less than 18 years). It should be used with caution in elderly patients (above 65 years of age). The most common side effects are nausea, vomiting, stomach pain, diarrhea or constipation. Consult your doctor if any of these above side effects worsen.
Uses Of ZNPRO D CAPSULE
It is used to manage:
- peptic ulcer
- Gastro-Esophageal Reflux Disease (GERD)
How ZNPRO D CAPSULE Works
ZNPRO D CAPSULE reduces stomach ulcers and acid reflux, where Rabeprazole acts by inhibiting the secretions of stomach acid and Domperidone acts by increasing bowel movements and facilitating gastric emptying, thus leading to rapid symptom relief and healing of stomach ulcers and esophageal lesions.
How to use ZNPRO D CAPSULE
- Take ZNPRO D CAPSULE as advised by your physician
- Swallow the medicine with a glass of water. Do not crush or chew the medicine
- Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition
Side Effects Of ZNPRO D CAPSULE
Common side effects of ZNPRO D CAPSULE:
- nausea, vomiting
- diarrhea, constipation, stomach pain, flatulence
- cough, sore throat, runny nose
- back pain
- headache, dizziness
- dry mouth
- benign polyps in the stomach
- indigestion, belching in the stomach (excess air accumulation in the stomach)
- urinary tract infection
Stop taking ZNPRO D CAPSULE and contact your doctor immediately if you experience the following side effects:
- severe allergic reaction (sudden wheezing, swelling of lips, face or body, rash, fainting or difficulties swallowing)
- symptoms of liver problems (yellow skin, dark urine and tiredness)
- severe skin reactions such as erythema multiforme, stevens-johnson syndrome or toxic epidermal necrolysis (reddening of skin with blisters or peeling and may be associated with a high fever and joint pains, also severe blisters and bleeding in the lips, eyes, mouth, nose and genitals)
- seizures
- involuntary movements of the face or arms and legs, excessive trembling, excessive muscle stiffness or muscle spasm
- heart rhythm disorders (rapid or irregular heartbeat)
Warning & Precautions
Pregnancy
ContraindicatedZNPRO D CAPSULE is not recommended for use in pregnant women.
Breastfeeding
ContraindicatedZNPRO D CAPSULE is not recommended for use in breast-feeding women.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you experience sleepiness, confusion or less control over your movements.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking ZNPRO D CAPSULE, as it could aggravate your existing condition.
Kidney
ContraindicatedZNPRO D CAPSULE is not recommended for use in patients with kidney impairment.
Liver
Consult your doctorZNPRO D CAPSULE is not recommended for use in patients with moderate or severe liver impairment and it should be used with caution in patients with liver problems.
Allergy
ContraindicatedDo not take ZNPRO D CAPSULE if you are allergic to Domperidone or Rabeprazole or any other ingredients of this medicine.
Heart Disease
ContraindicatedZNPRO D CAPSULE is not recommended for use in patients with heart problems such as prolongation of QT interval or congestive heart failure.
Use In Pediatrics
ContraindicatedZNPRO D CAPSULE is not recommended for use in children and adolescents (aged less than 18 years) due to lack of safety and effectiveness.
Use In Geriatrics
Use with CautionZNPRO D CAPSULE should be taken with caution in elderly patients (aged 65 years or above).
Others
ZNPRO D CAPSULE is not recommended for use if you:
- Have bloody stools or bleeding in the gut
- Have blockage or tear in the intestines
- Have severe fluid or electrolyte disturbances
- Have prolactinoma
- Have phenylketonuria
- Have problem that causes low levels of potassium or magnesium or high levels of potassium in the blood
- Have hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption
Before taking ZNPRO D CAPSULE, inform your physician if you:
- Have osteoporosis
- Have vitamin B12 deficiency (sore tongue, mouth ulcers, pale skin, depression)
- Are going to test Chromogranin A level
Interactions
A. Drug-Drug interactions:
Before taking the medicine, inform to your doctor if you are taking any of these medicines:
- Prokinetic agent (Ex. Cisapride, dolasetron, prucalopride, diphemanil)
- Cardiac glycosides (Ex. Digoxin, apomorphine, disopyramide, hydroquinidine, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol, diltiazem or verapamil)
- Ant-viral agents (Ex. Atazanavir, nelfinavir, saquinavir, Telaprevir)
- Antipsychotics (Ex. Haloperidol, pimozide, sertindole)
- Antidepressants (Ex. Escitalopram or citalopram)
- Antibiotics (Ex. Moxifloxacin, erythromycin, levofloxacin, clarithromycin, telithromycin or amoxicillin)
- Antimalarials (Ex. Halofantrine, lumefantrine)
- Antihistamines (Ex. Mizolastine, mequitazine)
- Nonsteroidal antiestrogens (Ex. Toremifene, vandetanib, vincamine, erlotinib, dasatinib, nilotinib)
- Antimetabolites (Ex. Methotrexate)
- Antihypertensives (Ex. Bepridil)
- Opioid narcotics (Ex. Methadone)
- Iron salts
- Immunosuppressants (Ex. Tacrolimus or mycophenolate mofetil)
- Antifungals (Ex. Ketoconazole, itraconazole)
- Anti-infective (Ex. Pentamidine)
- Anticoagulants (Ex. Warfarin)
Overdosage:
If you or anyone else take too much of ZNPRO D CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms are altered consciousness, agitation, convulsions, disorientation, sleepiness and extrapyramidal reactions (such as rigidity, tremor, drooling).
Synopsis
| Drug | : | Domperidone, Rabeprazole |
| Pharmacological Category | : | Dopamine antagonist, Proton pump inhibitor |
| Therapeutic Indication | : | Peptic ulcer, GERD |
| Dosage Forms | : | Tablet, Capsule |
More Information
FAQs About ZNPRO D CAPSULE
Q: Can ZNPRO D CAPSULE cause diarrhea?
A: Yes. ZNPRO D CAPSULE may cause diarrhea in some individuals. Keep yourself hydrated by drinking plenty of fluids, oral electrolytes and juices. Do not self-manage diarrhea if it persists for a longer period. Contact your doctor for advice.
Q: Can ZNPRO D CAPSULE cause acid reflux?
A: No. ZNPRO D CAPSULE is used to manage Gastro-Esophageal Reflux Disease (GERD) and does not cause acid reflux. If you experience any unusual symptoms after taking the medicine, consult your doctor for advice.
Q: Can ZNPRO D CAPSULE cause kidney damage?
A: ZNPRO D CAPSULE may rarely cause damage to your kidneys (Ex. interstitial nephritis). However, inform your doctor immediately if you experience any signs of kidney damage such as dark urine, blood in urine, painful urination or lower abdominal discomfort during management with this medicine.
Q: When and how should I take ZNPRO D CAPSULE?
A: Take ZNPRO D CAPSULE on an empty stomach or as advised by your physician. Swallow the medicine as a whole and do not crush or chew the medicine.
Q: Can ZNPRO D CAPSULE be used in children?
A: No. ZNPRO D CAPSULE is not recommended for use in children and adolescents (below 18 years) due to lack of safety and effectiveness. Consult your child’s doctor if your child experiences any symptoms of gastro-esophageal reflux disease or peptic ulcer (such as nausea, vomiting, discomfort in upper stomach, stomach pain, heartburn, burping, etc).
References
1. KD. Tripathi. Antiemetic, Prokinetic and Digestant drugs & Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page-666 & 651-653.
2. Keith A. Sharkey and John L. Wallace. Treatment of disorders of bowel motility and water flux; Antiemetics; Agents used in biliary and pancreatic disease and Pharmacotherapy of gastric acidity, peptic ulcer and gastroesophageal reflux disease. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page-1326 & 1317-1320.
3. Gerald G. Briggs and Roger K. Freeman. D. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page-1232 & -3337.
4. Janssen Research & Development, LLC. A Pharmacokinetics, Pharmacodynamics and Safety Study of Rabeprazole in Newborn Infants with Gastroesophageal Reflux Disease (GERD). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in April 2013] [Accessed on 1st October 2021] click here
5. Savita Shahani, Prabha Sawant, Preen Dabholkar. Rabeprazole plus domperidone: the answer for gastro-esophageal reflux disease. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. April 2008. [Accessed on 1st October 2021] click here
6. K Semmanaselvan, Qayum I Mukaddam, Manoj Naik. An Open Label, Prospective, Single Centre Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Rabeprazole (Enteric-Coated, EC) 20 mg + Domperidone (Sustained Release, SR) 30 mg Capsule in Treatment of Patients with Laryngopharyngeal Reflux Disease. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. July 2015. [Accessed on 1st October 2021] click here
7. Cipla Ltd. Rabicip D Capsules (Rabeprazole sodium + Domperidone). Ciplamed.com. [Revised in January 2020] [Accessed on 1st October 2021] click here
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