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Introduction About ZERODOL PG 200/75 TABLET
ZERODOL PG 200/75 TABLET is a combination of Aceclofenac and Pregabalin which belongs to the group of medicines called Analgesics and Anticonvulsants respectively. It is used to manage nerve pain (also known as neuropathic pain).
It can also be used to provide relief from joint pain (Ex. osteoarthritis, rheumatoid arthritis), back pain (Ex. ankylosing spondylitis), neck pain, sciatic nerve pain (pain from the nerve that runs at the back of the legs) and pain caused due to injuries or surgeries.
ZERODOL PG 200/75 TABLET is preferably taken with or after meals to avoid gastric irritation. Avoid smoking or consumption of alcohol as it could aggravate the risk of stomach problems. Do not take ZERODOL PG 200/75 TABLET if you have any ulcers, bleeding or perforations in the gut.
Before taking ZERODOL PG 200/75 TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have diabetes, hypertension, high blood cholesterol, any inflammation in the bowel or intestines, blood clots, bleeding problems or a previous history of stomach ulcers as a precaution. ZERODOL PG 200/75 TABLET is not recommended for use in pregnant or breastfeeding women.
The most common side effects of taking ZERODOL PG 200/75 TABLET are nausea, indigestion, heartburn, stomach pain, constipation, dizziness, drowsiness, headache, lack of attention, clumsiness, memory impairment, tingling or numbness, blurred vision, weight gain, difficulties with erection, decreased sexual drive, delayed ejaculation and muscle cramps. Consult your doctor if any of these side effect worsens.
Uses Of ZERODOL PG 200/75 TABLET
It is used to manage:
- nerve pain
- joint pain (Ex. osteoarthritis, rheumatoid arthritis)
- back pain (Ex. ankylosing spondylitis)
- neck pain
- sciatic nerve pain (pain from the nerve that runs at the back of the legs)
- post-surgical/injury pain
How ZERODOL PG 200/75 TABLET Works
ZERODOL PG 200/75 TABLET is a pain-relieving medicine. It reduces pain sensation by interfering with the pain signals travelling between the damaged nerves and the brain. It also blocks the release of certain chemicals (such as prostaglandins) in the body that causes pain, inflammation and swelling. As a result, it reduces nerve pain, joint pain and back pain.
How to use ZERODOL PG 200/75 TABLET
Take ZERODOL PG 200/75 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It is preferably taken with meals to avoid gastric irritation.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of ZERODOL PG 200/75 TABLET
Common
- dizziness, drowsiness, headache
- increased appetite
- increased mood, confusion, disorientation, irritability
- lack of attention, clumsiness, memory impairment
- tremor, difficulty in speaking
- tingling or numbness, sedation, lethargy
- difficulty in sleeping, tiredness
- blurred vision, double vision
- spinning sensation, problems with balance
- dry mouth, constipation, vomiting, flatulence, diarrhea, nausea, swelling in abdomen
- swelling of the extremities (such as hands, legs or fingers)
- feeling drunk, abnormal style of walking
- weight gain
- muscle cramps, joint or back pain, pain in limbs
- sore throat
- difficulties with erection, decreased sexual drive, delayed ejaculation
Uncommon
- loss of appetite, weight loss, flatulence
- high or low blood sugar
- hallucinations, mood changes
- mouth ulcers
- dry eyes, eye pain, watery eyes, eye swelling
- heart rate disturbances, high or low blood pressure
- flushing
- difficulty in breathing, dry nose, nasal congestion
- increased salivation, heartburn, numbness around mouth
- sweating, rash, chills, fever
- breast pain
- difficulty or painful urination
- allergic reaction (swollen face, itchiness, hives, runny nose, nose bleeding)
- painful menstruation
- cold hands and feet
- increase in blood urea levels
- increase in blood creatinine levels
Rare
- abnormal sense of smell
- cold sweat, tightness of the throat, swelling of tongue
- inflammation of the pancreas
- difficulty with writing properly
- fluid in the lungs
- muscle damage
- discharge from breasts, abnormal growth of breast in men
- low urine output
- signs of Parkinsonism (muscle stiffness, shaking and decreased ability to move)
- anemia
Stop taking ZERODOL PG 200/75 TABLET and consult your doctor immediately if you experience any of the following:
- signs of severe allergic reactions (such as skin rash, itching, swelling of the face, lips, throat or tongue causing difficulty in breathing or swallowing, chest tightness, fever, ulcers on the mucous membrane, oral sores)
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane, joint pain with fever)
- signs of brain inflammation (such as high fever, headache, vomiting, blotchy red rashes, neck stiffness, sensitivity and intolerance to light)
- bloody stools, vomits or urine
- heart attack or stroke
- difficulty in passing urine, painful urination, low urine output
- severe stomach pain with indigestion and heartburn
- signs of low blood count (causing tiredness, breathlessness, joint pain, repeated infections, increased bleeding and bruising)
- low potassium levels in blood causing blood vessel inflammation
- fall or accidental injury
- blurred vision or vision changes
- fits (convulsions)
- suicidal thoughts or thoughts of harming or killing themselves
How To Manage Side Effects
Nausea and Vomiting:
Take ZERODOL PG 200/75 TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly. Consult your doctor if the symptom did not improve.
Mouth ulcers:
Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.
Diarrhea
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhea and consult your doctor if the symptom gets worse.
Skin rash:
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.
Warning & Precautions
Pregnancy
ZERODOL PG 200/75 TABLET is generally not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it. Women of childbearing age must use a suitable contraceptive method (non-hormonal methods) to avoid pregnancy while undergoing therapy with ZERODOL PG 200/75 TABLET.
Breastfeeding
ZERODOL PG 200/75 TABLET is not recommended for use in breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if you feel dizzy or sleepy after taking ZERODOL PG 200/75 TABLET.
Alcohol
Avoid consumption of alcohol while taking ZERODOL PG 200/75 TABLET as it could make you feel dizzier and drowsier.
Kidney
ZERODOL PG 200/75 TABLET is not recommended for use in patients with moderate to severe kidney diseases. It should be used with caution in patients with other mild kidney problems. Therefore, consult your doctor before taking it.
Liver
ZERODOL PG 200/75 TABLET is not recommended in patients with severe liver problems (such as liver failure). It should be used with caution in patients with other mild liver problems. Therefore, consult your doctor before taking it.
Allergy
Do not take ZERODOL PG 200/75 TABLET if you are allergic to Pregabalin, Aceclofenac or to any other NSAIDs (such as aspirin, ibuprofen, naproxen or diclofenac).
Lungs
ZERODOL PG 200/75 TABLET is not recommended for use in patients who previous experienced asthma attack or breathing difficulties after taking any pain-relieving medicine. It should be used with caution in patients with asthma or any other breathing problems. Therefore, consult your doctor before taking it.
Heart Disease
ZERODOL PG 200/75 TABLET is not recommended for use in patients with severe heart problems (such as heart attack). It should be used with caution in patients with other heart problems (such as angina). Therefore, consult your doctor before taking it.
Others
ZERODOL PG 200/75 TABLET is not recommended for use if you:
- have GI bleeding (bloody stools or vomits)
- have ulcers in the stomach or intestines
- have stroke or any problems in blood circulation
- have bleeding or any blood clotting disorders
- recently had an operation to clear or bypass blockages
Before taking ZERODOL PG 200/75 TABLET inform your doctor if you:
- have porphyria
- have diabetes
- have high blood pressure
- have blood cholesterol levels
- have inflammation of the bowel (Ex. Ulcerative colitis, Crohn’s Disease)
- have holes or blockage in the gut
- have a history of stomach ulcers
- have any autoimmune disorders that affects the skin (Systemic lupus erythematosus)
- smoke
- are an alcoholic
- have a habit of drug abuse or dependence
- have blood clots in the body
- recently had any surgery
- have chickenpox
Use in Pediatrics:
ZERODOL PG 200/75 TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before taking it.
Use in Geriatrics:
ZERODOL PG 200/75 TABLET should be used with caution in elderly patients. Therefore, consult your doctor for advice before taking it.
Interactions
A. Drug-Drug Interactions:
Before taking ZERODOL PG 200/75 TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to manage pain (Ex. aspirin, ibuprofen, naproxen, celecoxib, etoricoxib)
- medicines used to manage increased blood pressure (Ex. enalapril, lisinopril, losartan, candesartan, methyldopa, clonidine, propranolol)
- diuretics (used to reduce edema and blood pressure) Ex. furosemide, hydrochlorothiazide
- cardiac glycosides (used to correct heart rhythm (Ex. digoxin)
- medicines used to suppress immune system after organ transplantation (Ex. ciclosporin or tacrolimus)
- medicines used to stop blood clotting (Ex. warfarin, heparin, clopidogrel)
- corticosteroids (used to manage pain and inflammation) Ex. hydrocortisone, prednisolone
- medicines used to manage infections (Ex. ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin)
- medicines used to manage depression (Ex. citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine and sertraline)
- medicines used to manage cancer and autoimmune disorders such as arthritis and skin conditions (Ex. methotrexate)
- mifepristone, ethinyl estradiol (birth control pills)
- medicines used to manage HIV infection (Ex. zidovudine)
- medicines used to manage diabetes (Ex. glibenclamide, gliclazide, tolbutamide)
- oxycodone (used as a pain killer)
- lorazepam (used for reducing anxiety)
- opioid analgesics (used for pain relief) such as morphine, pethidine, fentanyl
- medicines used to reduce muscle pain or spasms (baclofen, tizanidine, chlorzoxazone)
Overdosage:
If you or anyone else accidentally took more ZERODOL PG 200/75 TABLET, consult your doctor immediately or visit the nearby hospital straight away. Symptoms of overdosage might include sleepiness, confusion, agitation, restlessness and fits.
Synopsis
| Drug | : | Aceclofenac, Pregabalin |
| Pharmacological Category | : | COX-2 inhibitor, GABA Analogs |
| Therapeutic Indication | : | Pain Relief |
| Dosage Forms | : | Tablet |
More Information
- Keep ZERODOL PG 200/75 TABLET out of reach of children
- Store ZERODOL PG 200/75 TABLET at room temperature
- Protect from light and moisture
FAQs About ZERODOL PG 200/75 TABLET
Q: How long will it take for ZERODOL PG 200/75 TABLET to start acting?
A: ZERODOL PG 200/75 TABLET may start to exert its analgesic effects from day 2 of administration. An initial benefit of pain relief can be seen in patients after 2-4 weeks of therapy. However, it may take few months to show effects in some individuals.
Q: Can ZERODOL PG 200/75 TABLET manage diabetic neuropathy?
A: Yes. ZERODOL PG 200/75 TABLET can be used to manage diabetic neuropathy. It provides symptomatic pain relief in patients who have nerve pain caused due to diabetes.
Q: What happens if I stop taking ZERODOL PG 200/75 TABLET?
A: Do not stop taking ZERODOL PG 200/75 TABLET unless your doctor tells you as it may lead to withdrawal symptoms such as difficulty in falling asleep, anxiety, nausea, headache, diarrhea, flu-like symptoms, fits, nervousness, depression, dizziness, pain and sweating. Therefore, continue to take ZERODOL PG 200/75 TABLET as long as instructed by your doctor to achieve better results.
Q: Is taking ZERODOL PG 200/75 TABLET safe?
A: The safety of ZERODOL PG 200/75 TABLET varies with patient to patient. Your doctor will closely monitor your health condition while taking ZERODOL PG 200/75 TABLET to avoid the risk of side effects.
Q: Is ZERODOL PG 200/75 TABLET addictive?
A: Research has shown that ZERODOL PG 200/75 TABLET can cause drug abuse or dependence. Therefore, it is better to inform your doctor before taking this medicine, if you already have a previous history of substance abuse as a precaution.
Q: Can ZERODOL PG 200/75 TABLET cause weight gain? If so, how can I manage my weight?
A: ZERODOL PG 200/75 TABLET may increase your body weight. It increases your hunger (appetite) which makes you eat more and eventually leads to increase in body weight. Weight can be managed by doing regular exercise and by eating a healthy balanced diet. Avoid calorie-rich foods such as soft drinks, chips, cakes, biscuits and sweets. Research says that patients with diabetes tend to put on weight easily while taking ZERODOL PG 200/75 TABLET. Dose adjustments for antidiabetic medicines can help in such situations. If the symptom bothers you, consult your doctor for advice.
Q: Can ZERODOL PG 200/75 TABLET cause sleepiness or drowsiness?
A: Yes. ZERODOL PG 200/75 TABLET may cause sleepiness and drowsiness. Rest and relax while feeling sleepy. Avoid consumption of alcohol while taking ZERODOL PG 200/75 TABLET as it can make you feel drowsier. Do not drive or operate any tools or machines while you are feeling sleepy. Consult your doctor if the symptom bothers you.
Q: Will the use of ZERODOL PG 200/75 TABLET affect my sex life?
A: Yes. ZERODOL PG 200/75 TABLET can affect sexual life of both men and women. It decreases sexual desire in men and women and can cause difficulty in erection or delayed ejaculation in men. The exact mechanism behind these effects is not known. If you experience any such problems, contact your doctor immediately.
Q: Can I take ZERODOL PG 200/75 TABLET along with alcohol?
A: No. Avoid consumption of alcohol while taking ZERODOL PG 200/75 TABLET as it may make you feel drowsier. Moreover, ZERODOL PG 200/75 TABLET is not recommended for use in patients having alcohol abuse unless considered necessary. Therefore, consult your doctor before taking it.
Q: Can I take a higher dose of ZERODOL PG 200/75 TABLET to increase pain relieving effects?
A: No. Do not take a higher dose of ZERODOL PG 200/75 TABLET than recommended by your doctor. Taking a higher dose of ZERODOL PG 200/75 TABLET without consulting a doctor can increase the risk of toxicity and can lead to side effects. If the prescribed dose is not effective for you, consult your doctor for a suitable higher dose. Never consume a higher dose ZERODOL PG 200/75 TABLET without proper medical supervision.
Q: What to do if I forgot to take ZERODOL PG 200/75 TABLET?
A: Take ZERODOL PG 200/75 TABLET as soon as you remember until it’s time for the next one. If you missed a dose, skip the missed one and take the next dose at time normally you would take. Do not take a double dose to make up the missed one, as it may lead to overdosage. If you are not sure, consult your doctor. Your doctor may instruct you about the next steps.
Q: What are the precautions that I need to follow while taking ZERODOL PG 200/75 TABLET?
A: Before taking ZERODOL PG 200/75 TABLET, inform your doctor about your pre-existing disease conditions (such as liver problems, kidney problems, stomach problems) as a precaution. ZERODOL PG 200/75 TABLET should not be used if you are planning to become pregnant without consulting your doctor. ZERODOL PG 200/75 TABLET can cause extreme sleepiness and dizziness and therefore avoid taking other medicines or alcohol that can make you feel drowsier ever more. It can also impair memory, attention and thinking ability in few individuals and so avoid travelling or driving on your own for a while. If case of any queries, consult your doctor for advice.
Q: How to take ZERODOL PG 200/75 TABLET?
A: Take ZERODOL PG 200/75 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not chew or crush the medicine. It is preferably taken with meals to avoid gastric irritation.
Q: Can I take ZERODOL PG 200/75 TABLET daily?
A: Take ZERODOL PG 200/75 TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take ZERODOL PG 200/75 TABLET every day or not.
Q: Is ZERODOL PG 200/75 TABLET safe to use in diabetic patients?
A: ZERODOL PG 200/75 TABLET may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking ZERODOL PG 200/75 TABLET as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.
Q: Can the use of ZERODOL PG 200/75 TABLET affect the liver?
A: Yes. ZERODOL PG 200/75 TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it is not recommended for use in patients with liver failure. It should be used with caution in patients with other mild liver problems. Consult your doctor before taking it.
Q: How ZERODOL PG 200/75 TABLET works?
A: ZERODOL PG 200/75 TABLET is a pain-relieving medicine. It reduces pain sensation by interfering with the pain signals travelling between the damaged nerves and the brain. It also blocks the release of certain chemicals (such as prostaglandins) in the body that causes pain, inflammation and swelling. As a result, it reduces nerve pain, joint pain and back pain.
Q: What are the side effects of ZERODOL PG 200/75 TABLET?
The most common side effects of taking ZERODOL PG 200/75 TABLET are nausea, indigestion, heartburn, stomach pain, constipation, dizziness, drowsiness, headache, lack of attention, clumsiness, memory impairment, tingling or numbness, blurred vision, weight gain, difficulties with erection, decreased sexual drive, delayed ejaculation and muscle cramps. Consult your doctor if any of these side effect worsens.
References
1. KD. Tripathi. Nonsteroidal Anti-Inflammatory Drugs and Antipyretic-Analgesics. Antiepileptic Drugs. Essentials of Medical Pharmacology. Seventh edition. Page – 204 & 790.
2. K. Yashas Sree, B Mounica, L Chandini Devi, K Divya Vani, Dr. M Pratibha, Dr. M Sudhakar. A study on efficacy of aceclofenac versus aceclofenac plus pregabalin in management of nonspecific chronic low back pain. International Journal of Medical and Health Research. 2019. [Accessed on 14th January 2023]. http://www.medicalsciencejournal.com/archives/2019/vol5/issue6/5-6-11
3. Laboratories BTT. Aceclofenac 100 mg Film-coated Tablets Aceclofenac. Electronic Medicines Compendium. [Revised in January 2016]. [Accessed on 14th January 2023]. https://www.medicines.org.uk/emc/files/pil.2389.pdf
4. MSN Laboratories Europe Limited. Pregabalin. Electronic Medicines Compendium. [Revised in March 2022]. [Accessed on 14th January 2023]. https://www.medicines.org.uk/emc/files/pil.13402.pdf
5. Lyrica (Pregabalin). Frequently asked questions. [Accessed on 14th January 2023]. https://www.lyrica.com/frequently-asked-questions
6. Leeford Healthcare Pvt Ltd. Alcinac PG Forte. [Accessed on 14th January 2023]. https://www.leeford.in/product/870/alcinac-pg-forte
Useful Diagnostic Tests
- Nerve conduction test
- Electroencephalogram (EEG)
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