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Introduction About ZIONE L TABLET
ZIONE L TABLET is a combination of Chlorthalidone and Losartan which belongs to the group of medicines called Antihypertensive drugs. It is used in adults to manage mild to moderate high blood pressure which is not adequately controlled by monotherapy.
High blood pressure (also known as hypertension) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high and as a result it may lead to severe damage to the blood vessels supplying several organs, thus causing heart attack, heart or kidney failure, stroke or even blindness.
During the course of the management, your doctor might regularly monitor your blood pressure, kidney function and electrolyte balance to avoid any untoward side effects. Before taking ZIONE L TABLET, inform your doctor if you have kidney, liver or heart problems, including diabetes, gout or Adisson’s disease.
ZIONE L TABLET is not recommended for use in pregnant and breastfeeding women, so consult your doctor before taking it. This medicine is not recommended for use in children (6 years or younger) and those having kidney or liver problems.
The most common side effects of taking ZIONE L TABLET are dizziness, loss of appetite, upset stomach, weakness and extreme tiredness. Consult your doctor if any of the side effects worsen.
Uses Of ZIONE L TABLET
- Manage mild to moderate high blood pressure in adults
How ZIONE L TABLET Works
ZIONE L TABLET effectively reduces elevated blood pressure where losartan acts by blocking the actions of Angiotensin – II (a substance that causes narrowing of blood vessels and increase in blood pressure) at the angiotensin type-I receptors of the vascular smooth muscle and chlorthalidone acts by increasing the urinary excretion of sodium and water by inhibiting sodium-chloride reabsorption in the kidneys, thus leading to a marked decrease in blood pressure.
How to use ZIONE L TABLET
Take ZIONE L TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of ZIONE L TABLET for you depending upon your age, body weight and disease condition. Do not stop taking ZIONE L TABLET unless your doctor advises you to stop.
Side Effects Of ZIONE L TABLET
Common
- nettle rash, skin rash
- low blood pressure
- dizziness
- loss of appetite, upset stomach
- impotence in men
Uncommon
- gout (causing pain and swelling in the joints)
- sleepiness, sleep disorders
- headache
- throbbing heartbeat
- severe chest pain
- shortness of breath
- stomach pain, severe constipation, diarrhea, nausea, vomiting
- hives, itching, localized swelling (edema)
- cough
Rare
- yellowing of the skin or eyes due to liver or blood problems (jaundice)
- increased skin sensitivity to sunlight
- numbness or tingling sensation
- breathing problems
- allergy
- painless swelling under the skin
- brain stroke
Stop taking ZIONE L TABLET and consult your doctor immediately if you experience any of the following side effects:
- severe allergic reaction (signs include rash, itching, swelling of the face, lips, mouth or throat that may cause trouble swallowing or breathing)
- muscle weakness or abnormal heartbeat
How To Manage Side Effects
Nausea and vomiting:
Try to take ZIONE L TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating oil rich, fried or spicy foods. Consult your doctor if the symptom did not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
Diarrhoea:
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own to manage diarrhoea. Consult your doctor if the symptom did not improve.
Constipation:
Eat fibre-rich foods such as fresh fruits, vegetables, cereals and drink plenty of water. Try to exercise more regularly (such as daily walk). Consult your doctor if the symptom did not improve on its own.
Stomach pain:
Rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. Do not self-manage on your own and consult your doctor if the symptom did not improve on its own.
Warning & Precautions
Pregnancy
ZIONE L TABLET is not recommended in early pregnancy and if you are more than 3 months pregnant, as it may seriously harm your baby if used at that stage. Consult your doctor before taking ZIONE L TABLET.
Breastfeeding
ZIONE L TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking ZIONE L TABLET.
Driving and Using Machines
Do not drive or use any machines if you feel dizzy after taking ZIONE L TABLET.
Kidney
ZIONE L TABLET is not recommended for use in patients with severe kidney problems, kidney stones or if you are not passing any urine at all. It should be used with caution in patients with narrowing or blockage of the blood vessels leading to kidneys or if you have recently received a kidney transplant. Consult your doctor before taking ZIONE L TABLET.
Liver
ZIONE L TABLET is not recommended for use in patients with severe liver impairment. It should be used with caution in patients with impaired liver function. Consult your doctor before taking ZIONE L TABLET.
Allergy
Do not take ZIONE L TABLET if you are allergic to Chlorthalidone, Losartan or sulphonamides such as sulfamethoxazole.
Heart Disease
ZIONE L TABLET should be used with caution in patients with heart failure with or without concomitant severe life-threatening irregular heartbeat, problems with your heart valves or heart muscle, coronary heart disease, and cerebrovascular disease (caused by a reduced blood flow in the brain). Consult your doctor before taking ZIONE L TABLET.
Others
ZIONE L TABLET is not recommended for use if you:
- have low blood potassium levels (signs include muscle weakness, muscle twitching, abnormal heartbeat)
- have low blood sodium levels (signs include tiredness, confusion, muscle twitching, fits, coma)
- have high blood calcium levels (signs include loss of appetite, tiredness, muscle and weakness)
- ever had gout
- have Addison’s disease (your adrenal gland does not produce enough steroids)
- have diabetes (high blood sugar) and managed with a blood pressure-lowering medicine containing aliskiren
Before taking ZIONE L TABLET, inform your doctor if you:
- have a history of angioedema (face, lips, throat or tongue swelling)
- have excessive vomiting or diarrhoea or under dietary salt restriction leading to an extreme loss of fluid or salt from your body
- have primary hyperaldosteronism (increased secretion of the hormone aldosterone by the adrenal gland)
- have high cholesterol levels
Use in pediatrics:
ZIONE L TABLET is not recommended for use in children (under 6 years of age or younger) and those having kidney or liver problems. Your child’s doctor may adjust the dose depending on the child’s age and body weight. Consult your child’s doctor for advice.
Use in geriatrics:
ZIONE L TABLET should be used with caution in elderly patients. Your doctor may initiate the management with the lowest effective dose. Consult your doctor before taking ZIONE L TABLET.
Interactions
A. Drug - Drug interactions:
Before taking ZIONE L TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used to manage heart problems like high blood pressure, chest pain or irregular heartbeat (Ex. lisinopril, propranolol, methyldopa, nitroglycerin, amlodipine, guanethidine, digoxin, aliskiren, furosemide)
- adrenocorticotropic hormone (used to manage ulcerative colitis, Crohn's disease and rheumatoid arthritis)
- medicines used to manage allergic and inflammatory diseases and immune reactions (Ex. prednisolone, betamethasone)
- medicines used to manage stomach cramps (Ex. atropine, hyoscine)
- medicines used to manage cancer (Ex. cyclophosphamide, methotrexate)
- cholestyramine (used to reduce blood fat levels)
- medicines used to manage asthma (Ex. salbutamol, formoterol)
- amantadine (used to manage Parkinson’s disease)
- amphotericin (used to manage fungal infections)
- allopurinol (used to manage gout)
- carbenoxolone (used to manage ulcers)
- medicines used for replacement therapy (calcium salts, vitamin D)
- medicines used to manage high blood sugar levels (Ex. insulin, chlorpropamide, glibenclamide)
- medicines used to relieve pain or rheumatism (Ex. aspirin, indomethacin)
- ciclosporin (used after a transplant to manage organ rejection)
- lithium (used to manage mental illness)
- medicines used to make you insensitive or pain (Ex. lignocaine, midazolam)
Overdosage:
If you or anyone else accidentally take too much of ZIONE L TABLET, contact your doctor immediately or visit the nearby hospital. Overdosage symptoms of ZIONE L TABLET includes dizziness, nausea, vomiting, sleepiness, volume depletion, low blood pressure, electrolyte disturbances associated with irregular heartbeat and muscle spasms.
Synopsis
| Drug | : | Chlorthalidone, Losartan |
| Pharmacological Category | : | Thiazide diuretic, Angiotensin receptor-2 blocker |
| Therapeutic Indication | : | Hypertension |
| Dosage Forms | : | Tablet |
More Information
- Keep ZIONE L TABLET out of reach of children
- Store ZIONE L TABLET at room temperature
FAQs About ZIONE L TABLET
How long should I take ZIONE L TABLET?
Continue to take ZIONE L TABLET as long as your doctor tells you to do so. Do not stop taking this medicine on your own once your blood pressure is controlled without consulting your doctor as it could raise your blood pressure again. Generally, you may be asked to take ZIONE L TABLET for life-long because it can only control your blood pressure and does not manage it.
What is [GBNKEYWORD] and why is it prescribed?
ZIONE L TABLET is a combination of Chlorthalidone and Losartan which belongs to the group of medicines called Antihypertensive drugs. It is used in adults to manage mild to moderate high blood pressure which is not adequately controlled by monotherapy.
Can ZIONE L TABLET be taken during pregnancy?
No, ZIONE L TABLET is not recommended for use in early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to your baby. Consult your doctor before taking ZIONE L TABLET. Your doctor may prescribe the safest anti-hypertensive medicine which can be taken during pregnancy.
Is ZIONE L TABLET safe to use in patients with kidney problems?
ZIONE L TABLET is not recommended for use in patients with severe kidney problems, kidney stones or if you are not passing any urine at all. It should be used with caution in patients with narrowing or blockage of the blood vessels leading to kidneys or if you have recently received a kidney transplant. Consult your doctor before taking ZIONE L TABLET.
Can ZIONE L TABLET be used in children?
ZIONE L TABLET is not recommended for use in children (under 6 years of age or younger) and those having kidney or liver problems. Your child’s doctor may adjust the dose depending on the child’s age and body weight. Consult your child’s doctor for advice.
References
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Hypertension. Pharmacotherapy Handbook. Ninth edition. Page-87.
2. Sana Mulla, Waqas J. Siddiqui. Losartan. StatPearls [Internet]. NIH National Library of Medicine, National center for biotechnology information. February 2022. [Accessed on 8th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK526065/#article-707.s3
3. Connor C. Kerndt, Jayesh B. Patel. Chlorthalidone. StatPearls [Internet]. NIH National Library of Medicine, National center for biotechnology information. May 2022. [Accessed on 8th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK553174/#:~:text=Mechanism%20of%20Action,Chlorthalidone%20exerts%20its&text=Chlorthalidone%20inhibits%20sodium%20reabsorption%20at,retains%20a%20higher%20sodium%20content
4. GKM New Pharma. Losar-CH (Chlorthalidone + Losartan). Torrent Pharma. [Revised in February 2021]. [Accessed on 8th June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/3002.pdf
5. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). Revised in July 2019] [Accessed on 8th June 2022] https://www.medicines.org.uk/emc/files/pil.9045.pdf
6. Ipca Laboratories Ltd. Losanorm CH (Chlorthalidone + Losartan). [Accessed on 8th June 2022] https://www.ipca.com/pharmaceutical-formulations-manufacturers-india/?id=pr_113
7. Central Drugs Standard Control Organization (CDSCO). [Accessed 8th June 2022] https://cdscoonline.gov.in/CDSCO/Drugs
Useful Diagnostic Tests
- Kidney function test
- Liver function test
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